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| 1 | Multimorbidity patterns and association with mortality in 0.5 million Chinese adults显示文摘Background:Few studies have assessed the relationship between multimorbidity patterns and mortality risk in the Chinese population.We aimed to identify multimorbidity patterns and examined the associations of multimorbidity patterns and the number of chronic diseases with the risk of mortality among Chinese middle-aged and older adults.Methods:We used data from the China Kadoorie Biobank and included 512,723 participants aged 30 to 79 years.Multimorbidity was defined as the presence of two or more of the 15 chronic diseases collected by self-report or physical examination at baseline.Multimorbidity patterns were identified using hierarchical cluster analysis.Cox regression was used to estimate the associations of multimorbidity patterns and the number of chronic diseases with all-cause and cause-specific mortality.Results:Overall,15.8%of participants had multimorbidity.The prevalence of multimorbidity increased with age and was higher in urban than rural participants.Four multimorbidity patterns were identified,including cardiometabolic multimorbidity(diabetes,coronary heart disease,stroke,and hypertension),respiratory multimorbidity(tuberculosis,asthma,and chronic obstructive pulmonary disease),gastrointestinal and hepatorenal multimorbidity(gallstone disease,chronic kidney disease,cirrhosis,peptic ulcer,and cancer),and mental and arthritis multimorbidity(neurasthenia,psychiatric disorder,and rheumatoid arthritis).During a median of 10.8 years of follow-up,49,371 deaths occurred.Compared with participants without multimorbidity,cardiometabolic multimorbidity(hazard ratios[HR]=2.20,95%confidence intervals[CI]:2.14-2.26)and respiratory multimorbidity(HR=2.13,95%CI:1.97-2.31)demonstrated relatively higher risks of mortality,followed by gastrointestinal and hepatorenal multimorbidity(HR=1.33,95%CI:1.22-1.46).The mortality risk increased by 36%(HR=1.36,95%CI:1.35-1.37)with every additional disease.Conclusion:Cardiometabolic multimorbidity and respiratory multimorbidity posed the highest threat on mortality risk and deserved particular attention in Chinese adults. | Junning Fan Zhijia Sun Canqing Yu Yu Guo Pei Pei Ling Yang Yiping Chen Huaidong Du Dianjianyi Sun Yuanjie Pang Jun Zhang Simon Gilbert Daniel Avery Junshi Chen Zhengming Chen Jun Lyu Liming Li On Behalf of the China Kadoorie Biobank Collaborative Group | 2022 | Chinese Medical Journal2022,,6: | 17 |
| 2 | Tourism Demand Constraints:A Skiing Participation显示文摘 | | 2000 | Annals of Tourism Research2000,27,4: | 1 |
| 3 | Comparing outcomes of sheet grafting with 1:1 mesh grafting in patients with thermal burns: A randomized trial显示文摘 | Dariush Nikkhah Simon Booth Sherilyn Tay Phillip Gilbert Baljit Dheansa | 2014 | Burns2014,,: | 1 |
| 4 | Differential components of prospective memory? Evidence from fMRI显示文摘 | JS Simons ML Sch?lvinck SJ Gilbert | | 0,,02: | 1 |
| 5 | Differential components of prospective memory? Evidence from fMRI 显示文摘 | Simons JS Scholvinck ML Gilbert SJ | 2006 | Neuropsychologia2006,44,: | 1 |
| 6 | Functional Specialization with-in Rostral Prefrontal Cortex(Area 10):A Meta-analysis显示文摘 | Gilbert SJ Spengler S Simons JS | | 0,,: | 1 |
| 7 | Rab40b regulates trafficking of MMP2 and MMP9 during invadopodia formation and invasion of breast cancer cells显示文摘 | Abitha Jacob Jian Jing James Lee Pepper Schedin Simon M. Gilbert Andrew A. Peden Jagath R. Junutula Rytis Prekeris | 2013 | Journal of Cell Science2013,,: | 1 |
| 8 | Combined Oral Positive Inotropic and Beta-Blocker Therapy for Treatment of Refractory Class IV Heart Failure显示文摘 | Simon F Shakar William T Abraham Edward M Gilbert Alastair D Robertson Brian D Lowes Lawrence S Zisman Debra A Ferguson Michael R Bristow | 1998 | Journal of the American College of Cardiology1998,,: | 1 |
| 9 | Differential components of prospective memory? Evidence from fMRI 显示文摘 | Simons JS SchSlvinek ML Gilbert SJ | 2006 | Neuropsychologia2006,44,8: | 1 |
| 10 | Balancing risk and re- ward: a rat model of risky decision-making显示文摘 | Simon NW Gilbert RJ Mayse JD | 2009 | Neuropsycho- pharmacology2009,34,10: | 1 |
| 11 | Tourism Demand Constraints:A Skiing Participation显示文摘 | David Gilbert Simon Hudson | 2000 | Annals of Tourism Research2000,27,4: | 1 |
| 12 | Tourism demand constraints: A skiing participation 显示文摘 | Gilbert David Hudson Simon | 2000 | Annals of Tourism Research2000,27,4: | 1 |
| 13 | Differential compo- nents of prospective memory? :Evidence from fMRI显示文摘 | Simons JS Scholvinck M Gilbert S J | 2006 | Neuro-psychologia2006,44,8: | 1 |
| 14 | Differential components of prospective memory?Evidence from fMRI显示文摘 | Simons JS Scholvinck ML Gilbert SJ etal | 2006 | Neuropsychologia2006,44,8: | 1 |
| 15 | Discriminating imagined from perceived information engages brain areas implicated in schizophrenia显示文摘 | Simons J S Davis S W Gilbert S J Frith C D Burgess P W | 2006 | NeuroiImage2006,32,: | 1 |
| 16 | Effects of Pressure Overload on Extracellular Matrix Expression in the Heart of the Atrial Natriuretic Peptide–Null Mouse显示文摘 | Dajun Wang Suzanne Oparil Ji An Feng Peng Li Gilbert Perry Lan Bo Chen Meiru Dai Simon W.M. John Yiu-Fai Chen | 2003 | Hypertension: Journal of the American Heart Association2003,,1: | 1 |
| 17 | Tourism demand constraints显示文摘 | David Gilbert Simon Hudson | 2000 | Annals of Tourism Research2000,,: | 1 |
| 18 | Differential components of prospective memory? Evidence from fMRI显示文摘 | Simons J S Sch?lvinck M L Gilbert S J | 2006 | Neuropsychologia2006,44,: | 1 |
| 19 | Differential components of prospective memory? Evidence from fMRI显示文摘 | Simons JS Scholvinck M Gilbert SJ | | 0,,: | 1 |
| 20 | Collagen degradation and MMP9 activation by Enterococcus faecalis contribute to intestinal anastomotic leak显示文摘 | Benjamin D. Shogan Natalia Belogortseva Preston M. Luong Alexander Zaborin Simon Lax Cindy Bethel Marc Ward Joseph P. Muldoon Mark Singer Gary An Konstantin Umanskiy Vani Konda Baddr Shakhsheer James Luo Robin Klabbers Lynn E. Hancock Jack Gilbert Olga Za | 2015 | Science Translational Medicine . 2015 (286)2015,,286: | 1 |