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| 1 | 为早食道、胃的癌症的诊断的内视镜的超声使用超声探针显示文摘 Endoscopic ultrasound(EUS) devices were first designed and manufactured more than 30 years ago,and since then investigators have reported EUS is effective for determining both the staging and the depth of invasion of esophageal and gastric cancers.We review the present status,the methods,and the findings of EUS when used to diagnose and stage early esophageal and gastric cancer.EUS using high-frequency ultrasound probes is more accurate than conventional EUS for the evaluation of the depth of invasion of superficial esophageal carcinoma.The rates of accurate evaluation of the depth of invasion by EUS using high-frequency ultrasound probes were 70%-88% for intramucosal cancer,and 83%-94% for submucosal invasive cancer.But the sensitivity of EUS using high-frequency ultrasound probes for the diagnosis of submucosal invasive cancer was relatively low,making it difficult to confirm minute submucosal invasion.The accuracy of EUS using highfrequency ultrasound probes for early gastric tumor classification can be up to 80% compared with 63% for conventional EUS,although the accuracy of EUS using high-frequency ultrasound probes relatively decreases for those patients with depressed-type lesions,undifferentiated cancer,concomitant ulceration,expanded indications,type 0-Ⅰ lesions,and lesions located in the upper-third of the stomach.A 92% overall accuracy rate was achieved when both the endoscopic appearance and the findings from EUS using high-frequency ultrasound probes were considered together for tumor classification.Although EUS using high-frequency ultrasound probes has limitations,it has a high depth of invasion accuracy and is a useful procedure to distinguish lesions in the esophagus and stomach that are indicated for endoscopic resection. | Shigetaka Yoshinaga Ichiro Oda Satoru Nonaka Ryoji Kushima Yutaka Saito | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，6： | 21 |
| 2 | Management and associated factors of delayed perforation after gastric endoscopic submucosal dissection显示文摘AIM: To identify the actual clinical management and associated factors of delayed perforation after gastric endoscopic submucosal dissection(ESD).METHODS: A total of 4943 early gastric cancer(EGC) patients underwent ESD at our hospital between January 1999 and June 2012. We retrospectively assessed the actual management of delayed perforation. In addition, to determine the factors associated with delayed perforation, after excluding 123 EGC patients with perforations that occurred during the ESD procedure, we analyzed the following clinicopathological factors among the remaining 4820 EGC patients by comparing the ESD cases with delayed perforation and the ESD cases without perforation: age, sex, chronological periods, clinical indications for ESD, status of the stomach, location, gastric circumference, tumor size, invasion depth, presence/absence of ulceration, histological type, type of resection, and procedure time.RESULTS: Delayed perforation occurred in 7(0.1%) cases. The median time until the occurrence of delayed perforation was 11 h(range, 6-172 h). Three(43%) of the 7 cases required emergency surgery, while four were conservatively managed without surgical intervention. Among the 4 cases with conservative management, 2 were successfully managed endoscopically using the endoloop-endoclip technique. The median hospital stay was 18 d(range, 15-45 d). There were no delayed perforation-related deaths. Based on a multivariate analysis, gastric tube cases(OR = 11.0; 95%CI: 1.7-73.3; P = 0.013) were significantly associated with delayed perforation.CONCLUSION: Endoscopists must be aware of not only the identified factors associated with delayed perforation, but also how to treat this complicationeffectively and promptly. | Haruhisa Suzuki Ichiro Oda Masau Sekiguchi Seiichiro Abe Satoru Nonaka Shigetaka Yoshinaga Takeshi Nakajima Yutaka Saito | 2015 | World Journal of Gastroenterology2015，21，44： | 21 |
