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| 1 | Quantitative analysis of the ribbon synapse number of cochlear inner hair cells in C57BL/6J mice using the three-dimensional modeling method显示文摘In mammals,the ribbon synapses of cochlear inner hair cells are a synaptic structure of the first sensory nerve in the pathway of acoustical signal transmission to the acoustic center,and it is directly involved in voice coding and neurotransmitter release. It is difficult to quantitatively analyze the ribbon synaptic number only using an electron microscope,because the ribbon synaptic number is relatively limited and their location is deep. In this study,the specific presynaptic structure-RIBEYE,and non-specific postsynaptic structure-GluR 2 & 3 in C57BL/6J mouse basilar membrane samples were treated by immunofluorescent labeling. Serial section was performed on the samples using a laser scanning confocal microscope,and then the serial sections were used to build three-dimensional models using 3DS MAX software. Each fluorescein color pair indicates one synapse,so the number of ribbon synapses of inner hair cells is obtained. The spatial distribution and the number of ribbon synapses of cochlear inner hair cells were clearly shown in this experiment,and the mean number of ribbon synapses per inner hair cell was 16.10±1.03. Our results have demonstrated the number of ribbon synapses is accurately calculated by double immunofluorescent labeling to presynaptic and postsynaptic structures,serial sections obtained using a laser scanning confocal microscope,and three-dimensional modeling obtained using 3DS MAX software. The method above is feasible and has important significance for further exploring the mechanism of sensorineural deafness. | LIU Ke,LI ShuNa & JIANG XueJun Department of Otolaryngology,the First Affiliated Hospital,China Medical University,Shenyang 110001,China | 2009 | Science China(Life Sciences)2009，52，9： | 5 |
| 2 | One-pot synthesis of Pt-Cu bimetallic nanocrystals with different structures and their enhanced electrocatalytic properties显示文摘 | Daowei Gao Shuna Li Guolong Song Pengfei Zha Cuncheng Li Qin Wei Yipin Lv Guozhu Chen | 2018 | Nano Research2018，11，5： | 5 |
| 3 | Extranodal involvement in young patients with diffuse large B-cell lymphoma: distribution, prognostic value and treatment options显示文摘Objective: Extranodal involvement represents a peculiar presentation of diffuse large B-cell lymphoma(DLBCL). Previous studies have suggested that older patients are more prone to extranodal involvement. This study retrospectively addressed the distribution, prognostic value and treatment options of extranodal involvement in young patients with DLBCL.Methods: A total of 329 patients were enrolled according to the inclusion requirements. The effects of gender,extranodal involvement, age-adjusted international prognostic index(aa IPI), rituximab infusion and radiotherapy on patient outcomes were evaluated.Results: Among these patients, 59% presented extranodal involvement in 16 anatomic sites. More than one instance was linked to many poorer clinical characteristics and poorer survival compared with either nodal disease or one instance. In patients with one extranodal lesion, multivariate analysis revealed that the site of extranodal involvement, but not the aa IPI or rituximab infusion, was independently related to the outcome, and radiotherapy had a negative influence on survival.Conclusions: Extranodal involvement is common in younger patients and exhibits a ubiquitous distribution.The site of extranodal involvement is of strong prognostic significance. Radiotherapy for extranodal lesions does not improve patient outcomes. | Shuna Yao Junbo Li Zhihua Yao Yuanlin Xu Junfeng Chu Jiuyang Zhang Shuiling Jin Yangyang Huang Jianbo Zhang Jie Ma Yan Zhao Shujun Yang Yanyan Liu | 2017 | Chinese Journal of Cancer Research2017，29，1： | 3 |
