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| 1 | An easier method for performing a pancreaticojejunostomy for the soft pancreas using a fast-absorbable suture显示文摘AIM: To clarify the usefulness of a new method for performing a pancreaticojejunostomy by using a fast-absorbable suture material irradiated polyglactin 910, and a temporary stent tube for a narrow pancreatic duct with a soft pancreatic texture.METHODS: Among 63 consecutive patients with soft pancreas undergoing a pancreaticoduodenectomy from 2003 to 2006, 35 patients were treated with a new reconstructive method. Briefly, after the pancreatic transaction, a stent tube was inserted into the lumen of the pancreatic duct and ligated with it by a fast-absorbable suture. Another tip of the stent tube was introduced into the intestinal lumen at the jejunal limb, where a purse-string suture was made by another fast-absorbable suture to roughly fix the tube. The pancreaticojejunostomy was completed by ligating two fast-absorbable sutures to approximate the ductal end and the jejunal mucosa, and by adding a rough anastomosis between the pancreatic parenchyma and the seromuscular layer of the jejunum. The initial surgical results with this method were retrospectively compared with those of the 28 patients treated with conventional duct-to-mucosa anastomosis.RESULTS: The incidences of postoperative morbidity including pancreatic fistula were comparable between the two groups (new; 3%-17% vs conventional; 7%-14% according to the definitions). There was no mortality and re-admission. Late complications were also rarely seen.CONCLUSION: A pancreaticojejunostomy using an irradiated polyglactin 910 suture material and a temporary stent is easy to perform and is feasible even in cases with a narrow pancreatic duct and a normal soft pancreas. | Kenichi Hakamada Shunji Narumi Yoshikazu Toyoki Masaki Nara Kenosuke Ishido Takuya Miura Norihito Kubo Mutsuo Sasaki | 2008 | World Journal of Gastroenterology2008，14，7： | 9 |
| 2 | Statistical modeling of nitrogen-dependent modulation of root system architecture in Arabidopsis thaliana显示文摘Plant root development is strongly affected by nutrient availability. Despite the importance of structure and function of roots in nutrient acquisition,statistical modeling approaches to evaluate dynamic and temporal modulations of root system architecture in response to nutrient availability have remained as widely open and exploratory areas in root biology. In this study,we developed a statistical modeling approach to investigate modulations of root system architecture in response to nitrogen availability. Mathematical models were designed for quantitative assessment of root growth and root branching phenotypes and their dynamic relationships based on hierarchical con figuration of primary and lateral roots formulating the fishbone-shaped root system architecture in Arabidopsis thaliana. Time-series datasets reporting dynamic changes in root developmental traits on different nitrate or ammonium concentrations were generated for statistical analyses. Regression analyses unraveled key parameters associated with:(i) inhibition of primary root growth under nitrogen limitation or on ammonium;(ii) rapid progression of lateral root emergence in response to ammonium; and(iii) inhibition of lateral root elongation in the presence of excess nitrate or ammonium. This study provides a statistical framework for interpreting dynamic modulation of root system architecture,supported by metaanalysis of datasets displaying morphological responses of roots to diverse nitrogen supplies. | Takao Araya Takuya Kubo Nicolaus von Wiren Hideki Takahashi | 2016 | Journal of Integrative Plant Biology2016，58，3： | 2 |
| 3 | Resection of a locally advanced hilar tumor and the hepatic artery after stepwise hepatic arterial embolization: A case report显示文摘We herein report a case of a hilar tumor with extensive invasion to the proper hepatic artery, which was successfully treated with a radical resection in a 57-year-old female patient after a stepwise hepatic arterial embolization. She underwent right colectomy and partial hepatectomy for advanced colon cancer two years ago and radiofrequency ablation therapy for a liver metastasis one year ago, respectively. A recurrent tumor was noted around the proper hepatic artery with invasion to the left hepatic duct and right hepatic artery 7 mo previously. We planned a radical resection for the patient 5 mo after the absence of tumor progression was confirmed while he was undergoing chemotherapy. To avoid surgery-related liver failure, we tried to promote the formation of collateral hepatic arteries after stepwise arterial embolizationof the posterior and anterior hepatic arteries two weeks apart. Finally, the proper hepatic artery was occluded after formation of collateral flow from the inferior phrenic and superior mesenteric arteries was confirmed. One month later, a left hepatectomy with hepatic arterial resection was successfully performed without any major complications. | Takuya Miura Kenichi Hakamada Takashi Ohata Shunji Narumi Yoshikazu Toyoki Masaki Nara Keinosuke Ishido Motonari Ohashi Harue Akasaka Hiroyuki Jin Norihito Kubo Shuichi Ono Hiroshi Kijima Mutsuo Sasaki | 2008 | World Journal of Gastroenterology2008，14，22： | 1 |
