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| 1 | Treatment strategies using adefovir dipivoxil for individuals with lamivudine-resistant chronic hepatitis B显示文摘AIM:To investigate retrospectively the long-term efficacy of various treatment strategies using adefovir dipivoxil(adefovir) in patients with lamivudine-resistant chronic hepatitis B.METHODS:We included 154 consecutive patients in two treatment groups:the 'add-on' group(n = 79),in which adefovir was added to ongoing lamivudine treatment due to lamivudine resistance,and the 'switch/combination' group(n = 75),in which lamivudine was first switched to adefovir and then re-added later as needed.The 'switch/combination' group was then divided into two subgroups depending on whether participants followed(group A,n = 30) or violated(group B,n = 45) a proposed treatment strategy that determined whether to add lamivudine based on the serum hepatitis B virus(HBV) DNA levels(< 60 IU/mL or not) after 6 mo of treatment(roadmap concept).RESULTS:The cumulative probability of virologic response(HBV DNA < 60 IU/mL) was higher in group A than in the 'add-on' group and in group B(P < 0.001).In contrast,the cumulative probability of virologic breakthrough was lower in the 'add-on' group than in group B(P = 0.002).Furthermore,the risk of virologic breakthrough in the multivariate analysis was significantly lower in the 'add-on' group than in group A(hazard ratio = 0.096;95%CI,0.015-0.629;P = 0.015).CONCLUSION:The selective combination of adefovir with lamivudine based upon early treatment responses increased the odds of virologic breakthrough relative to the use of uniform combination therapy from the beginning of treatment. | Tae Jung Yun Jin Yong Jung Chang Ha Kim Soon Ho Um Hyonggin An Yeon Seok Seo Jin Dong Kim Hyung Joon Yim Bora Keum Yong Sik Kim Yoon Tae Jeen Hong Sik Lee Hoon Jai Chun Chang Duck Kim Ho Sang Ryu | 2012 | World Journal of Gastroenterology2012，18，47： | 19 |
| 2 | Superior mechanical properties and strengthening mechanisms of lightweight AlxCrNbVMo refractory high-entropy alloys(x=0,0.5,1.0)fabricated by the powder metallurgy process显示文摘Light and strong AlxCrNbVMo(x=0,0.5,and 1.0)refractory high-entropy alloys(RHEAs)were designed and fabricated via a the powder metallurgical process.The microstructure of the AlxCrNbVMo alloys consisted of a single BCC crystalline structure with a sub-micron grain size of 2-3μm,and small amounts(<4 vol.%)of fine oxide dispersoids.This homogeneous microstructure,without chemical segregation or micropores was achieved via high-energy ball milling and spark-plasma sintering.The alloys exhibited superior mechanical properties at 25 and 1000℃compared to those of other RHEAs.Here,CrNbVMo alloy showed a yield strength of 2743 MPa at room temperature.Surprisingly,the yield strength of the CrNbVMo alloy at 1000℃was 1513 MPa.The specific yield strength of the CrNbVMo alloy was increased by 27%and 87%at 25 and 1000℃,respectively,compared to the AlMo_(0.5) NbTa_(0.5)TiZr RHEA,which exhibited so far the highest specific yield strength among the cast RHEAs.The addition of Al to CrNbVMo alloy was advantageous in reducing its reduce density to below 8.0 g/cm^(3),while the elastic modulus decreased due to the much lower elastic modulus of Al compared to that of the CrNbVMo alloy.Quantitative analysis of the strengthening contributions,showed that the solid solution strengthening,arising from a large misfit effect due to the size and modulus,and the high shear modulus of matrix,was revealed to predominant strengthening mechanism,accounting for over 50%of the yield strength of the AlxCrNbVMo RHEAs. | Byungchul Kang Taeyeong Kong Ho Jin Ryu Soon Hyung Hong | 2021 | Journal of Materials Science & Technology2021，，10： | 9 |
