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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | How to manage inflammatory bowel disease during the COVID-19 pandemic:A guide for the practicing clinician显示文摘Managing inflammatory bowel disease(IBD)during the coronavirus disease 2019(COVID-19)pandemic has been a challenge faced by clinicians and their patients,especially concerning whether to proceed with biologics and immunosuppressive agents in the background of a global outbreak of a highly contagious new coronavirus(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2).The knowledge about the impact of this virus on patients with IBD,although it is still scarce,is rapidly evolving.In particular,concerns surrounding medications’impact for IBD on the risk of acquiring SARS-CoV-2 infection or developing COVID-19,and potentially exacerbate viral replication and the COVID-19 course,are a current thinking of both practicing clinicians and providers caring for patients with IBD.Managing patients with IBD infected with SARS-CoV-2 depends on both the clinical activity of the IBD and the occasional development and severity of COVID-19.In this review,we summarize the current data regarding gastrointestinal involvement by SARS-CoV-2 and pharmacologic and surgical management for IBD concerning this infection,and the COVID-19 impact on both the patient's psychological functioning and endoscopy services,and we concisely summarize the telemedicine roles during the COVID-19 pandemic. | Júlio Maria Fonseca Chebli Natália Sousa Freitas Queiroz Adérson Omar Mourão Cintra Damião Liliana Andrade Chebli Márcia Henriques de Magalhães Costa Rogério Serafim Parra | 2021 | World Journal of Gastroenterology2021，27，11： | 2 |
| 3 | Use of Raman micro-spectroscopy in the characterization of M^Ⅱ Fe2O4 (M= Fe, Zn) electric double layer ferrofluids 显示文摘 | Sousa M H Tourinho F A Rubim J C | 2000 | J Raman Spec2000，31，： | 1 |
| 4 | A randomized comparison of a sirolimus-eluting stent with a standard stent for coronary revaseularization显示文摘 | Morice M Serruys P Sousa J | 2002 | N Engl J Med2002，346，23： | 1 |
| 5 | Computer generated graphite pencil rendering of 3D polygonal models显示文摘 | Sousa M C Buchanan J W | 1999 | Computer Graphics Forum1999，18，3： | 1 |
| 6 | Character- ization of the products from the pyrolysis of sewage sludge in 1 kg/h rotating cylinder reactor 显示文摘 | Pedroza M M Sousa J F Vieira G E G | 2014 | Journal of Analpical and Applied Pyrolysis2014，105，： | 1 |
| 7 | Wnt2 regulates progenitor proliferation in the developing ventral midbrain 显示文摘 | Sousa K M Villaescusa J C Cajanek L | 2010 | Journal of Biological Chemistry2010，285，10： | 1 |
| 8 | Computer-generated graphite pencil rendering of 3D polygonal models显示文摘 | J W Buchanan | 1999 | Computer Graphics Forum1999，18，3： | 1 |
| 9 | New frontiers in cardiology:drug-eluting stents-part 1显示文摘 | SERRUYS P W COSTA M A | 2003 | Circulation2003，107，： | 1 |
| 10 | Suppression subtractive hybridization profiles of radial growth phase and metastatic melanoma cell lines reveal novel potential targets 显示文摘 | SOUSA J F ESPREAFICO E M | 2008 | BMCCancer2008，8，： | 1 |
| 11 | Mesoporous silica-magnetite nanocomposite synthesized by using a neutral surfactant显示文摘 | Souza K C Salazar-Alvarez G Ardisson J D Macedo W A A Sousa E M B | 2008 | Nanotechnology2008，19，18： | 1 |
| 12 | Transthyretin is not necessary for thyroid hormone metabolism in conditions of increased hormone demand显示文摘 | Sousa J C de Escobar G M Oliveira P | 2005 | J Endocrinol2005，187，2： | 1 |
| 13 | New electric double-layered magnetic fluids based on copper,nickel,and zinc ferrite nanostructures显示文摘 | SOUSA M H TOURINHO F A DEPEYROT J | 2001 | J Phys Chem2001，105，： | 1 |
| 14 | Computer generated graphite pencil rendering of 3D polygonal models 显示文摘 | Sousa M C Buchanan J W | 1999 | Computer Graphics Forum1999，18，3： | 1 |
| 15 | Fuzzy predictive control applied to an air-conditioning system显示文摘 | Sousa J M Babuska R Verbuggen H B | 1997 | Control Engineering Practice1997，5，10： | 1 |
| 16 | Restoration of lectin activity to a non-glycosylated ricin B chain mutant by the intraduction of a novel N-glycosylation site 显示文摘 | ZHAN J B de SOUSA M CHADDOCK J A | 1997 | FEBS Letters1997，407，3： | 1 |
| 17 | Use of Raman micro-spectroscopy in the characterization of MⅡ Fe2O4 (M =Fe,Zn) electric double layer ferrofluids显示文摘 | SOUSA M H TOURINHO F A RUBIN J C | 2000 | J Raman Spec2000，31，： | 1 |
| 18 | Advances in the study of proteolysis during cheese ripening显示文摘 | Sousa M J Ardo Y McSweeney P L H | 2001 | International Dairy Journal2001，，11： | 1 |
| 19 | Frustrated model to describe reentrant behavior in copper oxide superconductors 显示文摘 | Tavares I Pacobahyba J T M De Sousa J R | 2007 | Physica A: Stat Mech Its Appl2007，383，2： | 1 |
| 20 | Differential proteomic analysis of bronchoalveolar lavage fluid in asthmatics following segmaental antigen challenge显示文摘 | Wu J Kobayashi M Sousa E | 2005 | Mol Cell Proteomics2005，4，9： | 1 |
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