| 4 | Association between 15 known or potential breast cancer susceptibility genes and breast cancer risks in Chinese women显示文摘Objective:There are many hereditary breast cancer patients in China,and multigene panel testing has been a new paradigm of genetic testing for these patients and their relatives.However,the magnitude of breast cancer risks related to multiple breast cancer susceptibility genes are largely unknown in Chinese women.Methods:We screened pathogenic variants in 15 established or potential breast cancer susceptibility genes from 8,067 consecutive Chinese female breast cancer patients and 13,129 Chinese cancer-free female controls.These breast cancer patients were unselected for age at diagnosis or family history.Results:We found that pathogenic variants in TP53[odds ratio(OR):16.9,95%confidence interval(CI):5.2–55.2];BRCA2(OR:10.4,95%CI:7.6–14.2);BRCA1(OR:9.7,95%CI:6.3–14.8);and PALB2(OR:5.2,95%CI:3.0–8.8)were associated with a high risk of breast cancer.ATM,BARD1,CHEK2,and RAD51D were associated with a moderate risk of breast cancer with ORs ranging from 2-fold to 4-fold.In contrast,pathogenic variants of NBN,RAD50,BRIP1,and RAD51C were not associated with increased risk of breast cancer in Chinese women.The pathogenic variants of PTEN,CDH1,and STK11 were very rare,so they had a limited contribution to Chinese breast cancer.Patients with pathogenic variants of TP53,BRCA1,BRCA2,and PALB2 more often had earlyonset breast cancer,bilateral breast cancer,and a family history of breast cancer and/or any cancer.Conclusions:This study provided breast cancer risk assessment data for multiple genes in Chinese women,which is useful for genetic testing and clinical management of Chinese hereditary breast cancer. | Fenfen Fu Dongjie Zhang Li Hu Senthil Sundaram Dingge Ying Ying Zhang Shuna Fu Juan Zhang Lu Yao Ye Xu Yuntao Xie | 2022 | Cancer Biology & Medicine2022，19，2： | 3 |
| 5 | Defect-density control of platinum-based nanoframes with high-index facets for enhanced electrochemical properties显示文摘Structure-engineered platinum-based nanoframes(NFs)at the atomic level can effectively improve the catalytic performance for fuel cells and other heterogeneous catalytic fields.We report herein,a microwave-assisted wet-chemical method for the preparation of platinum-copper-cobalt NFs with tunable defect density and architecture,which exhibit enhanced activity and durability towards the electro-oxidation reactions of methanol(MOR)and formic acid(FAOR).By altering the reduction/capping agents and thus the nucleation/growth kinetics,trimetallic platinum-copper-cobalt hexapod NFs with different density high-index facets are achieved.Especially,the rough hexapod nanoframes(rh-NFs)exhibit excellent specific activities towards MOR and FAOR,7.25 and 5.20 times higher than those of benchmark Pt/C,respectively,along with prolonged durability.The excellent activities of the rh-NFs are assigned to a synergistic effect,including high density of defects and high-index facets,suitable d-band center,and open-framework structure.This synergistic working mechanism opens up a new way for enhancing their electrocatalytic performances by increasing defect density and high-index facets in open-framework platinum-based NFs. | Shaohan Yang Shuna Li Lianghao Song Yipin Lv Zhongyao Duan Chunsheng Li Raphael Francesco Praeg Daowei Gao Guozhu Chen | 2019 | Nano Research2019，12，11： | 3 |
| 6 | Enrichment of CO from syngas with Cu(I)Y adsorbent by five-bed VPSA显示文摘Cu (I) Y 吸附物被被离子交换在之间准备的 Cu (II ) Y 的减小准备否沸石和 Cu (II ) 的一个答案氯化物。为公司的 Cu (I) Y 的动态吸附能力被在 30o | Shuna LI Huawei YANG Donghui ZHANG | 2013 | Frontiers of Chemical Science and Engineering2013，7，4： | 1 |
| 7 | A logic-based controller for the mitigation of ventilation air methane in a catalytic flow reversal reactor显示文摘 | Zhikai LI Zhangfeng QIN Yagang ZHANG Zhiwei WU Hui WANG Shuna LI Mei DONG Weibin FAN Jianguo WANG | 2013 | Frontiers of Chemical Science and Engineering2013，7，3： | 1 |
| 8 | Catalytic performance of MnO x –NiO composite oxide in lean methane combustion at low temperature显示文摘 | Yagang Zhang Zhangfeng Qin Guofu Wang Huaqing Zhu Mei Dong Shuna Li Zhiwei Wu Zhikai Li Zhonghua Wu Jing Zhang Tiandou Hu Weibin Fan Jianguo Wang | 2013 | Applied Catalysis B: Environmental2013，，： | 1 |
