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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Raman spectrum of graphite foams显示文摘 | Barros E B Demir N S Souza Filho AG | 2005 | Phys Rev B2005，71，16： | 1 |
| 3 | Trends in lung cancer mortality in Brazil from the 1980s into early 21st century: age - period - cohort analysis 显示文摘 | Souza MC Vasconcelos AG Cruz OG | 2012 | Cad Saude Publica2012，28，1： | 1 |
| 4 | Transcriptionaland phenotypic comparisons of Ppara knockout and siRNA knockdown mice显示文摘 | De Souza A T Dal X Spencer AG | 2006 | Nucleic Acids Research2006，34，16： | 1 |
| 5 | Cochlear implanted children present vocal parameters within normal standards显示文摘 | de Souza LB Bevilacqua MC Brasolotto AG | 2012 | Int J Pediatr Otorhinolaryngol2012，76，8： | 1 |
| 6 | Trends in lung cancer mortality in Brazil from the 1980s int early 21st century: age-peri- od-cohort analysis 显示文摘 | Souza MC Vasconcelos AG Gruz OG | 2012 | Cad Saude Publica2012，28，1： | 1 |
| 7 | Trends in lung cancer mortality in Brazil from the 1980s into early 21st century:age-period-cohort analysis显示文摘 | Souza MC Vasconcelosv AG Cruz OG | 2012 | Cad Saude Publica2012，28，1： | 1 |
| 8 | Angiotensin II and angiotensin-( 1-7 ) inhibit the inner cortex Na + -AT- Pase activity through AT2 receptor 显示文摘 | De Souza AM Lopes AG Pizzino CP | 2004 | Regul Pept2004，120，13： | 1 |
| 9 | Factor V leiden and factorⅡG20210A mutation in patients with recurrent abortion显示文摘 | Souza SS Ferriani RA Pontes AG | 1999 | Hum Reprod1999，14，10： | 1 |
| 10 | Cochlear implanted children present vocal parameters within normal standards显示文摘 | de Souza LB Bevilacqua MC Brasolotto AG | | 0，，： | 1 |
| 11 | /nvasive cervical cancer risk among HIV-infected women is a function of CD4 count and screening显示文摘 | Abraham AG Strickler HD D'Souza G | 2013 | J Acquir Immune Defic Syndr2013，63，5： | 1 |
| 12 | Transcriptional and phenotypic comparisons of Ppara knockout and siRNA knockdown mice显示文摘 | De Souza AT Dai XD Spence AG | 2006 | Nucleic Acids Research2006，34，16： | 1 |
| 13 | Dispersive Raman Spectra Observed in Graphite and Single wall Carbon Nanotubes显示文摘 | Saito R Jorio A Souza AG Grueneis A Pimenta MA Dresselhaus G Dresselhaus MS | 2002 | Physica B-Condensed Matter2002，323，14： | 1 |
| 14 | Characterizing Carbon Nanotube Samples with Resonance Raman Scattering显示文摘 | Jorio A Pimenta M A AG Souza Filho | | 0，，01： | 1 |
| 15 | Monitoring the authenticity of Brazilian UHT milk: a chemometric ap- proach显示文摘 | Souza SS Cruz AG Walter EHM | 2011 | Food Chemistry2011，124，2： | 1 |
| 16 | Leprosy assess- ment : experience report of nursing students 显示文摘 | Pereira SV Bachion MM Souza AG | 2008 | Rev Bras Enferm2008，61，： | 1 |
| 17 | Invasive Cervi- cal Cancer Risk Among HIV-Infected Women Is a Function of CD4 Count and Screening显示文摘 | Abraham AG Striekler HD D'Souza G | 2013 | Acquit Immune Defic Syndr2013，63，5： | 1 |
| 18 | Factor V Leiden and factor Ⅱ G20210A mutations in patients with recurrents abortion显示文摘 | FERRIANI RA PONTES AG | 1999 | Human Repord1999，14，： | 1 |
| 19 | Outcome in Children from Cryopreserved Embryos显示文摘 | Sutcliffe AG D'Souza SW Cadman J | 1995 | Arch Dis Child1995，72，4： | 1 |
| 20 | SCL/Tal-1 is essential for hematopoietic commitment of the hemangioblast but not for its development显示文摘 | Elefanty AG Keller G | 2005 | Blood2005，105，10： | 1 |
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