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| 1 | Modulation of liver tolerance by conventional and nonconventional antigen-presenting cells and regulatory immune cells显示文摘肝是有有免疫力的规定的优美机制的一个 tolerogenic 机关保证本地、全身的有免疫力的忍耐的保养到自我和外国抗原,但是那也能对病原体装有效有免疫力的回答。尽管有主要 histo 相容性建筑群失配,肝 allografts 的有免疫力的特权在猪首先被认出,并且称为 “肝忍耐 effect”。而且,肝移植自发地与仅仅低剂量的免疫力的抑制被接受,并且为一样的施主的非肝的共同移植的 allografts 导致忍耐。尽管这 immunotolerogenic 环境在机关移植的背景是有利的,它在象肝炎 B 一样的长期的传染的肝疾病是有害的,导致 tumorigenesis 完成的病原体坚持和弱反肿瘤或 C,疟疾,血吸虫病或。肝是 T 房间激活的一个主要地点,但是它得到 T 房间的差或不完全的激活,导致他们的未成功的激活,疲劳,他们的受动器功能的抑制和早死亡。这被病原体利用并且能损害病原体控制和清理或允许肿瘤生长。T 房间的肝的 priming 被传统的很多个本地人和 nonconventional 调停介绍抗原的房间(APC ) 由有免疫力的偏差支持忍耐, T 房间变应力缺乏或 apoptosis 感应,并且产生并且膨胀规章的 T 房间。这评论将集中于通讯在之间古典并且在在感应的忍耐和愿望的肝的 nonclassical APC 和淋巴细胞在这个过程讨论最近的卓见进天生的淋巴细胞的角色。 | Andrea Kristina Horst Katrin Neumann Linda Diehl Gisa Tiegs | 2016 | Cellular & Molecular Immunology2016，13，3： | 26 |
| 2 | Development of high-temperature superconducting filters operating at temperatures above 90 K显示文摘This paper represents the development of a high temperature superconducting (HTS) filter, the highest operating temperature of which is up to 93 K. The filter is designed for S band with 4% fractional bandwidth and fabricated using thallium-barium-calcium-copper oxide (Tl2Ba2CaCu2O8) thin films. At 93 K, the measurements of the filter show that the insertion loss in the passband is less than 0.22 dB, the return loss is better than 20 dB, and the out-of-band rejection is more than 80 dB. The analysis on the characteristics of the filter operating at different temperatures shows that the filter can work well at temperatures around 90 K. The temperature of 93 K is the highest among the previous reports for HTS filters. The result reported in this paper is significant for HTS filters to be used in the field of microwave communication requiring high sensitivity. | XIA HouHai ZHOU ChunXia ZUO Tao HE Ming JI Lu ZHOU TieGe ZHAO XinJie FANG Lan YAN ShaoLin | 2009 | Chinese Science Bulletin2009，54，19： | 9 |
| 3 | HTS filter subsystem for future mobile communication system显示文摘A high-temperature superconducting(HTS) filter subsystem consisting of a 10-pole HTS filter with group delay self-equalization,a cryogenic low noise amplifier(LNA) ,and a cooling device is presented in this paper. The HTS filter has a 0.51% fractional bandwidth at 1955 MHz,simulated in Sonnet,and is fabricated using double-sided Tl2Ba2CaCu2O8 films on 0.5 mm thick LaAlO3 substrate. Measured responses show that the minimum insertion loss of the filter is 0.16 dB,and the out-of-band rejection is better than 75 dB. The slope is 27 dB MHz-1 at the low band edge and 22 dB MHz-1 at the upper band edge. The HTS filter subsystem has a gain of 19.3 dB and a noise figure(NF) of 0.8 dB. Furthermore,the phase distortion of HTS filters is considered,and an efficient design approach for self-equalized HTS filters is proposed. | ZUO Tao FANG Lan ZHAO XinJie ZUO Xu ZHOU TieGe YAN ShaoLin | 2008 | Science in China(Series F)2008，51，9： | 5 |
| 4 | Antigen presentation,autoantibody production,and therapeutic targets in autoimmune liver disease显示文摘The liver is an important immunological organ that controls systemic tolerance.The liver harbors professional and unconventional antigen-presenting cells that are crucial for tolerance induction and maintenance.Orchestrating the immune response in homeostasis depends on a healthy and well-toned immunological liver microenvironment,which Is maintained by the crosstalk of liver-resident antigen-presenting cells and intrahepatic and liver-infiltrating leukocytes.In response to pathogens or autoantigens,tolerance is disrupted by unknown mechanisms.Intrahepatic parenchymal and nonparenchymal cells exhibit unique antigen-presenting properties.The presentation of microbial and endogenous lipid-,metabolite-and peptide-derived antigens from the gut via conventional and nonconventional mechanisms can educate intrahepatic immune cells