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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Protection to + 12Gz显示文摘 | Burns J W Ivan D J Stern C H | 2001 | Aviat Space Environ Med2001，72，5： | 1 |
| 3 | The level of synthesis and secretion of Gaussia princeps luciferase in transfected CHO cells is heavily dependent on the choice of signal peptide显示文摘 | Knappskog S Ravneberg H Gjerdrum C Trosse C Stern B Pryme I F | 2007 | J Biotechnol2007，128，： | 1 |
| 4 | Physical volcanology of the submarine Mariana and volcano arcs显示文摘 | Bloomer S H Stern R J Smoot N C | 1989 | Bulletin of Volcanology1989，51，： | 1 |
| 5 | Effect of cooling rate and dehydration regimen on the histological appearance of human ovarian cortex following cryopreservation in 1,2-propanediol 显示文摘 | GOOK A EDGAR D H STERN C | 1999 | Hum Reprod1999，14，8： | 1 |
| 6 | The Chlamydomonas reinhardtii plastid chromosome:islands of genes in a sea of repeats显示文摘 | MAUL J E LILLY J W CUI L DE PAMPHILIS C W MILLER W HARRIS E H STERN D B | 2002 | Plant Cell2002，14，11： | 1 |
| 7 | Physical volcanology of the submarine Mariana and volcano arcs显示文摘 | Bloomer S H Stern R J Smoot N C | 1989 | Bulletin of Volcanology1989，51，： | 1 |
| 8 | Physical volcanology of the submarine Mariana and volcano arcs 显示文摘 | Bloomer S H Stern R J Smoot N C | 1989 | Bulletin of Volcanology 511989，，： | 1 |
| 9 | Examining the out-of-center distortion in the ^2- anion 显示文摘 | IZUMI H K KIRSCH J E STERN C L | 2005 | Inorg Chem2005，44，4： | 1 |
| 10 | 查看详情显示文摘 | Woo J H Treu T Barth A J Wright S A Walsh J L Bentz M C Martini P Bennert A N Canalizo G Filippenko A V Gates E Greene J Malkan M A Stern D Minezaki T | | 0，，： | 1 |
| 11 | Analysis of the transcription factor WUSCHEL and its functional homologue in Antirrhinum reveals a potential mechanism for their roles in meristem maintenance显示文摘 | Kieffer M Stern Y Cook H Clerici E Maulbetsch C Laux T Davies B | | 0，，： | 1 |
| 12 | Effect of cooling rate and dehydration regimen on the histological appearanee of human ovarian cortex following eryopreservafion in 1,2-propanediol 显示文摘 | GOOK D A EDGAR D H STERN C | 1999 | Hum Reprod1999，14，： | 1 |
| 13 | A viscous flow approach to the computation of propeller-hull intera- ction显示文摘 | STERN F KIM H T PATEL V C | 1988 | Journal of Ship Research1988，32，4： | 1 |
| 14 | Worker representation on boards of directors : A study of competing roles 显示文摘 | Hammer T H Currall S C Stern R N | 1991 | Industrial & Labor Relations Review1991，44，4： | 1 |
| 15 | Chromosome translocations in couples with in vitro fertilization implantation failure 显示文摘 | Stern C Pertile M Norris H | 1999 | Hum Reprod1999，14，： | 1 |
| 16 | DNA repair gene XRCC1 polymorphisms,smoking,and bladder cancer risk显示文摘 | STERN M C UMBACH D M GILS C H | 2001 | Cancer Epidemiol Biomarkers Prev2001，10，2： | 1 |
| 17 | Effect of cooling rate and dehydration regimen on the histological appearance of human ovarian cortex following cryopreserration in 1, 2 -propanediol 显示文摘 | GOOK D A EDGAR D H STERN C | 1999 | Hum Reprod1999，14，8： | 1 |
| 18 | Metasomatie origin of garnet orthopyroxenites in the subeontinental lithospheric mantle underlying the Pall Aike volcanic field, southern South Ameriea显示文摘 | Wang J Hattori K H Stern C R | 2008 | Mineralogy and Petrology2008，94，： | 1 |
| 19 | Evaporation of NaNOa ,KNOa and NaNO2 显示文摘 | KRAMER C M MUNIR Z A STERN K H | 1983 | High Temperature Science1983，16，4： | 1 |
| 20 | Endothelial receptor-mediated binding of glucose-modified albumin is associated with increased monolayer permeability and modulation of cell surface coagulant properties显示文摘 | Esposito C Gerlach H Brett J Stern D Vlassara H | 1989 | J Exp Med1989，170，4： | 1 |
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