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| 1 | Surgical outcome of pancreatic cancer using radical antegrade modular pancreatosplenectomy procedure显示文摘AIM:To evaluate the surgical outcomes following radical antegrade modular pancreatosplenectomy (RAMPS) for pancreatic cancer. METHODS:Twenty-four patients underwent RAMPS with curative intent between January 2005 and June 2009 at the National Cancer Center, South Korea. Clinicopathologic data, including age, sex, operative findings, pathologic results, adjuvant therapy, postop-erative clinical course and follow-up data were retro-spectively collected and analyzed for this study. RESULTS:Twenty-one patients (87.5%) underwent distal pancreatectomy and 3 patients (12.5%) underwent total pancreatectomy using RAMPS. Nine patients (37.5%) underwent combined vessel resection, including 8 superior mesenteric-portal vein resections and 1 celiac axis resection. Two patients (8.3%) underwent combined resection of other organs, including the colon, stomach or duodenum. Negative tangential margins were achieved in 22 patients (91.7%). The mean tumor diameter for all patients was 4.09 ± 2.15 cm. The 2 patients with positive margins had a mean diameter of 7.25 cm. The mean number of retrieved lymph nodes was 20.92 ± 11.24 and the node positivity rate was 70.8%. The median survival of the 24 patients was 18.23 ± 6.02 mo. Patients with negative margins had a median survival of 21.80 ± 5.30 mo and those with positive margins had a median survival of 6.47 mo (P = 0.021). Nine patients (37.5%) had postoperative complications, but there were no postoperative mortalities. Pancreatic fistula occurred in 4 patients (16.7%):2 patients had a grade A fistula and 2 had a grade B fistula. On univariate analysis, histologic grade, positive tangential margin, pancreatic fistula and adjuvant therapy were significant prognostic factors for survival. CONCLUSION:RAMPS is a feasible procedure for achieving negative tangential margins in patients with carcinoma of the body and tail of the pancreas. | Ye Rim Chang Sung-Sik Han Sang-Jae Park Seung Duk Lee Tae Suk Yoo Young-Kyu Kim Tae Hyun Kim Sang Myung Woo Woo Jin Lee Eun Kyung Hong | 2012 | World Journal of Gastroenterology2012，18，39： | 9 |
| 2 | Clinical course of ulcerative colitis patients who develop acute pancreatitis显示文摘AIM To investigate the clinical course of ulcerative colitis(UC)patients who develop acute pancreatitis.METHODS We analyzed 3307 UC patients from the inflammatory bowel disease registry at Asan Medical Center from June 1989 to May 2015.The clinical course of UC patients who developed acute pancreatitis was compared with that of non-pancreatitis UC patients.RESULTS Among 51 patients who developed acute pancreatitis,13(0.40%)had autoimmune,10(0.30%)had aminosalicylate-induced,and 13(1.73%)had thiopurineinduced pancreatitis.All 13 patients with autoimmune pancreatitis(AIP)had type 2 AIP.Two(15.4%)patients had pre-existing AIP,and three(23.1%)patients developed AIP and UC simultaneously.Compared to non-pancreatitis patients,AIP patients had UC diagnosed at a significantly younger age(median,22.9 years vs 36.4 years;P=0.001).AIP and aminosalicylate-induced pancreatitis patients had more extensive UC compared to non-pancreatitis patients.All patients with pancreatitis recovered uneventfully,and there were no recurrences.Biologics were used more frequently in aminosalicylate-and thiopurine-induced pancreatitis patients compared to non-pancreatitis