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| 1 | Long-term outcome of percutaneous ethanol injection therapy for minimum-sized hepatocellular carcinoma显示文摘AIM: To evaluate long-term follow-up of minimum-sized hepatocellular carcinoma (HCC) treated with percutaneous ethanol injection (PEI). METHODS: PEI was applied to 42 lesions in 31 patients (23 male and eight female) with HCC < 15 mm in diameter, over the past 15 years. RESULTS: Overall survival rate was 74.1% at 3 years, 49.9% at 5 years, 27.2% at 7 years and 14.5% at 10 years. These results are superior to, or at least the same as those for hepatic resection and radiofrequency ablation. Survival was affected only by liver function, but not by sex, age, etiology of Hepatitis B virus or Hepatitis C virus, α-fetoprotein levels, arterial and portal blood flow, histological characteristics, and tumor multiplicity or size. Patients in Child-Pugh class A and B had 5-, 7- and 10-years survival rates of 76.0%, 42.2% and 15.8%, and 17.1%, 8.6% and 0%, respectively (P = 0.025). CONCLUSION: Treatment with PEI is best indicated for patients with HCC < 15 mm in Child-Pugh class A. | Miyuki Taniguchi Soo Ryang Kim Susumu Imoto Hirotsugu Ikawa Kenji Ando Keiji Mita Shuichi Fuki Noriko Sasase Toshiyuki Matsuoka Masatoshi Kudo Yoshitake Hayashi | 2008 | World Journal of Gastroenterology2008，14，13： | 16 |
| 2 | Diagnostic sensitivity of imaging modalities for hepatocellular carcinoma smaller than 2 cm显示文摘AIM:To compare the imaging results with histology and to evaluate the diagnostic sensitivity of imaging modalities for hepatocellular carcinoma(HCC)smaller than 2 cm.METHODS:Nodules smaller than 2 cm(n=34)revealed by ultrasonography(US)in 29 patients with liver cirrhosis were analyzed.Histological diagnosis of HCC was performed by ultrasonographic guidance:moderately-differentiated HCC(n=24);well-differentiated HCC(n=10).The patterns disclosed by the four imaging modalities defined the conclusive diagnosis of HCC:(1)contrast-enhanced computed tomography(CECT),hypervascularity in the arterial phase and washout in the equilibrium phase;(2)Sonazoid contrast-enhanced US(CEUS),hypervascularity in the early vascular phase and defect in the Kupffer phase;(3)gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid(Gd-EOBDTPA)-enhanced magnetic resonance imaging(MRI),hypervascularity in the arterial phase and/or defect in the hepatobiliary phase;and(4)CT arterioportal angiography:hypervascularity by CT during arteriography and/ or perfusion defect by CT during arterial portography.RESULTS:Overall,the sensitivity of diagnosing HCC smaller than 2 cm was 52.9%(18/34)(95%CI:35.170.2)by CECT;67.6%(23/34)(95%CI:49.5-82.6)by Sonazoid CEUS;76.5%(26/34)(95%CI:58.8-89.3) by Gd-EOB-DTPA MRI;and 88.2%(30/34)(95%CI: 72.5-96.7)by CT arterioportal angiography.The diagnostic sensitivity of detecting moderately-differentiated HCC by CECT,Sonazoid CEUS,Gd-EOB-DTPA MRI and CT arterioportal angiography was 62.5%(15/24)(95%CI: 40.6-81.2),79.2%(19/24)(95%CI:57.8-92.9),75.0% (18/24)(95%CI:53.3-90.2)and 95.8%(23/24)(95% CI:78.9-99.9),respectively.A significant difference(P< 0.05)was observed between CECT and CT arterioportal angiography in all nodules.There was no difference between Sonazoid CEUS,Gd-EOB-DTPA MRI,and CT arterioportal angiography.The combined sensitivity of Sonazoid CEUS and Gd-EOB-DTPA MRI was 94.1%(32/34).CONCLUSION:Changing the main diagnostic modality for HCC smaller than 2 cm from CT arterioportal angiography to Sonazoid CEUS and Gd-EOB-DTPA MRI is recommended. | Keiji Mita Soo Ryang Kim Masatoshi Kudo Susumu Imoto Taisuke Nakajima Kenji Ando Katsumi Fukuda Toshiyuki Matsuoka Yoko Maekawa Yoshitake Hayashi | 2010 | World Journal of Gastroenterology2010，16，33： | 7 |
