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您的检索式：作者名="T.Thompson"
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| 1 | 中国大庆糖尿病预防研究中生活方式干预对预防糖尿病的长期影响——20年随访研究显示文摘在《中华内科杂志》第九届编委会第一次会议上,通过了创建一个新栏目的建议:将发表在国外被美国科学引文索引(SCI)收录杂志上的优秀中国研究论文以中文给予重点介绍。但在实际操作过程中遇到许多问题,使得该栏目一直未能与读者见面。今年初召开的在京部分编委座谈会上,就如何解决这些问题进行了讨论,并达成共识:栏目名称确定为“海外发表论文选读”,对已在海外发表的文章以摘要形式介绍给读者,对该类文稿的审稿程序予以简化。我们希望这一栏目能受到读者欢迎,同时期望广大读者、作者关爱这一栏目,积极投稿或向我们推荐稿件。
本期我们介绍李光伟等发表在国际著名医学杂志Lancet上的研究,这是我国学者在糖尿病相关领域对全世界做出的重大贡献。中国大庆糖尿病预防研究、芬兰糖尿病预防研究和美国糖尿病预防研究3个大型随机试验已经表明,饮食和运动干预能推迟或预防糖耐量减低进展为糖尿病。本研究则首次证明此种获益可持续很久。是受试者多年继续坚持了他们改善了的生活方式,抑或是6年的干预已经足以长久获益尚不清楚,但两者无不证明将这种研究结果转化为实践是正确的。该项研究虽然尚没有足够的证据证明生活方式干预能降低心血管事件或死亡,但它显示了与以往药物干预研究同样的趋势,即延缓糖耐量减低进展为糖尿病可能改善心血管疾病的后果。该研究最为惊人之处是20年后对照组中有93%的受试者发生了糖尿病,尽管干预组80%最终也发生了糖尿病,但被推迟了3.6年。这些发现表明,一线内科医师尽早发现糖耐量减低者并在这一阶段给予强化干预具有重要的临床意义。 | 李光伟 张平 王金平 E.Gregg 杨文英 巩秋红 黎辉 李宏亮 姜亚云 安雅莉 帅英 张波 张景玲 T.Thompson R.B.Gerzoff G.Roglic 胡英华 P.H.Bennett | 2008 | 中华内科杂志2008，47，10： | 58 |
| 2 | Feasibility of dexmedetomidine in facilitating extubation in the intensive care unit显示文摘 | P. A.Arpino K.Kalafatas B. T.Thompson | 2008 | Journal of Clinical Pharmacy and Therapeutics2008，，1： | 1 |
| 3 | Human embryoid bodies to hepatocyte-like clusters:Preparing for translation显示文摘End-stage liver disease and acute liver failure are some of the most common causes of death worldwide,affecting over 40,000 patients in the United States,for most of whom liver transplantation is the only treatment.Transplantable livers are obtained primarily from deceased donors in the west and living donors in the east,with demand outstripping supply,leading to thousands of deaths each year for those on the transplant waiting lists.As a bridge to liver transplantation,human primary hepatocytes have been transplanted with low success,owing to their inability to grow and expand in vitro,their high sensitivity to cold storage-induced damage,and their dedifferentiation following two-dimensional culture.In the past decade,human induced pluripotent stem cells(hiPSCs)have been studied as a potential alternative to liver and primary hepatocyte transplantation through their differentiation into hepatocyte-like cells(HLCs).Differentiation of hiPSCs into HLCs is limited by the low percentage of differentiated cells that reach a mature hepatic phenotype,poor reproducibility of existing differentiation protocols,and inadequate long-term viability and function in vitro and in vivo.In this review,we will discuss the mechanisms of the various techniques that aim to improve the hepatic differentiation of hiPSCs into mature and genotypically stable HLCs for use in drug studies,as a potential bridge for liver transplantation after liver failure or as therapy for liver regeneration and replacement. | Giuseppe Pettinato Melissa T.Thompson Robert A.Fisher | 2017 | Liver Research2017，1，2： | 0 |
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