| 9 | Programmable deaminase-free base editors for G-to-Y conversion by engineered glycosylase显示文摘Current DNA base editors contain nuclease and DNA deaminase that enables deamination of cytosine(C)or adenine(A),but no method for guanine(G)or thymine(T)editing is available at present.Here we developed a deaminase-free glycosylase-based guanine base editor(gGBE)with G editing ability,by fusing Cas9 nickase with engineered N-methylpurine DNA glycosylase protein(MPG).By several rounds of MPG mutagenesis via unbiased and rational screening using an intron-split EGFP reporter,we demonstrated that gGBE with engineered MPG could increase G editing efficiency by more than 1500 fold.Furthermore,this gGBE exhibited high base editing efficiency(up to 81.2%)and high G-to-T or G-to-C(i.e.G-to-Y)conversion ratio(up to 0.95)in both cultured human cells and mouse embryos.Thus,we have provided a proof-of-concept of a new base editing approach by endowing the engineered DNA glycosylase the capability to selectively excise a new type of substrate. | Huawei Tong Nana Liu Yinghui Wei Yingsi Zhou Yun Li Danni Wu Ming Jin Shuna Cui Hengbin Li Guoling Li Jingxing Zhou Yuan Yuan Hainan Zhang Linyu Shi Xuan Yao Hui Yang | 2023 | National Science Review2023，10，8： | 1 |
| 10 | Study of the Reaction Between the Nucleic Acid and Y-BPMPHD-CTMAB Complex and Its Analytical Application显示文摘 | Xia Wu Shuna Sun Jinghe Yang Yuebo Wang Yuxiang Li Benyu Su | 2004 | Journal of Fluorescence2004，，1： | 1 |
| 11 | Folic acid supplement rescues ethanol-induced developmental defects in the zebrafish embryos显示文摘Fetal alcohol syndrome(FASD)describes a range of birth defects.Mechanisms of FASD-associated defects are not well understood.It has great significance to investigate whether nutrient sup-plements like folic acid(FA)can effectively rescue etha nol-induced defects.Moreover,it is very important to determine the optimal time for FA supplementation when it can most effectively antagonize the teratogenic effects of ethanol during embryonic development.Our results indicated that ethanol exposure interrupted the development of zebrafish embryos and induced multiple defects in cardiac function,pharyngeal arch arteries,vessel,craniofacial cartilage,pharyngeal arches,brain,somite and hemoglobin formation.The expressions of critical genes that play important roles in above organs such as tbx1,flk-1,|hand2,ngn1,huc,titin,gata-1 and c-myb were reduced,and the apoptosis was increased in ethanol-treated group.FA supplementation could reverse ethanol-induced defects,improve the decreased expressions of above genes and reduce the apoptosis.We also found that giving FA at 6-12 h post-fertilization(hpf),which is at the gastrula period(5.25--10 hpf),can obviously prevent the teratogenicity of ethanol.This research provides clues for elucidating the mechanism of fetal abnormalties caused by alcohol intake and for preventing FASD. | Qiu Jiang Ding Lu Feng Wang Yawen Zhang Li Cao Yonghao Gui Shuna Sun | 2020 | Acta Biochimica et Biophysica Sinica2020，52，5： | 1 |
| 12 | Preparation of Peanut Shell Cellulose Double-Network Hydrogel and Its Adsorption Capacity for Methylene Blue显示文摘To achieve optimal recovery and value-added utilisation of cellulose in peanut shells,the cellulose in peanut shells was first extracted using the sodium hydroxide-sodium chlorite method.Then,cellulose hydrogel was prepared by graft copolymerisation using N,N’-methylenebisacrylamide as the cross-linking agent,sodium persulfate as the initiator,and acrylic acid as the monomer.Orthogonal optimisation experiments were designed to obtain optimal process parameters for hydrogel preparation with the cellulose dosage of 0.40 g,initiator dosage of 0.20 g,polymerisation temperature of 70°C,cross-linking agent of 0.25 g,and monomer dosage of 3.0 mL.The effect of initiator dosage on hydrogel synthesis was the most significant,followed by monomer dosage and reaction temperature.Characterisation using X-ray diffraction analysis and scanning electron microscopy revealed that the hydrogel was amorphous and exhibited a distinct three-dimensional double network structure.Hydrogel swelling kinetic analysis showed that the hydrogel swelling process was divided into three stages,and fitted the Schott secondary swelling kinetic model.The prepared hydrogel had a good adsorption effect on methylene blue;the adsorption of methylene blue by the hydrogel was 1.259 mg/g at 25°C when the initial concentration of methylene blue was 5 mg/L.The adsorption kinetics of the hydrogel fit the pseudo-first-order kinetic model,pseudo-secondorder kinetic model,Eovich model and particle diffusion model.The best fitting effect was obtained with the pseudo-second-order kinetic model.The adsorption isotherm analysis of methylene blue on hydrogel showed that the adsorption process was consistent with Langmuir and Freundlich models.The correlation coefficient of the Freundlich isotherm model was higher,indicating that the adsorption of methylene blue on hydrogel was mainly chemisorption. | Yalin Li Lei Liu Wenbao Huang Junpu Xie Zhaoxia Song Shuna Guo Enci Wang | 2023 | Journal of Renewable Materials2023，11，7： | 0 |
