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| 1 | National trends in resection of the distal pancreas显示文摘AIM:To investigate national trends in distal pancreatectomy(DP) through query of three national patient care databases.METHODS:From the Nationwide Inpatient Sample(NIS,2003-2009),the National Surgical Quality Improvement Project(NSQIP,2005-2010),and the Surveillance Epidemiology and End Results(SEER,2003-2009) databases using appropriate diagnostic and procedural codes we identified all patients with a diagnosis of a benign or malignant lesion of the body and/or tail of the pancreas that had undergone a partial or distal pancreatectomy.Utilization of laparoscopy was defined in NIS by the International Classification of Diseases,Ninth Revision correspondent procedure code;and in NSQIP by the exploratory laparoscopy or unlisted procedure current procedural terminology codes.In SEER,patients were identified by the International Classification of Diseases for Oncology,Third Edition diagnosis codes and the SEER Program Code Manual,third edition procedure codes.We analyzed the databases with respect to trends of inpatient outcome metrics,oncologic outcomes,and hospital volumes in patients with lesions of the neck and body of the pancreas that underwent operative resection.RESULTS:NIS,NSQIP and SEER identified 4242,2681 and 11 082 DP resections,respectively.Overall,laparoscopy was utilized in 15%(NIS) and 27%(NSQIP).No significant increase was seen over the course of the study.Resection was performed for malignancy in 59%(NIS) and 66%(NSQIP).Neither patient Body mass index nor comorbidities were associated with operative approach(P = 0.95 and P = 0.96,respectively).Mortality(3% vs 2%,P = 0.05) and reoperation(4% vs 4%,P = 1.0) was not different between laparoscopy and open groups.Overall complications(10% vs 15%,P < 0.001),hospital costs [44 741 dollars,interquartile range(IQR) 28 347-74 114 dollars vs 49 792 dollars,IQR 13 299-73 463,P = 0.02] and hospital length of stay(7 d,IQR 4-11 d vs 7 d,IQR 6-10,P < 0.001) were less when laparoscopy was utilized.One and two year survival after resection for malignancy were unchanged over the course of the study(ductal adenocarinoma 1-year 63.6% and 2-year 35.1%,P = 0.53;intraductal papillary mucinous neoplasm and nueroendocrine 1-year 90% and 2-year 84%,P = 0.25).The majority of resections were performed in teaching hospitals(77% NIS and 85% NSQIP),but minimally invasive surgery(MIS) was not more likely to be used in teaching hospitals(15% vs 14%,P = 0.26).Hospitals in the top decile for volume were more likely to be teaching hospitals than lower volume deciles(88% vs 43%,P < 0.001),but were no more likely to utilize MIS at resection.Complication rate in teaching and the top decile hospitals was not significantly decreased when compared to non-teaching(15% vs 14%,P = 0.72) and lower volume hospitals(14% vs 15%,P = 0.99).No difference was seen in the median number of lymph nodes and lymph node ratio in N1 disease when compared by year(P = 0.17 and P = 0.96,respectively).CONCLUSION:There appears to be an overall underutilization of laparoscopy for DP.Centralization does not appear to be occurring.Survival and lymph node harvest have not changed. | Armando Rosales-Velderrain Steven P Bowers Ross F Goldberg Tatyan M Clarke Mauricia A Buchanan John A Stauffer Horacio J Asbun | 2012 | World Journal of Gastroenterology2012，18，32： | 8 |
| 2 | Total pancreatectomy: Short- and long-term outcomes at a high-volume pancreas center显示文摘AIM To identify the current indications and outcomes of total pancreatectomy at a high-volume center. METHODS A single institutional retrospective study of patients undergoing total pancreatectomy from 1995 to 2014 was performed.RESULTS One hundred and three patients underwent totalpancreatectomy for indications including: Pancreatic ductal adenocarcinoma(n = 42, 40.8%), intraductal papillary mucinous neoplasms(n = 40, 38.8%), chronic pancreatitis(n = 8, 7.8%), pancreatic neuroendocrine tumors(n = 7, 6.8%), and miscellaneous(n = 6, 5.8%). The mean age was 66.2 years, and 59(57.3%) were female. Twenty-four patients(23.3%) underwent a laparoscopic total pancreatectomy. Splenic preservation and portal vein resection and reconstruction were performed in 24(23.3%) and 18 patients(17.5%), respectively. The 