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| 1 | Preparation and in vitro-in vivo evaluation of intestinal retention pellets of Berberine chloride to enhance hypoglycemic and lipid-lowing efficacy显示文摘Berberine chloride(BBR) is a pharmacokinetic profile of drug with poor bioavailability but good therapeutic efficacy,which is closely related to the discovery of BBR intestinal target.The major aim of this paper is to develop BBR intestinal retention type sustained-release pellets and evaluate their in vivo and in vitro behaviors base on the aspect of local action on intestinal tract. Here,wet milling technology is used to improve dissolution and dissolution rate of BBR by decreasing the particle size and increasing the wettability. The pellets are prepared by liquid layer deposition technology,and then the core pellets are coated with Eudragit~?L30 D-55 and Eudragit~?NE30 D aqueous dispersion. The prepared pellets show high drug loading capacity,and the drug loading up to 93%. Meanwhile,it possesses significant sustained drug release effect in purified water which is expected to improve the pharmacokinetic behavior of BBR. The pharmacokinetics results demonstrate that the halflife of BBR was increased significantly from 24 h to 36 h and the inter-and intra-subject variability are decreased compared to commercial BBR tablets. The retention test results indicate that the pellet size and Eudragit~?NE30 D plays an important role in retention time of the pellet,and it is found that the pellets with small particle size and high Eudragit~?NE30 D coating content can stay longer in the intestine than the pellets with large particle size. All in all,BBR intestinal retention type pellets are prepared successfully in this study,and the pellets show satisfactory in vivo and in vitro behaviors. | Guofei Li Mingming Zhao Xianying Su Lin Song Limei Zhao | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，5： | 5 |
| 2 | Synthesis and biological evaluation of sophocarpinic acid derivatives as anti-HCV agents显示文摘Chronic hepatitis C virus(HCV)infection has become a major public health burden worldwide.Twenty-two sophocarpinic acid or matrine derivatives were synthesized and their anti-HCV activities were evaluated in vitro.The structure-activity analysis revealed that(i)sophocarpinic acids with a D-seco 3-ring structure scaffold were more favorable than matrines with a 4-ring scaffold;(ii)the introduction of an electron-withdrawing group on the phenyl ring in 12-N-benzenesulfonylΔβγsophocarpinic acids was beneficial for the antiviral activity against HCV.Among them,compounds 9h and 9j exhibited the most potent inhibitory activities on HCV replication with selectivity indies of 70.3 and 30.9,respectively.Therefore,both were selected as antiviral candidates for further investigation. | Yinghong Li Zonggen Peng Limei Gao Danqing Song | 2014 | Acta Pharmaceutica Sinica B2014，4，4： | 4 |
| 3 | The RALF1-FERONIA complex interacts with and activates TOR signaling in response to low nutrients显示文摘Target of rapamycin(TOR)kinase is an evolutionarily conserved major regulator of nutrient metabolism and organismal growth in eukaryotes.In plants,nutrients are remobilized and reallocated between shoots and roots under low-nutrient conditions,and nitrogen and nitrogen-related nutrients(e.g.,amino acids)are key upstream signals leading to TOR activation in shoots under low-nutrient conditions.However,how these forms of nitrogen can be sensed to activate TOR in plants is still poorly understood.Here we report that the Arabidopsis receptor kinase FERON IA(FER)interacts with the TOR pathway to regulate nutrient(nitrogen and amino acid)signaling under low-nutrient conditions and exerts similar metabolic effects in response to nitrogen deficiency.We found that FER and its partner,RPM1-induced protein kinase(RIPK),interact with the TOR/RAPTOR complex to positively modulate TOR signaling activity.During this process,the receptor complex FER/RIPK phosphorylates the TOR complex component RAPTOR1B.The RALF1 peptide,a ligand of the FER/RIPK receptor complex,increases TOR activation in the young leaf by enhancing FER-TOR interactions,leading to promotion of true leaf growth in Arabidopsis under lownutrient conditions.Furthermore,we showed that specific amino acids(e.g.,Gin,Asp,and Gly)promote true leaf growth under nitrogen-deficient conditions via the FER-TOR axis.Collectively,our study reveals a mechanism by which the RALF1-FER pathway activates TOR in the plant adaptive response to low nutrients and suggests that plants prioritize nutritional stress response over RALF1-mediated inhibition of cell growth under low-nutrient conditions. | Limei Song Guoyun Xu Tingting Li Huina Zhou Qinlu Lin Jia Chen Long Wang Dousheng Wu Xiaoxu Li Lifeng Wang Sirui Zhu Feng Yu | 2022 | Molecular Plant2022，15，7： | 2 |