| 3 | In-situ synthesis of TiC/Fe alloy composites with high strength and hardness by reactive sintering显示文摘Fe alloy composites reinforced with in-situ titanium carbide(Ti C) particles were fabricated by reactive sintering using different reactant C/Ti ratios of 0.8,0.9,1 and 1.1 to investigate the microstructure and mechanical properties of in-situ Ti C/Fe alloy composites.The microstructure showed that the in-situ synthesized Ti C particles were spherical with a size of 1–3 μm,irrespective of C/Ti ratio.The stoichiometry of in-situ Ti C increased from 0.85 to 0.88 with increasing C/Ti ratio from 0.8 to 0.9,but remained almost unchanged for C/Ti ratios between 0.9 and 1.1 due to the same driving force for carbon diffusion in Ti Cxat the common sintering temperature.The in-situ Ti C/Fe alloy composite with C/Ti = 0.9 showed improved mechanical properties compared with other C/Ti ratios because the presence of excess carbon(C/Ti = 1 and 1.1) resulted in unreacted carbon within the Fe alloy matrix,while insufficient carbon(C/Ti = 0.8)caused the depletion of carbon from the Fe alloy matrix,leading to a significant decrease in hardness.This study presents that the maximized hardness and superior strength of in-situ Ti C/Fe alloy composites can be achieved by microstructure control and stoichiometric analysis of the in-situ synthesized Ti C particles,while maintaining the ductility of the composites,compared to those of the unreinforced Fe alloy.Therefore,we anticipate that the in-situ synthesized Ti C/Fe alloy composites with enhanced mechanical properties have great potential in cutting tool,mold and roller material applications. | Junho Lee Dongju Lee Myung Hoon Song Wonhyuk Rhee Ho Jin Ryu Soon Hyung Hong | 2018 | Journal of Materials Science & Technology2018，34，8： | 8 |
| 4 | Primary signet ring cell carcinoma of the appendix:A rare case report and our 18-year experience显示文摘Primary adenocarcinoma of the appendix is a rare ma-lignancy that constitutes < 0.5% of all gastrointestinal neoplasms. Moreover, primary signet ring cell carci-noma of the appendix is an exceedingly rare entity. We have encountered 15 cases of primary appendiceal cancer among 3389 patients who underwent appen-dectomy over the past 18 years. In the present report, we describe a rare case of primary signet ring cell carcinoma of the appendix with ovarian metastases and unresectable peritoneal dissemination occurring in a 67-year-old female patient. She underwent ap-pendectomy and bilateral salpingo-oophorectomy with a laparoscopy procedure. She then received palliative systemic chemotherapy with 12 cycles of oxaliplatin, 5-flurorouracil, and leucovorin (FOLFOX-4). The patient currently is well without progression of disease 12 mo after beginning chemotherapy. | Yoon Ho Ko Chan-Kwon Jung Soon Nam Oh Tae Hee Kim Hye Sung Won Jin Hyoung Kang,Hyung Jin Kim, Won Kyung Kang, Seong Taek Oh, Young Seon Hong Jin Hyoung Kang Hyung Jin Kim Won Kyung Kang Seong Taek Oh Young Seon Hong | 2008 | World Journal of Gastroenterology2008，14，37： | 5 |
| 5 | Computed tomography findings for predicting severe acute hepatitis with prolonged cholestasis显示文摘AIM: To evaluate the significance of computed tomography (CT) findings in relation to liver chemistry and the clinical course of acute hepatitis. METHODS: Four hundred and twelve patients with acute hepatitis who underwent enhanced CT scanning were enrolled retrospectively. Imaging findings were analyzed for the following variables: gallbladder wall thickness (GWT), arterial heterogeneity, periportal tracking, number and maximum size of lymph nodes, presence of ascites, and size of spleen. The serum levels of alanine aminotransferase, alkaline phosphatase, bilirubin, albumin, and prothrombin time were measured on