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| 1 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 2 | Electrochemical single nucleotide polymorphisms genotyping on surface immobilized three-dimensional branched DNA nanostructure显示文摘An electrochemical assay for single nucleotide polymorphisms (SNPs) genotyping is reported. Although electrochemical method is sensitive for DNA detection on surfaces, the ability of surface assay to precisely recognize DNA hybridization event is sacrificed to some extent due to the crowded confined surfaces environments that disfavor DNA hybridization. In the present study, we employed branched tetrahedron structure probes (TSPs) to replace regular linear single stranded DNA capture probes that were immobilized on solid surfaces. This three-dimensional DNA nanostructure lowers the density of immobilized DNA probes on confined surfaces, providing a hybridization environment that is similar to homogenous solution. This TSP-based electrochemical assay reveals excellent performance for SNPs genotyping with concentration as low as 1 nM. | GE ZhiLei PEI Hao WANG LiHua SONG ShiPing FAN ChunHai | 2011 | Science China Chemistry2011，54，8： | 13 |
| 3 | Design of a Carbon Nanotube/Magnetic Nanoparticle-Based Peroxidase-Like Nanocomplex and Its Application for Highly Efficient Catalytic Oxidation of Phenols显示文摘We report a novel nanotechnology-based approach for the highly efficient catalytic oxidation of phenols and their removal from wastewater.We use a nanocomplex made of multi-walled carbon nanotubes(MWNTs)and magnetic nanoparticles(MNPs).This nanocomplex retains the magnetic properties of individual MNPs and can be effectively separated under an external magnetic fi eld.More importantly,the formation of the nanocomplex enhances the intrinsic peroxidase-like activity of the MNPs that can catalyze the reduction of hydrogen peroxide(H2O2).Significantly,in the presence of H2O2,this nanocomplex catalyzes the oxidation of phenols with high effi ciency,generating insoluble polyaromatic products that can be readily separated from water. | Xiaolei Zuo Cheng Peng Qing Huang Shiping Song Lihua Wang Di Li Chunhai Fan | 2009 | Nano Research2009，2，8： | 8 |
| 4 | Bimetallic nano-mushrooms with DNA-mediated interior nanogaps for high-efficiency SERS signal amplification显示文摘有为散布的提高表面的拉曼(重量的单位) 分析的 ultrasensitive 的明确的 nanogaps 抓住伟人诺言的一致包含银的金属 nanostructures。不过,有强壮、稳定的重量的单位的如此的 nanostructures 的直接合成表明极其质问的遗体。这里,我们与内部 nanogaps 为金银的 nano 蘑菇的直接合成报导一条调停 DNA 的途径。这些 nano 蘑菇的重量的单位紧张极其依赖于在金头和银帽子之间的 nanogap 的区域。我们发现 nanogaps 的形成由控制在金 nanoparticles 上标记搁浅单人赛的 DNA (ssDNA ) 的 6-carboxy-X-rhodamine (ROX ) 的表面密度是细微地悦耳的。我们与 1.0 的一个高重量的单位信号改进因素在高产量获得了 nano 蘑菇我们作为一项 retrofit 措施在 CHS 在用阶段变化材料(脉冲编码调制) 的热存储的采纳以后。结果显示那与融化 23 的温度使用脉冲编码调制 ? 訄吗?? | Jianlei Shen Jing Su Juan Yan Bin Zhao Dongfang Wang Siyi Wang Kun Li Mengmeng Liu Yao He Sanjay Mathur Chunhai Fan Shiping Song | 2015 | Nano Research2015，8，3： | 4 |
| 5 | A nanoresonant gold-aptamer probe for rapid and sensitive detection of thrombin显示文摘Resonance light scattering (RLS) is a sensitive technique for monitoring scattered light induced by extended aggregates of chromophores. It has been widely used to study aggregations for its simple manipulation, high sensitivity and great versatility. Gold nanoparticles generate colorful light-scattering signals due to their unique surface plasmon resonances, hence extraordinary light scattering upon aggregation. In this paper we report a rapid and sensitive method based on gold nanoparticles and DNA aptamer to detect protein biomarkers by RLS. Thiol modified thrombin aptamer was covalently assembled to the surface of gold nanoparticles as nanobio probes. As thrombin has two specific binding sites for its aptamer, it can bridge the well dispersed nanoparticles and lead to a network of particle aggregations. The formation of aggregation ia measured by RLS, and the specific detection of thrombin at nM level is achieved. The method has good specificity. | ZHENG Xiaoxue WEN Yanqin ZHANG Juan WANG Lihua SONG Shiping ZHANG Hua FAN Chunhai | 2012 | Nuclear Science and Techniques2012，23，5： | 4 |
| 6 | A Nano-and Micro-Integrated Protein Chip Based on Quantum Dot Probes and a Microfluidic Network显示文摘A novel nano-and micro-integrated protein chip(NMIPC)that can detect proteins with ultrahigh sensitivity has been fabricated.A microfl uidic network(μFN)was used to construct the protein chips,which allowed facile patterning of proteins and subsequent biomolecular recognition.Aqueous phase-synthesized,water-soluble fl uorescent CdTe/CdS core-shell quantum dots(aqQDs),having high quantum yield and high photostability,were used as the signaling probe.Importantly,it was found that aqQDs were compatible with microfluidic format assays,which afforded highly sensitive protein chips for cancer biomarker assays. | Juan Yan Mei Hu Di Li Yao He Rui Zhao Xingyu Jiang Shiping Song Lianhui Wang Chunhai Fan | 2008 | Nano Research2008，1，6： | 3 |