| 4 | A molecular link between autophagy and circadian rhythm in plants显示文摘Extremely high or low autophagy levels disrupt plant survival under nutrient starvation.Recently,autophagy has been reported to display rhythms in animals.However,the mechanism of circadian regulation of autophagy is still unclear.Here,we observed that autophagy has a robust rhythm and that various autophagy-related genes(ATGs)are rhythmically expressed in Arabidopsis.Chromatin immunoprecipitation(Ch IP)and dual-luciferase(LUC)analyses showed that the core oscillator gene TIMING OF CAB EXPRESSION 1(TOC1)directly binds to the promoters of ATG(ATG1 a,ATG2,and ATG8 d)and negatively regulates autophagy activities under nutritional stress.Furthermore,autophagy defects might affect endogenous rhythms by reducing the rhythm amplitude of TOC1 and shortening the rhythm period of CIRCADIAN CLOCK-ASSOCIATED 1(CCA1).Autophagy is essential for the circadian clock pattern in seedling development and plant sensitivity to nutritional deficiencies.Taken together,our studies reveal a plant strategy in which the TOC1-ATG axis involved in autophagy-rhythm crosstalk to fine-tune the intensity of autophagy. | Weijun Chen Zhaotun Hu MengTing Yu Sirui Zhu Junjie Xing Limei Song Wenxuan Pu Feng Yu | 2022 | Journal of Integrative Plant Biology2022，64，5： | 2 |
| 5 | Characterization of a Novel Weak Allele of RGA1/D1 and Its Potential Application in Rice Breeding显示文摘Semi-dwarfing improves the lodging resistance and yield of rice,and the vast majority of modern rice varieties harbor the sd1 allele to decrease plant height,resulting in reduced genetic diversity and negative agronomic traits.Thus,exploring alternative sources of dwarfism is imperative for rice breeding.Here,we identified a novel RGA1 allele,d1-w,from a local indica variety Xiaolixiang(XLX)using a map-based cloning approach.Compared with other rice varieties,RGA1 in XLX contained a unique single nucleotide polymorphism that resulted in an additional transcript and reduced functional RGA1 transcript level.The RGA1 from Nipponbare was introduced into XLX to estimate the value of d1-w in rice breeding.Compared with transgenic XLX plants(XLX^(D1)),XLX exhibited reduced plant height,increased stem strength,lower reactive oxygen species accumulation,delayed senescence,stronger photosynthesis,higher grain yield and quality(including external,milling and nutritional qualities),and enhanced resistance to drought and Rhizoctonia solani.Therefore,we proposed that the d1-w allele has potential as an excellent dwarfism resource for rice breeding. | LIU Yantong LI Ting JIANG Zhishu ZENG Chuihai HE Rong QIU Jiao LIN Xiaoli PENG Limei SONG Yongping ZHOU Dahu CAI Yicong ZHU Changlan FU Junru HE Haohua XU Jie | 2022 | Rice science2022，29，6： | 2 |
| 6 | High preci- sion camera calibration in vision measurement 显示文摘 | Song Limei Wang Mingping Huang Lulu | 2007 | Optics Laser Technology2007，39，： | 1 |
| 7 | 3D Geological Modeling with Multi-source Data Integration in Polymetallic Region:A Case Study of Luanchuan,Henan Province,China显示文摘The development of 3D geological models involves the integration of large amounts of geological data,as well as additional accessible proprietary lithological, structural,geochemical,geophysical,and borehole data.Luanchuan,the case study area,southwestern Henan Province,is an important molybdenum-tungsten -lead-zinc polymetallic belt in China. | Gongwen Wang~(1,2),Shouting Zhang~(1,2),Changhai Yan~3,Yaowu Song~3,Limei Wang~1 1.School of Earth Sciences and Resources,China University of Geosciences(Beijing),Beijing 100083,China. 2.State Key laboratory of Geological Processes and Mineral Resources,China University of Geosciences,Beijing 100083,China 3.Henan Institute of Geological Survey,Zhengzhou 450007,China | 2009 | 地学前缘2009，16，S1： | 1 |
| 8 | 3D visualiz-ation technique of human organs显示文摘 | Song Limei Huang Jinghuan | | 0，，02： | 1 |
| 9 | A prophenoloxidase from the Chinese mitten crab Eriocheir sinensis : Gene cloning, expression and activity analysis显示文摘 | Yunchao Gai Jianmin Zhao Linsheng Song Chenghua Li Peilin Zheng Limei Qiu Duojiao Ni | 2007 | Fish and Shellfish Immunology2007，，2： | 1 |
| 10 | A new phase unwrapping algorithm based on Three Wavelength Phase Shift Profilometry method显示文摘 | Limei Song Xiaoxiao Dong Jiangtao Xi Yanguang Yu Chaokui Yang | 2013 | Optics and Laser Technology2013，，： | 1 |
| 11 | Three-Dimensional Shape Recovery Based on Single Historical Image显示文摘 | Song Limei Wen Yuhua | 2009 | CSO 20092009，1，： | 1 |
| 12 | High Precision Camera Calibration in Vision Measurement显示文摘 | LiMei Song MingPing Wang Lu Lu Huang | 2007 | Optics and Laser Technology2007，39，7： | 1 |
| 13 | Two Cameras Vision Model for the 3D Shape Recovery显示文摘 | LiMei Song Jing Luo BaoShan Sun | 2009 | ICNC 20092009，5，： | 1 |
| 14 | Improved SFS 3D Measurement Based on BP Neural Network显示文摘 | LiMei Song XingHua Qu ShengHua Ye | 2007 | Image and Vision Computing2007，5，25： | 1 |
| 15 | Novel SFS-NDT in the field of defect detection显示文摘 | Song Limei Qu Xinghua Xu Kexin | 2005 | International NDT&E2005，38，5： | 1 |
| 16 | Three-dimensional measurement and defect detection based on single image 显示文摘 | SONG Limei QU Xinghua XU Kexin | 2005 | Optoelectronics and Advanced Materials2005，7，2： | 1 |
| 17 | 显示文摘 | Song Limei Gao Jianhua Song Ruijuan | 2010 | J Lumin2010，130，： | 1 |
| 18 | Novel SFS NDT in the Field of Defect Detection显示文摘 | Song Limei Qu Xinghua Xu Kexin el al | 2005 | NDT & E International2005，38，5： | 1 |
| 19 | High precision cameracalibration in vision measurement显示文摘 | Limei Song Mingping Wang Lu Lu | 2007 | Optics&Laser Technology2007，39，： | 1 |
| 20 | Auto-detection of Strip Area in 3D Measurement显示文摘 | Song Limei Wang Danv Liu Xianyong | 2006 | NDT & E International2006，39，2： | 1 |
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