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| 1 | Peginterferon and ribavirin treatment for hepatitis C virus infection显示文摘Pegylated interferon α (IFNα) in combination with ribavirin is currently recommended as a standard-of-care treatment for chronic hepatitis C virus (HCV) infection. This combination therapy has drastically improved the rate of sustained virological response, specifically in difficult-to-treat patients. Recently, individualized treatment, such as response-guided therapy, is being developed based on host-, HCV- and treatment-related factors. Furthermore, modified regimens with currently available medications, novel modified IFNα and ribavirin or combinations with specifically targeted antiviral therapy for HCV agents, are currently being investigated. The purpose of this review is to address some issues and epoch-making topics in the treatment of chronic HCV infection, and to discuss more optimal and highly individualized therapeutic strategies for HCV-infected patients. | Akihito Tsubota Kiyotaka Fujise Yoshihisa Namiki Norio Tada | 2011 | World Journal of Gastroenterology2011，17，4： | 16 |
| 2 | Role of bile acids in the regulation of the metabolic pathways显示文摘Recent studies have revealed that bile acids(BAs)are not only facilitators of dietary lipid absorption but also important signaling molecules exerting multiple physiological functions.Some major signaling pathways involving the nuclear BAs receptor farnesoid X receptor and the G protein-coupled BAs receptor TGR5/M-BAR have been identified to be the targets of BAs.BAs regulate their own homeostasis via signaling pathways.BAs also affect diverse metabolic pathways including glucose metabolism,lipid metabolism and energy expenditure.This paper suggests the mechanism of controlling metabolism via BA signaling and demonstrates that BA signaling is an attractive therapeutic target of the metabolic syndrome. | Hiroki Taoka Yoko Yokoyama Kohkichi Morimoto Naho Kitamura Tatsuya Tanigaki Yoko Takashina Kazuo Tsubota Mitsuhiro Watanabe | 2016 | World Journal of Diabetes2016，7，13： | 11 |
| 3 | Association between tear film break up time and blink interval in visual display terminal users显示文摘AIM:To investigate the association between tear film break up time(TBUT)and blinking interval in visual display terminal(VDT)users.METHODS:Nine hundred and thirty VDT users underwent dry eye testing,and functional visual acuity(FVA)test.The blinking interval during FVA was compared with TBUT.Subjects with longer blinking interval than TBUT were considered as unstable tear film.Logistic regression analysis revealed the risk factors for unstable tear group.RESULTS:Among 930 workers,858 subjects(92.3%)participated in this study.Almost 80% of the subjects were categorized into the unstable tear group.Unstable tear group has significantly lower Schirmer values and TBUT(17.5±11.6 vs 21.1±11.5 mm,3.7±2.6 vs 5.7±2.7s,both P<0.001).There were no significant differences in epithelial staining or severity of symptoms.Logistic regression showed that over 40y was a risk for being unstable tear group[odds ratio(OR)=1.53;95%confidence interval(CI)=1.06-2.20].Contact lens use was protective factor for being in the unstable tear group(OR=0.37;95%CI=0.26-0.53).CONCLUSION:Subjects with shorter TBUT than blinking interval are prevalent among VDT users.Subjects over the age of 40 shows an increased risk for unstable tear film. | Miki Uchino Motoko Kawashima Yuichi Uchino Kazuo Tsubota Norihiko Yokoi | 2018 | International Journal of Ophthalmology(English edition)2018，11，10： | 5 |
