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| 1 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | Epithelial-mesenchymal transitions in tumourprogression显示文摘 | Thiery J P | 2002 | Nat Rev Cancer2002，2，6： | 1 |
| 3 | Fully automatic PMD compensation at 40 Gbit/s显示文摘 | Lanne S Idler W Thiery J P | 2002 | Electron let2002，38，1： | 1 |
| 4 | Epithelial-mesenchymal transitions in development and disease 显示文摘 | Thiery J P Acloque H Huang R Y | 2009 | Cell2009，139，5： | 1 |
| 5 | Epithelial - mesenchymal transitions in tumor progression显示文摘 | THIERY J P | 2002 | Nat Rev Cancer2002，2，6： | 1 |
| 6 | Epithelial-mesen chymal transitions in cancer onset and progression 显示文摘 | Thiery J P | 2009 | Bull Acad Natl Med2009，193，9： | 1 |
| 7 | Landslide susceptibility assessment by bivariate methods at large scales:Application to a complex mountainous environment显示文摘 | Thiery Y Malet J P Sterlacchini S | 2007 | Geomorphology2007，92，12： | 1 |
| 8 | SnapShot: The epithelial -mesen- chymal transition显示文摘 | SLEEMAN J P THIERY J P | 2011 | Cell2011，145，1： | 1 |
| 9 | Clinical implications for loss or diminution of expression of Raf1 kinase inhibitory protein and its phosphorylated form in ductal breast cancer显示文摘 | AlMulla F Bitar M S Thiery J P | 2013 | Am J Cancer Res2013，3，5： | 1 |
| 10 | Fibroblast growth factor-2 显示文摘 | OKADA B M THIERY J P JOUANNEAU J | 2000 | Int J Biochem Cell Biol2000，32，3： | 1 |
| 11 | Fibroblast growth factor-2 显示文摘 | OKADA-BAN M THIERY J P JOUANNEAU J | 2000 | Int J Biochem Cell Biol2000，32，： | 1 |
| 12 | Epithelial-mesenchymal transitions in development and disease 显示文摘 | Thiery J P Acloque H Huang R Y | 2009 | Cell2009，139，5： | 1 |
| 13 | Melatonin and the seasonal control of reproduction显示文摘 | Malpaux B Thiery J C Chemoneau P | 1999 | Reprod Nutr Dev1999，39，： | 1 |
| 14 | Epithelial-mesenchymal transitions in development and disease 显示文摘 | THIERY J P ACLOQUE H HUANG R Y | 2009 | Cell2009，139，5： | 1 |
| 15 | Fibroblast growth factor-2显示文摘 | Okada-Ban M Thiery J P Jouanneau J | 2000 | Int J Biochem2000，32，3： | 1 |
| 16 | Epithelial-mesenchymal transitions in tumour progression显示文摘 | Thiery J P | 2002 | Nat Rev Cancer2002，2，6： | 1 |
| 17 | Seasonal breeding in sheep: Mechanism of action of melatonin显示文摘 | MALPAUX B THIERY J C CHEMINEAU P | 1996 | Anim Reprod Res Prac1996，42，： | 1 |
| 18 | Epithelial- mesenchymal transitions in development and disease显示文摘 | Thiery J P Acloque H Huang R Y | 2009 | Cell2009，139，5： | 1 |
| 19 | Epithelial-mesenchymal transitions in development and pathologies显示文摘 | Thiery J P | | 0，，： | 1 |
| 20 | Epithelial-mesenchymal transitions in tumour progression 显示文摘 | Thiery J P | 2002 | Nat Rev Cancer2002，2，6： | 1 |
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