patients[adjusted OR(95%CI),5.16(1.42-18.67)and6.90(1.83-25.98),respectively].Biologic utilization rate was similar among AIP and non-pancreatitis patients[OR(95%CI),0.84(0.11-6.66)].Colectomy rates for autoimmune,aminosalicylate-induced,and thiopurineinduced pancreatitis,and for non-pancreatitis patients were 15.4%(2/13),20%(2/10),15.4%(2/13),and7.3%(239/3256),respectively;the rates were not significantly different after adjusting for baseline disease extent.CONCLUSION Pancreatitis patients show a non-significant increase in colectomy,after adjusting for baseline disease extent. | Jong Wook Kim Sung Wook Hwang Sang Hyoung Park Tae Jun Song Myung-Hwan Kim Ho-Su Lee Byong Duk Ye Dong-Hoon Yang Kyung-Jo Kim Jeong-Sik Byeon Seung-Jae Myung Suk-Kyun Yang | 2017 | World Journal of Gastroenterology2017，23，19： | 3 |
| 3 | Sex-dependent difference in the effect of metformin on colorectal cancer-specific mortality of diabetic colorectal cancer patients显示文摘AIM To assess factors associated with the higher effect of metformin on mortality in diabetic colorectal cancer(CRC) patients,since the factors related to the effectiveness of metformin have not been identified yet.METHODS Between January 2000 and December 2010,413 patients diagnosed with both stage 3/4 CRC and diabetes mellitus were identified. Patients' demographics and clinical characteristics were analyzed. The effect of metformin on CRC-specific mortality and the interactions between metformin and each adjusted factor were evaluated.RESULTS Total follow-up duration was median 50 mo(range: 1-218 mo). There were 85 deaths(45.9%) and 72 CRC-specific deaths(38.9%) among 185 patients who used metformin,compared to 130 total deaths(57.0%) and 107 CRC-specific deaths(46.9%) among 228 patients who did not use metformin. In multivariate analysis,survival benefit associated with metformin administration was identified(HR = 0.985,95%CI: 0.974-0.997,P = 0.012). Interaction test between metformin and sex after adjustment for relevant factors revealed that female CRC patients taking metformin exhibited a significantly lower CRC-specific mortality rate than male CRC patients taking metformin(HR = 0.369,95%CI: 0.155-0.881,P = 0.025). Furthermore,subgroup analysis revealed significant differences in CRC-specific mortality between the metformin and non-metformin groups in female patients(HR = 0.501,95%CI: 0.286-0.879,P = 0.013) but not male patients(HR = 0.848,95%CI: 0.594-1.211,P = 0.365). There were no significant interactions between metformin and other adjusted factors on CRC-specific mortality.CONCLUSION We showed a strong sex-dependent difference in the effect of metformin on CRC-specific mortality in advanced stage CRC patients with diabetes. | Jung Won Park Jin Ha Lee Ye Hyun Park Soo Jung Park Jae Hee Cheon Won Ho Kim Tae Il Kim | 2017 | World Journal of Gastroenterology2017，23，28： | 3 |
| 4 | Prohepcidin accumulates in renal insufficiency显示文摘 | Taes YE Wuyts B Boelaert JR | 2004 | Clin Chem Lab Med2004，42，4： | 1 |
| 5 | Diagnostic utility of anti- Saccharomyces cerevisiae antibody (ASCA) and Interferon-γ assay in the differential diagnosis of Crohn’s disease and intestinal tuberculosis显示文摘 | You Sun Kim Young-Ho Kim Won Ho Kim Joo Sung Kim Young Sook Park Suk-Kyun Yang Byong Duk Ye Byung Ik Jang Sung-Ae Jung Yoon Tae Jeen Jae Hee Cheon Yong Sung Choi Jai Hyun Choi Beom Jin Kim Chang Hwan Choi Dong Soo Han | 2011 | Clinica Chimica Acta2011，，17： | 1 |