| 13 | Atomically-precise Au_(24)Ag_(1) Clusterzymes with Enhanced Peroxidase-like Activity for Bioanalysis显示文摘Atomically-precise clusterzymes have been widely studied for their special physicochemical properties,but it is still a challenge to enhance their peroxidase-like activity.Herein,we demonstrated that by substituting a single Ag atom into Au25 nanoclusters to form Au_(24)Ag_(1) nanoclusters,the peroxidase-like activity was enhanced greatly.In the presence of H_(2)O_(2),Au_(24)Ag_(1) could produce reactive oxygen species(ROS)to oxidize colorless 3,3'5,5'-tetramethylbenzidine(TMB)to the blue oxidized TMB(oxTMB).It is worth mentioning that pyrophosphate compounds inhibit the activity of Au_(24)Ag_(1).Since alkaline phosphatase(ALP)can dephosphorylate the substrate phosphate compound,that is,remove the phosphate group on the substrate by hydrolysis,the enzymatic activity of the clusterzyme is restored.Based on this,we have developed a sensitive and reliable colorimetric sensing system for the detection of pyrophosphate ion(PPi),adenosine triphosphate(ATP),adenosine diphosphate(ADP)and ALP,respectively.Importantly,the detection limit of the assay system is lower than those of most of the assays that have been reported.In addition,we also built a simple optical logic gate on this basis,further extending the application of metal nanoclusters as peroxidase mimics in bioanalysis.This work could help to shed light on the structure-activity relationship of nanozyme. | WANG Shuna LI Zhe XIA Mingyuan ZHAO Xiaoxue CHEN Chuanxia JIANG Yuanyuan NI Pengjuan LU Yizhong | 2023 | Chemical Research in Chinese Universities2023，39，6： | 0 |
| 14 | Interfacial synergistic effect in SnO_(2)/PtNi nanocrystals enclosed by high-index facets for high-efficiency ethylene glycol electrooxidation显示文摘Strengthening the oxide-metal interfacial synergistic interaction in nanocatalysts is identified as potential strategy to boost intrinsic activities and the availability of active sites by regulating the surface/interface environment of catalysts.Herein,the SnO_(2)/PtNi concave nanocubes(CNCs)enclosed by high-index facets(HIFs)with tunable SnO_(2)composition are successfully fabricated through combining the hydrothermal and self-assembly method.The interfacial interaction between ultrafine SnO_(2)nanoparticles and PtNi with HIFs surface structure is characterized by analytical techniques.The as-prepared 0.20%SnO_(2)/PtNi catalyst exhibits extraordinarily high catalytic performance for ethylene glycol electrooxidation(EGOR)in acidic conditions with specific activity of 3.06 mA/cm^(2),which represents 6.2-fold enhancement compared with the state-of-the-art Pt/C catalyst.Additionally,the kinetic study demonstrates that the strong interfacial interaction between SnO_(2)and PtNi not only degrades the activation energy barrier during the process of EGOR but also enhances the CO-resistance ability and long-term stability.This study provides a novel perspective to construct highly efficient and stable electrocatalysts for energy conversions. | Shuna Li Haixiao Sun Jiaai Zhang Longjiao Zheng Yunrui Li Xu Fang Yujie Liu Qi Song Zhen Wang Yufeng Gao Xin Zhang Xiaoping Dai Yandi Cai Fei Gao | 2022 | Nano Research2022，15，9： | 0 |
| 15 | Aqueous synthesis of bright near-infrared-emitting Zn-Cu-In-Se quantum dots for multiplexed detection of tumor markers显示文摘Aqueous synthesis is a green but challenging pathway to produce cadmium-free,bright,and near-infrared(NIR)emitting quantum dots(QDs).Herein,we develop a straightforward aqueous phase approach to prepare Zn-Cu-In-Se QDs with tunable emission from 630 to 800 nm through varying the molar ratio of Zn and Cu.The ultrasmall nanoparticle size remains nearly fixed(~2.6 nm)when the QD composition is varied,allowing for the effects of composition on the optical properties of QDs to be decoupled from the impact of particle size.By leveraging the off-stoichiometric effect on photoluminescence(PL),Zn-Cu-In-Se QDs with a Zn:Cu molar ratio of 1.0 show a long PL decay lifetime of 211 ns and an absolute photoluminescence quantum yield(PLQY)of 14.2%.The PLQY is further enhanced by overcoating a ZnS shell,reaching up to 25.8%.Based on the bright,biocompatible,and emission-tunable QDs,nanoprobes with targeting capability for multiple tumor markers are further constructed and employed to simultaneously ascertain targets in the cytoplasm and cell membrane.This study provides a green and effective strategy for achieving bright and biocompatible NIR quantum dots for multiplexed biodetection applications. | Hui Liu Peng Cai Kevin J.McHugh Collin F.Perkinson Laishuo Li Shuna Wang Wei Wang Mingxia Jiao Xiliang Luo Lihong Jing | 2022 | Nano Research2022，15，9： | 0 |
