|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis显示文摘The pool of microbes inhabiting our body is known as 'microbiota' and their collective genomes as 'microbiome'. The colon is the most densely populated organ in the human body, although other parts, such as the skin, vaginal mucosa, or respiratory tract, also harbour specific microbiota. This microbial community regulates some important metabolic and physiological functions of the host, and drives the maturation of the immune system in early life, contributing to its homeostasis during life. Alterations of the intestinal microbiota can occur by changes in composition(dysbiosis), function, or microbiota-host interactions and they can be directly correlated with several diseases. The only disease in which a clear causal role of a dysbiotic microbiota has been demonstrated is the case of Clostridium difficile infections. Nonetheless, alterations in composition and function of the microbiota have been associated with several gastrointestinal diseases(inflammatory bowel disease, colorectal cancer, or irritable bowel syndrome), as well as extra-intestinal pathologies, such as those affecting the liver, or the respiratory tract(e.g., allergy, bronchial asthma, and cystic fibrosis), among others. Species of Bifidobacterium genus are the normal inhabitants of a healthy human gut and alterations in number and composition of their populations is one of the most frequent features present in these diseases. The use of probiotics, including bifidobacteria strains, in preventive medicine to maintain a healthy intestinal function is well documented. Probiotics are also proposed as therapeutic agents for gastrointestinal disorders and other pathologies. The World Gastroenterology Organization recently published potential clinical applications for several probiotic formulations, in which species of lactobacilli are predominant. This review is focused on probiotic preparations containing Bifidobacterium strains, alone or in combination with other bacteria, which have been tested in human clinical studies. In spite of extensive literature on and research into this topic, the degree of scientific evidence of the effectiveness of probiotics is still insufficient in most cases. More effort need to be made to design and conduct accurate human studies demonstrating the efficacy of probiotics in the prevention, alleviation, or treatment of different pathologies. | Rafael Tojo Adolfo Suárez Marta G Clemente Clara G de los Reyes-Gavilán Abelardo Margolles Miguel Gueimonde Patricia Ruas-Madiedo | 2014 | World Journal of Gastroenterology2014，20，41： | 33 |
| 2 | 达比加群酯、利伐沙班或阿哌沙班与依诺肝素用于全髋关节或膝关节置换术后的血栓预防:系统综述、荟萃分析和间接治疗比较显示文摘目的 分析新型口服抗凝药预防全髋或全膝关节置换术后静脉血栓栓塞的临床转归.设计系统综述、荟萃分析以及间接治疗比较.数据来源 Medline和CENTRAL(至2011年4月为止)、临床试验注册中心、会议论文集以及药品监管机构的网站.研究选择利伐沙班、达比加群酯或阿哌沙班与依诺肝素相比,预防全髋或全膝关节置换术后静脉血栓栓塞症的随机对照试验.由两名研究者独立提取数据.采用随机效应荟萃分析估计症状性静脉血栓栓塞、临床相关出血、死亡和净临床终点(症状性静脉血栓栓塞、严重出血和死亡的复合转归)的相对危险度.分别使用RevMan和ITC软件进行直接和间接比较.结果 共纳入16项试验,共计38 747例患者.与依诺肝素组相比,利伐沙班组(RR:0.48;95%CI:0.31~0.75)和阿哌沙班组(RR:0.82;95%CI:0.41~1.64)的症状性静脉血栓栓塞发生风险较低,达比加群酯组(RR:0.71;95%CI:0.23~2.12).与依诺肝素组相比,利伐沙班组的临床相关出血相对危险度较高(RR:1.25;95%CI:1.05~1.49),达比加群酯组与依诺肝素组相似(RR:1.12;95%CI:0.94~1.35),而阿哌沙班组的相对危险度则较低(RR:0.82;95%CI:0.69~0.98).直接和间接比较的结果显示,各种治疗的净临床终点均无差异.结论新型口服抗凝药的有效性较高,同时普遍有较高的出血倾向.新型口服抗凝药之间的有效性和安全性无显著差异. | Antonio Gómez-Outes Ana Isabel Terleira-Fernández M Luisa Suárez-Gea Emilio Vargas-Castrillón | 2013 | 中华关节外科杂志(电子版)2013，7，6： | 4 |
| 3 | 云南昭通中新世末期鸟类动物群的组成及其时代意义显示文摘近年来,作者等人曾在云南昭通地区进行了多次野外大型化石发掘工作,在昭通组含褐煤的组合层中出土了大量的脊椎动物化石,其中以鸟类化石为最多,初步鉴定约860余件。经统计,这些鸟类分属于11目18科。此外,一同产出的还有鱼类、两栖类、爬行类,哺乳动物中的灵长类、长鼻类、奇蹄类、偶蹄类、食肉类、啮齿类、兔形类等化石,它们共同组成了一个新近纪早期(中新世末期)西南地区以鸟类为主的脊椎动物化石群。另外,从20世纪至今,在昭通组的时代界定上,长期以来观点尚不统一。文中根据新发现的动物群,特别是小哺乳动物的最新分析研究,结合古地磁测定结果,推测该动物群的年代应为中新世末期,较之以前的上新世—早更新世的时代结论大大提前。同时,昭通地区中新世鸟类动物群的发现,不仅填补了这一时期我国鸟类化石群的空白,而且对于新近纪鸟类演化的研究也具有重要意义。 | 张玉光 吉学平 Jablonski N G Su D F 王晓斌 杨馨 李志恒 付丽娅 | 2013 | 古生物学报2013，52，3： | 3 |
