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您的检索式：作者名="Stephanie H.Y.Lau"
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| 1 | Methods of vascular control technique during liver resection:a comprehensive review显示文摘BACKGROUND:Significant hemorrhage together with blood transfusion increases postoperative morbidity and mortality of hepatic resection.Hepatic vascular occlusion is effective in minimizing bleeding during hepatic parenchymal transection.This article aimed to review the current role and status of various techniques of hepatic vascular occlusion during hepatic resection.DATA SOURCES:The relevant manuscripts were identified by searching MEDLINE,and PubMed for articles published between January 1980 and April 2010 using the keywords ' vascular control','vascular clamping','vascular exclusion' and 'hepatectomy'.Additional papers were identified by a manual search of the references from the key articles.RESULTS:One randomized controlled trial(RCT) and 5 RCTs showed intermittent Pringle maneuver and ischemic preconditioning followed by continuous Pringle maneuver were superior to continuous Pringle maneuver alone,respectively.Two RCTs compared the outcomes of hepatectomy with and without intermittent Pringle maneuver.One showed Pringle maneuver to be beneficial,while the other failed to show any benefit.One RCT showed that ischemic preconditioning had significantly less blood loss than using intermittent Pringle maneuver.Four RCTs evaluated the use of hemihepatic vascular occlusion.One RCT showed it had significantly less blood loss than Pringle maneuver,while the other 3 showed no significant difference.Only 1 RCT showed it had significantly less liver ischemic injury.No RCT had been carried out to assess segmental vascular occlusion.Two RCTs compared the outcomes of total hepatic vascular exclusion(THVE) and Pringle maneuver.One RCT showed THVE resulted in similar blood loss,but a higher postoperative complication.The other RCT showed less blood loss using THVE but the postoperative complication rate was similar.Both studies showed similar degree of liver ischemic injury.Only one RCT showed that selective hepatic vascular exclusion(SHVE) had less blood loss and liver ischemic injury than Pringle maneuver.CONCLUSION:Due to the great variations in these studies,it is difficult to draw a definitive conclusion on the best technique of hepatic vascular control. | Wan-Yee Lau Eric C.H.Lai Stephanie H.Y.Lau | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，5： | 27 |
| 2 | The current role of neoadjuvant/adjuvant/chemoprevention therapy in partial hepatectomy for hepatocellular carcinoma:a systematic review显示文摘BACKGROUND:Following curative treatment for hepato-cellular carcinoma(HCC),50%-90% of postoperative death is due to recurrent disease.Intra-hepatic recurrence is frequently the only site of recurrence.Thus,any neoadjuvant or adjuvant therapy,which can decrease or delay the incidence of intra-hepatic recurrence,or any cancer chemoprevention which can prevent a new HCC from developing in the liver remnant,will improve the results of liver resection.This article systematically reviewed the current evidence of neoadjuvant,adjuvant, and chemoprevention in partial hepatectomy of HCC. DATA SOURCES:Studies were identified by searching MEDLINE and PubMed databases for articles from January 1990 to November 2008 using the keywords 'hepatocellular carcinoma','hepatectomy','adjuvant therapy','neoadjuvant therapy',and'regional therapy'. Additional papers and book chapters were identified by a manual search of the references from the key articles. RESULTS:Neoadjuvant transarterial chemoembolization or adjuvant regional transarterial chemotherapy± embolization+systemic chemotherapy did not add benefit. Both adjuvant transarterial radioembolization with 131 I-lipiodol and adjuvant systemic interferon showed promising results.However,there were only a limited number of such studies.CONCLUSIONS:Further randomized controlled studies need to be carried out.Currently,there is no consensus on a standard neoadjuvant/adjuvant/chemoprevention therapy in partial hepatectomy for HCC. | Wan-Yee Lau Eric C.H.Lai Stephanie H.Y.Lau | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，2： | 24 |
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