| 6 | Vitamin D binding protein, bone status and body composition in community-dwelling elderly men显示文摘 | TAES YE GOEMAERE S HUANG G | 2006 | Bone2006，38，： | 1 |
| 7 | Prohepcidin accumulates in renal insufficiency显示文摘 | Taes YE Wuyts B Boelaert JR | 2004 | Clin Chem Lab Med2004，42，4： | 1 |
| 8 | Thyroid hormone levels within reference range are assoeiated with heart rate, cardiac structure, and function in middle-aged men and women显示文摘 | Roef GL Taes YE Kaufman JM | 2013 | Thyroid2013，23，8： | 1 |
| 9 | Prohepcidin accumulates in renal insufficiency显示文摘 | YE Taes B Wuyts JR Boelaert | 2004 | Clin Chem Lab Med2004，42，4： | 1 |
| 10 | Outcome and safety of self-expandable metallic stents for malignant colon obstruction: a Korean multicenter randomized prospective study显示文摘 | Dae Young Cheung Jin Yong Kim Sung Pil Hong Min Kyu Jung Byong Duk Ye Sang Gyun Kim Jin Hong Kim Kang Moon Lee Kyung Ho Kim Gwang Ho Baik Ho Gak Kim Chang Soo Eun Tae Il Kim Sang Woo Kim Chang Duck Kim Chang Heon Yang | 2012 | Surgical Endoscopy2012，，11： | 1 |
| 11 | Vitamin D binding pro- tein, bone status and body composition in community-dwelling elderly men显示文摘 | Taes YE Goemaere S Huang G | 2006 | Bone2006，38，5： | 1 |
| 12 | 显示文摘 | Taes YE Wuyts B Boelaert JR | 2004 | Clin Chem Lab Med2004，42，4： | 1 |
| 13 | Vitamin D binding protein, bone status and body composition in community- dwelling elderly men显示文摘 | Taes YE Goemaere S Huang G | 2006 | Bone2006，38，5： | 1 |
| 14 | Thyroid hormone levels within reference range are associated with heart rate,cardiac structure and function in middle-aged men and women显示文摘 | Roef GL Taes YE Kaufman JM | 2013 | Thyroid2013，23，8： | 1 |
| 15 | Fat mass is negatively associated with cortical bone size in young healthy male siblings显示文摘 | Taes YE Lapauw B Vanbillemont G | | 0，，07： | 1 |
| 16 | Prohepcidin accumulates in renal insufficiency显示文摘 | YE Taes B Wuyts JR Boelaert AS De Vriese and JR Delanghe | 2004 | Clin Chem Lab Med2004，42，4： | 1 |
| 17 | Synergistically targeting synovium STING pathway for rheumatoid arthritis treatment显示文摘Rheumatoid arthritis(RA)is a common autoimmune disease leading to pain,disability,and even death.Although studies have revealed that aberrant activation of STING was implicated in various autoimmune diseases,the role of STING in RA remains unclear.In the current study,we demonstrated that STING activation was pivotal in RA pathogenesis.As the accumulation of dsDNA,a specific stimulus for STING,is a feature of RA,we developed a spherical polyethyleneimine-coated mesoporous polydopamine nanoparticles loaded with STING antagonist C-176(PEI-PDA@C-176 NPs)for treating RA.The fabricated NPs with biocompatibility had high DNA adsorption ability and could effectively inhibit the STING pathway and inflammation in macrophages.Intra-articular administration of PEI-PDA@C-176 NPs could effectively reduce joint damage in mice models of dsDNA-induced arthritis and collagen-induced arthritis by inhibiting STING pathway.We concluded that materials with synergistic effects of STING inhibition might be an efficacious strategy to treat RA. | Haotian Shen Lulu Jin Qiangqiang Zheng Ziqiang Ye Linxiang Cheng Yuxu Wu Honghao Wu Tae Gyong Jon Wenduo Liu Zongyou Pan Zhengwei Mao Yue Wang | 2023 | Bioactive Materials2023，，6： | 1 |
| 18 | Prostaglandin E2 and interleukin-1β reduce E-cadherin expression by enhancing snail expression in gastric cancer cells 显示文摘 | Ye Seob Jee Tae Jung Jang Ki Hoon Jung | 2012 | J Korean Med Sci2012，27，9： | 1 |
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