| 4 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 5 | Occurrence and characteristics of polybrominated dibenzo-p-dioxins and dibenzofurans in stack gas emissions from industrial thermal processes显示文摘 | Du B Zheng M H Tian H Liu A Huang Y Li L Ba T Li N Ren Y Li Y Dong S Su G | | 0，，10： | 1 |
| 6 | Decreased hephhaestin activity in the intestine of copper-deficient mice causes systemic iron deficiency 显示文摘 | CHEN Huijun HUANG G N G SU T | 2006 | Nutr2006，136，： | 1 |
| 7 | Theoretical Study on Density Wave Oscillation of Two-phase Natural Circulation under Low Quality Conditions显示文摘 | Su G H Jia D N Fukuda K | 2001 | Joumal of Nuclear Science and Technology2001，38，8： | 1 |
| 8 | Theoretical and Experimental Study on Density Wave Oscillation of Two-phase Natural Circulation under the Condition of Low Quality显示文摘 | Su G H Jia D N Fukuda K | 2002 | Nuclear Engineering and Design2002，215，3： | 1 |
| 9 | Feature-independent aperture evaluator for the curvilinear SAR显示文摘 | Su Z G Peng Y N Wang X T | 2007 | IEEE Geoscience and Remote Sensing Letters2007，4，2： | 1 |
| 10 | Reconnoitering the effect of shallow groundwater on land surface temperature and surface energy balance using MODIS and SEBS显示文摘 | ALKHAIER F SU Z B FLERCHINGER G N | 2012 | Hy- dmlogy and Earth System Sciences Discussions2012，16，7： | 1 |
| 11 | Humidity sensors based on TiO2 nanoparticles/ polypyrrole composite thin films显示文摘 | Su P G Huang L N | 2007 | Sensors and Actuators B: Chemical2007，123，1： | 1 |
| 12 | Direct oral anticoagulants in the treatment of acute venous thromboembolism: A systematic review and meta-analysis显示文摘 | Antonio Gómez-Outes Ana Isabel Terleira-Fernández Ramón Lecumberri M. Luisa Suárez-Gea Emilio Vargas-Castrillón | 2014 | Thrombosis Research2014，，： | 1 |
| 13 | Acute retroviral syndrome and high baseline viral load are predictors of rapid HIV progression among un- treated Argentinean seroconverters 显示文摘 | Soclas ME Sued O Laufer N Lfzaro ME Mingrone H Pryluka D Remondegui C Figueroa MI Cesar C Gun A Turk G Bouzas MB Kavasery R Krolewiecki A P6rez H Salom6u H Cahn P Grupo Argentino de Seroconversi6r Study Group | 2011 | J Int AIDS Soc2011，14，1： | 1 |
| 14 | Many human medulloblastoma tumors overexpress rcpressor element - 1 silencing transcription (REST)/neuron- restrictive silencer factor( NRSF ), which can be functionally countered by REST -VP16 显示文摘 | Fuller G N Su X Price R E | 2005 | Mol Cancer Ther2005，4，： | 1 |
| 15 | Modeling studies of the longitudinal variation in TEC at equatorial-anomaly latitudes显示文摘 | Su Y Z Bailey G J Balan N | 1995 | J Atmos Terr Phys1995，57，8： | 1 |
| 16 | The signal subspace approach for multi- ple wide-band emitter location显示文摘 | Su G N Morf M | 1983 | IEEE Transactions on Acoustics Speech and Signal Processing1983，31，6： | 1 |
| 17 | Plasma adiponectin levels inversely correlate to clinical parameters in type 2 diabetes mellitus patients with macrovascular diseases显示文摘 | Wang G Gao S Su N | 2015 | Ann Clin Lab Sci2015，45，3： | 1 |
| 18 | Pharmaeokineties of a novel antibiotic bitespiramycin in rats 显示文摘 | Shi X G Zhong D F Su N L | 2003 | Asian d Drug Metabol Pharmacokinet2003，3，2： | 1 |
| 19 | Diferential proteomic analysis of cyclospofine A-induced toxicity in renal proximal tubule cells显示文摘 | Puigmulé M López-Hellin J Su (n)é G | | 0，，： | 1 |
| 20 | Astrocyte elevated gene-1 contributes to the pathogenesis of neuroblastoma显示文摘 | Lee S G Jeon H Y Su Z Z Richards J E Vozhilla N Sarkar D | 2009 | Oneogene2009，28，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员