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| 1 | A thorough analysis of diabetes research in China from 1995 to 2015: current scenario and future scope显示文摘The prevalence of diabetes has increased dramatically over the past three decades, and currently, China has the largest number of diabetics worldwide; this number continues to grow and puts ongoing strains on the medical resources. In this review, we reviewed the diabetes research conducted in China from 1995 to 2015 with the aim of providing new insights regarding the current status and future perspectives for researchers, diabetes health providers, and respective policy-makers. Remarkable progress has been made in diabetes research in China during the past two decades in terms of both the quantity and publication influence. The progress, however, struggles to adequately manage diabetes in China. Here we addressed opportunities to strengthen researches, including new drug development, high quality studies on health economics, and healthcare quality improvement studies. As the expected wave of diabetic complications is upcoming and overwhelming, we therefore recommend that immediate improvements are required to implement the researches regarding their prevention and treatment. | Zekai Wu Tianru Jin Jianping Weng | 2019 | Science China(Life Sciences)2019，62，1： | 13 |
| 2 | Pakl mediates the stimulatory effect of insulin and curcumin on hepatic ChREBP expression显示文摘 | Kejing Zeng Lili Tian Adam Sirek Weijuan Shao Ling Liu Yu-Ting Chiang Jonathan Chernoff Dominic S. Ng Jianping Weng Tianru Jin | 2017 | Journal of Molecular Cell Biology2017，9，5： | 4 |
| 3 | High-resolution characterization of hexagonal boron nitride coatings exposed to aqueous and air oxidative environments显示文摘六角形的硼氮化物(h-BN ) 被相信由于它的绝缘的性质比 graphene 把更好的钝化提供给金属性的表面,它便于堵住电子的流动,从而阻止流电的反应的出现。不过,当 h-BN-protected 材料暴露于水的环境时,这不能是盒子。在这个工作,我们分析了暴露于 H 2 O 2 和大气的条件。当暴露了到 H 2 O 2 。多层的 h-BN 提供了保护的好度。单层 h-BN 被发现也在空气气氛无效。甚至 10-15 层厚的 h-BN 栈不能完全在考虑下面保护金属的表面。由联合钻电子光谱学和第二等的离子团 spectrometry 技术,我们观察到氧能通过 h-BN 栈的谷物边界扩散到达金属性的底层。因为这个过程的散开的性质,一旦一个浸透的状态被到达,幸好,氧化区域没与时间增加。这成为多层(不单层) h-BN 一个合适的长期的氧化障碍。氧渗入不能被 X 光检查光电子光谱学观察。这种技术不能估计材料的更深的层的化学作文。因此,以前的报告,依靠了 XPS 分析 h-BN 和 graphene 的使钝化的性质,可能忽略了一些重要表面下的现象。在这研究获得的结果在水的媒介和暴露于空气环境的 h-BN-coated 金属的降级动力学提供新卓见进单音、多层的 h-BN 的使钝化的性质。 | Lanlan Jiang Na Xiao Bingru Wang Enric Grustan-Gutierrez Xu Jing Petr Babor Miroslav Kogbal Guangyuan Lu Tianru Wu Haomin Wang Fei Hui Yuanyuan Shi Bo Song Xiaoming Xie Mario Lanza | 2017 | Nano Research2017，10，6： | 2 |
| 4 | Current understanding and dispute on the function of the Wnt signaling pathway effector TCF7L2 in hepatic gluconeogenesis显示文摘Approximately 10 years ago,the Wnt signaling pathway effector TCF7L2(ZTCF-4)was recognized as a type 2 diabetes(T2D)risk gene through a genome wide association study(GWAS).As the correlation between TCF7L2 polymorphisms and T2D susceptibility has been reproducibly observed by numerous follow-up investigations among different ethnic groups,great efforts have been made to explore the function of TCF7L2 in metabolic organs including the pancreas,liver and adipose tissues.Although these explorations have enriched our general knowledge on the Wnt signaling cascade in metabolic homeostasis,studies conducted to date have also generated controversial suggestions.Here I will provide a brief review on the Wnt signaling pathway as well as the milestone GWAS discovery and the follow-up studies.I will then discuss the two different opinions on the correlation between TCF7L2 variants and T2D risk,a gain-of-function event versus a loss-of-function event.This will be followed by summarizing the relevant investigations on the metabolic function of hepatic TCF7L2 and presenting our view on the discrepancy and perspectives. | Tianru Jin | 2016 | Genes & Diseases2016，3，1： | 1 |
