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| 1 | Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system显示文摘允许的技术内长的基因的特定的规定为基因功能的学习是珍贵的并且在治疗学有大潜力。我们创造了在 CRISPR 上系统,由核酸酶死者 Cas9 (dCas9 ) 蛋白质组成的二部件的 transcriptional 使活跃之物与互补顺序与 transcriptional 激活域和单个指南 RNA (sgRNAs ) 熔化了到基因倡导者。我们证明在 CRISPR 上能高效地以一种悦耳的方式在人和老鼠房间激活外长的记者基因。另外,我们证明在 vivo 的柔韧的记者基因激活能被把系统部件注入老鼠接合子完成。而且,我们证明在 CRISPR 上能激活内长的 IL1RN, SOX2,和 OCT4 基因。最有效的基因激活被对近似倡导者有约束力的 3-4 sgRNAs 的簇完成,建议他们在基因正式就职的 synergistic 行动。显著地,当指向多重基因的 sgRNAs 同时被介绍进房间时,柔韧的多路的内长的基因激活被完成。染色体宽的表示介绍表明了系统的高特性。 | Albert W Cheng Haoyi Wang Hui Yang Linyu Shi Yarden Katz Thorold W Theunissen Sudharshan Rangarajan Chikdu S Shivalila Daniel B Dadon Rudolf Jaenisch | 2013 | Cell Research2013，23，10： | 65 |
| 2 | Proliferating cell nuclear Antigen immunostaining and survival in astrocytoma显示文摘 | Theunissen PHMH Blaauw G | 1993 | Histopathol1993，23，： | 2 |
| 3 | Paracrine Hedgehog signalingin cancer 显示文摘 | Theunissen JW de Sauvage FJ | 2009 | Cancer Res2009，69，15： | 1 |
| 4 | Influence of temperature and relative humidity on thesurvival of Chamydia pmeumoniae in aerosols显示文摘 | Theunissen H J Lemmens-den Toom N A Burggraaf A | 1993 | Appl Environ Microbial1993，59，8： | 1 |
| 5 | Nanog Is the Gateway to the Pluripotent Ground State显示文摘 | Jose Silva Jennifer Nichols Thorold W. Theunissen Ge Guo Anouk L. van Oosten Ornella Barrandon Jason Wray Shinya Yamanaka Ian Chambers Austin Smith | 2009 | Cell2009，，： | 1 |
| 6 | Galactoman-nan and computed tomography-based preemptive antifungal therapy in neutropenic patients at high risk for invasive fungal infection: a prospective feasibility study 显示文摘 | Maertens J Theunissen K Verhoef G el al | 2005 | Clin Infec t Dis2005，41，9： | 1 |
| 7 | Mediastinal lymph node dissection in resected lung cancer:morbidity and accuracy of staging 显示文摘 | Bollen ECM Van Duin CJ Theunissen PHMH | 1993 | Ann Thorac Surg1993，55，： | 1 |
| 8 | Prospective clinical evaluation of lower cut-offs for galactomannan detection in adult neutropenic cancer patients and haematological stem cell transplant recipients显示文摘 | Maertens J Theunissen K Verbeken E | 2004 | Br J Haematol2004，126，： | 1 |
| 9 | Analy-sis and design of doubly curved piezoelectric strip-actuated ap- erture antennas显示文摘 | YOON H S WASHINGTON G N THEUNISSEN W H | | 0，，05： | 1 |
| 10 | Reconfigurable contour beam reflector antennas using ad- justable subreflector and adjustable single feed显示文摘 | THEUNISSEN W H YOON H S WASHINGTON G N | | 0，，06： | 1 |
| 11 | Androgen, estrogen and progesterone receptor expression in the human uterus during the menstrual cycle显示文摘 | Mertens H J Heineman M J Theunissen P H | 2001 | Eur J Obstet Gynecol Reprod Biol2001，95，1： | 1 |
| 12 | Complementa- ry detection of embryotoxic properties of substances in the neural and cardiac embryonic stem cell tests显示文摘 | Theunissen PT Pennings JL van Dartel DA | 2013 | Toxicol Sci2013，132，1： | 1 |
| 13 | Peer Victimization Experienced by Children and Adolescents Who Are Deaf or Hard of Hearing显示文摘 | Kouwenberg M Rieffe C Theunissen SCPM | 2012 | PLoS ONE2012，7，52： | 1 |
| 14 | Bronchoalveolar layage fiuid galactomannan for the diagnosis of invasive pulmonary aspergillosis in patients with hematologic diseases 显示文摘 | Maertens J Maertens V Theunissen K | 2009 | Clin Infect Dis2009，，： | 1 |
| 15 | Hypertrophic scars after therapy with CO2 laser for treatment of multiple cutaneous neurofibromas显示文摘 | OSTERTAG J U THEUNISSEN C C NEUMANN H A | 2002 | Dermatol Surg2002，28，3： | 1 |
| 16 | Hypertrophic scars after therapy with CO2 laser for treatment of multiple cutaneous neurofibromas 显示文摘 | Ostertag JU Theunissen CC Neumannh A | 2002 | Dermatol Surg2002，28，： | 1 |
| 17 | Andro- gen, estrogen and progesterone receptor expression in the human uterus during the menstrual cycle 显示文摘 | Mertens HJ Heineman MJ Theunissen PH | 2001 | Eur J Obstect Gynecol Reprod Biol2001，98，1： | 1 |
| 18 | Basic fibroblast growth factor,glutamine synthetase,and interleukin-6 in vitreous fluid from eyes with retinal detachment complicated by proliferative vitreo-retinopathy显示文摘 | La Heij EC van de Waarenburg MP Blaauwgeer HG Kessels AG Liem AT Theunissen C | 2002 | Am J Ophthalmol2002，134，3： | 1 |
| 19 | Hypertrophic scars after therapywith CO2 laser for treatment ofmultip le cutaneous neurofibromas显示文摘 | Ostertag JU Theunissen CC Neumannh A | 2002 | Dermatol Surg2002，28，： | 1 |
| 20 | Paracrine Hedgehog signaling in cancer 显示文摘 | Theunissen JW de Sauvage FJ | 2009 | Cancer Res2009，69，15： | 1 |
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