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| 1 | Herbal cardiotonic pills prevent gut ischemia/reperfusion-induced hepatic microvascular dysfunction in rats fed ethanol chronically显示文摘AIM: Cardiotonic Pill (CP), an oral herbal medicine that includes Danshen (Salviae Miltiorrhizae), Panax notoginseny and Dyroblanops aromatica gaertn, has been clinically used for vascular diseases such as occlusive vasculitis, coronary diseases, atherosclerosis, and cerebral infarction. The main component, SaMae Miltiorrhizae, has been reported to prevent cerebral and intestinal reperfusion injury. However, little is known about the effect of CP on hepatic microcirculation.Thus, this study aimed to determine whether CP could affect hepatic microvascular dysfunction elicited by gut ischemia/reperfusion (I/R) in rats fed ethanol chronically.METHODS: Male Wistar rats were pair-fed with a liquid diet containing ethanol or isocaloric control diet for 6 wk. After laparotomy, one lobe of the liver was examined through an inverted intravital microscope. The rats were exposed to 30 rain of gut ischemia followed by 60 rain of reperfusion.Rhodamine-6G-labeled leukocytes in the sinusoids were observed 90 rain after the onset of superior mesenteric artery ocdusion. Plasma tumor necrosis factor (TNF)-α and endotoxin levels were measured 1 h after the onset of reperfusion.Plasma alanine aminotransferase (ALT) activities were measured 6 h after the onset of reperfusion. In another set of experiments, CP (0.8 g/kg, intragastrically) was administered 1 and 24 h before the onset of ischemia.RESULTS: In control rats, gut I/R elicited increases in the number of stationary leukocytes, and plasma TNF-α and endotoxin levels and plasma ALT activities. These changes were mitigated by pretreatment with CP. In ethanol-fed rats,the gut I/R-induced increases in the number of stationary leukooltes, plasma endotoxin levels and ALT activities were enhanced. Pretreat^nent with CP attenuated the enhancement of gut I/R-induced responses by chronic ethanol consumption.CONCLUSION: These results suggest that CP prevents the gut I/R-induced hepatic microvascular dysfunction and hepatocellular injury. A reduction of inflammatory responses such as TNF-α production via reduction of blood endotoxin levels appears to be involved in the mechanisms. Chronic ethanol consumption enhances gut I/R-induced hepatic microvascular and hepatocellular injury. CP also attenuates an enhancement of gut I/R-induced responses by chronic ethanol consumption via the reduction of blood endotoxin levels. | Yoshinori Horie Shuka Mori Masahiro Konishi Mikio Kajihara Takehiko Kaneko Yoshiyuki Yamagishi Shinzo Kato Hiromasa Ishii Toshifumi Hibi | 2005 | World Journal of Gastroenterology2005，11，4： | 13 |
| 2 | BCAA-enriched snack improves nutritional state of cirrhosis显示文摘 | Yutaka Nakaya Kiwamu Okita Kazuyuki Suzuki Hisataka Moriwaki Akinobu Kato Yoshiyuki Miwa Koichi Shiraishi Hiroaki Okuda Morikazu Onji Hidenori Kanazawa Hirohito Tsubouchi Shinzo Kato Masahiko Kaito Akiharu Watanabe Daiki Habu Susumu Ito Tomohisa Ishikawa | 2007 | Nutrition2007，，2： | 1 |
| 3 | Japanese herbal medicine, Saiko-keishi-to, prevents gut ischemia/reperfusion-induced liver injury in rats via nitric oxide显示文摘AIM: To determine whether Saiko-keishioto (TJ-10), a Japanese herbal medicine, could protect liver injury induced by gut ischemia/reperfusion (I/R), and to investigate the role of NO.METHODS: Male Wistar rats were exposed to 30-min gut ischemia followed by 60 min of reperfusion. Intravital microscopywas used to monitor leukocyte recruitment. Plasma tumor necrosis factor (TNF) levels and alanine aminotransferase (ALT) activities were measured. T]-10 1 gl(kg.d) was intragastrically administered to rats for 7 d. A NO synthase inhibitor was administered.RESULTS: In control rats, gut I/R elicited increases in the number of stationary leukocytes, and plasma TNF levels and ALT activities were mitigated by pretreatment withT]-10. Pretreatment with the NO synthase inhibitor diminished the protective effects of TJ-10 on leukostasis in the liver, and the increase of plasma TNF levels and ALT activities. Pretreatment with TL-10 increased plasma nitrite/nitrate levels.CONCLUSION: TJ-10 attenuates the gut I/R-induced hepalJc microvascular dysfunction and sequential hepatocellular injury via enhancement of NO production. | Yoshinori Horie Mikio Kajihara Shuka Mori Yoshiyuki Yamagishi Hiroyuki Kimura Hironao Tamai Shinzo Kato Hiromasa Ishii | 2004 | World Journal of Gastroenterology2004，10，15： | 1 |
| 4 | BCAA-enriched snack improves nutritional state of cirrhosis显示文摘 | Yutaka Nakaya Kiwamu Okita Kazuyuki Suzuki Hisataka Moriwaki Akinobu Kato Yoshiyuki Miwa Koichi Shiraishi Hiroaki Okuda Morikazu Onji Hidenori Kanazawa Hirohito Tsubouchi Shinzo Kato Masahiko Kaito Akiharu Watanabe Daiki Habu Susumu Ito Tomohisa Ishikawa | 2007 | Nutrition2007，，2： | 1 |
| 5 | A new prognostic formula for adult acute liver failure using computer tomography-derived hepatic volumetric analysis显示文摘 | Yoshiyuki Yamagishi Hidetsugu Saito Hirotoshi Ebinuma Masahiro Kikuchi Keisuke Ojiro Hideaki Kanamori Shinichiro Tada Yoshinori Horie Shinzo Kato Toshifumi Hibi | 2009 | Journal of Gastroenterology2009，，6： | 1 |
| 6 | BCAA-enriched snack improves nutritional state of cirrhosis显示文摘 | Yutaka Nakaya Kiwamu Okita Kazuyuki Suzuki Hisataka Moriwaki Akinobu Kato Yoshiyuki Miwa Koichi Shiraishi Hiroaki Okuda Morikazu Onji Hidenori Kanazawa Hirohito Tsubouchi Shinzo Kato Masahiko Kaito Akiharu Watanabe Daiki Habu Susumu Ito Tomohisa Ishikawa | 2007 | Nutrition2007，，2： | 1 |
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