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| 1 | Sitagliptin in patients with non-alcoholic steatohepatitis: A randomized, placebo-controlled trial显示文摘AIM To evaluate the effect of sitagliptin vs placebo on histologic and non-histologic parameters of nonalcoholic steatohepatitis(NASH).METHODS Twelve patients with biopsy-proven NASH were randomized to sitagliptin(100 mg daily)(n=6)or placebo(n=6)for 24 wk.The primary outcome was improvement in liver fibrosis after 24 wk.Secondary outcomes included evaluation of changes in NAFLD activity score(NAS),individual components of NAS(hepatocyte ballooning,lobular inflammation,and steatosis),glycemic control and insulin resistance[including measurements of glycated hemoglobin(Hb A1C)and adipocytokines],lipid profile including free fatty acids,adipose distribution measured using magnetic resonance imaging(MRI),and thrombosis markers(platelet aggregation and plasminogen activator inhibitor 1 levels).We also sought to determine the correlation between changes in hepatic fat fraction(%)[as measured using the Iterative Decomposition of water and fat with Echo Asymmetry and Least-squares estimation(IDEAL)MRI technique]and changes in hepatic steatosis on liver biopsy.RESULTS Sitagliptin was not significantly better than placebo at reducing liver fibrosis score as measured on liver biopsy(mean difference between sitagliptin and placebo arms,0.40,P=0.82).There were no significant improvements evident with the use of sitagliptin vs placebo for the secondary histologic outcomes of NAS total score as well as for the individual components of NAS.Compared to baseline,those patients who received sitagliptin demonstrated improved Hb A1C(6.7%±0.4%vs 7.9%±1.0%,P=0.02),and trended towards improved adiponectin levels(4.7±3.5μg/m L vs 3.9±2.7μg/m L,P=0.06)and triglyceride levels(1.26±0.43 mmol/L vs 2.80±1.64 mmol/L,P=0.08).However,when compared with placebo,sitagliptin did not cause a statistically significant improvement in Hb A1C(mean difference,-0.7%,P=0.19)nor triglyceride levels(mean difference-1.10mmol/L,P=0.19)but did trend towards improved adiponectin levels only(mean difference,0.60μg/m L,P=0.095).No significant changes in anthropometrics,liver enzymes,other adipocytokines,lipid profile,thrombosis parameters,or adipose distribution were demonstrated.The MRI IDEAL procedure correlated well with steatosis scores obtained on liver biopsy in both groups at baseline and post-treatment,and the Spearman correlation coefficients ranged from r=0.819(baseline)to r=0.878(post-treatment),P=0.002.CONCLUSION Sitagliptin does not improve fibrosis score or NAS after 24 wk of therapy.The MRI IDEAL technique may be useful for non-invasive measurement of hepatic steatosis. | Tisha R Joy Charles A McKenzie Rommel G Tirona Kelly Summers Shannon Seney Subrata Chakrabarti Neel Malhotra Melanie D Beaton | 2017 | World Journal of Gastroenterology2017，23，1： | 18 |
| 2 | Digital fluoroscopy to quantify lung tumor motion:potential for patient-specific planning target volumes显示文摘 | Sixel KE Ruschin M Tirona R | 2003 | Int J Radiat Oncol Biol Phys2003，57，3： | 1 |
| 3 | Reproducibility of lung tumor position and reduction of lung mass within the planning target volume using active breathing control(ABC)显示文摘 | Cheung P C Sixel K E Tirona R | 2003 | Int J Radiat Oncol Biol Phys2003，57，5： | 1 |
| 4 | Use of CT simula- tion for treatment of cervical cancer to assess the adequacy of lymph node corverage of conventional pelvic dields based on bony land-marks显示文摘 | Finlay M H Ackerman I Tirona R G | 2006 | Int J Radiat Oncol Biol Phys2006，64，： | 1 |
| 5 | The orphan nuclear receptor HNF4alpha determines PXR-and CAR-mediated xenobiotic induction of CYP3A4显示文摘 | Tirona R G Lee W Leake B F | 2003 | Nat Med2003，9，2： | 1 |
| 6 | Correlation of lung tumor motion with external surrogate indicators of resp- iration显示文摘 | Hoisak J D Sixel K E Tirona R | 2004 | Int J Radiat Oncol Biol Phys2004，60，4： | 1 |
| 7 | Reproducibility of lung tumor position and reduction of lung mass within the planning target volume using active breathing control (ABC)显示文摘 | Cheung PC Sixel KE Tirona R | 2003 | Int J Radiat Oncol Phys2003，57，5： | 1 |
| 8 | Nuclear receptors and drug disposition gene regulation显示文摘 | Tirona R G Kim R B | 2005 | Journal of Pharmaceutical Sciences2005，94，6： | 1 |
| 9 | Reproducibility of Lung tumor position and reduction of Lung mass within the planning target volume using active breathing control(ABC)显示文摘 | sixel KE Tirona R | 2003 | Int J Radiat Oncol Biol Phys2003，57，5： | 1 |
| 10 | Pharmacogenetics of ATPbinding cassette transporters in cancer and chemotherapy 显示文摘 | LOCKHART A C TIRONA R G KIM R B | 2003 | Mol Cancer Ther2003，2，7： | 1 |
| 11 | Correlation of lung tumor motion with external surrogate indicators of respiration显示文摘 | Hoisak J D Sixel K E Tirona R | 2004 | Int J Radiat Oncol Biol Phys2004，60，4： | 1 |
| 12 | Breast cancer resistance protein (ABCG2) and drug disposition: intestinal expression, polymorphisms and sulfasalazine as an in vivo probe显示文摘 | URQUHART B L WARE J A TIRONA R G | 2008 | Pharmacogenet Genomics2008，18，5： | 1 |
| 13 | Herbal product-drug interactions mediated by induction显示文摘 | Tirona R G Bailey D G | 2006 | Br J Clin Pharmacol2006，61，6： | 1 |
| 14 | Polymorphisms in OATP-C:identification of multiple allelic variants associated with altered transport activity among European-and African-Americans显示文摘 | Tirona R G Leake B F Merino G | 2001 | J Biol Chem2001，276，35： | 1 |
| 15 | Reproducibility of lung tumor position and reduction of lung mass within the planning target volume using active breathing control (ABC)显示文摘 | Cheung PC Sixel KE Tirona R | 2003 | Int J Radiat Oncol Biol Phys2003，57，5： | 1 |
| 16 | Reproducibility of lung tumor position and reduction of lung mass within the planning target volume using active breathing control (ABC)显示文摘 | Cheung P C Sixel K E Tirona R | 2003 | Int J Radiat Oncol Biol Phys2003，57，： | 1 |
| 17 | Reproducibility of lung tumor position and reduction of lung mass within the planning target volume using active breathing control (ABC) 显示文摘 | Cheung P C Sixel K E Tirona R | 2003 | Int J Radiat Oncol Biol Phys2003，57，5： | 1 |
| 18 | Pharmacogenomics of the OATP and OAT families显示文摘 | MARZOLINI C TIRONA R G KIM R B | 2004 | Pharmacogenomics2004，5，3： | 1 |
| 19 | Prevention of breast cancer (Part II): risk reduction strategies显示文摘 | Tirona MT Sehgal R Ballester O | 2010 | Cancer Invest2010，28，： | 1 |
| 20 | Interplay between the nuclear receptor pregnane X receptor and the uptake transporter organic anion transporter polypeptide 1A2 selectively enhances estrogen effects in breast cancer显示文摘 | Meyer Z U Schwabedissen H E Tirona R G | 2008 | Cancer Res2008，68，： | 1 |
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