| 3 | Scirrhous hepatocellular carcinoma displaying atypical findings on imaging studies显示文摘We describe a 15-mm scirrhous hepatocellular carcinoma(HCC) in a 60-year-old man with B-type cirrhosis.Ultrasound disclosed a 15-mm hypoechoic nodule in segment 7.Contrast-enhanced US revealed heterogeneous,not diffuse,hypervascularity in the early phase and a defect in the Kupffer phase.Contrast-enhanced computed tomography(CT) revealed a heterogeneous hypervascular nodule in the early phase and a low-density area in the late phase.Magnetic resonance imaging(MRI) revealed iso-to hypointensity at T1 and high intensity at T2-weighted sequences.Contrast-enhanced MRI also revealed a heterogeneous hypervascular nodule in the early phase and washout in the late phase.Super-paramagnetic iron oxide-MRI revealed a hyperintense nodule.CT during hepatic arteriography and CT during arterial portography revealed heterogeneous hyperattenuation and a perfusion defect,respectively.Based on these imaging findings the nodule was diagnosed as a mixed well-differentiated and moderately-differentiated HCC.Histologically,the nodule was moderately-differentiated HCC characterized by typical cytological and structural atypia with dense fibrosis.Immunohistochemically,the nodule was positive for heterochromatin protein 1 and alpha-smooth muscle actin,and negative for cytokeratin 19.From the above findings,the nodule was diagnosed as scirrhous HCC.Clinicians engaged in hepatology should exercise caution with suspected scirrhous HCC when imaging studies reveal atypical findings,as shown in our case on the basis of chronic liver disease. | Soo Ryang Kim Susumu Imoto Taisuke Nakajima Kenji Ando Keiji Mita Katsumi Fukuda Ryo Nishikawa Yu-ichiro Koma Toshiyuki Matsuoka Masatoshi Kudo Yoshitake Hayashi | 2009 | World Journal of Gastroenterology2009，15，18： | 4 |
| 4 | Multistep hepatocarcinogenesis from a dysplastic nodule to well-differentiated hepatocellular carcinoma in a patient with alcohol-related liver cirrhosis显示文摘We describe a rare case of the transformation of a dysplastic nodule into well-differentiated hepato- cellular carcinoma (HCC) in a 56-year-old man with alcoholrelated liver cirrhosis. Ultrasound (US) disclosed a 10 mm hypoechoic nodule and contrast enhanced US revealed a hypovascular nodule, both in segment seven. US-guided biopsy revealed a high-grade dysplastic nodule characterized by enhanced cellularity with a high N/C ratio, increased cytoplasmic eosinophilia, and slight cell atypia. One year later, the US pattern of the nodule changed from hypoechoic to hyperechoic without any change in size or hypovascularity. US-guided biopsy revealed well-differentiated HCC of the same features as shown in the first biopsy, but with additional pseudoglandular formation and moderate cell atypia. Moreover, immunohistochemical staining of cyclase- associated protein 2, a new molecular marker of well- differentiated HCC, turned positive. This is the first case of multistep hepatocarcinogenesis from a dysplastic nodule to well-differentiated HCC within one year in alcohol-related liver cirrhosis. | Soo Ryang Kim Hirotsugu Ikawa Kenji Ando Keiji Mita Shuichi Fuki Michiie Sakamoto Yoshihiro Kanbara Toshiyuki Matsuoka Masatoshi Kudo Yoshitake Hayashi | 2007 | World Journal of Gastroenterology2007，13，8： | 4 |