and elicit effector responses or tolerance.Perturbation of this balance results in autoimmune liver diseases,such as autoimmune hepatitis,primary biliary cholangitis,and primary sclerosing cholangitis.Although the exact etiologies of these autoimmune liver diseases are unknown,it is thought that the disruption of tolerance towards self-antigens and microbial metabolites and lipids,as well as alterations in bile acid composition,may result in changes in effector cell activation and polarization and may reduce or impair protective antiinflammatory regulatory T and B cell responses.Additionally,the canonical and noncanonical transmission of antigens and antigen:MHC complexes via trogocytosis or extracellular vesicles between different(non)immune cells in the liver may play a role in the induction of hepatic inflammation and tolerance.Here,we summarize emerging aspects of antigen presentation,autoantibody production,and the application of novel therapeutic approaches in the characterization and treatment of autoimmune liver diseases. | Andrea Kristina Horst Kingsley Gideon Kumashie Katrin Neumann Linda Diehl Gisa Tiegs | 2021 | Cellular & Molecular Immunology2021，18，1： | 2 |
| 5 | A T cell dependent experimental liver injury in mice inducible by concanavalin A显示文摘 | HENTSCHEL J WENDEL A | 1992 | J Clin Invest1992，90，1： | 1 |
| 6 | The Flame Retardants Tetrabromobisphenol A-Bisallylether Suppress the Induction of Interleukin-2 Receptor a Chain (CD25) in Murine Splenocytes显示文摘 | Sabine Pullen Ronald Boecker Gisa Tiegs | 2003 | Toxicology2003，184，： | 1 |
| 7 | Immune-mediated liver injury显示文摘 | Herkel J Schuchmann M Tiegs G | 2005 | J Hepatol2005，42，6： | 1 |
| 8 | A T cell-dependent experimental liver injury in mice inducible by concanavalin A显示文摘 | Tiegs G Hentschel F Wendel A | 1992 | J C linInvest1992，90，： | 1 |
| 9 | Effects of a vitamin E and selenium deficient diet supplemented with 3% cod liver oil, vitamin E or selenium显示文摘 | Tiege J | 1978 | Acta vet Scand1978，19，： | 1 |
| 10 | The spectrum of herpes simplex encephalitis in children 显示文摘 | De Tiege X Rozenberg F H~ron Be | 2008 | Eur J Paediatr Neurol2008，12，： | 1 |
| 11 | Thermal shock behavior of an alumina-SiC whicker composite显示文摘 | TIEGS T BECHER P | 1987 | J Am Ceram Soc1987，70，5： | 1 |
| 12 | The flame retardants tetrabromobisphenol A and tetrabromobisphenol A- bisallylether suppress the induction of interleukin-2 receptor alpha chain (CD25) in murine splenocytes 显示文摘 | Pullen S Boecker R Tiegs G | 2003 | Toxicology2003，184，1： | 1 |
| 13 | A T cell-dependent experimental liver injury in mice inducible by concanavalin A显示文摘 | Tiegs G Hentschel J Wendel A | 1992 | J Clin Invest1992，90，1： | 1 |
| 14 | NFkappaB and caspase-3 activity in apoptotic hepatocytes of galactosamine- sensitized mice treated with TNFalpha显示文摘 | Tapalaga D Tiegs G Angermuller S | 2002 | J Histochem Cytochem2002，50，12： | 1 |
| 15 | Zellul?re und zytokinvermittelte Mechanismen der Entzündungsantwort und ihrer Regulation bei Lebersch?digung显示文摘 | G Tiegs | 2007 | Z Gastroenterol2007，，01： | 1 |
| 16 | Toughening behavior involving multiple mechanisms:whisker reinforcement and zirconia toughening显示文摘 | P F Becher T N Tiegs | 1987 | Journal of American Ceramic Society1987，70，9： | 1 |
| 17 | A T cell dependent experimental liver injury in mice inducible by eoneanavalin A显示文摘 | Tiegs G Hentschel J Wendel A | 1992 | J Clin Invest1992，90，1： | 1 |
| 18 | A T cell-dependent experimental liver injury in mice inducible by concanavalin A显示文摘 | Tiegs G Hentschel J Wendel A | 1992 | The Journal of clinical investigation1992，90，1： | 1 |
| 19 | Paget' s disease of bone: Indications for treament and goals of therapy 显示文摘 | Tiegs RD | 1997 | Clinical Therapeutics1997，19，： | 1 |
| 20 | T Cell-dependent experimental liver injury in mice inducible by Concanavalin A显示文摘 | Tiegs C Hentschel J Wendel A | 1992 | J Clin Invest1992，90，1： | 1 |
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