| 5 | Cell Type-specific autoregulation of the caudal-related homeobox gene Cdx-2/3·显示文摘 | Fenghao Xu Huiqin Li Tianru Jin | 1999 | J Biol Chem1999，274，34： | 1 |
| 6 | Mechanical properties and microstructure of 3D orthogonal quartz fiber reinforced silica composites fabricated by silicasol-infiltration-sintering显示文摘 | Chengdong Li Zhaofeng Chen Jianxun Zhu Yong Liu Yun Jiang Tianru Guan Binbin Li Long Lin | 2011 | Materials and Design2011，，： | 1 |
| 7 | Application of the Regulations on Drawing of a Safe Firing Area Map in Weather Modification Operation显示文摘Technology for safe firing area maps was introduced firstly,and then potential danger after the launching of shells by an antiaircraft gun and a rocket was analyzed.Finally,problems in the process of applying the regulations and their solutions were discussed.The application of safe firing area maps can provide technical support for the efficient development of weather modification operation. | Wang Xiaoli Wang Tianru Zhang Na Xu Tai’an Lu Dan Zhang Xiuzhen | 2017 | Meteorological and Environmental Research2017，8，1： | 1 |
| 8 | Commentary:Can FXR serve as a potential target for COVID-19 prevention?显示文摘A research article has been accepted by Nature very recently entitled:FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2.This is a multiple-author study by 80 scientists from 40 different research units in UK,Germany,Greece,USA,Austria,Sweden,and Norway,with Teresa Brevini as the 1st author and one of the senior authors^(1).The pre-print of this study was posted online back to June 7,2021(bioRxiv). | Juan Pang Jia Nuo Feng Wenhua Ling Tianru Jin | 2023 | Acta Pharmaceutica Sinica B2023，13，4： | 1 |
| 9 | Hepatic hormone FGF21 and its analogues in clinical trials显示文摘Fibroblast growth factor 21(FGF21)is a fasting or stress inducible metabolic hormone produced mainly in the liver.It plays important roles in regulating both glucose and lipid homeostasis via interacting with a heterodimeric receptor complex comprising FGF receptor 1(FGFR1)andβ-klotho(KLB).For the past decade,great effort has been made on developing FGF21 derivatives or specific FGF21 receptor agonists into therapeutic agents for various metabolic disorders including type 2 diabetes(T2D),obesity,and more importantly,nonalcoholic fatty liver disease(NAFLD).Here we have reviewed FGF21 gene and protein structures,its expression pattern,cellular signaling cascades that mediate FGF21 production and function.We have then summarized the six clinical trials utilizing four FGF21 analogues.Finally,two recent literatures on the development of GLP-1 and FGF21 dual agonists were presented briefly. | Weijuan Shao Tianru Jin | 2022 | Chronic Diseases and Translational Medicine2022，8，1： | 1 |
| 10 | Mechanisms underlying proglucagon gene expression 显示文摘 | TIANRU J | 2008 | Endocrinol0gy2008，15，9： | 1 |
| 11 | Bile Acids Induce Ectopic Expression of Intestinal Guanylyl Cyclase C Through Nuclear Factor-κB and Cdx2 in Human Esophageal Cells显示文摘 | Philip R. Debruyne Matthew Witek Li Gong Ruth Birbe Inna Chervoneva Tianru Jin Claire Domon–Cell Juan P. Palazzo Jean–Noel Freund Peng Li Giovanni M. Pitari Stephanie Schulz Scott A. Waldman | 2006 | Gastroenterology2006，，4： | 1 |
