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| 1 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 2 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 3 | A two-stage technique for the digestion of forage crops显示文摘 | Tilley J M A Terry R A | 1963 | Br Grassl Soc1963，18，： | 1 |
| 4 | Marine fouling and its effects on off shore structures in the North Sea-a review 显示文摘 | Edyvean R G Terry L A Picken G B | 1985 | In- teraational Biodeterioration1985，21，4： | 1 |
| 5 | Hydroxylamine oxidoreductase: a 20- heme, 200 000 molecular weight cytot:hromee with unusual denaturation properties which forms a 63 000 molecular weight monomer after heme removal显示文摘 | Terry K R Hooper A B | 1981 | Biocheudstry1981，20，24： | 1 |
| 6 | X ray spectra estimation using attenuation measurements from 25 kVp to 18 MV显示文摘 | Waggener R G Blough M B Terry J A | 1999 | Med Phys1999，26，12： | 1 |
| 7 | A two-stage technique for in vitro digestion for crops显示文摘 | Tilley J M A Terry R A | 1963 | Briish Grassland Society1963，18，： | 1 |
| 8 | The electroanalysis of mannitol,xylose and lactulose at copper electrodes:voltammetric studies and bioanalysis in human urine by means of HPLC with electrochemical detection显示文摘 | Wring SA Terry A Causon R | 1998 | J Pharm Biomed Anal1998，16，7： | 1 |
| 9 | Outside Directors and the Adoption of Poison Pills 显示文摘 | Brickley J A J L Coles R L Terry | 1994 | Joumal of Financial Economics1994，，35： | 1 |
| 10 | Interaction Effects inthe Theory of Planned Behavior:The Interplay of Self-Identityand Past Behavior显示文摘 | Smith J R Terry D J Manstead A S R | 2007 | Journal of Applied Social Psychology2007，37，11： | 1 |
| 11 | A Two-stage technique for the in vitro digestion of forage crop显示文摘 | Tilley J M A Terry R A | 1963 | J Brit Grassland Soc1963，18，： | 1 |
| 12 | A two stage technique for the in vitro digestion of forage crops显示文摘 | Tilly J M A Terry R A | 1963 | Journal of the British Grassland Society1963，18，： | 1 |
| 13 | Groundbased forest harvesting effects on soil physical properties and Douglasfir growth 显示文摘 | Ares A Terry T A Miller R E | 2005 | Soil Science Society of America Journal2005，69，6： | 1 |
| 14 | A two stage technique for the in vitro digestion of forage crops显示文摘 | Tilly J M Terry R A | 1963 | Journal of the British Grassland Society1963，18，2： | 1 |
| 15 | A two stage technique for the in vitro digestion of forage crops显示文摘 | TILLY J M A TERRY R A | 1963 | Journal of the British Grassland Society1963，18，： | 1 |
| 16 | A two stage technique for the in vitro digestion of forage crops 显示文摘 | Tiltey J M Terry R A | 1963 | Journal of the British Grassland Society1963，18，： | 1 |
| 17 | A twostage technique for the digestion of forage crops显示文摘 | TILLEY J M A TERRY R A | 1963 | J Br Grassl Soc1963，18，10： | 1 |
| 18 | Marketing Actions and the Value of Customer Asset显示文摘 | Berger P D Bolton R N Bowman D Briggs E Kumar V Parasuraman A Terry C | 2002 | Journal of Services Research2002，15，1： | 1 |
| 19 | A two-stage technique for the in vitro digestion of forage crops 显示文摘 | TILLY J M A R A TERRY | 1963 | Journal of the British Grassland Society1963，，8： | 1 |
| 20 | Rank analysis of incomplete block designs I: the method of paired comparisons显示文摘 | Bradley R A Terry M E | 1952 | Biometrika1952，39，34： | 1 |
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