| 16 | Epidemiological,Clinical and Serological Characteristics of Children with Coronavirus Disease 2019 in Wuhan:A Single-centered,Retrospective Study显示文摘Dear Editor,In December 2019,SARS-Co V-2 was first detected in the samples obtained from three adult patients who suffered from an unknown viral pneumonia in Wuhan(Li et al.2020).This unknown viral pneumonia is further named as coronavirus disease 2019(COVID-19)by the World Health Organization. | Dan Luo Zhi Xia Heng Li Danna Tu Ting Wang Wei Zhang Lu Peng Wenfu Yi Sai Zhang Junhua Shu Hui Xu Yong Li Buyun Shi Chengjiao Huang Wen Tang Shuna Xiao Xiaolan Shu Yan Liu Yuan Zhang Shan Guo Zhi Yu Baoxiang Wang Yuan Gao Qinxue Hu Hanzhong Wang Xiaohui Song Hong Mei Xiaoqin Zhou Zhenhua Zheng | 2020 | Virologica Sinica2020，35，6： | 0 |
| 17 | Synthesis and mechanical and elevated temperature tribological properties of a novel high-entropy(TiVNbMoW)C_(4.375) with carbon stoichiometry deviation显示文摘High-entropy carbides are a nascent group of ceramics that are promising for high-temperature applications due to the combination of good stability,high hardness(H),high strength,and superior creep resistance that they display.Due to high melting points and low lattice diffusion coefficients,however,the high-entropy carbides are usually difficult to consolidate to a nearly full density.To cope with this challenge,herein,binary carbides including TiC,V_(8)C_(7),NbC,Mo_(2)C,and WC with different carbon stoichiometry were used to prepare dense high-entropy(TiVNbMoW)C_(4.375),and the influence of carbon vacancy on formation ability and mechanical properties of carbon-deficient high-entropy(TiVNbMoW)C_(4.375) were investigated.Intriguingly,although the starting binary carbides have different crystal structures and carbon stoichiometry,the as-prepared high-entropy material showed a rock-salt structure with a relatively high density(98.1%)and good mechanical properties with hardness of 19.4±0.4 GPa and fracture toughness(KIC)of 4.02 MPa·m^(1/2).More importantly,the high-entropy(TiVNbMoW)C_(4.375) exhibited low coefficient of friction(COF)at room temperature(RT)and 800℃.Wear rate(W)gradually increased with the temperature rising,which were attributed to the formation of low-hardness oxidation films at high temperatures to aggravate wear.At 800℃,lubricating films formed from sufficient oxidation products of V_(2)O_(5) and MoO_(3) effectively improved tribological behavior of the high-entropy(TiVNbMoW)C_(4.375).Wear mechanisms were mainly abrasive wear resulting from grain pullout and brittle fracture as well as oxidation wear generated from high-temperature reactions.These results are useful as valuable guidance and reference to the synthesis of high-entropy ceramics(HECs)for sliding parts under high-temperature serving conditions. | Jicheng LI Yanchun ZHOU Yunfeng SU Shuna CHEN Qiuan SUN Hengzhong FAN Junjie SONG Litian HU Yongsheng ZHANG | 2023 | Journal of Advanced Ceramics2023，12，2： | 0 |
| 18 | Influence of binder systems on sintering characteristics, microstructures, and mechanical properties of PcBN composites fabricated by SPS显示文摘Cubic boron nitride(cBN)with high hardness,thermal conductivity,wear resistance,and chemical inertness has become the most promising abrasive and machining material.Due to the difficulty of fabricating pure cBN body,generally,some binders are incorporated among cBN particles to prepare polycrystalline cubic boron nitride(PcBN).Hence,the binders play a critical factor to the performances of PcBN composites.In this study,the PcBN composites with three binder systems containing ceramic and metal phases were fabricated by spark plasma sintering(SPS)from 1400 to 1700℃.The sintering behaviors and mechanical properties of the composites were investigated.Results show that the effect of binder