the day of admission and CT scan, and laboratory data were evaluated every 2-4 d for all subjects during hospitalization. RESULTS: The mean age of patients was 34.4 years, and the most common cause of hepatitis was hepatitis A virus (77.4%). The mean GWT was 5.2 mm. The number of patients who had findings of arterial heterogeneity, periportal tracking, lymph node enlargement > 7 mm, and ascites was 294 (80.1%), 348 (84.7%), 346 (84.5%), and 56 (13.6%), respectively. On multivariate logistic regression, male gender [odds ratio (OR) = 2.569, 95%CI: 1.477-4.469, P = 0.001], toxic hepatitis (OR = 3.531, 95%CI: 1.444-8.635, P = 0.006), level of albumin (OR = 2.154, 95%CI: 1.279-3.629, P = 0.004), and GWT (OR = 1.061, 95%CI: 1.015-1.110, P = 0.009) were independent predictive factors for severe hepatitis. The level of bilirubin (OR = 1.628, 95%CI: 1.331-1.991, P < 0.001) and GWT (OR = 1.172, 95%CI: 1.024-1.342,P = 0.021) were independent factors for prolonged cholestasis in multivariate analysis. CONCLUSION: In patients with acute hepatitis, GWT on CT scan was an independent predictor of severe hepatitis and prolonged cholestasis. | Sang Jung Park Jin Dong Kim Yeon Seok Seo Beom Jin Park Min Ju Kim Soon Ho Um Chang Ha Kim Hyung Joon Yim Soon Koo Baik Jin Yong Jung Bora Keum Yoon Tae Jeen Hong Sik Lee Hoon Jai Chun Chang Duck Kim Ho Sang Ryu | 2013 | World Journal of Gastroenterology2013，19，16： | 4 |
| 6 | Diabetic factors associated with gastrointestinal symptoms in patients with type 2 diabetes显示文摘AIM: To determine whether gastrointestinal (GI) symptoms are more frequent in type 2 diabetic patients and to examine which diabetic factors are associated with the symptoms. METHODS: Consecutive subjects with diabetes and age-/gender-matched normal controls were recruited for this study. GI symptoms were assessed using a structured questionnaire divided into two GI symptomcategories (upper and lower GI symptoms), and consisting of 11 individual symptoms. In the diabetic patient group, diabetic complications including peripheral neuropathy, nephropathy and retinopathy, glycosylated hemoglobin (HbA1c) level and diabetes duration were evaluated. RESULTS: Among the total 190 diabetic patients and 190 controls enrolled, 137 (72%) of the diabetic patients and 116 (62%) of the controls had GI symptoms. In the diabetic patient group, 83 (43%) had upper GI symptoms and 110 (58%) lower GI symptoms; in the control group, 59 (31%) had upper GI symptoms and 104 (55%) lower GI symptoms. This difference between the two groups was significant for only the upper GI symptoms (P = 0.02). Among the diabetic factors, the HbA1c level was the only independent risk factor for upper GI symptoms in the multiple logistic regression analysis (odds ratio = 2.01, 95% confidence interval: 1.02-3.95). CONCLUSION: Type 2 diabetes was associated with an increased prevalence of upper GI symptoms and these symptoms appeared to be independently linked to poor glycemic control, as measured by the HbA1c levels. | Jeong Hwan Kim Hyung Seok Park Soon Young Ko Sung Noh Hong In-Kyung Sung Chan Sub Shim Kee-Ho Song Dong-Lim Kim Sook Kyung Kim Jeeyoung Oh | 2010 | World Journal of Gastroenterology2010，16，14： | 3 |
| 7 | Comparison of Clevudine and Entecavir for Treatment-naive Patients With Chronic Hepatitis B Virus Infection: Two-Year Follow-up Data显示文摘 | Eileen L. Yoon Hyung Joon Yim Hyun Jung Lee Young Sun Lee Jeong Han Kim Eun Suk Jung Ji Hoon Kim Yeon Seok Seo Jong Eun Yeon Hong Sik Lee Soon Ho Um Kwan Soo Byun | 2011 | Journal of Clinical Gastroenterology2011，，10： | 3 |
