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| 1 | Hypoxia,HIF-1α,and COVID-19:from pathogenic factors to potential therapeutic targets显示文摘The pandemic of coronavirus disease 2019(COVID-19)and its pathogen,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)have become the greatest current threat to global public health.The highly infectious SARS-CoV-2 virus primarily attacks pulmonary tissues and impairs gas exchange leading to acute respiratory distress syndrome(ARDS)and systemic hypoxia.The current pharmacotherapies for COVID-19 largely rely on supportive and anti-thrombi treatment and the repurposing of antimalarial and antiviral drugs such as hydroxychloroquine and remdesivir.For a better mechanistic understanding of COVID-19,our present review focuses on its primary pathophysiologic features:hypoxia and cytokine storm,which are a prelude to multiple organ failure and lethality.We discussed a possible link between the activation of hypoxia inducible factor 1α(HIF-1α)and cell entry of SARS-CoV-2,since HIF-1αis shown to suppress the angiotensin-converting enzyme 2(ACE2)receptor and transmembrane protease serine 2(TMPRSS2)and upregulate disintegrin and metalloproteinase domain-containing protein 17(ADAM17).In addition,the protein targets of HIF-1αare involved with the activation of pro-inflammatory cytokine expression and the subsequent inflammatory process.Furthermore,we hypothesized a potential utility of so-called“hypoxic conditioning”to activate HIF-1α-induced cytoprotective signaling for reduction of illness severity and improvement of vital organ function in patients with COVID-19.Taken together,we would propose further investigations into the hypoxia-related molecular mechanisms,from which novel targeted therapies can be developed for the improved management of COVID-19. | Zoya O.Serebrovska Elisa Y.Chong Tetiana V.Serebrovska Lesia V.Tumanovska Lei Xi | 2020 | Acta Pharmacologica Sinica2020，41，12： | 5 |
| 2 | Antiviral activity of Basidiomycete mycelia against influenza type A(serotype H1N1) and herpes simplex virus type 2 in cell culture显示文摘In this study, we investigated the in vitro antiviral activity of the mycelia of higher mushrooms against influenza virus type A(serotype H1N1) and herpes simplex virus type 2(HSV-2), strain BH. All 10 investigated mushroom species inhibited the reproduction of influenza virus strain A/FM/1/47(H1N1) in MDCK cells reducing the infectious titer by 2.0–6.0 lg ID50. Four species, Pleurotus ostreatus, Fomes fomentarius, Auriporia aurea, and Trametes versicolor, were also determined to be effective against HSV-2 strain BH in RK-13 cells, with similar levels of inhibition as for influenza. For some of the investigated mushroom species—Pleurotus eryngii, Lyophyllum shimeji, and Flammulina velutipes—this is the first report of an anti-influenza effect. This study also reports the first data on the medicinal properties of A. aurea, including anti-influenza and antiherpetic activities. T. versicolor 353 mycelium was found to have a high therapeutic index(324.67), and may be a promising material for the pharmaceutical industry as an anti-influenza and antiherpetic agent with low toxicity. Mycelia with antiviral activity were obtained in our investigation by bioconversion of agricultural wastes(amaranth flour after CO2 extraction), which would reduce the cost of the final product and solve some ecological problems. | Tetiana Krupodorova Svetlana Rybalko Victor Barshteyn | 2014 | Virologica Sinica2014，29，5： | 4 |
| 3 | Theoretical simulation of T2SLs InAs/GaSb cascade photodetector for HOT condition显示文摘The investigation of the interband type-II superlattice In As/Ga Sb cascade photodetector in the temperature range of 320–380 K is presented. The article is devoted to the theoretical modeling of the cascade detector characteristics by the use of the Simu Apsys platform and the 4-band model(k?p 8 × 8 method). The obtained theoretical characteristics are comparable with experimentally measured ones, suggesting that transport in the absorber is determined by the dynamics of intrinsic carriers and by their lifetime. An overlap equal to 120 me V was used in calculations and a correction term in the 'non-common atom' model H_(xy) = 700 me V was added to the Hamiltonian. The electron and hole effective masses from dispersion curves were estimated and absorption coefficient α was calculated. Based on the simulation detectivity, D* characteristics in the temperature range 320–380 K were calculated. The simulated theoretical characteristics at 320 K are comparable to experimentally measured ones, however at higher temperatures, the experimental value of D* does not reach the theoretical values due to the low resistance of the device and short diffusion length. | Tetiana Manyk Klaudia Hackiewicz Jaroslaw Rutkowski Piotr Martyniuk | 2018 | Journal of Semiconductors2018，39，9： | 2 |
