|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | MicroRNA-135a Modulates Hepatitis C Virus Genome Replication through Downregulation of Host Antiviral Factors显示文摘Cellular microRNAs(miRNAs) have been shown to modulate HCV infection via directly acting on the viral genome or indirectly through targeting the virus-associated host factors. Recently we generated a comprehensive map of HCV–miRNA interactions through genome-wide miRNA functional screens and transcriptomics analyses. Many previously unappreciated cellular miRNAs were identified to be involved in HCV infection, including miR-135a, a human cancerrelated miRNA. In the present study, we investigated the role of miR-135a in regulating HCV life cycle and showed that it preferentially enhances viral genome replication. Bioinformatics-based integrative analyses and subsequent functional assays revealed three antiviral host factors, including receptor interacting serine/threonine kinase 2(RIPK2), myeloid differentiation primary response 88(MYD88), and C-X-C motif chemokine ligand 12(CXCL12), as bona fide targets of miR-135a. These genes have been shown to inhibit HCV infection at the RNA replication stage. Our data demonstrated that repression of key host restriction factors mediated the proviral effect of miR-135a on HCV propagation. In addition,miR-135a hepatic abundance is upregulated by HCV infection in both cultured hepatocytes and human liver, likely mediating a more favorable environment for viral replication and possibly contributing to HCV-induced liver malignancy.These results provide novel insights into HCV–host interactions and unveil molecular pathways linking miRNA biology to HCV pathogenesis. | Catherine Sodroski Brianna Lowey Laura Hertz T.Jake Liang Qisheng Li | 2019 | Virologica Sinica2019，34，2： | 5 |
| 2 | The human immunodeficiency virus (HIV-1) Envelope glycoproteins: fusogens,antigens and immunogens显示文摘 | Sodroski J | 1998 | Science1998，288，： | 1 |
| 3 | The HIV-1 envelope glycoproteins:fusogena,antigens,and immunogens显示文摘 | Wyatt R Sodroski J | | 0，，： | 1 |
| 4 | Effect of mutations ',affecting the p6 gag protein on human immunodeficiency virus particle release显示文摘 | HG Gottlinger T Dorfman JG Sodroski | 1991 | Proc Natl Aead Sci USA1991，88，： | 1 |
| 5 | CD4 mimetics sensitize HIV-l-infected cells to ADCC 显示文摘 | Richard J Veillette M Brassard N Iyer SS Roger M Martin L Pazgier M Schon A Freire E Routy JP SmithAB 3rd Park J Jones DM Courter JR Melillo BN Kaufmann DE Hahn BH Permar SR Haynes BF MadaniN Sodroski JG Finzi A | 2015 | Proc Natl Acad Sci USA2015，112，20： | 1 |
| 6 | Identification of a protein encoded by the vpu gene of HIV-1 显示文摘 | Cohen E A Terwilliger E F Sodroski J G | 1988 | Nature1988，334，： | 1 |
| 7 | The HIV-1 envelope glyeoproteins: fusogens, antigens, and immunogens显示文摘 | Wyatt R Sodroski J | 1998 | Science1998，280，5371： | 1 |
| 8 | A defective HIV-1 vector for gene transfer to human lymphocytes显示文摘 | Parolin C Sodroski J | 1995 | J Mol Med1995，73，6： | 1 |
| 9 | The cytoplasmic body compo- nent TRIM5alpha restricts HIV-1 infection in Old World monkeys显示文摘 | Stremlau M ()wens C M Perron M J Kiessling M Autissier P Sodroski J | 2004 | Nature2004，427，6977： | 1 |
| 10 | The trans - activator gene of the human T- cell lymphotropic virus type III is required for replication显示文摘 | Sodroski J G Rosen C A | 1986 | Cell1986，4，： | 1 |
| 11 | Ligand-independent dimerization of CXCR4, a pricipal HIV-1 coreceptor 显示文摘 | Babcock GJ Farzan M Sodroski J | 2003 | Biol Chem2003，278，5： | 1 |
| 12 | Intrabody-mediated knockout of the high-affinity IL-2 receptor in primary human T cells using a bicistronic lentivirus vector显示文摘 | Richardson JH Hofmann W Sodroski JG | 1998 | Gene Ther1998，5，5： | 1 |
| 13 | Characterization of stable,soluble trimers containing complete ectodomains of human immunodeficiency virus type 1envelope glycoproteins显示文摘 | Yang X Farzan M Wyatt R Sodroski J | 2000 | J Virol2000，74，12： | 1 |
| 14 | A defective HIV-1 vector for gene t ransfer to human lymphocytes显示文摘 | PAROLIN C SODROSKI J | 1995 | J Mol Med(Berl)1995，73，6： | 1 |
| 15 | Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01显示文摘 | Zhou T Georgiev I Wu X Yang ZY Dai K Finzi A Kwon YD Scheid JF Shi W Xu L Yang Y Zhu J Nussenzweig MC Sodroski J Shapiro L Nabel GJ Mascola JR Kwong PD | 2010 | Science2010，329，5993： | 1 |
| 16 | Identifica- tion of a protein encoded by the Vpu gene of HIV-1 显示文摘 | Cohen EA Terwilliger EF Sodroski JG | 1988 | Na- ture1988，334，6182： | 1 |
| 17 | The HIV-1 envelope glycoproteins:fusogens,antigens and immunogens显示文摘 | Wyatt R Sodroski J | 1998 | Science1998，280，5371： | 1 |
| 18 | Elicitation ofneutralizing antibodies with DNA vaccines expressingsoluble stabilized human immunodeficiency virus type1 envelope glycoprotein trimers conjugated to C3d显示文摘 | Bower J F Yang X Sodroski J | 2004 | J Virol2004，78，9： | 1 |
| 19 | Elicitation of neutralizing antibodies with DNA vaccines expressing soluble stabilized human immunodeficiency virus type 1 envelope glycoprotein trimers conjugated to C3d显示文摘 | Bower JF Yang XZ Sodroski J | 2004 | J Virol2004，78，： | 1 |
| 20 | Improved elicitation of neutralizing antibodies against primary human immunodeficiency viruses by soluble stabilized envelope glycoprotein trimers显示文摘 | YANG X WYATT R SODROSKI J | 2001 | J Virol2001，75，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员