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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Therapeutic efficacy of tradit- ional Chinese medicine, Shen-Mai San, in cancer patients un- dergoing chemotherapy or radiotherapy: study protocol for a r- andomized, double-blind, placebo-controlled trial显示文摘 | Lo LC Chen CY Chen ST | 2012 | Trials2012，13，： | 1 |
| 3 | Cytochrome P450 1B1 is overexpressed and regulated by hypomethylation in prostate cancer显示文摘 | Tokizane T Shiina H Igawa M Enokida H Urakami S Kawakami T Ogishima T Okino ST Li LC Tanaka Y Nonomura N Okuyama A Dahiya R | 2005 | Clin Cancer Res2005，11，16： | 1 |
| 4 | Confocal microscopic analysis reveals sprouting of primary afferent fibres in rat dorsal horn after spinal cord injury显示文摘 | Wong ST Atkinson BA Weaver LC | 2000 | Neurosci Lett2000，296，23： | 1 |
| 5 | Regulation of inflammation by Rac2 in immune complex-mediated acute lung injury 显示文摘 | Dooley JL Abdel-Latif D St LC | 2009 | Am J Physiol Lung Cell Mol Physiol2009，297，6： | 1 |
| 6 | Small dsRNAs induce transcriptional activation in human cells显示文摘 | Li LC Okino ST Zhao H | 2006 | Proc Natl Acad Sci USA2006，103，17： | 1 |
| 7 | Small dsRNAs induce transcriptional activation in human cells显示文摘 | Li LC Okino ST Zhao H | 2006 | Proc Natl Acad Sci U S A2006，103，17： | 1 |
| 8 | Hepatitis B virus markers in Chinese twins显示文摘 | Lin TM Chen CJ Wu MM Yang CS Chen JS Lin CC Kwang TY Hsu ST Lin SY Hsu LC | 1989 | Anticancer Res1989，9，3： | 1 |
| 9 | Neuropsychiatric symptom clusters of Alzheimer disease in Hong Kong Chinese:correlates with caregiver burden and depression显示文摘 | Cheng ST Lam LC Kwok T | | 0，，10： | 1 |
| 10 | Familial microtia with meatal atresia in two sibships显示文摘 | Ellwood LC Winter ST Dar H | 1968 | J Med Genet1968，5，4： | 1 |
| 11 | Combined periacetabular and femoral osteotomies for severe hip deformities显示文摘 | Clohisy JC St John LC Nunley RM | 2009 | Clin Orthop Relat Res2009，，467： | 1 |
| 12 | Xanthine oxidase inhibition ameliorates cardiovascular dysfunction in dogs with pacing-induced heart failure显示文摘 | Amado LC Saliaris AP Raju SV Lehrke S St John M Xie J | 2005 | J Mol Cell Cardiol2005，39，： | 1 |
| 13 | Neuropsychiatric symptom clusters of Alzheimer disease in Hong Kong Chinese:correlates with caregiver burden and depression显示文摘 | Cheng ST Lam LC Kwok T | 2013 | Am J Geriatr Psychiatry2013，21，10： | 1 |
| 14 | Pancreatic solid-cystic-papillary tumor:clinicopathologic features in eight patients from Hong Kong and review of the literature显示文摘 | Lam KY Lc CY Fan ST | 1999 | World J Surg1999，23，10： | 1 |
| 15 | DNA methylation in prostate cancer 显示文摘 | Li LC Okino ST Dahiya R | 2004 | Biochim Biophys Acta2004，1704，2： | 1 |
| 16 | Association of stere-otypes about physicians to health care satisfaction,help-seeking behavior,and adherence to treatment显示文摘 | Bogart LM Bird ST Walt LC | | 0，，6： | 1 |
| 17 | Small dsRNAs induce tran scriptional activation in human cells显示文摘 | Li LC Okino ST Zhao H | 2006 | Proc Natl Acad Sci USA2006，103，17： | 1 |
| 18 | Role of oral sodium phosphate and its effectiveness in large bowel preparation for out-patient colonoscopy显示文摘 | Chia YW Cheng LC Goh PM Ngoi SS Isaac J Chan ST Ti TK | 1995 | J R Coll Surg Edinb1995，40，6： | 1 |
| 19 | Port-access coronary artery bypass with cardioplegic arrest: Acute and chronic canine studies 显示文摘 | Stevens JH Burdon TA Siegel LC Peters WS Pompili MF St Goar FG Berry GJ Ribakove GH Vierra MA Mitchell RS Toomasian JM Reitz BA | 1996 | Ann Thorac Surg1996，62，2： | 1 |
| 20 | Epigenetic inac tivation of the dioxin responsive cytochrome P450 1AI gene in human prostate cancer显示文摘 | Okino ST Pookot D Li LC | 2006 | Cancer Res2006，66，15： | 1 |
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