| 12 | Synthesis of a Photochromic Bisphenoxynaphthacenequinone Compound by Two-step Method显示文摘A new photochromic bisphenoxynaphthacenequinone compound, 6,6’-[1-methylethylidenebis (4-1-phenyleneoxy)]bis (5,12-naphthacenequinone) (1), was synthesized by a two-step method, i.e.,synthesis of 6-[4(2-(4-hydroxyphenyl)isopropyl) phenoxy]-5, 12-naphthacenequinone (2) from 6-chloro-5, 12-naphthacenequinone (3) and bisphenol-A, and a further reaction of compound 2 in DMF/acetone mixed solvent in the presence of anhydrous potassium carbonate and potassium iodide. The crude product is obtained in a precipitate form and can easily be purified by recrystallization. The solvent composition has marked influence on the yield of the precipitated crude product in the second step. | Fang, Zheng Liu, Jingyu Fu, Liangshe Xu, Suxian Fang, Tianru
| 1999 | Journal of Materials Science & Technology1999，15，2： | 1 |
| 13 | Changing Features of Sunshine Duration and Effects on Greenhouse Production in Shouguang City显示文摘Based on data of monthly sunshine duration in Shouguang City during 1961-2013,changing features of sunshine duration and effects on greenhouse production in Shouguang City were analyzed by using linear tendency method,M-K mutation test and Molet wavelet analysis. The results show that in Shouguang City,sunshine duration in a year and each season reduced obviously from 1961 to 2013,and sunshine duration in a year and autumn changed suddenly in the 1990s,while sunshine duration in winter and spring changed suddenly in the 1980s. There existed obvious periodic variations of sunshine duration in a year and various seasons from 1961 to 2013. The reduction of sunshine duration and the increase of cloudy days resulted in the decrease in the yield of crops in solar greenhouses,so some effective measures should be taken to enhance the light intensity and time in solar greenhouses to promote crop growth. | Wang Xiaoli Yan Fengjun Wang Tianru Xu Tai an Lu Dan Zhang Xiuzhen | 2016 | Meteorological and Environmental Research2016，7，6： | 1 |
| 14 | The Wnt Signaling Pathway Effeetor TCF7L2 and Type 2 Diabetes Mellitus显示文摘 | Jin Tianru L Ling | 2008 | Mol Endocrinol2008，22，11： | 1 |
| 15 | Mechanisms underlying proglucagon gene expression显示文摘 | Tianru J | 2008 | Endocrinology2008，15，9： | 1 |
| 16 | Cell type-specific autoregulation of the caudal-related homeobox gene Cdx2/3显示文摘 | Fenghao Xu Huiqin Li Tianru Jin | 1999 | J Biol Chem1999，274，34： | 1 |
| 17 | The anti-inflammatory feature of glucagon-like peptide-1 and its based diabetes drugs-Therapeutic potential exploration in lung injury显示文摘Since 2005,GLP-1 receptor(GLP-IR)agonists(GLP-IRAs)have been developed as therapeutic agents for type 2 diabetes(T2D).GLP-IR is not only expressed in pancreatic islets but also other organs,especially the lung.However,controversy on extra pancreatic GLP-IR expression still needs to be further resolved,utilizing different tools including the use of more reliable GLP-IR antibodies in immune-staining and co-immune-staining.Extra-pancreatic expression of GLP-IR has triggered extensive investigations on extra-pancreatic functions of GLP-1RAs,aiming to repurpose them into therapeutic agents for other disorders.Extensive studies have demonstrated promising anti-infammatory features of GLP-IRAs.Whether those features are directly mediated by GLP-IR expressed in immune cells also remains controversial.Following a brief review on GLP-1 as an incretin hormone and the development of GLP-IRAs as therapeutic agents for T2D,we have summarized our current understanding of the antiinflammatory features of GLP-IRAS and commented on the controversy on extra-pancreatic GLP-IR expression.The main part of this review is a literature discussion on GLP-IRA utilization in animal models with chronic airway diseases and acute lung injuries,including studies on the combined use of mesenchymal stem cell(MSC)based therapy.This is followed by a brief summary. | Juan Pang Jia Nuo Feng Wenhua Ling Tianru Jin | 2022 | Acta Pharmaceutica Sinica B2022，12，11： | 0 |
