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| 1 | Analysis of the phosphatidylinosit ol 3'-kinase signaling pathway in glioblastoma patients in vivo显示文摘Deregulated signaling through the p hosphatidylinositol 3-kinase(PI3K)pathway is common in many types of can cer,including glioblastoma.Dissecting the molecular events associated with activation of this pathway in glioblastoma p atients in vivo presents an important challenge that has implic ations for the development and clini cal testing of PI3K pathway inhibito rs.Using an immunohistochemical analysis appl ied to a tissue microarray,we performed hierarchical clustering and mul tidimensional scaling,as well as univariate and multivariate analyses,to dissect the PI3K pathway in v ivo.We demonstrate that loss of the t umor suppressor protein PTEN,which antagonizes PI3K pathwa y activation,is highly correlated w ith activation of the main PI3K effec tor Akt in vivo.We also show that Akt activation is signific antly correlated with phosphorylation of mammalian target of rapamycin(mTOR),the family of forkhead transcription factors(FOXO1,FOXO3a,and FOXO4),and S6,which are thought to promote its effects.Expression of the mutan t epidermal growth factor receptor vIII is also tightly correlated with phosphorylation of these effectors,d emonstrating an additional route to PI3K pathway activation in glioblastomas in vivo.These results provide the first dissection of the PI3K path way in glioblastoma in vivo and suggest an approach to stratifying patients for targeted kinase inhi bitor | Choe G Horvath S Cloughesy TF Crosby K Seligson D Palotie A Inge L Smith BL Sawyers CL Mischel PS | 2003 | 癌症2003，22，7： | 41 |
| 2 | 在血压控制不良的高血压患者中使用数字化干预的家庭和在线血压管理:随机对照试验显示文摘HOME BP试验(The home and online management and evaluation of blood pressure)的目的是评估在初级预防中结合自我监测和自我管理的数字化干预在高血压管理中的作用。研究者纳入英国76个治疗中心经过治疗但血压控制不好(>140/90 mm Hg, 1 mm Hg=0.133 kPa)并能上网的患者622例,进行自动确定主要终点的公开随机对照试验。 | McMa-nus RJ Little P Stuart B Morton K Raftery J Kelly J Bradbury K Zhang J Zhu S Murray E May CR Mair FS Michie S Smith P Band R Ogburn E AllenJ Rice C Nut-tall J Williams B Yardley L 陈嘉睿(译) 叶鹏(审校) | 2021 | 中华高血压杂志2021，29，5： | 15 |
| 3 | 健康领域的文化能力显示文摘1背景
尽管人类对其他社会的兴趣纵贯历史的各个阶段,但是检验不同文化概念对人类健康实践的影响从20世纪才开始,当时是伴随着长期的人类学田野调查产生的,这些田野调查揭露了不同文化之间相关卫生实践的多样性、复杂性和连续性。 | Napier A D Ancarno C Butler B Calabrese j Chater A Chatterjee H Guesnet F Home R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams AC Willott C Wilson J Woolf K | 2016 | 中国卫生政策研究2016，9，2： | 5 |
| 4 | 文化、不平等性与卫生服务提供显示文摘1动态不平等性对基层医疗卫生人力的影响
政治、社会、文化、专业群体皆建立在一致且常规的人类行为之上。当遭受巨大变革和内外压力时,这些群体会变得十分脆弱。尤其在动荡时期,这些群体往往更关注社会和文化的差异性,而非二者的一致性。尽管社会中的个体思维和行为会呈现较大的差异,但对健康的感知具有统一性,并在更广范围人群内尤为突出,这主要归因于文化价值观的作用。广义的文化心态会随着时间和地理位置的不同而不同,就像健康的社会决定因素也会因文化类型的不同而产生差异。 | Napier A D Ancarno C Butler B Calabrese J Chater A Chatterjee H Guesnet F Horne R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams A C Willott C Wilson J Woolf K | 2016 | 中国卫生政策研究2016，9，3： | 2 |
| 5 | Ground-State Properties of Ferromagnetic Metal/Conjugated Polymer Interfaces显示文摘 | Xie S J Ahn K H Smith D L | 2003 | Phys Rev B2003，67，12： | 2 |