| 4 | “双一流”大学建设背景下教育硕士专业学位课程设计与教学评价研究显示文摘我国教育硕士与教育学硕士培养模式界限始终模糊,教育硕士职业性、应用性特点未有凸显。在创建一流大学一流学科的新形势下,教育硕士培养模式应与国际接轨,构建反映教师职业特色的课程设计与教学评价体系,采用差异课程设计、多维度追踪式评价。 | 周雁 Vankhalska Tetiana | 2017 | 中国高等教育评估2017，0，2： | 2 |
| 5 | Plasmon-Enhanced Photoluminescence of SiC Quantum Dots for Cell Imaging Applications显示文摘 | Yuriy Zakharko Tetiana Serdiuk Tetyana Nychyporuk Alain Gélo?n Mustapha Lemiti Vladimir Lysenko | 2012 | Plasmonics2012，，4： | 1 |
| 6 | A study of the impact of radiation exposure on the uniformity of large CsI(T1)crystals for the BABAR detector显示文摘 | TETIANA H PETER K MARTIN K | 2004 | Nucl Instrum Methods A2004，535，： | 1 |
| 7 | Cre-recombinase systems for induction of neuronspecific knockout models:a guide for biomedical researchers显示文摘Gene deletion has been a valuable tool for unraveling the mysteries of molecular biology.Early approaches included gene trapping and gene targetting to disrupt or delete a gene randomly or at a specific location,respectively.Using these technologies in mouse embryos led to the generation of mouse knocko ut models and many scientific discoveries.The efficacy and specificity of these approaches have significantly increased with the advent of new technology such as cluste red regula rly inters paced short palindromic repeats for targetted gene deletion.However,several limitations including unwanted off-target gene deletion have hindered their widespread use in the field.Crerecombinase technology has provided additional capacity for cell-specific gene deletion.In this review,we provide a summary of currently available literature on the application of this system for targetted deletion of neuronal genes.This article has been constructed to provide some background info rmation for the new trainees on the mechanism and to provide necessary information for the design,and application of the Cre-recombinase system thro ugh reviewing the most f requent promoters that are currently available for genetic manipulation of neuro ns.We additionally will provide a summary of the latest technological developments that can be used for targeting neurons.This may also serve as a general guide for the selection of appropriate models for biomedical research. | Tetiana Shcholok Eftekhar Eftekharpour | 2023 | Neural Regeneration Research2023，18，2： | 1 |
| 8 | HCV-GenoFibrotest: A combination of viral, liver and genomic (IL28b, ITPA, UGT1A1) biomarkers for predicting treatment response in patients with chronic hepatitis C显示文摘 | Jean-Marc Costa Dmytro Telehin Mona Munteanu Tetiana Kobryn Yen Ngo Vincent Thibault Moussalli Joseph Vlad Ratziu Yves Benhamou Volodymyr Koz'ko Galyna Dubins'ka Jean-Dominique Poveda Thierry Poynard | 2011 | Clinics and Research in Hepatology and Gastroenterology2011，，3： | 1 |
| 9 | Removal of inorganic arsenic from water using metal organic frameworks显示文摘It has been estimated that between 94 million and 220 million people around the world are at risk of consuming drinking water that contain arsenic concentrations higher than 10μg/L(Podgorski and Berg,2020). | Tetiana Davydiuk Xiaojian Chen Lijin Huang Qin Shuai X.Chris Le | 2020 | Journal of Environmental Sciences2020，32，11： | 1 |
| 10 | Model Identification of Integrated ARMA Processes显示文摘 | Tetiana Stadnytska Simone Braun Joachim Werner | 2008 | Multivariate Behavioral Research2008，，1： | 1 |
| 11 | Immigrant underemployment across US metropolitan areas: from a spatial perspective 显示文摘 | WANG Qingfang Tetiana Lysenko | 2014 | Urban Studies2014，51，10： | 1 |
| 12 | A study of the impact of radiation exposure on the uniformity of large CsI(T1) crystals for the BaBar detector显示文摘 | TETIANA H PETER K MARTIN K | 2004 | Nucl Instrum Methods2004，535，： | 1 |
| 13 | Effects of Dietary Intake of Arsenosugars and Other Organic Arsenic Species on Studies of Arsenic Methylation Efficiency in Humans显示文摘Extensive research has used dimethylarsinic acid(DMA)in urine as a marker of arsenic methylation.The premise is that humans methylate inorganic arsenicals to monomethylarsonic acid(MMA)and DMA and excrete these arsenic species into the urine.However,DMA in urine not only comes from the methylation of inorganic arsenic but also could be a result of metabolism of other arsenic species,such as arsenosugars and arsenolipids.Most environmental health and epidemiological studies of arsenic methylation might have overlooked confounding factors that contribute to DMA in urine.Here we critically evaluate reported studies that used methylation indexes,concentration ratios of methylated arsenicals,or the percentage of DMA in urine as markers of arsenic methylation efficiency.Dietary intake of arsenosugars potentially confounds the calculation and interpretation of the arsenic methylation efficiencies.Many studies have not considered incidental dietary intake of arsenosugars,arsenolipids,and other organic arsenic species.Future studies should consider the dietary intake of diverse arsenic species and their potential effect on the urinary concentrations of DMA. | Tetiana Davydiuk Jeffrey Tao Xiufen Lu X.Chris Le | 2023 | Environment & Health2023，1，4： | 0 |