| 4 | Gender differences in adolescent dry eye disease:a health problem in girls显示文摘AIM: To evaluate the signs and symptoms of dry eye disease(DED) in adolescents. METHODS: This was a cross-sectional, case-control study and outpatients aged 10 to 19y were recruited from six eye clinics of various practices and locations in Japan, and 253 non-DED subjects and 70 DED patients were enrolled. Participants were examined for DED-related signs. Patients were also interviewed to ascertain the presence or absence of six common DED-related symptoms: dryness, irritation, pain, eye fatigue, blurring, and photophobia. Main outcome measures were differences in signs and symptoms of dry eye disease between boys and girls.RESULTS: Of the 323 adolescents recruited, 70(21.7%) were diagnosed with DED. Significant differences between the non-DED and DED groups were found for short tear break-up time(BUT; ≤5s; P=0.000) and superficial punctate keratopathy(SPK; staining score ≥3; P=0.000). Late adolescent girls reported fewer symptoms than late adolescent boys, although their DED-related signs were worse compared to other groups. The prevalence and severity of DED were similar in the Tokyo area compared with suburban and local areas but myopic errors were worse. CONCLUSION: We find that adolescents reported symptoms of DED similar to those found in adults, and the majority have short BUT-type DED. The prevalence and severity of DED in late adolescent girls is comparable with adults. Adolescents with DED are underserved and we believe that DED is a hidden but potentially serious health problem for this age group. | Masahiko Ayaki Motoko Kawashima Miki Uchino Kazuo Tsubota Kazuno Negishi | 2018 | International Journal of Ophthalmology(English edition)2018，11，2： | 5 |
| 5 | Multi-scale modeling of hemodynamics in the cardiovascular system显示文摘The human cardiovascular system is a closedloop and complex vascular network with multi-scaled heterogeneous hemodynamic phenomena. Here, we give a selective review of recent progress in macro-hemodynamic modeling, with a focus on geometrical multi-scale modeling of the vascular network, micro-hemodynamic modeling of microcirculation, as well as blood cellular, subcellular,endothelial biomechanics, and their interaction with arterial vessel mechanics. We describe in detail the methodology of hemodynamic modeling and its potential applications in cardiovascular research and clinical practice. In addition,we present major topics for future study: recent progress of patient-specifi hemodynamic modeling in clinical applications, micro-hemodynamic modeling in capillaries and blood cells, and the importance and potential of the multi-scale hemodynamic modeling. | Hao Liu Fuyou Liang Jasmin Wong Takashi Fujiwara Wenjing Ye Ken-iti Tsubota Michiko Sugawara | 2015 | Acta Mechanica Sinica2015，31，4： | 4 |
| 6 | A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details显示文摘 | Hisanori Umehara Kazuichi Okazaki Yasufumi Masaki Mitsuhiro Kawano Motohisa Yamamoto Takako Saeki Shoko Matsui Takayuki Sumida Tsuneyo Mimori Yoshiya Tanaka Kazuo Tsubota Tadashi Yoshino Shigeyuki Kawa Ritsuro Suzuki Tsutomu Takegami Naohisa Tomosugi Nozo | 2012 | Modern Rheumatology2012，，1： | 4 |
| 7 | Effects of denosumab treatment in chronic liver disease patients with osteoporosis显示文摘BACKGROUND Effective treatment of osteoporosis is essential for improving morbidity and health-related quality of life in chronic liver disease(CLD)patients.Denosumab has been shown to increase bone mineral density(BMD)and decrease the risk of osteoporotic fracture in the general population.However,there are few reports evaluating the efficacy of denosumab in CLD patients.AIM To investigated the effects and safety of denosumab in CLD patients with osteoporosis.METHODS Sixty CLD patients with osteoporosis were subcutaneously administered denosumab once