| 6 | CXCR4 regulates growth of both prima ry and metastatic breast cancer显示文摘 | Smith M C Luker K E Garbow J R Prior J L Jackson E Piwnica-Worms D | 2004 | Cancer Res2004，64，： | 1 |
| 7 | Use of the FAO CROPWAT model in deficit irrigation studies显示文摘 | Smith M Kivumbi D Heng L K | | Defieit Irrigation Practices0，22，： | 1 |
| 8 | Comparison of parametric and nonparametric models for traffic flow forecasting 显示文摘 | Smith B L Williams B M Oswald R K | 2002 | Transportation Research Part C : Emerging Technologies2002，10，4： | 1 |
| 9 | Antigenic variants of J subgroup avian leucosis virus: sequence analysis reveals multi- ple changes in env gene 显示文摘 | Venugoal K Smith L M Howes K | 1998 | J Gen Virol1998，79，： | 1 |
| 10 | Comparison of parametric and nonparametric models for traffic flow forecasting显示文摘 | SMITH B L WILLAIMS B M OSWALD R K | 2003 | Transportation Research Part C2003，10，4： | 1 |
| 11 | Systematic review: the lower gas- trointestinal adverse effects of non-steroidal anti-inflammatory drugs 显示文摘 | Laine L Smith R Min K | 2006 | Aliment Pharmacol Ther2006，24，5： | 1 |
| 12 | The three dimensional structure of the atmospheric energy budget: Methodology and evaluation显示文摘 | TRENBERTH K E SMITH L | 2008 | Clim Dyn2008，32，78： | 1 |
| 13 | Vanadium alloys-overview and recent results 显示文摘 | Muroga T Nagasaka T Abe K Chemov V M Matsui H Smith D L Xu Z Y Zinkle S J | 2002 | Journal of Nuclear Materials2002，，307311： | 1 |
| 14 | The potential for low NOx from a precessing jet burner of coal显示文摘 | Megalos N P Smith N L Zhang D K | 2001 | Combustion and Flame2001，124，1： | 1 |
| 15 | Volatile food attractants for Oryzaephilus surinamensis from oats显示文摘 | Mikolajczak K L Zilkowski B W Jr Smith C R | 1984 | J Chem Ecolo1984，，2： | 1 |
| 16 | Development of serum-free media in CHO-DG44 using a central composite statistical design显示文摘 | Parampalli A Eskridge K Smith L | | 0，，01： | 1 |
| 17 | Managing Strategic Contradictions:A Top Management Model for Managing Innovation Streams 显示文摘 | SMITH W K TUSHMAN M L | 2005 | Organization Science2005，16，5： | 1 |
| 18 | High diversity andwidespread occurrence of mitotic spore mats in ectomycorrhizalPezizales显示文摘 | Healy R A Smith M E Bonito G M Pfister D H Ge Z W Guevara G G ’ Williams G Stafford K Kumar L Lee T HobartC Trappe J Vilgalys R McLaughlin D J | 2013 | Molecular Ecology2013，22，： | 1 |
| 19 | 医疗卫生保健文化的反思及促进健康与文化融合的建议显示文摘1医疗卫生保健文化的反思1.1健康文化与医学知识如果医务人员有充足的时间对患者进行诊断并帮助患者进行社区护理,就可在节省卫生费用的同时改善健康结果。整合型社区护理能缩小不同文化背景和群体健康需求的差异。然而,全球范围内对整合型社区护理的投入较少,原因之一就是20世纪对临床服务的重视弱化了卫生服务提供过程中的同情心理。当然,患者也对医学知识存在显性和隐性的影响(特别是当其因不遵医嘱而受到指责时)。 | Napier A D Ancarno C Butler B Calabrese J Chater A Chatterjee H Guesnet F Horne R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams A C Willott C Wilson JWoolf K | 2016 | 中国卫生政策研究2016，9，4： | 1 |
| 20 | Salmonella enterica serotype urbana interference with Brucellosis serology显示文摘 | Nielsen K Smith P Yu W L | 2007 | J Immunoassay Immunochem2007，28，3： | 1 |
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