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| 1 | Gastroenterologist perceptions of faecal microbiota transplantation显示文摘AIM: To explore gastroenterologist perceptions towards and experience with faecal microbiota transplantation(FMT).METHODS: A questionnaire survey consisting of 17 questions was created to assess gastroenterologists' attitude towards and experience with FMT. This was anonymously distributed in hard copy format amongst attendees at gastroenterology meetings in Australia between October 2013 and April 2014. Basic descriptive statistical analyses were performed.RESULTS: Fifty-two clinicians participated. Twenty one percent had previously referred patients for FMT,8% more than once. Ninety percent would refer patients with Clostridium difficile infection(CDI) for FMT if easily available,37% for ulcerative colitis,13% for Crohn's disease and 6% for irritable bowel syndrome. Six percent would not refer any indication,including recurrent CDI. Eighty-six percent would enroll patients in FMT clinical trials. Thirty-seven percent considered the optimal mode of FMT administration transcolonoscopic,17% nasoduodenal,13% enema and 8% oral capsule. The greatest concerns regarding FMT were: 42% lack of evidence,12% infection risk,10% non infectious adverse effects/lack of safety data,10% aesthetic,10% lack of efficacy,4% disease exacerbation,and 2% inappropriate use; 6% had no concerns. Seventy seven percent believed there is a lack of accessibility while 52% had an interest in learning how to provide FMT. Only 6% offered FMT at their institution.CONCLUSION: Despite general enthusiasm,most gastroenterologists have limited experience with,or access to,FMT. The greatest concerns were lack of supportive evidence and safety issues. However a significant proportion would refer indications other than CDI for FMT despite insufficient evidence. These data provide guidance on where education and training are required. | Sudarshan Paramsothy Alissa J Walsh Thomas Borody Douglas Samuel Johan van den Bogaerde Rupert WL Leong Susan Connor Watson Ng Hazel M Mitchell Nadeem O Kaakoush Michael A Kamm | 2015 | World Journal of Gastroenterology2015，21，38： | 5 |
| 2 | Evaluation of the string test for the detection of Helicobacter pylori显示文摘AIM: Helicobacter pylori can be diagnosed by invasive ornon-invasive tests but to obtain bacteria for culture andantibiotic susceptibility testing, an upper GI endoscopy isoften required. The string test may be a minimally-invasivealternative method of obtaining H. pylori samples. This studyevaluates the sensitivity and specificity of the string test inthe diagnosis of H. pylori in comparison with endoscopicmeans of diagnosis.METHODS: This was a prospective open comparative studyof patients with dyspepsia with endoscopy-based tests asgold standard (defined as a positive CLO test and antralhistology). Fasting patients swallowed the encapsulated-string(Entero-test Hp), which was withdrawn after 1 hour. Thegastric juice from the string was plated onto H. pylori-selectivemedia for culture. Helicobacter pylori was identified by typicalcolony morphology, gram stain and biochemical test results.RESULTS: Thirty dyspeptic patients were recruited of whom21 (70 %) were positive for H. pylori according to the goldstandard. The sensitivity, specificity, positive predictive value,and negative predictive value for the string test were 38 %,100 %, 100 % and 41% respectively, and for endoscopicbiopsies 81%, 100 %, 100 %, 69 % respectively (P=0.004).Logistic regression showed that only abundant growthdensity from endoscopic biopsy cultures to be a predictor ofa positive string test (P=0.018).CONCLUSION: The string test is an alternative method toendoscopy in obtaining H. pylori but has a low sensitivitycompared to endoscopic biopsies. | Rupert WL Leong Ching C Lee Thomas KW Ling WaiK Leung Joseph JY Sung | 2003 | World Journal of Gastroenterology2003，9，2： | 3 |