| 4 | Fully automated liquid chromatography-mass spectrometry determination of 17β-estradiol in river water 显示文摘 | YOSHIYUKI WATABE TAKUYA KUBO TEPPEI NISHIKAWA | 2006 | Journal of Chromatography A2006，1120，： | 1 |
| 5 | Y-box binding protein-1 (YB-1) promotes cell cycle progression through CDC6-dependent pathway in human cancer cells显示文摘 | Yuji Basaki Ken-ichi Taguchi Hiroto Izumi Yuichi Murakami Takuya Kubo Fumihito Hosoi Kosuke Watari Kenji Nakano Hidetoshi Kawaguchi Shinji Ohno Kimitoshi Kohno Mayumi Ono Michihiko Kuwano | 2009 | European Journal of Cancer2009，，5： | 1 |
| 6 | Clinicopathological Features of Recurrence in Patients After 10-year Disease-free Survival Following Curative Hepatic Resection of Hepatocellular Carcinoma显示文摘 | Masaki Kaibori Shoji Kubo Hiroaki Nagano Michihiro Hayashi Seiji Haji Takuya Nakai Morihiko Ishizaki Kosuke Matsui Takahiro Uenishi Shigekazu Takemura Hiroshi Wada Shigeru Marubashi Koji Komeda Fumitoshi Hirokawa Yasuyuki Nakata Kazuhisa Uchiyama A-Hon Kw | 2013 | World Journal of Surgery2013，，4： | 1 |
| 7 | Acquiring non-parametric scattering phase function from a single image显示文摘Acquiring accurate scattering properties is important for rendering translucent materials. In particular, the phase function, which determines the distribution of scattering directions, plays a significant role in the appearance of a material. We propose a distinctive scattering theory that approximates the effect of single scattering to acquire the non-parametric phase function from a single image. Furthermore, in various experiments, we measured the phase functions from several real diluted media and rendered images of these materials to evaluate the effectiveness of our theory. | Yuki Minetomo Hiroyuki Kubo Takuya Funatomi Mikio Shinya Yasuhiro Mukaigawa | 2018 | Computational Visual Media2018，4，4： | 1 |
| 8 | Complete isolation of target solute from multicomponent similar mixture using continuous rotating annular chromatograph with double-stage partial recycling of effluent显示文摘 | Takuya Fukumura Hiroki Honda Masaki Kubo Toshikuni Yonemoto | | 0，，： | 1 |
| 9 | Trace level determination of polycyclic aromatic hydrocarbons in river water with automated pretreatment HPLC显示文摘 | Yoshiyuki Watabe Takuya Kubo Tetsuya Tanigawa Yoshihiro Hayakawa Koji Otsuka Ken Hosoya | 2013 | J Sep Science2013，，6： | 1 |
| 10 | Prospect of lenvatinib for unresectable hepatocellular carcinoma in the new era of systemic chemotherapy显示文摘The phase III clinical trial of the novel molecular targeted agent(MTA)lenvatinib for patients with advanced hepatocellular carcinoma(HCC)(REFLECT trial)found that lenvatinib was non-inferior to sorafenib in overall survival.Recently,the efficacy of multiple MTAs,including lenvatinib,in practice has been reported,and therapeutic strategies for Barcelona Clinic Liver Cancer(BCLC)intermediate stage HCC are undergoing major changes.Based on these results,lenvatinib could be recommended for patients with transcatheter arterial chemoembolization(TACE)-refractory,ALBI grade 1,within the up-to-seven criteria in the BCLC intermediate stage.Lenvatinib provides a more favorable outcome than TACE,even in cases with large or multinodular HCC beyond the up-to-seven criteria with Child-Pugh grade A.When patients meet the definitions of TACE-refractory or TACE-unsuitable,switching to systemic chemotherapy,including lenvatinib,is for favorable for preserving liver function.If initial treatment,including MTA,has a significant therapeutic effect and downstaging of HCC is obtained,additional TACE or surgical resection should be considered.Lenvatinib also has a therapeutic effect for poorly differentiated type and non-simple nodular type HCC thanks to the survival-prolonging effect of this drug.Furthermore,a significant therapeutic effect is expected in tumors with more than 50%liver involvement or main portal vein invasion,which have traditionally been considered to have a poor prognosis in patients.This suggests that at the start of lenvatinib treatment,HCC patients with ALBI grade 1 may be able to maintain liver functional reserve. | Takuya Sho Kenichi Morikawa Akinori Kubo Yoshimasa Tokuchi Takashi Kitagataya Ren Yamada Taku Shigesawa Mugumi Kimura Masato Nakai Goki Suda Mitsuteru Natsuizaka Koji Ogawa Naoya Sakamoto | 2021 | World Journal of Gastrointestinal Oncology2021，13，12： | 1 |