90 d major complications, readmission, and mortality rates were 32%, 17.5%, and 6.8% respectively. The 1-, 3-, 5-, and 7-year survival for patients with benign indications were 84%, 82%, 79.5%, and 75.9%, and for malignant indications were 64%, 40.4%, 34.7% and 30.9%, respectively.CONCLUSION Total pancreatectomy, including laparoscopic total pancreatectomy, appears to be an appropriate option for selected patients when treated at a high-volume pancreatic center and through a multispecialty approach. | Hazem M Zakaria John A Stauffer Massimo Raimondo Timothy A Woodward Michael B Wallace Horacio J Asbun | 2016 | World Journal of Gastrointestinal Surgery2016，8，9： | 3 |
| 3 | Morphology of the uvula in obstructive sleep apnea显示文摘 | Stauffer J L Buick M K Bixler E O | | 0，，03： | 1 |
| 4 | Retinoic acid decreases targeting of p27 for degradation via an N-mycdependent decrease in p27 phosphorylation and an Nmyc-independent decrease in Skp2显示文摘 | Nakamura M Matsuo T Stauffer J | 2003 | Cell Death Differ2003，10，2： | 1 |
| 5 | Atmospheric methane, record from a Greenland ice core over the last 1000 year显示文摘 | Blunier T Chappnllaz J Schwander J Barnola J M Desperts T Stauffer B Raynaud D | 1993 | Geophys Res Lett1993，20，20： | 1 |
| 6 | One-step 3D shaping using a gray-tone mask for optical and microelectronic applications 显示文摘 | Oppliger Y Sixt P Stauffer J M etal | 1994 | Microelectronic Engineering1994，23，： | 1 |
| 7 | Retinoic acid de- creases targeting of p27 for degradation via an N-myc- dependent decrease in p27 phosphorylation and an N-myc- independent decrease in Skp2 显示文摘 | Nakamura M Matsuo T Stauffer J | 2003 | Cell Death Differ2003，10，2： | 1 |
| 8 | Chemical shift mapping of shikimate-3-phosphate binding to the isolated N-terminal domain of 5-enolpyruvylshikimate-3-phosphosate synthase显示文摘 | Young J K Helms G L | 2001 | FEBS leters2001，499，： | 1 |
| 9 | Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-10- nase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity 显示文摘 | MAIRA S M STAUFFER F BRUEGGEN J | 2008 | Mol Cancer Ther2008，7，7： | 1 |
| 10 | Comparison of mercury concentrations in liver, muscle, whole bodies, and composites of fish from the red river of the north 显示文摘 | Goldstein R M Brigham M E Stauffer J C | 1996 | Canadian Journal of Fisheries and Aquatic Sciences1996，53，2： | 1 |
| 11 | Application of advanced methods to design loads determination for the L-1011 transport 显示文摘 | Stauffer W A Lewoh J G Hoblit F M | 1973 | Journal of Aircraft1973，10，8： | 1 |
| 12 | Laparoscopic surgery performed through a single incision: A systematic review of the current literature显示文摘 | Pfluke J M Parker M Stauffer J A | 2011 | J Am Coil Surg2011，212，1： | 1 |
| 13 | Practical applications of genotypic surveys for forensic STR testing显示文摘 | Holt C L Stauffer C Wallin J M | 2000 | Forensic Sci2000，112，2： | 1 |
| 14 | Combined effects of water temperature and salinity on growth and feed utilization of juvenile Nile tilapia Oreochromis niloticus (Linneaus)显示文摘 | Likongwe J S Stecko T M Stauffer J R | 1996 | Aquaculture1996，146，： | 1 |
| 15 | Starting up the Sherritt zinc pressure leach process at Hudson Bay显示文摘 | Collins M J McConaghy E J Stauffer R F | 1994 | JOM1994，64，4： | 1 |
| 16 | Combined effects of water temperature and salinity on growth and feed utilization of juvenile Nile tilapia Oreochromis niloticus ( Lin neaus ) 显示文摘 | LIKONWE J S STECKO T M STAUFFER J R | 1996 | Aquaculture1996，146，： | 1 |
| 17 | Current capabilities of MEMS capacitive accelerometers in a harsh environment显示文摘 | Stauffer J M | | 0，，： | 1 |
| 18 | Retinoic acid decreases targeting of p27 for degradation via an N-myc-dependent decrease in p27 phosphorylation and an N-myc-independent decrease in Skp2显示文摘 | Nakamura M Matsuo T Stauffer J | 2003 | Cell Death Differ2003，10，2： | 1 |
| 19 | A prospective ran- domized comparison between pac'titaxel and sirohmus stents in the real world of interventional cardiology : the TAXi trial显示文摘 | Goyj J Stauffer JC Siegenthal E M | 2005 | J Am Coll Cardiol2005，45，2： | 1 |
| 20 | A prospective randomized comparison between paclitaxel and sirolimus stents in the real world of interventional cardiology: the TAXi trial显示文摘 | GOY J J STAUFFER J C SIEGENTHALER M | 2005 | J Am Coll Cardiol2005，45，： | 1 |
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