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| 1 | Phenylpropanoid Biosynthesis显示文摘一般 phenylpropanoid 新陈代谢作为核心单位基于 shikimate 小径的很少中介产生第二等的代谢物的一个庞大的数组。产生 hydroxycinnamic 酸和酉旨被导致一个机关和代谢物的发展地特定的模式的 reductases, oxygenases,和 transferases 的联合在几串联放大,为每植物种特征。在最后十年期间,驾驶的方法论指向了,在几植物种的非指向的途径启用了这复杂 biosynthetic 机械的参与的酶的鉴定,并且为规定和分隔揭示了众多的基因,酶,和代谢物必需品。在结构、计算的生物学的可观的成功,与分析敏感结合了在代谢物,抄本,或酶模式检测甚至踪迹混合物和 smallest changes,向对它的关於生命、不能生活的环境的植物反应的一个全面看法便于进步。转基因的途径被用来揭示卓见进为各种各样的 phenylpropanoid biosynthetic 小径的功能的正直和粘性要求的显然冗余的基因和酶模式。不过,一个基因家庭的所有成员的功能和影响尚待完全被证实。这评论试图在一般 phenylpropanoid 小径的各种各样的方面上给更改,它是不仅限制了为普通木质素或 flavonoid 生合成,但是喂进许多另外的芳香的代谢物喜欢香豆素,酉分的 volatiles,或 hydrolyzable 丹宁。 | Thomas Vogt | 2010 | Molecular Plant2010，3，1： | 158 |
| 2 | Ephrin-B2 is differentially expressed in the intestinal epithelium in Crohn's disease and contributes to accelerated epithelial wound healing in vitro显示文摘AIM: Eph receptor tyrosine kinases and their membrane bound receptor-like ligands, the ephrins, represent a bi-directional cell-cell contact signaling system that directs epithelial movements in development. The meaning of this system in the adult human gut is unknown. We investigated the Eph/ephrin mRNA expression in the intestinal epithelium of healthy controls and patients with inflammatory bowel disease (IBD).METHODS: mRNA expression profiles of all Eph/ephrin family members in normal small intestine and colon were established by real-time RT-PCR. In addition, differential expression in IBD was investigated by cDNA array technology, and validated by both real-time RT-PCR and immunohistochemistry. Potential effects of enhanced EphB/ephrin-B signaling were analyzed in an in vitro IEC-6 cell scratch wound model.RESULTS: Human adult intestinal mucosa exhibits a complex pattern of Eph receptors and ephrins. Beside the known prominent co-expression of EphA2 and ephrinA1,we found abundantly co-expressed EphB2 and ephrin-B1/2.Interestingly, cDNA array data, validated by real-time PCR and immunohistochemistry, showed upregulation of ephrin-B2 in both perilesional and lesional intestinal epithelial cells of IBD patients, suggesting a role in epithelial homeostasis. Stimulation of ephrin-B signaling in ephrinB1/2 expressing rat IEC-6-cells with recombinant EphB1Fc resulted in a significant dose-dependent acceleration of wound closure. Furthermore, fluorescence microscopy showed that EphB1-Fc induced coordinated migration of wound edge cells is associated with enhanced formation of lamellipodial protrusions into the wound, increased actin stress fiber assembly and production of laminin at the wound edge.CONCLUSION: EphB/ephrin-B signaling might represent a novel protective mechanism that promotes intestinal epithelial wound healing, with potential impact on epithelial restitution in IBD. | Christian Hafner Stefanie Meyer Thomas Langmann Gerd Schmitz Frauke Bataille Ilja Hagen Bernd Becker Alexander Roesch Gerhard Rogler Michael Landthaler Thomas Vogt | 2005 | World Journal of Gastroenterology2005，11，26： | 9 |
| 3 | The quasiparticle band dispersion in epitaxial multilayer silicene显示文摘 | Paola De Padova Jose Avila Andrea Resta Ivy Razado-Colambo Claudio Quaresima Carlo Ottaviani Bruno Olivieri Thomas Bruhn Patrick Vogt Maria Carmen Asensio Guy Le Lay | 2013 | Journal of Physics: Condensed Matter2013，，： | 4 |
| 4 | Ephrin-B reverse signaling induces expression of wound healing associated genes in IEC-6 intestinal epithelial cells显示文摘AIM: Eph receptors and ephrin ligands play a pivotal role in development and tissue maintenance. Since previous data have indicated an involvement of ephrin-B2 in epithelial healing, we investigated the gene expression and downstream signaling pathways induced by ephrin-B mediated cell-cell signaling in intestinal epithelial cells.METHODS: Upon stimulation of ephrin-B pathways in IFC-6 cells with recombinant rat EphB1-Fc, gene expression was analyzed by Affymetrix(R) rat genome 230 high density arrays at different time points. Differentially expressed genes were confirmed by real-time RT-PCR. In addition, MAP kinase pathways and focal adhesion kinase (FAK) activation downstream of ephrin-B were investigated by immunoblotting and fluorescence microscopy.RESULTS: Stimulation of the ephrin-B reverse signaling pathway in IEC-6 cells induces predominant expression of genes known to be involved into wound healing/cell migration, antiapoptotic pathways, host defense and inflammation. Cox-2, c-Fos, Egr-1, Egr-2, and MCP-1 were found among the most significantly regulated genes.Furthermore, we show that the expression of repairrelated genes is also accompanied by activation of the ERK1/2 MAP kinase pathway and FAK, two key regulators of epithelial restitution.CONCLUSION: Stimulation of the ephrin-B reverse signaling pathway induces a phenotype characterized by upregulation of repair-related genes, which may partially be mediated by ERK1/2 pathways. | Christian Hafner Stefanie Meyer Ilja Hagen Bernd Becker Alexander Roesch Michael Landthaler Thomas Vogt | 2005 | World Journal of Gastroenterology2005，11，29： | 2 |