formulas on mechanical properties mainly related to the compactness,mechanical performances,and thermal expansion coefficient of binder phases,which affect the carrying capacity of the composites and the bonding strength between binder phases and cBN particles.The PcBN composite with SiAlON phase as binder presented optimal flexural strength(465±29 MPa)and fracture toughness(5.62±0.37 MPa·m^(1/2)),attributing to the synergistic effect similar to transgranular and intergranular fractures.Meanwhile,the excellent mechanical properties can be maintained a comparable level when the temperature even rises to 800℃.Due to the weak bonding strength and high porosity,the PcBN composites with Al_(2)O_(3)–ZrO_(2)(3Y)and Al–Ti binder systems exhibited inferior mechanical properties.The possible mechanisms to explain these results were also analyzed. | Shuna CHEN Hengzhong FAN Yunfeng SU Wensheng LI Jicheng LI Bing YAN Junjie SONG Litian HU Yongsheng ZHANG | 2022 | Journal of Advanced Ceramics2022，11，2： | 0 |
| 19 | PtNiCu nanowires with advantageous lattice-plane boundary for enhanced ethanol electrooxidation显示文摘It is generally accepted that the interface effect and surface electronic structure of catalysts have vital impact on catalytic properties.Understanding and tailoring the atomic arrangement of interface structure are of great importance for electrocatalysis.Herein,we proposed a simple method to synthesize etching-PtNiCu nanowires(e-PtNiCu NWs)enclosed by both(110)and(100)facets evolving from PtNiCu nanowires(PtNiCu NWs)mainly with(111)facets by selectively etching process.After acetic acid etching treatment,the e-PtNiCu NWs possess high total proportions(88.3%)of(110)and(100)facets,whereas the(111)facet is dominant in PtNiCu NWs(64%)by qualitatively and quantitatively evaluation.Combining the structure characterizations and performance tests of ethanol electrooxidation reaction(EOR),we find that the e-PtNiCu NWs display remarkably performance for EOR,which is nearly 4.5 times and 1.5 times enhancement compared with the state-of-the-art Pt/C catalyst,as well as 2.2 and 1.4 times of PtNiCu NWs,in specific activity and mass activity,respectively.The improved performance of e-PtNiCu NWs is attributed to synergistic catalytic effect between(110)and(100)facets that not only significantly decreases the onset potentials of adsorbed CO(CO_(ads))but also favors the oxidation of CO_(ads)on the surface of catalyst.Furthermore,thermodynamics and kinetic studies indicate that the synergistic effect of both(110)and(100)facets in e-PtNiCu NWs can decrease the activation energy barrier and facilitate the charge transfer during the reaction.This work provides a promising approach to construct catalysts with tunable surface electronic structure towards efficient electrocatalysis. | Shuna Li Yao Wang Yunrui Li Xu Fang Yujie Liu Mingxuan Li Zhen Wang Yufeng Gao Haixiao Sun Fei Gao Xin Zhang Xiaoping Dai | 2022 | Nano Research2022，15，4： | 0 |
| 20 | Molecular evolution and species-specific expansion of the NAP members in plants显示文摘The NAP(NAC-Like, Activated by AP3/PI) subfamily is one of the important plant-specific transcription factors, and controls many vital biological processes in plants. In the current study, 197 NAP proteins were identified from 31 vascular plants,but no NAP members were found in eight non-vascular plants.All NAP proteins were phylogenetically classified into two groups(NAP I and NAP II), and the origin time of the NAP I group might be relatively later than that of the NAP II group.Furthermore, species-specific gene duplications, caused by segmental duplication events, resulted in the expansion of the NAP subfamily after species-divergence. Different groups have different expansion rates, and the NAP group preference was found during the expansion in plants. Moreover, the expansion of NAP proteins may be related to the gain and loss of introns.Besides, functional divergence was limited after the gene duplication. Abscisic acid(ABA) might play an important role in leaf senescence, which is regulated by NAP subfamily. These results could lay an important foundation for expansion and evolutionary analysis of NAP subfamily in plants. | Kai Fan Hao Shen Noreen Bibi Feng Li Shuna Yuan Ming Wang Xuede Wang | 2015 | Journal of Integrative Plant Biology2015，57，8： | 0 |
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