| 14 | Euthanasia:National and International Experience(Based on the European Court of Human Rights Practice Materials)显示文摘Purpose:The relevance of the study is that today,there is no unanimous position on the right to euthanasia implementation.The European Court of Human Rights(ECtHR),in making its decision,relies on the national legislation of the respective state,as there is no single decision on the right to euthanasia in the European space.Therefore,the aim of the article is to comprehensively study the phenomenon of euthanasia,elaborate the decisions of the ECtHR on euthanasia and related rights,and develop recommendations on the possibility of legalizing euthanasia in Ukraine and prospects for the right to die implementation.Methodology:The leading method of research of this issue is comparative and law,which allows to comprehensively consider the right to euthanasia and its positive and negative components and helps to establish trends in the implementation of the outlined phenomenon.Findings:The article analyzes the current state of international and domestic legislation of some states on the use of euthanasia,reveals the meaning of the term“euthanasia,”provides a classification of euthanasia,analyzes the decisions of the ECtHR,and presents examples of national legislation of states within which euthanasia is legalized,the peculiarities of euthanasia recognition in the world are analyzed,as well as the research on the possibility of euthanasia legalization in Ukraine is presented.Value:The materials of the article have practical value for all those interested in euthanasia and the realization of the right to die,as well as for practicing lawyers and judicial authorities. | Olena O.Orlova Tetiana M.Alforova Tetiana M.Lezhnieva Stanislav V.Chernopiatov Oleh V.Kyrychenko | 2023 | Journal of Forensic Science and Medicine2023，9，1： | 0 |
| 15 | Identification and heterologous expression of the globomycin biosynthetic gene cluster显示文摘Globomycin is a cyclic lipodepsipeptide originally isolated from several Streptomyces species which displays strong and selective antibacterial activity against Gram-negative pathogens.Its mode of action is based on the competitive inhibition of the lipoprotein signal peptidase II(LspA),which is absent in eukaryotes and considered an attractive target for the development of new antibiotics.Despite its interesting biological properties,the gene cluster encoding its biosynthesis has not yet been identified.In this study we employed a genome-mining approach in the globomycin-producing Streptomyces sp.CA-278952 to identify a candidate gene cluster responsible for its biosynthesis.A null mutant was constructed using CRISPR base editing where production was abolished,strongly suggesting its involvement in the biosynthesis.The putative gene cluster was then cloned and heterologously expressed in Streptomyces albus J1074 and Streptomyces coelicolor M1146,therefore unambigu-ously linking globomycin and its biosynthetic gene cluster.Our work paves the way for the biosynthesis of new globomycin derivatives with improved pharmacological properties. | Daniel Oves-Costales Tetiana Gren Eva Baggesgaard Sterndorff Jesús Martín Francisco Javier Ortiz-Lopez Tue S.Jørgensen Xinglin Jiang Fernando Roman-Hurtado Fernando Reyes Olga Genilloud Tilmann Weber | 2023 | Synthetic and Systems Biotechnology2023，8，2： | 0 |