every 6 mo.The study period for evaluating efficacy and safety was 12 mo.Changes from baseline in BMD at the lumbar spine,femoral neck,and total hip were evaluated at 12 mo of denosumab treatment.Bone turnover and quality were assessed by measuring serum tartrate-resistant acid phosphatase-5b(bone resorption marker),serum total procollagen type I N-terminal propeptide(bone formation maker),and plasma pentosidine(bone quality marker).RESULTS Among the 405 CLD patients,138(34.1%)patients were diagnosed with osteoporosis;among these,78 patients met the exclusion criteria and thus 60 patients were finally included in the present study.The median percentage changes from baseline to 12 mo of denosumab treatment in BMD at the lumbar spine,femoral neck,and total hip were+4.44%,+3.71%,and+4.03%,respectively.Denosumab significantly improved BMD,regardless of sex,patient age,and presence of liver cirrhosis.Serum tartrate-resistant acid phosphatase-5b and procollagen type I N-terminal propeptide levels constantly and significantly declined after denosumab treatment(P<0.001).Plasma pentosidine levels were also significantly lower at 12 mo of treatment(P=0.010).No patients experienced fractures and moderate-to-severe adverse events,except for transient hypocalcemia.CONCLUSION Denosumab treatment was safe and increased BMD,suppressed bone turnover,and improved bone quality marker levels in CLD patients with osteoporosis,irrespective of differences in baseline characteristics. | Chisato Saeki Mitsuru Saito Tsunekazu Oikawa Masanori Nakano Yuichi Torisu Masayuki Saruta Akihito Tsubota | 2020 | World Journal of Gastroenterology2020，26，33： | 3 |
| 8 | A mutation of the start codon in the X region of hepatitis B virus DNA in a patient with non-B,non-C chronic hepatitis显示文摘There are cases of hepatitis involving occult hepatitis B virus(HBV)infection in which,even though the HB surface antigen(HBsAg)is negative,HBV-DNA is detected by a polymerase chain reaction(PCR).We con-ducted a sequence analysis of the entire HBV region in a case of non-B non-C chronic hepatitis in a 46-yearold female.A diagnosis of non-B non-C chronic hepatitis was made.Although HBV markers,such as HBs antibody(anti-HBs),anti-HBc,HBeAg and anti-HBe,were negative,HBV-DNA was positive.Nested PCR was performed to amplify the precore region of HBV-DNA and all remaining regions by long nested PCR.Sequence analysis of the two obtained bands was conducted by direct sequencing.Compared with the control strains,the ATG(Methionine)start codon in the X region had mut ated to GTG(Valine).It is assumed that a mutation at the start codon in the X region may be the reason why HBV markers are negative in some cases of hepatitis that involve occult HBV infection. | Kiyotaka Fujise Keiko Tatsuzawa Midori Kono Sadayori Hoshina Akihito Tsubota Minoru Niiya Yoshihisa Namiki Norio Tada Hisao Tajiri | 2011 | World Journal of Hepatology2011，3，2： | 3 |
| 9 | Enhancing soil water holding capacity and provision of a potassium source via optimization of the pyrolysis of bamboo biochar显示文摘Rapid expansion of cultivated bamboo negatively impacts on biodiversity and soil microbial community.As such,it is important to properly manage and use bamboo to prevent and control such issues.This study focuses on optimizing pyrolysis conditions to produce bamboo biochar for agricultural soil amendment,particularly soil potassium(K)and water holding capacity.Bamboo chips were pyrolyzed under nitrogen gas at 400,600,and 800℃ for 1 and 2 h of retention.A total of six biochar products were created:400-1(i.e.,400℃ in 1 h),400-2,600-1,600-2,800-1,and 800-2.The 600℃ bamboo biochar products were observed to have the greatest potential in increasing soil K and water