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1篇 您的检索式:作者名="Suthagar Pillai Piaru"
    题名 作者 年代 出处 被引量
1Antioxidant and antiangiogenic activities of the essential oils of Myristica fragrans and Morinda citrifolia显示文摘Objective:Toinvestigate the anti-angiogenic activity and antioxidant properties of Myristica fragrans(M.fragrans)(nutmeg) and Morinda citrifolia(M.citrifolia)(mengkudu) oils. Methods:The nutmeg and megkudu essential oils were obtained by steam distillation. The antioxidant activities of both essenlial oils were delermined by beta-carotene/ linoleic acid bleaching assay and reducing power while the anti-angiogenic activity was investigated using rat aortic ring assay using various concentrations.Results:The results showed that nutmeg oil has higher antioxidant activity than mengkudu oil.The nutmeg oil effectively inhibited the oxidation of linoleic acid with(88.68±0.1)%while the inhibition percentage of oxidation of linoleic acid of the mengkudu oil is(69.44±0.4)%.The nutmeg oil and mengkudu oil showed reducing power with an EC50 value of 181.4μg/mL and 3 043.0μg/mL,respectively.The anliangiogenic activity of nutmeg oil showed significant antiangiogenic activity with IC50 of 77.64μg/mL comparing to mengkudu oil which exhibits IC50 of 109.30μg/mL.Conclusion:Bioactive compound(s) will be isolated from the nutmeg essential oil to be developed as antiangiogenic drugs.Suthagar Pillai Piaru Roziahanim Mahmud Amin Malik Shah Abdul Majid Zeyad Daoud Mahmoud Nassar 2012Asian Pacific Journal of Tropical Medicine2012,5,4:3
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