| 3 | Dose-related antihypertensive effects of irbesartan in patients with mild-to-moderatehypertension显示文摘 | Robort MG Thomas WL | 1998 | Am J Hypertens1998，11，4： | 1 |
| 4 | Quantum mechanical/molecular mechanical modeling finds Diels-Al- der reactions are accelerated less on the surface of water than in water显示文摘 | THOMAS L TIRADO-RIVES J JORGENSEN WL | 2010 | J Am Chem Soc2010，132，： | 1 |
| 5 | Nonsurgical treat- ment of ectopic pregnancy显示文摘 | Gary HL Thomas GS Frank WL | 2000 | The New England Journal of Medicine2000，343，18： | 1 |
| 6 | C677T methylenete- trahydrofolate reductase polymorphism interferes with the effects of folic acid and zinc sulftate on sperm concentration 显示文摘 | Ebisch IM van Heerde WL Thomas CM | 2003 | Fertil Steril2003，80，： | 1 |
| 7 | Proteolytic cleavage of Ii to p25显示文摘 | Thomas LJ Nguyen QV Elliott WL | 1988 | J Immunol1988，140，8： | 1 |
| 8 | Methylenetetrahydrofolate reductase polymorphism affects the change in homocysteine and folate concentrations resulting form low dose folic acid supplementation in women with unexplained recurrent miscarriages显示文摘 | Nelen WL Blom HJ Thomas CM | 1998 | J Nutr1998，128，8： | 1 |
| 9 | Giant petrous carotidaneurysm: Persistent epistaxis despite internal carotid arteryligation显示文摘 | Singh H Thomas J Hoe WL | 2008 | J Laryngol Dtol2008，1228，： | 1 |
| 10 | Over-the-counter nonsteroidal anti- inflammatory drugs and risk of gastrointestinal symptoms 显示文摘 | Thomas J Straus WL Bloom BS | 2002 | Am J Gastroenterol2002，97，9： | 1 |
| 11 | Breakthrough cancer pain 显示文摘 | Thomas WL Lynn JH Amy PA | 2016 | Supp Cancer Care2016，2，2： | 1 |
| 12 | An hypothesis on the binding of an amphipathic,alpha helical sequence in Ii to the desetope of class Ⅱ antigens显示文摘 | Elliott WL Stille CJ Thomas LJ | 1987 | J Immunol1987，138，9： | 1 |
| 13 | Dose- related antihypertensive effects of irbesartan in patients with mid - to - moderade hypertension显示文摘 | James LP Robort MG Thomas WL | 1988 | Am J Hypertens1988，11，： | 1 |
| 14 | Compliance with guidelines for treating sepsis 显示文摘 | Barletta JF Thomas WL Slot MG | 2007 | Am J Health Syst Pharm2007，64，2： | 1 |
| 15 | Ethyl carbamate in al- coholic beverages from Mexico (Tequila, Mezcal, Bacanora, Sotol) and Guatemala (Cuxa) : market survey and risk as- sessment显示文摘 | Dirk WL Fotis K Thomas K | 2009 | Int J Environ Res Public Health2009，6，1： | 1 |
| 16 | Automated determination of ethyl carba- mate in stone - fruit spirits using headspace solid - phase microextrac- tion and gas chromatography - tandem mass spectrometry 显示文摘 | Dirk WL Uta N Thomas K | 2006 | J of Chroma~ogr A2006，1108，1： | 1 |
| 17 | A 5-kilobase pair promoter fragment of the murine epididymal retinoic acid-binding protein gene drives the tissue-specific, cell-specific, and androgen-regulated expression of a foreign gene in the epididymis of transgenic mice 显示文摘 | Thomas TZ Zheng WL | 1999 | J Biol Chem1999，274，12： | 1 |
| 18 | Diabetic retinopathy:more than meets the eye显示文摘 | Thomas WG David A Alistair JB Kathryn FL Steven WL The penn state retina research group | 2002 | Surv Ophthalmol2002，47，2： | 1 |
| 19 | Giant petrous carotid aneurysm:Persistent epistaxis despite internal carotid artery ligation 显示文摘 | Singh H Thomas J Hoe WL | 2008 | J Laryngol Otol2008，122，8： | 1 |
| 20 | Methylenetetrahydrofolate reductase polymorphism affects the change in homocysteine and folate concentrations resulting form low dose folic acid supplementation in women with unexplained recurrent miscarriages显示文摘 | Nelen WL Blom HJ Thomas CM | | J Nu0，，： | 1 |
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