| 5 | A Novel Molecular Targeting Compound as K-samII/FGF-R2 Phosphorylation Inhibitor, Ki23057, for Scirrhous Gastric Cancer显示文摘 | Kazunori Nakamura Masakazu Yashiro Tasuku Matsuoka Masashige Tendo Toshiyuki Shimizu Atsushi Miwa Kosei Hirakawa | 2006 | Gastroenterology2006，，5： | 2 |
| 6 | Modified Glasgow prognostic score in patients with incurable stage IV colorectal cancer显示文摘 | Tomokazu Kishiki Tadahiko Masaki Hiroyoshi Matsuoka Takaaki Kobayashi Yutaka Suzuki Nobutsugu Abe Toshiyuki Mori Masanori Sugiyama | 2013 | The American Journal of Surgery2013，，2： | 1 |
| 7 | Evidence-based clinical practice guidelines for Crohn’s disease, integrated with formal consensus of experts in Japan显示文摘 | Fumiaki Ueno Toshiyuki Matsui Takayuki Matsumoto Katsuyoshi Matsuoka Mamoru Watanabe Toshifumi Hibi | 2013 | Journal of Gastroenterology2013，，1： | 1 |
| 8 | Secure placement of a peripancreatic drain after a distal pancreatectomy显示文摘 | Masanori Sugiyama Yutaka Suzuki Nobutsugu Abe Hiroyoshi Matsuoka Osamu Yanagida Tadahiko Masaki Toshiyuki Mori Yuaka Atomi | 2010 | The American Journal of Surgery2010，，2： | 1 |
| 9 | Hepatocellular carcinoma metastasizing to the skull base involving multiple cranial nerves显示文摘We describe a rare case of HCV-related recurrent multiple hepatocellular carcinoma (HCC) metastasizing to the skull base involving multiple cranial nerves in a 50-year- old woman. The patient presented with symptoms of ptosis, fixation of the right eyeball, and left abducens palsy, indicating disturbances of the right oculomotor and trochlear nerves and bilateral abducens nerves. Brain contrast-enhanced computed tomography (CT) revealed an ill-defined mass with abnormal enhancement around the sella turcica. Brain magnetic resonance imaging (MRI) disclosed that the mass involved the clivus, cavernous sinus, and petrous apex. On contrast-enhanced MRI with gadolinium-chelated contrast medium, the mass showed inhomogeneous intermediate enhancement. The diagnosis of metastatic HCC to the skull base was made on the basis of neurological findings and imaging studies including CT and MRI, without histological examinations. Further studies may provide insights into various methods for diagnosing HCC metastasizing to the craniospinal area. | Soo Ryang Kim Fumio Kanda Hiroshi Kobessho Koji Sugimoto Toshiyuki Matsuoka Masatoshi Kudo Yoshitake Hayashi | 2006 | World Journal of Gastroenterology2006，12，41： | 1 |
| 10 | Evidence-based clinical practice guidelines for Crohn’s disease, integrated with formal consensus of experts in Japan显示文摘 | Fumiaki Ueno Toshiyuki Matsui Takayuki Matsumoto Katsuyoshi Matsuoka Mamoru Watanabe Toshifumi Hibi | 2013 | Journal of Gastroenterology2013，，1： | 1 |
| 11 | Frequency and Risk Factors of Various Complications After Computed Tomography–Guided Radiofrequency Ablation of Lung Tumors显示文摘 | Tomohisa Okuma Toshiyuki Matsuoka Akira Yamamoto Yoshimasa Oyama Masami Toyoshima Kenji Nakamura Yuichi Inoue | 2008 | CardioVascular and Interventional Radiology2008，，1： | 1 |
| 12 | Percutaneous Radiofrequency Ablation for Pulmonary Metastases from Hepatocellular Carcinoma: Results of a Multicenter Study in Japan显示文摘 | Takao Hiraki Koichiro Yamakado Osamu Ikeda Toshiyuki Matsuoka Toshio Kaminou Takuji Yamagami Hideo Gobara Hidefumi Mimura Koichi Kawanaka Kan Takeda Yasuyuki Yamashita Yuichi Inoue Toshihide Ogawa Tsunehiko Nishimura Susumu Kanazawa | 2011 | Journal of Vascular and Interventional Radiology2011，，6： | 1 |