holding capacity.The 600-1 product had the highest potassium content(4.87%),with a water holding capacity of 3.73 g g^(−1),while the 600-2 product had the second-highest potassium content(4.13%)and the highest water holding capacity(4.21 g g^(−1))and cation exchange capacity.The K release in 600℃ products was larger and slower than that of the 400℃ and 800℃ products,respectively.The results also indicated that the physicochemical characteristics of bamboo biochar,such as yield,pH,surface area,water holding capacity,and K content,were significantly impacted by temperature,retention time,or a combination of these parameters.The outcomes from this study are a valuable reference for bamboo biochar production targeting agricultural soil amendment,particularly when it is directed at increasing soil K and water holding capacity. | Tran Thi Thu Hien Toshiki Tsubota Tomoyuki Taniguchi Yoshiyuki Shinogi | 2021 | Biochar2021，3，1： | 3 |
| 10 | Early apoptosis and cell death induced by ATX-S10Na(Ⅱ)-mediated photodynamic therapy are Bax- and p53-dependent in human colon cancer cells显示文摘AIM: To investigate the roles of Bax and p53 proteins in photosensitivity of human colon cancer cells by using lysosome-localizing photosensitizer, ATX-S10Na (Ⅱ).METHODS: HCT116 human colon cancer cells and Bax-null or p53-null isogenic derivatives were irradiated with a diode laser. Early apoptosis and cell death in response to photodynamic therapy were determined by MTT assays, annexin V assays, transmission electron microscopy assays, caspase assays and western blotting.RESULTS: Induction of early apoptosis and cell death was Bax- and p53-dependent. Bax and p53 were required for caspase-dependent apoptosis. The levels of anti-apoptotic Bcl-2 family proteins, Bcl-2 and Bcl-xL, were decreased in Bax- and p53-independent manner.CONCLUSION: Our results indicate that early apoptosis and cell death of human colon cancer cells induced by photodynamic therapy with lysosome-localizing photosensitizer ATX-S10Na (Ⅱ) are mediated by p53-Bax network and low levels of Bcl-2 and Bcl-xL proteins. Our results might help in formulating new therapeutic approaches in photodynamic therapy. | Makoto Mitsunaga Akihito Tsubota Kohichi Nariai Yoshihisa Namiki Makoto Sumi Tetsuya Yoshikawa Kiyotaka Fujise | 2007 | World Journal of Gastroenterology2007，13，5： | 3 |
| 11 | Four-week pegylated interferon a-2a monotherapy for chronic hepatitis C with genotype 2 and low viral load:A pilot,randomized study显示文摘AIM:To assess the efficacy and advantages of 4-wk pegylated interferon a-2a(peg-IFN-a2a) monotherapy for chronic hepatitis C patients with strong predictors of sustained virologic response(SVR).METHODS:Patients(n = 33) with genotype 2 and low viral load(< 100 KIU/mL),who became HCV RNA negative after 1 wk of IFN treatment,were randomly allocated to receive a 4-or 12-wk treatment course at a ratio of 2:1,respectively,with a subsequent 24-wk follow-up period.Peg-IFN-a2a was administered subcutaneously at a dose of 180 μg or 90 μg once weekly.SVR was defined as absence of serum HCV RNA at the end of the follow-up period.RESULTS:All patients completed the treatment schedule,and more than half were symptom-free during the treatment.In the 4-wk treatment group,20 of 22(91%) patients achieved SVR.Two patients relapsed,but achieved SVR following re-treatment with peg-IFN-a2a alone.In the 12-wk treatment group,11 of 11(100%) patients attained SVR.CONCLUSION:Our results show that a 4-wk course of peg-IFN-a2a monotherapy can achieve a high SVR rate in 'IFN-sensitive' patients,without negatively affecting outcome. | Akihito Tsubota Ken-ichi Satoh Mashu Aizawa Seishi Takamatsu Yoshihisa Namiki Toshifumi Ohkusa Kiyotaka Fujise Hisao Tajiri | 2008 | World Journal of Gastroenterology2008，14，47： | 3 |