| 8 | Adding adefovir vs. switching to entecavir for lamivudine‐resistant chronic hepatitis B ( ACE study): a 2‐year follow‐up randomized controlled trial显示文摘 | Hyung Joon Yim Yeon Seok Seo Eileen L. Yoon Chang Wook Kim Chang Don Lee Sang Hoon Park Myung Seok Lee Choong Kee Park Hee Bok Chae Moon Young Kim Soon Koo Baik Yun Soo Kim Ju Hyun Kim Jung Il Lee Jin Woo Lee Sun Pyo Hong Soon Ho Um | 2013 | Liver Int2013，，2： | 2 |
| 9 | Activation of macrophages by polysaccharide isolated from Paecilomyces cicadae through toll-like receptor 4显示文摘 | Hyung Sook Kim Yeon Jin Kim Hong Kyung Lee Hwa Sun Ryu Ji Sung Kim Mi Jung Yoon Jong Soon Kang Jin Tae Hong Youngsoo Kim Sang-Bae Han | 2012 | Food and Chemical Toxicology2012，，9： | 1 |
| 10 | Adefovir and Lamivudine Combination Therapy in Patients with Entecavir-Resistant Chronic Hepatitis B: Antiviral Responses and Evolution of Mutations显示文摘 | Yim Hyung Joon Lee Hyun Jung Suh Sang Jun Seo Yeon Seok Kim Chang Wook Lee Chang Don Park Sang Hoon Lee Myung Seok Park Choong Kee Chae Hee Bok Kim Moon Young Baik Soon Koo Kim Yun Soo Kim Ju Hyun Lee Jung Il Lee Jin Woo Hong Sun Pyo Um | 2014 | Intervirology2014，，5： | 1 |
| 11 | Effect of thermomechanical treatments on microstructure and p roperties of Cu-base lead frame alloy显示文摘 | Ho Jryu Hyung K Balk Soon H Hong | 2000 | J Mater Sci2000，35，： | 1 |
| 12 | Effect of thermomechanical treatments on microstructure and properties of Cu-base leadframe alloy显示文摘 | Ho J. Ryu Hyung K. Baik Soon H. Hong | 2000 | Journal of Materials Science2000，，14： | 1 |
| 13 | Psychometric Hepatic Encephalopathy Score for the detection of minimal hepatic encephalopathy in Korean patients with liver cirrhosis显示文摘 | Yeon Seok Seo Sun Young Yim Jin Yong Jung Chang Ha Kim Jin Dong Kim Bora Keum Hyonggin An Hyung Joon Yim Hong Sik Lee Chang Duck Kim Ho Sang Ryu Soon Ho Um | 2012 | Journal of Gastroenterology and Hepatology2012，，11： | 1 |
| 14 | p - ZnO/ n - GaN heterostructure ZnO light - emitting diodes 显示文摘 | Dae - Kue Hwang Soon - Hyung Kang Jae - Hong Lim | 2005 | Applied Physits Letters2005，86，22： | 1 |
| 15 | Comparison of Surface Roughness and Bacterial Adhesion Between Cosmetic Contact Lenses and Conventional Contact Lenses显示文摘 | Yong Woo Ji Young Joo Cho Chul Hee Lee Soon Ho Hong Dong Yong Chung Eung Kweon Kim Hyung Keun Lee | 2015 | Eye & Contact Lens: Science & Clinical Practice2015，，1： | 1 |
| 16 | Effect of thermomechanical treatments on microstructure and properties of Cu-base leadframe alloy显示文摘 | Ho J. Ryu Hyung K. Baik Soon H. Hong | 2000 | Journal of Materials Science2000，，14： | 1 |
| 17 | Effect of thermomechanical treatments on microstructure and proprieties of Cu-base leadframe alloy显示文摘 | Ho J Ryu Hyung K Baik Soon H Hong | 2000 | Journal of Materials Science2000，，35： | 1 |
| 18 | Effects of Korean Red Ginseng ( Panax ginseng ), urushiol ( Rhus vernicifera Stokes), and probiotics ( Lactobacillus rhamnosus R0011 and Lactobacillus acidophilus R0052) on the gut–liver axis of alcoholic liver disease显示文摘 | Chang Seok Bang So Hyung Hong Ki Tae Suk Jin Bong Kim Sang Hak Han Hotaik Sung Eun Ji Kim Myoung Jo Kim Moon Young Kim Soon Koo Baik Dong Joon Kim | 2014 | Journal of Ginseng Research2014，，： | 1 |
| 19 | Smooth muscle progenitor cells from peripheral blood promote the neovascularization of endothelial colony-forming cells显示文摘 | Hyung Joon Joo Ha-Rim Seo Hyo Eun Jeong Seung-Cheol Choi Jae Hyung Park Cheol Woong Yu Soon Jun Hong Seok Chung Do-Sun Lim | 2014 | Biochemical and Biophysical Research Communications2014，，： | 1 |
| 20 | Prognosis of hepatitis B‐related liver cirrhosis in the era of oral nucleos(t)ide analog antiviral agents显示文摘 | Chang Ha Kim Soon Ho Um Yeon Seok Seo Jin Yong Jung Jin Dong Kim Hyung Joon Yim Bora Keum Yong Sik Kim Yoon Tae Jeen Hong Sik Lee Hoon Jai Chun Chang Duck Kim Ho Sang Ryu | 2012 | Journal of Gastroenterology and Hepatology2012，，10： | 1 |
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