| 16 | The effect of two COVID-19 lockdowns on physical activity of school-age children显示文摘The introduction of strict quarantine restrictions in many countries initiated a direction in science to study the behavioral characteristics of children and adolescents during the social isolation at the population level.We present our observations during the two lockdowns in Ukraine.The objective of this study was to determine:a)the level of light(LPA)and moderate-to-vigorous(MVPA)physical activity among school-age children,and b)the impact of the external and internal factors on their physical activity during the lockdown.Global Physical Activity Questionnaire(GPAQ)as part of our questionnaire Q-RAPH was used.Parents of 1091 children 6–18 years old(54%boys)filled Q-RAPH at two measurement points in 2020 and 2021.After performing ANCOVA and logistic regression,we found a significant decrease in MVPA by 12.7%in 2021 compared to 2020(p<0.001)while LPA was about 1.5 h a day during both periods.The proportion of children who reach the recommended levels of MVPA also decreased by 13.7%in 2021(p<0.001).Factors negatively affecting the achievement of 60 min a day of MVPA were female gender,chronic diseases,overweight/obesity,non-participation in organized sports,and a decrease in the average air temperature.This study evidences the insufficient level of preventive measures and requires an intensification of health education among the Ukrainian population.When developing preventive measures,special attention should be paid to groups vulnerable to MVPA reduction as children who have chronic diseases and/or overweight/obesity as well as non-participation in sports. | Olena Yelizarova Tetiana Stankevych Alla Parats Nadiya Polka Oksana Lynchak Nataliya Diuba Svitlana Hozak | 2022 | Sports Medicine and Health Science2022，4，2： | 0 |
| 17 | Discovery of gargantulides B and C,new 52-membered macrolactones from Amycolatopsis sp.Complete absolute stereochemistry of the gargantulide family显示文摘Gargantulides B and C,two new and highly complex 52-membered glycosylated macrolactones,were isolated from Amycolatopsis sp.strain CA-230715 during an antibacterial screening campaign.The structures of these giant macrolides were elucidated by 2D NMR spectroscopy and shown to be related to gargantulide A,although containing additional β-glucopyranose and/orα-arabinofuranose monosaccharides separately attached to their backbones.Genome sequencing allowed the identification of a strikingly large 216 kbp biosynthetic gene cluster,among the largest type Ⅰ PKS clusters described so far,and the proposal of a previously unreported biosynthetic pathway for gargantulides A-C.The absolute configurations of gargantulides B and C were assigned based on a combination of NMR and bioinformatics analysis of ketoreductase and enoylreductase domains within the multimodular type Ⅰ PKS.In addition,the absolute stereochemistry of gargantulide A has now been revised and completed.Gargantulides B and C display potent antibacterial activity against a set of drug-resistant Gram-positive bacteria and moderate activity against the clinically relevant Gram-negative pathogen Acinetobacter baumannii. | Daniel Carretero-Molina Francisco Javier Ortiz-López Tetiana Gren Daniel Oves-Costales Jesús Martín Fernando Román-Hurtado Tue Sparholt Jorgensen Mercedes de la Cruz Caridad Díaz Francisca Vicente Kai Blin Fernando Reyes Tilmann Weber Olga Genilloud | 2022 | Organic Chemistry Frontiers2022，9，2： | 0 |
| 18 | Peculiarities of Structural Transformations in HAZ Metal of Rail Steel M76 Joint Produced by Flash-Butt Welding显示文摘 | Georgy Grigorenko Valery Kostin Victor Zhukov Tetiana Zuber | 2016 | Journal of Physical Science and Application2016，6，5： | 0 |
| 19 | The Positioning Strategies of Immigrants: A Case Study of Female Immigrants to Germany From Former Soviet Countries显示文摘 | Tetiana Havlin | 2013 | Journal of Sociology Study2013，3，8： | 0 |
| 20 | Confronting Nuclear Tyranny: Role of Eco-nationalism in Development of Environmental Movement in Ukraine显示文摘In the USSR there has never been a “pure” environmental movement. Dictate of Moscow in decision-making led to the location of a disproportionately large number of the nuclear power stations and industrial enterprises on the territory of Ukraine. Chernobyl accident demonstrated the consequences of this approach and became the symbol of inequality of relations between the member nations in the Soviet Union. Therefore, environmentalism and nationalism in many Soviet Republics had convergence albeit to varying degrees. The purpose of this research is to contribute to the further understanding and interpretation of the concept of eco-nationalism, proposed by J. Dawson. The article demonstrates that the basis for its development in Ukrainian USSR was not only the Chernobyl accident, but also the expansion of the nuclear facilities in Ukraine (what can be considered nuclear tyranny) along with the existence of a large number of industrial enterprises that polluted the environment. The article also explores the role of nationalism in the originating the environmental movement in the republic. | Tetiana Perga | 2018 | Cultural and Religious Studies2018，6，9： | 0 |
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