| 12 | Pulmonary resection for metastases from colorectal cancer显示文摘 | Sakamoto T Tsubota N Iwanaga K | | 0，，： | 3 |
| 13 | Amniotic membrane transplantation for ocular surface reconstruction in patients with chemical and thermal burns显示文摘 | Shimazaki J Yaug HY Tsubota K | 1997 | Ophthalmology1997，104，8： | 2 |
| 14 | Amniotic membrane transplantation for ocular surface reconstruction in patients with chemical and thermal burns 显示文摘 | Shimazaki J Yang HY Tsubota K | 1997 | Ophthalmology1997，104，12： | 2 |
| 15 | Is segmentectomy with lymph node assessment an alternative to lobectomy for non–small cell lung cancer of 2 cm or smaller?显示文摘 | Morihito Okada Koichi Yoshikawa Takeshi Hatta Noriaki Tsubota | 2001 | The Annals of Thoracic Surgery2001，，3： | 2 |
| 16 | Influence of Separated Vortex on Aerodynamic Noise of an Airfoil Blade显示文摘In order to clarify the mechanism by which aerodynamic noise is generated from separated flow around an airfoil blade,the relation between the attack angle and the aerodynamic noise of the blade was analyzed using a wind tunnel experiment and a CFD code.In the case of rear surface separation,the separated vortex which has a large-scale structure in the direction of the blade chord is transformed into a structure that concentrates at the trailing edge with an increase in the attack angle.The aerodynamic noise level then becomes small according to the vortex scale in the blade chord.When the flow is separated at the leading edge,a separated vortex of low pressure is formed at the vicinity of the trailing edge.The pressure fluctuations on the blade surface at the vicinity of the trailing edge become large due to the vortex in the wake.It is considered that the aerodynamic noise level increases when the flow is separated at the leading edge because the separated vortex is causing the fluctuations due to wake vortex shedding. | Soichi Sasaki Hajime Takamatsu Masao Tsujino Haruhiro Tsubota Hidechito Hayashi | 2010 | Journal of Thermal Science2010，19，1： | 2 |
| 17 | Gene expression analysis in the larval silk gland of the eri silkworm Samia ricini显示文摘昆虫为目的一个范围生产丝绸。在鳞翅目,丝绸为茧生产作为材料被利用并且服务保护幼虫免受不利环境条件或食肉动物的伤害。在 Saturniidae 家庭的种类例如,生产茧的一个特别宽的变化有许多小洞的大、金色的有颜色的茧和那些。尽管在国内蚕(Bombyx mori L.) 的丝绸腺的基因表示广泛地被学习了,更加,更少调查集中了于天蚕蛾家庭的成员。这里,我们从 eri 蚕(Samia ricini ) 的丝绸腺建立了表示顺序标签,天蚕蛾种,并且使用这些分析基因表示。尽管我们识别了丝心蛋白在确定的图书馆的重链基因,为另外的主要丝绸蛋白质的基因例如丝心蛋白光链和 fibrohexamerin,是不在的。这发现与这些后者蛋白质缺乏天蚕蛾丝绸的以前的报告一致。最近,一系列象 fibrohexamerin 一样基因在 Bombyx 染色体被识别。我们使用了这个信息进行这里建立的图书馆的详细分析。这分析识别了这些基因的通常认为的相当或相同事物。我们也发现几编码也是在另外的鳞翅目的丝绸的现在的小丝绸蛋白质分子的基因。基因表示模式在 eri 和国内蚕之间被比较,并且保存并且 nonconserved 表示模式为测试基因被识别。如此的微分基因表示可能是在在这些之间的丝绸性质的差别的主要原因之一种类。我们相信我们的学习能作为为丝绸腺基因表示的一个基本目录具有值,它将让步到丝绸进化的进一步的理解。 | Takuya Tsubota Kimiko Yamamoto Kazuei Mita Hideki Sezutsu | 2016 | Insect Science2016，23，6： | 2 |
| 18 | Combination of fluvastatin with pegylated interferon/ribavirin therapy reduces viral relapse in chronic hepatitis C infected with HCV genotype 1b显示文摘 | Masanori Atsukawa Akihito Tsubota Chisa Kondo Norio Itokawa Yoshiyuki Narahara Katsuhisa Nakatsuka Satomi Hashimoto Takeshi Fukuda Yoko Matsushita Hideko Kidokoro Tamaki Kobayashi Hidenori Kanazawa Choitsu Sakamoto | 2012 | J Gastroenterol Hepatol2012，，1： | 2 |
| 19 | Analytical studies on local damage to reinforce concrete structures under impact loading by discrete element method显示文摘 | Sawamoto Y Tsubota H Kasai Y | 1998 | Nuclear Engineering and Design1998，179，： | 1 |
| 20 | Amnoitic membrane transplantation for ocular surface reconstruction in patients with chemical and thermal burns显示文摘 | Yang HY Tsubota K | 1997 | Ophthalmology1997，104，12： | 1 |
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