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| 1 | Ultrasound-assessed non-culprit and culprit coronary vessels differ by age and gender显示文摘AIM: To investigate age-and gender-related differences in non-culprit versus culprit coronary vessels assessed with virtual histology intravascular ultrasound (VH-IVUS). METHODS: In 390 patients referred for coronary angiography to a single center (Luzerner Kantonsspital, Switzerland) between May 2007 and January 2011, 691 proximal vessel segments in left anterior descending, circumflex and/or right coronary arteries were imaged by VH-IVUS. Plaque burden and plaque composition(fibrous, fibro-fatty, necrotic core and dense calcium volumes) were analyzed in 3 age tertiles, according to gender and separated for vessels containing non-culprit or culprit lesions. To classify as vessel containing a culprit lesion, the patient had to present with an acute coronary syndrome, and the VH-IVUS had to be performed in a vessel segment containing the culprit lesion according to conventional coronary angiography. RESULTS: In non-culprit vessels the plaque burden increased significantly with aging (in men from 37% ± 12% in the lowest to 46% ± 10% in the highest age tertile, P < 0.001; in women from 30% ± 9% to 40% ± 11%, P < 0.001); men had higher plaque burden than women at any age (P < 0.001 for each of the 3 age tertiles). In culprit vessels of the lowest age tertile, plaque burden was significantly higher than that in non- culprit vessels (in men 48% ± 6%, P < 0.001 as compared to non-culprit vessels; in women 44% ± 18%, P = 0.004 as compared to non-culprit vessels). Plaque burden of culprit vessels did not significantly change during aging (plaque burden in men of the highest age tertile 51% ± 9%, P = 0.523 as compared to lowest age tertile; in women of the highest age tertile 49% ± 8%, P = 0.449 as compared to lowest age tertile). In men, plaque morphology of culprit vessels became increasingly rupture-prone during aging (increasing percentages of necrotic core and dense calcium), whereas plaque morphology in non-culprit vessels was less rupture-prone and remained constant during aging. In women, necrotic core in non-culprit vessels was very low at young age, but increased during aging resulting in a plaque morphology that was very similar to men. Plaque morphology in culprit vessels of young women and men was similar. CONCLUSION: This study provides evidence that age-and gender-related differences in plaque burden and plaque composition significantly depend on whether the vessel contained a non-culprit or culprit lesion. | Andreas W Schoenenberger Nadja Urbanek Stefan Toggweiler Andreas E Stuck Thérèse J Resink Paul Erne | 2013 | World Journal of Cardiology2013，5，3： | 7 |
| 2 | T-cadherin is present on endothelial microparticles and is elevated in plasma in early atherosclerosis 显示文摘 | Philippova M Suter Y Toggweiler S | 2011 | Eur Heart J2011，32，6： | 1 |
| 3 | Isolated posterior mitral valve cleft显示文摘 | ToggweilerS Hürlimann D Grüenfelder J | 2009 | Kardiovaskulüre Medizin2009，，： | 1 |
| 4 | Midlatitude westerlies,atmospheric CO2,and climate change during the ice ages显示文摘 | Toggweiler J R Russell J L Carson S R | | 0，，： | 1 |
| 5 | Shifting westerlies显示文摘 | Toggweiler J R | | 0，，： | 1 |
| 6 | Ocean carbon-cycle dynamics and atmospheric Pco2 显示文摘 | SARMIENTO J L TOGGWEILER J R NAJJAR R | 1988 | Philosophical Transactions of the Royal Society of London A1988，325，： | 1 |
| 7 | Prognostic value of N-terminal pro-B-type natriuretic peptide in patients with acute coronary syn- dromes undergoing left main percutaneous coronary intervention 显示文摘 | Jaberg L Toggweiler S Puck M | 2011 | Circ J2011，75，11： | 1 |
| 8 | Comparison of different approaches for optimization of atrioventricular and interventricular delay in biventricular pacing 显示文摘 | Zuber M Toggweiler S Roos M | 2008 | Europace2008，10，3： | 1 |
| 9 | Simulations of radiocarbon in a coarse-resolution world ocean model, 2,Distributions of bomb-produced carbon 14 显示文摘 | TOGGWEILER J R DIXON R BRYAN K | 1989 | J Geophys Res1989，94，： | 1 |
| 10 | In-stent restenosis and thrombosis 41 months after drug-eluting stent implantation 显示文摘 | JAMSHIDI P TOGGWEILER S ERNE P | 2008 | International Journal of Cardiology2008，130，3： | 1 |
| 11 | The control of atmospheric pCO2 by ocean ventilation change:The effect of the oceanic storage of biogenic carbon显示文摘 | Kwon E Y Sarmiento J L Toggweiler J R | | 0，，： | 1 |
| 12 | Transcatheter valve-in-valve implantation for failed balloon-expandable transcatheter aortic valves显示文摘 | Toggweiler S Wood DA Rodes-Cabau J | | 0，，： | 1 |
| 13 | Challenges in transcatheter aortic valve implantation显示文摘 | Toggweiler S Webb JG | | 0，，： | 1 |
| 14 | Improved Response to Cardiac Resynchronization Therapy Through Optimization of Atrioventricular and Interventricular Delays Using Acoustic Cardiography: A Pilot Study显示文摘 | Stefan Toggweiler Michel Zuber Richard Kobza Markus Roos Peiman Jamshidi Rolf Meier Paul Erne | 2007 | Journal of Cardiac Failure2007，，8： | 1 |
| 15 | Instability of the lhermohalinc eirculation with respect to mixed boundary conditions: Is it really a problem for realistic models? 显示文摘 | Tziperman E Toggweiler J R Feliks Y | 1994 | Journal of Physical Oceanography1994，24，： | 1 |
| 16 | Hydrography, chemistry and radioisotopes in the southeast asian basins显示文摘 | Broecker W Patzert W Toggweiler J | 1986 | Journal of Geophysical Research1986，91，14： | 1 |
| 17 | 5-year outcome after transcatheter aortic valve implantation显示文摘 | Toggweiler S Humphries KH Lee M | | 0，，： | 1 |
| 18 | Ocean carbon-cycle dy- namics and atmospheric pCO2 显示文摘 | Sarraiento J L Toggweiler J R Najjar R | 1988 | Phil Trans R Soc Lond A1988，325，： | 1 |
| 19 | T-cadherin is present on endothelial microparticles and is elevated in plasma in early atherosclerosis 显示文摘 | Philippova M Surer Y Toggweiler S | 2011 | Eur Heart J2011，32，6： | 1 |
| 20 | Analysis of coronary bifurcations by intravascular ultrasound and virtual histol- ogy显示文摘 | Toggweiler S Urbanek N Schoenenberger AW | 2010 | Atherosclerosis2010，212，2： | 1 |
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