| 7 | The enzyme-amplified amperometric DNA sensor using an electrodeposited polymer redox mediator显示文摘A highly sensitive method for the detection of a breast cancer-associated BRCA-1 gene is reported. The detection is based on a classical sandwich-type assay using horseradish peroxidase (HRP) as a catalytic label and electrodeposited Os2+/3+ conducting polymer (PAA-PVI-Os) as a redox mediator. Target DNA could be detected by the HRP-catalyzed reduction of H2O2, leading to a limit of detection as low as 10 fM. | ZHANG LanYong WAN Ying ZHANG Jiong LI Di WANG LiHua SONG ShiPing FAN ChunHai | 2009 | Science China Chemistry2009，52，6： | 2 |
| 8 | Target-responsive structural switching for nucleic acid-based sensors 显示文摘 | Li Di Song Shiping Fan Chunhai | 2010 | Accounts of Chemi-cal Research2010，43，5： | 1 |
| 9 | Functional nanoprobes for ultrasensitive detection of biomolecules 显示文摘 | Song Shiping Qin Yu He Yao | 2010 | Chemical Society Re- views2010，39，11： | 1 |
| 10 | A target-respon- sive electrochemical aptamer switch (TREAS) for reagentless de- tection of nanomolar ATP 显示文摘 | Zuo Xiaolei Song Shiping Zhang Jiong | 2007 | Journal of the American Chemical Society2007，129，5： | 1 |
| 11 | Sequence-specific detection of femtomolar DNA via a chrono coulometric DNA sensor(CDS) : effects of nanoparticle-mediated amplification and nanoscale control of DNA assembly at electrodes显示文摘 | ZHANG Jiong SONG Shiping ZHANG Lanyong | 2006 | J Am Chem Soc2006，128，26： | 1 |
| 12 | Transgenic elite Indica rice varieties, resistant to Xanthomonas oryzae pv. oryzae显示文摘 | Shiping Zhang Wen-Yuan Song Lili Chen Deling Ruan Nigel Taylor Pamela Ronald Roger Beachy Claude Fauquet | 1998 | Molecular Breeding1998，，6： | 1 |
| 13 | Aptamer-based biosensors显示文摘 | Shiping Song Lihua Wang Jiang Li Chunhai Fan Jianlong Zhao | 2007 | Trends in Analytical Chemistry2007，，2： | 1 |
| 14 | Design of an oligonucleotide-incorporated nonfouling surface and its application in electrochemical DNA sensors for highly sensitive and sequence-specific detection of target DNA 显示文摘 | Zhang Jiong Lao Ruojun Song Shiping | 2008 | Anal Chem2008，80，23： | 1 |
| 15 | An On - Nanoparticle Roiling - Circle Amplification Platform for Uhrasensitive Protein Detection in:Bio- logical Fluids 显示文摘 | Juan Yan Shiping Song Bing Li Qingzhi Zhang Qing Huang Hua Zhang Chunhai Fan | 2010 | small2010，22，6： | 1 |
| 16 | Optical and transport properties in a doped two-leg ladder antiferromagnet显示文摘 | Qin Jihong Song Yun Feng Shiping | 2002 | Phys Rev2002，65，15： | 1 |
| 17 | An on-nanoparticle rolling circle amplification platform for ultrasensitive protein detection in biological fluids显示文摘 | Yan Juan Song Shiping Li Bing | 2010 | Srnali2010，22，6： | 1 |
| 18 | Transgenic elite Indica rice varieties, resistant to Xanthomonas oryzae pv. oryzae显示文摘 | Shiping Zhang Wen-Yuan Song Lili Chen Deling Ruan Nigel Taylor Pamela Ronald Roger Beachy Claude Fauquet | 1998 | Molecular Breeding1998，，6： | 1 |
| 19 | Feasibility of terahertz spectroscopy for hybrid purity verification of rice seeds显示文摘The purity of hybrid rice seeds reflects the typical consistency of seed varieties in characteristics.The accuracy and reliability of seed purity detecting are of great significance to ensure the quality of seeds.In this study,the feasibility of identifying the purity of hybrid rice seeds,Xinong 1A/89,by terahertz(THz)time-domain spectroscopy system combined with chemometrics was explored.Three quantitative identification models for testing the purity of Xinong 1A/89 hybrid rice seed were developed and compared by THz absorption spectroscopy with extreme learning algorithm(ELM),Principal cComponent Regression(PCR)and Partial Least Squares Regression(PLSR).Experimental results showed that comparing with classical PLSR and PCR models,ELM presents a better feasibility and stability.For the testing set,the quantitative prediction result of ELM(ELoo=2.005×10^(-5),R^(2)=96.75%)is significantly better than those of PCR(ELoo=7.346×10^(-5),R^(2)=88.10%)and PLSR(ELoo=8.007×10^(-5),R^(2)=87.03%).The results highlight the feasibility of THz spectroscopy combined with ELM as an efficient and reliable method for verification of hybrid rice seeds. | Yaling Yang Shengling Zhou Jie Song Jie Huang Guanglin Li Shiping Zhu | 2018 | International Journal of Agricultural and Biological Engineering2018，11，5： | 1 |
| 20 | A Highly Sensitive Amperometric Immunosensor for Clenbuterol Detection in Livestock Urine显示文摘 | Shengxi Li Jiong Zhang Wangping Deng Xizhong Shen Shiping Song Chunhai Fan | 2012 | Electroanalysis2012，，4： | 1 |
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