| 13 | The novel and orally active thrombin receptor antagonist E5555 (Atopaxar) inhibits arterial thrombosis without affecting bleeding time in guinea pigs显示文摘 | Motoji Kogushi Toshiyuki Matsuoka Tsutomu Kawata Hiroko Kuramochi Shinki Kawaguchi Kimiyo Murakami Hironobu Hiyoshi Shuichi Suzuki Tetsuya Kawahara Akiharu Kajiwara Ieharu Hishinuma | 2011 | European Journal of Pharmacology2011，，1： | 1 |
| 14 | Oral administration of the thrombin receptor antagonist E5555 (atopaxar) attenuates intimal thickening following balloon injury in rats显示文摘 | Motoji Kogushi Toshiyuki Matsuoka Hiroko Kuramochi Kimiyo Murakami Tsutomu Kawata Akifumi Kimura Kenichi Chiba Takashi Musha Shuichi Suzuki Tetsuya Kawahara Akiharu Kajiwara Ieharu Hishinuma | 2011 | European Journal of Pharmacology2011，，1： | 1 |
| 15 | Cholecystectomy by a combined transgastric and transparietal approach using two flexible endoscopes显示文摘 | Nobutsugu Abe Hirohisa Takeuchi Hisayo Ueki Hiroyoshi Matsuoka Osamu Yanagida Tadahiko Masaki Toshiyuki Mori Masanori Sugiyama Yutaka Atomi | 2009 | Journal of Hepato-Biliary-Pancreatic Surgery2009，，1： | 1 |
| 16 | Radiofrequency Ablation of Liver Tumors in Combination with Local OK-432 Injection Prolongs Survival and Suppresses Distant Tumor Growth in the Rabbit Model with Intra- and Extrahepatic VX2 Tumors显示文摘 | Ken Kageyama Akira Yamamoto Tomohisa Okuma Shinichi Hamamoto Toru Takeshita Yukimasa Sakai Norifumi Nishida Toshiyuki Matsuoka Yukio Miki | 2013 | CardioVascular and Interventional Radiology2013，，5： | 1 |
| 17 | Evidence-based clinical practice guidelines for Crohn’s disease, integrated with formal consensus of experts in Japan显示文摘 | Fumiaki Ueno Toshiyuki Matsui Takayuki Matsumoto Katsuyoshi Matsuoka Mamoru Watanabe Toshifumi Hibi | 2013 | Journal of Gastroenterology2013，，1： | 1 |
| 18 | Radiofrequency Ablated Lesion in the Normal Porcine Lung: Long-Term Follow-Up with MRI and Pathology显示文摘 | Yoshimasa Oyama Kenji Nakamura Toshiyuki Matsuoka Masami Toyoshima Akira Yamamoto Tomohisa Okuma Yoshihiro Ikura Makiko Ueda Yuichi Inoue | 2005 | CardioVascular and Interventional Radiology2005，，3： | 1 |
| 19 | Well to moderately differentiated HCC manifesting hyperattenuation on both CT during arteriography and arterial portography显示文摘We present a rare case of well-to moderately-differentiated hepatocellular carcinoma (HCC) in a 71-year-old woman with hepatitis C virus-related cirrhosis and unusual radiologic features. A 20-mm hypoechoic nodule disclosed by ultrasound in segment two showed hyperattenuation on both computed tomography hepatic arteriography and computed tomography during arterial portography. Contrast-enhanced ultrasound revealed hypervascularity in the early vascular phase and defect in the post-vascular phase, with the same pattern detected by the two imaging techniques. SPIO-MRI revealed a hyperintense nodule. These findings were compatible with those of moderately-differentiated HCC. An ultrasound-guided biopsy showed histological features of well-to moderately-differentiated HCC characterized by more than two-fold the cellularity of the non-tumorous area, fatty change, clear cell change and mild cell atypia with a thin to mid-trabecular pattern. Further studies may provide insights into the correlation between tumor neovascularity in multistep hepatocarcinogenesis and dual hemodynamics, including the artery and the portal vein. | Soo Ryang Kim Susumu Imoto Hirotsugu Ikawa Kenji Ando Keiji Mita Shuichi Fuki Michiie Sakamoto Yoshihiro Kanbara Toshiyuki Matsuoka Masatoshi Kudo Yoshitake Hayashi | 2007 | World Journal of Gastroenterology2007，13，43： | 0 |
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