| 18 | Role of cyclic AMP signaling in the production and function of the incretin hormone glucagon-like peptide-1显示文摘胰腺的房间表示 proglucagon 基因(gcg ) 并且从而生产肽荷尔蒙 glucagon,它刺激肝的葡萄糖生产并且从而增加血葡萄糖层次。一样的 gcg 基因也在大脑在肠的内分泌的 L 房间和某些神经房间被表示。在内脏, gcg 表示导致象 glucagon 一样 peptide-1 (GLP-1 ) 的生产。当血葡萄糖水平高时,这 incretin 荷尔蒙刺激胰岛素分泌物。另外, GLP-1 刺激胰腺的房间增长,禁止房间 apoptosis,并且在胰岛素生产的 trans 区别被利用了房间。今天,长期的有效 GLP-1 受体收缩筋在治疗糖尿病并且潜在地作为药被开发了另外的新陈代谢的混乱。广泛的调查证明了 gcg 和 GLP-1 的生产的表示能被第二个送信人的举起激活周期的安培(营地) 。最近的研究建议除了蛋白质 kinase A (PKA ) ,交换蛋白质由营地(Epac ) 激活,营地发信号的另一个受动器,和在 PKA 和 Wnt 发信号小径之间的串音,也涉及刺激营地的 gcg 表示和 GLP-1 生产。而且,在胰腺的房间的 GLP-1 的功能被也表明小径的 cAMP-PKA, cAMP-Epac 和 Wnt 主要调停。 | Zhiwen Yu | 2008 | Science Foundation in China2008，16，2： | 0 |
| 19 | Fibroblast growth factor 21 and dietary interventions: what we know and what we need to know next显示文摘Dietary interventions include the change of dietary styles,such as fasting and dietary or nutrient restrictions;or the addition of plant-derived compounds(such as polyphenols known as curcumin,resveratrol,or anthocyanin,or other nutraceuticals)into the diet.During the past a few decades,large number of studies have demonstrated therapeutic activities of these dietary interventions on metabolic and other diseases in human subjects or various animal models.Mechanisms underlying those versatile therapeutic activities,however,remain largely unclear.Interestingly,recent studies have shown that fibroblast growth factor 21(FGF21),a liver-derived hormone or hepatokine,mediates metabolic beneficial effects of certain dietary polyphenols as well as protein restriction.Here I have briefly summarized functions of FGF21,highlighted related dietary interventions,and presented literature discussions on role of FGF21 in mediating function of dietary polyphenol intervention and protein restriction.This is followed by presenting my perspective view,with the involvement of gut microbiota.It is anticipated that further breakthroughs in this field in the near future will facilitate conceptual merge of classical medicine and modern medicine. | Tianru Jin | 2022 | Medical Review2022，2，5： | 0 |
| 20 | Properties of Boron-doped μc-Ge:H Films Deposited by Hot-wire CVD显示文摘Boron-doped hydrogenated microcrystalline Germanium(μc-Ge:H) fi lms were deposited by hot-wire CVD. H2 diluted Ge H4 and B2H6 were used as precursors and the substrate temperature was kept at 300 ℃. The properties of the samples were analyzed by XRD, Raman spectroscopy, Fourier transform infrared spectrometer and Hall Effect measurement with Van der Pauw method. It is found that the fi lms are partially crystallized, with crystalline fractions larger than 45% and grain sizes smaller than 50 nm. The B-doping can enhance the crystallization but reduce the grain sizes, and also enhance the preferential growth of Ge(220). The conductivity of the fi lms increases and tends to be saturated with increasing diborane-to-germane ratio. All the Hall mobilities of the samples are larger than 3.8 cm2·V-1·s-1. A high conductivity of 41.3 Ω-1·cm-1 is gained at =6.7%. | 黄海宾 沈鸿烈 WU Tianru LU Linfeng TANG Zhengxia SHEN Jiancang | 2015 | Journal of Wuhan University of Technology(Materials Science)2015，30，3： | 0 |
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