| 11 | Chromatographic separation for domoic acid using a fragment imprinted polymer显示文摘 | Makoto Nomachi Koji Nemoto | 2006 | Analytica Chimica Acta2006，1，1： | 1 |
| 12 | Fully automated liquid chromatography mass spectrometrydetermination of 17-β estradiol in river water显示文摘 | Yoshiyuki Watabe Takuya Kubo Teppei Nishikawa | 2006 | Journal of Chromatography A2006，1120，： | 1 |
| 13 | Study of High Power ICRF Antenna Design in LHD显示文摘In large helical device (LHD), antenna loadings are different for minority ioncyclotron heating (MICH with 38.47 MHz) and mode-converted ion Bernstein wave heating(MC-IBW with 28.4 MHz), and it is necessary to improve antenna loading with low heatingefficiency to avoid arching on transmission line. To design a new ion cyclotron range of frequencies(ICRF) antenna in LHD, calculation for a simple antenna model is conducted usingthree-dimensional electrical magnetic code (high frequency structure simulator, HFSS) for anwater loading as an imaginary plasma with low heating efficiency. At resonant frequencies,antenna loading is sensitive to strap width, and resonant frequencies are strongly related tostrap height. There is no differences of RF current profile on the strap surface between resonantfrequency and non-resonant frequency. The strap should be perpendicularly placed against themagnetic field line, since Faraday-shield angle will lead to a decrease in the effective antenna height. | Hiroshi KASAHARA Tetsuo SEKI Kenji SAITO Ryuhei KUMAZAWA Takashi MUTOH Goro NOMURA Fujio SHIMPO Shin KUBO Takashi SHIMOZUMA Yasuo YOSHIMURA Hiroe IGAMI Hiromi TAKAHASHI 赵燕平 Takuya OOSAKO Yuichi TAKASE | 2010 | Plasma Science and Technology2010，12，1： | 0 |
| 14 | Synthesis and Properties of a Through-Space Interacting Diradicaloid显示文摘Knowledge about electronic structures is important to gain an understanding of the unique functional properties of diradicaloids.In this study,we synthesized and characterized a diradicaloid in which two phenalenyl radical sites are coupled antiferromagnetically via a through-space interaction.The results of quantum chemical,physicochemical(^(1)H NMR,electronic absorption,cyclic voltammetry,SQUID,ESR),and chemical reactivity studies show that this diradicaloid has singlet diradical character.An assessment of the nature of the bonding interaction between two radical sites in this species using DFT calculations demonstrates that a small spatial overlap between the two SOMOs in this diradicaloid provides an efficient electron exchange path for the singlet state to be substantially lower in energy than the triplet state. | Takuya Kodama Yasukazu Hirao Takashi Kubo | 2023 | Precision Chemistry2023，1，3： | 0 |
| 15 | Pre-sarcopenia and Mac-2 binding protein glycosylation isomer as predictors of recurrence and prognosis of early-stage hepatocellular carcinoma显示文摘BACKGROUND The Mac-2 binding protein glycosylation isomer(M2BPGi),a fibrosis marker in various liver diseases,is reportedly a prognostic marker in patients with hepatocellular carcinoma(HCC)who underwent hepatectomy.AIM To evaluate whether the M2BPGi value,M2BP,and pre-sarcopenia before radiofrequency ablation(RFA)could be useful recurrence and prognostic markers in patients with early-stage HCC.METHODS In total,160 patients with early-stage primary HCC treated with RFA were separately analyzed as hepatitis C virus(HCV)-positive and HCV-negative.Factors contributing to recurrence and liver-related death,including M2BP,M2BPGi,and skeletal muscle mass index,were statistically analyzed.Eighty-three patients were HCV-positive and 77 were HCV-negative.RESULTS In HCV-positive patients,only des-γ-carboxy-prothrombin≥23 mAU/mL was a significant poor prognostic factor affecting survival after RFA.In HCV-negative patients,M2BPGi≥1.86 cutoff index was significantly associated with tumor recurrence,while M2BP was not.M2BPGi≥1.86 cutoff index(hazard ratio,4.89;95%confidence interval:1.97-12.18;P<0.001)and pre-sarcopenia(hazard ratio,3.34,95%confidence interval:1.19-9.37;P=0.022)were independent significant poor prognostic factors in HCV-negative patients.CONCLUSION In HCV-negative patients with primary HCC treated with RFA,lower M2BPGi contributed to a lower tumor recurrence rate and longer survival period.Pre-sarcopenia contributed to the poor prognosis independently in HCV-negative patients.These factors might be useful recurrence and prognostic markers for early-stage primary HCC. | Masato Nakai Kenichi Morikawa Shunichi Hosoda Sonoe Yoshida Akinori Kubo Yoshimasa Tokuchi Takashi Kitagataya Ren Yamada Masatsugu Ohara Takuya Sho Goki Suda Koji Ogawa Naoya Sakamoto | 2022 | World Journal of Hepatology2022，14，7： | 0 |
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