| 5 | Influence of combined treatment of low dose rapamycin and cyclosporin A on corneal allograft survival显示文摘 | Svetlana Stanojlovic Stephan Schlickeiser Christine Appelt Katrin Vogt Isabela Schmitt-Knosalla Stefanie Haase Thomas Ritter Birgit Sawitzki Uwe Pleyer | 2010 | Graefe’s Archive for Clinical and Experimental Ophthalmology2010，，10： | 1 |
| 6 | Autosomal recessive hy percholesterolemia in three sisters with phenotypic homozygous familial hypercholesterolemia: diagnostic and therapeutic proce- dures显示文摘 | Thomas HP Vogt A Wilund KR | 2004 | Ther Apher Dial2004，8，4： | 1 |
| 7 | Evaluating the environmental impact of payments for ecosystem services in Coatepec (Mexico) using remote sensing and on-site interviews显示文摘 | Scullion J Thomas C W Vogt K A | 2011 | Environmental Conservation2011，38，4： | 1 |
| 8 | Recent advances in betalain research 显示文摘 | Dieter Dieter Strack Thomas Vogt Willibald Schliemann | 2003 | Phytochemistry2003，62，： | 1 |
| 9 | A Temporarily Distinct Subpopulation of Slow-Cycling Melanoma Cells Is Required for Continuous Tumor Growth显示文摘 | Alexander Roesch Mizuho Fukunaga-Kalabis Elizabeth C. Schmidt Susan E. Zabierowski Patricia A. Brafford Adina Vultur Devraj Basu Phyllis Gimotty Thomas Vogt Meenhard Herlyn | 2010 | Cell2010，，4： | 1 |
| 10 | Regulation of mitochondrial respiration and apoptosis through cell signaling: Cytochrome c oxidase and cytochrome c in ischemia/reperfusion injury and inflammation显示文摘 | Maik Hüttemann Stefan Helling Thomas H. Sanderson Christopher Sinkler Lobelia Samavati Gargi Mahapatra Ashwathy Varughese Guorong Lu Jenney Liu Rabia Ramzan Sebastian Vogt Lawrence I. Grossman Jeffrey W. Doan Katrin Marcus Icksoo Lee | 2011 | BBA - Bioenergetics2011，，4： | 1 |
| 11 | Recent advances in betalain research显示文摘 | Dieter Strack Thomas Vogt Willibald Schliemann | 2003 | Phytochemistry2003，，62： | 1 |
| 12 | Recent advances in betalain research显示文摘 | Dieter Strack Thomas Vogt Willibald Schliemann | 2003 | Phytochemistry2003，，3： | 1 |
| 13 | Iterative image reconstruction techniques: Applications for cardiac CT显示文摘 | Matthias Renker Ashok Ramachandra U. Joseph Schoepf Rainer Raupach Paul Apfaltrer Garrett W. Rowe Sebastian Vogt Thomas G. Flohr J. Matthias Kerl Ralf W. Bauer Christian Fink Thomas Henzler | 2011 | Journal of Cardiovascular Computed Tomography2011，，4： | 1 |
| 14 | Evaluating the environmental impact of payments for ecosystem services in Coatepec (Mexico) using remote sensing and on-site interview显示文摘 | Scullion J Thomas C W Vogt K A | 2011 | Environmental Conservation2011，38，4： | 1 |
| 15 | Autosomal recessive bypercholesterolemia in three sisters with phenotypic homozygous familial hypercholesterolemia: diagnostic and therapeutic procedures显示文摘 | Thomas HP Vogt A Wilund KR | 2004 | Ther Apher Dial2004，8，4： | 1 |
| 16 | Recent advances in betalain research 显示文摘 | Dieter Strack Thomas Vogt Willibald Schliemann | 2003 | Phytochemistry2003，69，： | 1 |
| 17 | The Energy Balance Experiment EBEX-2000. Part I: overview and energy balance显示文摘 | Steven P. Oncley Thomas Foken Roland Vogt Wim Kohsiek H. A. R. DeBruin Christian Bernhofer Andreas Christen Eva van Gorsel David Grantz Christian Feigenwinter Irene Lehner Claudia Liebethal Heping Liu Matthias Mauder Andrea Pitacco Luis Ribeiro Tamas Weid | 2007 | Boundary - Layer Meteorology2007，，1： | 1 |
| 18 | Regulation of mitochondrial respiration and apoptosis through cell signaling: Cytochrome c oxidase and cytochrome c in ischemia/reperfusion injury and inflammation显示文摘 | Maik Hüttemann Stefan Helling Thomas H. Sanderson Christopher Sinkler Lobelia Samavati Gargi Mahapatra Ashwathy Varughese Guorong Lu Jenney Liu Rabia Ramzan Sebastian Vogt Lawrence I. Grossman Jeffrey W. Doan Katrin Marcus Icksoo Lee | 2011 | BBA - Bioenergetics2011，，： | 1 |
| 19 | Autosomal recessive hypercholesterolemia in three sisters with phenotypic homozygous familial hypercholesterolemia: diagnostic and therapeutic procedures 显示文摘 | Thomas HP Vogt A Wilund KR | 2004 | Ther Apher Dial2004，8，4： | 1 |
| 20 | Autosomal recessive hypercholesterolemia in three sisters with phenotypic homozygous familial hypercholesterolemia: diagnostic and therapeutic proeedures显示文摘 | Thomas HP Vogt A Wilund KR | 2004 | Ther apher Dial2004，8，4： | 1 |
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