|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Analysis of the phosphatidylinosit ol 3'-kinase signaling pathway in glioblastoma patients in vivo显示文摘Deregulated signaling through the p hosphatidylinositol 3-kinase(PI3K)pathway is common in many types of can cer,including glioblastoma.Dissecting the molecular events associated with activation of this pathway in glioblastoma p atients in vivo presents an important challenge that has implic ations for the development and clini cal testing of PI3K pathway inhibito rs.Using an immunohistochemical analysis appl ied to a tissue microarray,we performed hierarchical clustering and mul tidimensional scaling,as well as univariate and multivariate analyses,to dissect the PI3K pathway in v ivo.We demonstrate that loss of the t umor suppressor protein PTEN,which antagonizes PI3K pathwa y activation,is highly correlated w ith activation of the main PI3K effec tor Akt in vivo.We also show that Akt activation is signific antly correlated with phosphorylation of mammalian target of rapamycin(mTOR),the family of forkhead transcription factors(FOXO1,FOXO3a,and FOXO4),and S6,which are thought to promote its effects.Expression of the mutan t epidermal growth factor receptor vIII is also tightly correlated with phosphorylation of these effectors,d emonstrating an additional route to PI3K pathway activation in glioblastomas in vivo.These results provide the first dissection of the PI3K path way in glioblastoma in vivo and suggest an approach to stratifying patients for targeted kinase inhi bitor | Choe G Horvath S Cloughesy TF Crosby K Seligson D Palotie A Inge L Smith BL Sawyers CL Mischel PS | 2003 | 癌症2003，22，7： | 41 |
| 2 | Aquaporin CHIP: the archetypal molecular water channel显示文摘 | Agre P Preston GM Smith BL | 1993 | Am J Physiol1993，265，42： | 1 |
| 3 | CH IP28 water channels are localized in constitutively water-permeable segments of the nephron显示文摘 | Nielson S Smith BL ChristensenM | 1993 | Cell Biol1993，120，： | 1 |
| 4 | Identification,Purification,and Characterization of a Novel Mr 28,000Integral Membrane Protein from Erythrocytes and Renal Tubules显示文摘 | Smith BL Kuhajda FP | 1988 | J Bio Chem1988，263，15： | 1 |
| 5 | Dynamic echo-planar imaging of the breast:experience in diagnosing breast carcinoma and correlation with tumor angiogenesis显示文摘 | Hulka CA Edmister WB Smith BL | 1997 | Radiology1997，205，3： | 1 |
| 6 | Evaluation of predictors of weaning from mechanical ventilation in pediatric patients显示文摘 | Baumeister BL el - Khatib M Smith PG | 1997 | Pediatr Pulmonol1997，24，5： | 1 |
| 7 | Mac-ular comeal dystrophy types I and II are caused by distinct mu-tations in the CHST6 gene in Iceland显示文摘 | Liu NP Smith CF Bowling BL Jonasson F Klintworth GK | 2006 | Mol Vis2006，12，8： | 1 |
| 8 | Surgical management of phyllodes tumors 显示文摘 | Mangi AA Smith BL Gadd MA | 1999 | Arch Surg1999，134，5： | 1 |
| 9 | Polymorphism in the Mr 32,000 Rh protein purified from Rh (D)-positive and -negative erythrocytes 显示文摘 | Smith BL Agre P | 1988 | Proc Natl Acad Sci U S A1988，85，11： | 1 |
| 10 | Expansion of human adult stem cells from bone marrow stromal conditions than maximize the yields of early progenitors and evaluate their quality显示文摘 | Sekiya I Larson BL Smith JR | 2002 | Stem Cells2002，20，6： | 1 |
| 11 | Surgical management of phyllodes tumors显示文摘 | Man AA Smith BL Gadd MA | 1999 | Arch surg1999，134，： | 1 |
| 12 | Aquaporin CHIP: the archetypal molecular water channel 1 显示文摘 | Arge P Preston GM Smith BL | 1993 | Am J Physiol1993，256，10： | 1 |
| 13 | Differential Expression of CYPI A,2B,and 3A Genes in the F344 Rat following Exposure to a Polybrominated Diphenyl Ether Mixture or Individual Components显示文摘 | Sanders JM BL Smith CS Black W | 2005 | Toxicol Sci2005，88，1： | 1 |
| 14 | Portial lumbosaoral transitional Vebrea resection for Contralateral face to genic pain 显示文摘 | Brault JS smith J Currier BL | 2001 | Spine2001，26，2： | 1 |
| 15 | 显示文摘 | Preston GM Smith BL Zeidel ML | 1994 | Science1994，265，： | 1 |
| 16 | Expansion of human adult stem cells from bone marrow stroma: conditions that max- imize the yields of early progenitors and evaluate their quality 显示文摘 | Sekiya I Larson BL Smith JR | 2002 | Stem Cells2002，20，6： | 1 |
| 17 | Aquaporin CHIP: the archetypal molecular water channel 显示文摘 | Preston GM Smith BL | 1993 | Am J Physiol1993，265，42： | 1 |
| 18 | Vitamin D deficiency in a healthy group of mothers and newborn infants显示文摘 | Lee JM Smith JR Philipp BL | 2007 | Clin Pediatr(Phila)2007，46，1： | 1 |
| 19 | Primary management of cystosarcoma tumors显示文摘 | Mangi AA Smith BL Gadd MA | 1999 | Arch Surg1999，487，： | 1 |
| 20 | Dynamic echo-planar imaging of the breast:experiance in diagnosing breast carcino- ma and correlation with tumor angiogenesis显示文摘 | Hulka CA Edmistar WB Smith BL | 1997 | Radiology1997，205，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员