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| 1 | Value of a comprehensive geriatric assessment for predicting one-year outcomes in patients undergoing transcatheter aortic valve implantation: results from the CGA-TAVI multicentre registry显示文摘Background In a three-month report from the CGA-TAVI registry, we found the Multidimensional Prognostic Index (MPI) and Short Physical Performance Battery (SPPB) to be of value for predicting short-term outcomes in elderly patients undergoing transcatheter aortic valve implantation (TAVI). In the present analysis, we examined the association of these tools with outcomes up to one year post-TAVI. Methods CGA-TAVI is an international, observational registry of geriatric patients undergoing TAVI. Patients were assessed using the MPI and SPPB. Efficacy of baseline values and any postoperative change for predicting outcome were established using logistic regression. Kaplan- Meier analysis was carried out for each comprehensive geriatric assessment tool, with survival stratified by risk category. Results One year after TAVI, 14.1% of patients deceased, while 17.4% met the combined endpoint of death and/or non-fatal stroke, and 37.7% the combined endpoint of death and/or hospitalisation and/or non-fatal stroke. A high-risk MPI score was associated with an increased risk of all-cause mortality (aOR = 36.13, 95% CI: 2.77–470.78, P = 0.006) and death and/or non-fatal stroke (aOR = 10.10, 95% CI: 1.48–68.75, P = 0.018). No significant associations were found between a high-risk SPPB score and mortality or two main combined endpoints. In contrast to a worsening SPPB, an aggravating MPI score at three months post-TAVI was associated with an increased risk of death and/or non-fatal stoke at one year (aOR = 95.16, 95% CI: 3.41–2657.01). Conclusions The MPI showed value for predicting the likelihood of death and a combination of death and/or non-fatal stroke by one year after TAVI in elderly patients. | Martijn S.van Mourik Nathalie van der Velde Giulio Mannarino Marie-Pierre Thibodeau Jean-Bernard Masson Gennaro Santoro Jan Baan Sofie Jansen Jana Kurucova Martin Thoenes Cornelia Deutsch ANDreas W.Schoenenberger ANDrea Ungar Peter Bramlage M Marije Vis | 2019 | Journal of Geriatric Cardiology2019，16，6： | 3 |
| 2 | Non-steroidal mineralocorticoid receptor antagonism for the treatment of cardiovascular and renal disease 显示文摘 | Bramlage P Swift S L Thoenes M | 2016 | Eur J Heart Fail2016，18，1： | 1 |
| 3 | Novel approaches in anti-angiogenic treat- ment targeting endothelial F-aetin: a new anti-angiogenic strategy?显示文摘 | Thoenes L GO nther M | 2008 | Curr Opin Mol Ther2008，10，6： | 1 |
| 4 | The effects of extended-release niacin on carotid intimal media thick- ness, endothelial function and inflammatory, markers in patients with the metabolic syndrome 显示文摘 | THOENES M OQUCHI A VACCARI C S | 2007 | International Journal of Clinical Practice2007，61，11： | 1 |
| 5 | Changes in the Th1 or Th2 cytokine dominance in the synovium of rheumatoid arthritis (RA):A kinetic study of the Th subsets in one unusual RA patient显示文摘 | Aarvak T Chabaud M Thoen J | 2000 | Rheumatology2000，39，5： | 1 |
| 6 | RhabdomyOlysis: when exercising becomes a risk显示文摘 | Thoenes M | 2010 | Jour- nal of Pediatric Health Care2010，24，3： | 1 |
| 7 | Association of cardio vascular risk factors with microalbuminuria in hypertensive indi viduals: the i-SEARCH global study显示文摘 | Bohm M Thoenes M Danchin N | 2007 | J Hypertens2007，25，： | 1 |
| 8 | Atrial fibrillation and heart rate independently correlate to microalbuminuria in hypertensive patients显示文摘 | B(O)hm M Thoenes M Neuberger HR | 2009 | Eur Heart J2009，30，11： | 1 |
| 9 | Antihypertensive drug therapy and blood pressure control in men and women:an international perspective显示文摘 | Thoenes M Neuberger HR Volpe M | | 0，，： | 1 |
| 10 | Association of cardiovascular risk factors with microalbuminuria in hypertensive individuals the i-SEARCH global study显示文摘 | B6hm M Thoenes M Danchin N | 2007 | J Hypertens2007，25，： | 1 |
| 11 | Biological and Prognostic significance of stratified epithelial cytokeratins in infiltrating ductal breast carcinomas显示文摘 | Malzahn K Mitze M Thoenes M | 1998 | Virchows Arch1998，433，2： | 1 |
| 12 | Study of circumferential waves and their interaction with defects on cylindrical shells using line-source laser ultrasonics显示文摘 | Gao W M Glorieux C Thoen J | 2002 | J Appl Phys2002，91，9： | 1 |
| 13 | Changes in the Thl or Th2 cytokine dominance in the synovium of rheumatoid arthritis (RA):a kinetic study of the Th subsets in one unusual RA patient显示文摘 | CHABAUD M THOEN J | 2000 | Rheumatology (Oxford)2000，39，5： | 1 |
| 14 | Application of the plug flow with axial dispersion model for continuous emulsion polymerization in a pulsed packed column显示文摘 | Mayer M J J Meuldijk J Thoenes D | 1996 | Chemical Engineering Science1996，51，13： | 1 |
| 15 | Reactive pol- ymer membranes for ethylene/ethane separation显示文摘 | Sungpet A Way J D Thoen P M | 1997 | J Membr Sci1997，136，11： | 1 |
| 16 | Adaptive loading for OFDM/SDMA-based wireless networks 显示文摘 | Thoen S Van der Perre L Engels M | 2002 | IEEE Transactions on Communications2002，50，11： | 1 |
| 17 | Biological and prognosticsignificance of stratified epithelial cytokeratins in infiltrating ductalbreast carcinomas显示文摘 | Malzahn K Mitze M Thoenes M | 1998 | Virchows Arch1998，433，2： | 1 |
| 18 | Changes in the Th1 or Th2 cytokine dominance in the synovium of rheumatoid arthritis (RA):a kinetic study of the Th subsets in one unusual RA patient显示文摘 | Aarvak T Chabaud M Thoen J | 2000 | Rheumatology2000，39，： | 1 |
| 19 | Association of cardiovascular risk factors with microalbuminuria in hypertensive individuals:the i-SEARCH Global Study显示文摘 | Bohm M Thoenes M Danchin N | 2007 | J Hypertens2007，25，11： | 1 |
| 20 | Parenteral nutrition additive shortages:the short-term,long-term and potential ep- igenetic implications in premature and hospitalized infants显示文摘 | Hanson C Thoene M Wagner J | 2012 | Nutrients2012，4，12： | 1 |
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