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您的检索式：作者名="Silmara de Lima"
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| 1 | Injection of bone marrow mesenchymal stem cells by intravenous or intraperitoneal routes is a viable alternative to spinal cord injury treatment in mice显示文摘In spite of advances in surgical care and rehabilitation,the consequences of spinal cord injury(SCI)ar still challenging.Several experimental therapeutic strategies have been studied in the SCI field,and recen advances have led to the development of therapies that may act on the inhibitory microenvironment.As sorted lineages of stem cells are considered a good treatment for SCI.This study investigated the effect o systemic transplantation of mesenchymal stem cells(MSCs)in a compressive SCI model.Here we presen results of the intraperitoneal route,which has not been used previously for MSC administration after comveI.WeafC57BL/6nt lmy atb spinal cord compression for 1 minute with a 30-g vascular clip.The animals were divided into five groups DMEM at 7 days after SCI),DMEM i.v.(intravenous injection of 500μL of DMEM at 7 days after SCI)The effects of MSCs transplantation in white matter sparing were analyzed by luxol fast blue staining.Th number of preserved fibers was counted in semithin sections stained with toluidine blue and the presenc of trophic factors was analyzed by immunohistochemistry.In addition,we analyzed the locomotor perfor mance with Basso Mouse Scale and Global Mobility Test.Our results showed white matter preservation and a larger number of preserved fibers in the MSC groups than in the DMEM groups.Furthermore,th MSC groups had higher levels of trophic factors(brain-derived neurotrophic factor,nerve growth factor neurotrophin-3 and neurotrophin-4)in the spinal cord and improved locomotor performance.Our result indicate that injection of MSCs by either intraperitoneal or intravenous routes results in beneficial out comes and can be elected as a choice for SCI treatment. | Bruna dos Santos Ramalho FernANDa Martins de Almeida Conrado Mendonca Sales Silmara de Lima Ana Maria Blanco Martinez | 2018 | Neural Regeneration Research2018，13，6： | 12 |
| 2 | Past,present and future of preserving and restoring function in the visual system:removing galectin-3 as a promising treatment显示文摘Great advances in retinal ganglion cells survival(RGCs),optic nerve preservation and regeneration have been made in the past 15years.Nowadays,we know that RGCs are capable of regenerating the full length of the optic nerve,cross the chiasm,enter the brain and reinnervate visual targets.In order to obtain successful regen- | Silmara de Lima Henrique Rocha Mendonca Camila Oliveira Goulart Ana M.Blanco Martinez | 2017 | Neural Regeneration Research2017，12，1： | 1 |
| 3 | Parasite Fauna of Lutjanus synagris Commercialized in the Fish Market from Bragança-PA,Brazil显示文摘Studies about the parasite fauna of marine fish highlights as an important problem for public health with zoonotic parasites or affecting the fish quality.Thus,this study evaluated the parasite fauna of Lutjanus synagris commercialized in the fish market from Bragança-PA.In laboratory,58 fish were measured,weighted and conducted to parasitological analysis to determine parasitological indexes and relative dominance.Every parasite was fixed and identified until to the lowest taxonomic level.Through the parasitological analysis,it found Cymothoidae,Digenea,Cucullanus sp.and Procamallanus(Spirocamallanus)sp.,with total prevalence 67.24%.Digenea showed the highest prevalence and mean intensity values.For nematode,Cucullanus sp.obtained the greater prevalence and relative dominance,while Procamallanus(Spirocamallanus)sp.showed the greater mean intensity and abundance.Cymothoidae showed the lowest prevalence and mean intensity values.As conclusion,the parasite fauna of L.synagris has been noted with low diversity,reporting the nematode occurrence Procamallanus(Spirocamallanus). | Natalino da Costa Sousa Daiana Silva dos Santos Silmara Rosa Silva Alexandre Vaz da Silva Jucimauro de Araújo P.Junior João Vitor Antunes Miranda Pedro Rodrigo Nery de Souza Matheus Carvalho de Melo Fagner de Melo Xavier Wellington Lima da Silva Junior Fabricio Ramos Menezes Márcia Valeria Silva do Couto | 2019 | Journal of Zoological Research2019，1，3： | 0 |
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