|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk显示文摘AIM:To investigate the association of variations in the cyclooxygenase-2(COX2) and uridine diphosphate glucuronosyltransferase 1A6(UGT1A6) genes and non-steroidal anti-inflammatory drugs(NSAIDs) use with risk of colon cancer.METHODS:NSAIDs,which are known to reduce the risk of colon cancer,act directly on COX2 and reduce its activity.Epidemiological studies have associated variations in the COX2 gene with colon cancer risk,but others were unable to replicate this finding.Similarly,enzymes in the UGT1A6 gene have been demonstrated to modify the therapeutic effect of NSAIDs on colon adenomas.Polymorphisms in the UGT1A6 gene have been statistically shown to interact with NSAID intake to influence risk of developing colon adenomas,but not colon cancer.Here we examined the association of tagging single nucleotide polymorphisms(SNPs) in the COX2 and UGT1A6 genes,and their interaction with NSAID consumption,on risk of colon cancer in a population of 422 colon cancer cases and 481 population controls.RESULTS:No SNP in either gene was individually statistically significantly associated with colon cancer,nor did they statistically significantly change the protective effect of NSAID consumption in our sample.Like others,we were unable to replicate the association of variants in the COX2 gene with colon cancer risk(P > 0.05),and we did not observe that these variants modify the protective effect of NSAIDs(P > 0.05).We were able to confirm the lack of association of variants in UGT1A6 with colon cancer risk,although further studies will have to be conducted to confirm the association of these variants with colon adenomas.CONCLUSION:Our study does not support a role of COX2 and UGT1A6 genetic variations in the development of colon cancer. | Cheryl L Thompson Sarah J Plummer Alona Merkulova Iona Cheng Thomas C Tucker Graham Casey Li Li | 2009 | World Journal of Gastroenterology2009，15，18： | 11 |
| 2 | No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer显示文摘AIM: To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer. METHODS: We utilized a population-based casecontrol study of incident colon cancer individuals (n= 421) and controls (n = 483) aged ≥ 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene. RESULTS: None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer. CONCLUSION: Our study does not support PTEN as a colon cancer susceptibility gene. | Lynette S Phillips Cheryl L Thompson Alona Merkulova Sarah J Plummer Thomas C Tucker Graham Case Li Li | 2009 | World Journal of Gastroenterology2009，15，30： | 2 |
| 3 | The United Kingdom public health re- sponse to an imported laboratory confirmed case of a no- vel coronavirus in September 2012显示文摘 | Pebody R G Chand M A Thomas H L Green H K Boddington N L Carvalho C Brown C S Anderson S R Rooney C Crawley-Boevey E Irwin D J Aarons E Tong C Newsholme W Price N Langrish C Tucker D Zhao H Phin N Crofts J Bermingham A Gil- gunn-Jones E Brown K E Evans B Catchpole M Watson J M | 2012 | Euro Surveill2012，17，20： | 1 |
| 4 | Extended depth of field and aberration control for inexpensive digital microscope systems显示文摘 | Sara C Tucker W Thomas Cathey Edward R Dowski | 1999 | Optics Express1999，4，11： | 1 |
| 5 | Molecular control of odontogenic patterning; positional dependent initiation and morphogenesis显示文摘 | Tucker AS Ferguson C | 1998 | Eur J Oral Sci1998，106，1： | 1 |
| 6 | Extended depth of field and aberration control for inexpensive digital microscope systems显示文摘 | Tucker Sara C Dowski Edward R Cathey W Thomas | 1999 | Optics Express1999，4，8： | 1 |
| 7 | Inoculum effects on fungal morphology: shake flasks vs agitated bioreactors显示文摘 | Tucker K G Thomas C R | 1994 | Biotechnology Techniques1994，8，3： | 1 |
| 8 | Sorbsan in the management of leg ulcers 显示文摘 | Thomas S Tucker C A | 1989 | Pharm J1989，243，： | 1 |
| 9 | Flow cytometuic asdessment of three different methods for the measurement of in vitro apoptosis显示文摘 | Pepper C Thomas A Tucker H | 1998 | Leuk Res1998，22，： | 1 |
| 10 | Flow cytometric assessment of three different methods for the measurement of in vitro apoptosis显示文摘 | Thomas A Tucker H | 1998 | Leuk Res1998，22，5： | 1 |
| 11 | Extend- ed depth of field and aberration control for inexpensive digital microscope systems 显示文摘 | Sara C Tucker W Thomas Cathey Edward R l)owski | 1999 | Optics Express1999，4，11： | 1 |
| 12 | Stress and counterproductive work behavior: Multiple relationships between de- mands, control, and soldier indiseipline over time 显示文摘 | Tucker J S Sinclair R R Mohr C D Adler A B Thomas J L Salvi A D | 2009 | Journal of Occupational Health Psychology2009，14，3： | 1 |
| 13 | Flow cytometric assessment of three different methods for the measurement of in vitro apoptosis 显示文摘 | Pepper C Thomas A Tucker H | 1998 | Leuk Res1998，22，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员