| 3 | Acute pancreatitis associated with peroral double-balloon enteroscopy: A case report显示文摘人有的一个 58 岁的日本人逗留凳子和严重贫血症。既不上面也不更低胃肠(官方补给) 内视镜检查法显示出任何局部性的损害。因此,他的官方补给的流血的来源被怀疑在小肠,并且他用 EN-450T5 每口头的双汽球肠寄生物(DBE ) 经历了(Fujinon 东芝 ES 系统公司,东京,日本) 。没有损害,考虑是官方补给的流血的来源。在过程以后,病人开始经历了腹的疼痛。实验室测试揭示了血淀粉酶过多,腹的计算断层摄影术揭示了胰和仙子胰的发炎。他因此被诊断有尖锐胰腺炎。保守疗法导致了临床并且实验室改善。他没有白酒摄取,胆石疾病或胰腺炎的历史。磁性的回声 cholangiopancreatography 没在 pancreatobiliary 管的系统表明结构的改变和没有石头。当他的腹的疼痛在过程以后开始了,他的尖锐胰腺炎因此被认为与 per 有关是口头的 DBE。这是可能与联系的尖锐胰腺炎的首先报导的案例每口头的 DBE。 | Kuniomi Honda Takahiro Mizutani Kazuhiko Nakamura Naomi Higuchi Kenji Kanayama Yorinobu Sumida Shigetaka Yoshinaga Soichi Itaba Hirotada Akiho Ken Kawabe Yoshiyuki Arita Tetsuhide Ito | 2006 | World Journal of Gastroenterology2006，12，11： | 11 |
| 4 | Complications of Gastric Endoscopic Submucosal Dissection显示文摘 | Ichiro Oda Haruhisa Suzuki Satoru Nonaka Shigetaka Yoshinaga | 2013 | Digestive Endoscopy2013，，： | 7 |
| 5 | Dehiscence following successful endoscopic closure of gastric perforation during endoscopic submucosal dissection显示文摘Gastric perforation is one of the most serious complications that can occur during endoscopic submucosal dissection(ESD).In terms of the treatment of such perforations,we previously reported that perforations immediately observed and successfully closed with endoclips during endoscopic resection could be managed conservatively.We now report the first case in our medical facility of a gastric perforation during ESD that was ineffectively treated conservatively even after successful endoscopic closure.In December 2006,we performed ESD on a recurrent early gastric cancer in an 81-year-old man with a medical history of laparotomy for cholelithiasis.A perforation occurred during ESD that was immediately observed and successfully closed with endoclips so that ESD could be continued resulting in an en-bloc resection.Intensive conservative management was conducted following ESD,however,an endoscopic examination five days after ESD revealed dehiscence of the perforation requiring an emergency laparotomy. | Masau Sekiguchi Haruhisa Suzuki Ichiro Oda Shigetaka Yoshinaga Satoru Nonaka Makoto Saka Hitoshi Katai Hirokazu Taniguchi Ryoji Kushima Yutaka Saito | 2012 | World Journal of Gastroenterology2012，18，31： | 7 |
| 6 | Arabidopsis CBL-Interacting Protein Kinases Regulate Carbon/Nitrogen-Nutrient Response by Phosphorylating Ubiquitin Liqase ATL31显示文摘响应可得到的碳(C) 和氮(N) 营养素的比率,植物调整他们的新陈代谢,生长,和发展,一个过程叫了 C/N-nutrient 反应。然而, C/N-nutrient 发信号的分子的基础仍然保持大部分不清楚。在这研究,我们识别了交往的三 CALCINEURIN 象 B 一样(CBL ) 蛋白质 KINASES (CIPK ) , CIPK7, CIPK12,和 CIPK14,在 Arabidopsis 在萌芽以后的生长期间给 C/N-nutrient 反应的管理者调音。CIPK7, CIPK12,和 CIPK14 的单个大美人的异种显示出超敏性到高 C/low N 条件,它在他们的三倍大美人的异种被提高,显示他们起一个否定作用并且部分至少在 C/N-nutrient 反应冗余地工作。而且,这些 CIPK 被发现调整 ATL31,经由 phosphorylation 依赖的 ubiquitination 涉及 C/N-nutrient 反应的 ubiquitin ligase 和 14-3-3 蛋白质的 proteasomal 降级的功能。CIPK7, CIPK12,和 CIPK14 身体上与 ATL31,和 CIPK14 交往了,与 CBL8 行动,直接以一种 Ca 2+-dependent 方式的 phosphorylated ATL31。进一步的分析证明这些 CIPK 为 ATL31 phosphorylation 和稳定被要求,它调停响应 C/N-nutrient 的 14-3-3 蛋白质的降级调节。这些调查结果提供新卓见进 C/N-nutrient 发信号由蛋白质 phosphorylation 调停了。 | Shigetaka Yasuda Shoki Aoyama Yoko Hasegawa Takeo Sato Junji Yamaguchi | 2017 | Molecular Plant2017，10，4： | 5 |
| 7 | Endoscopic submucosal dissection for small submucosal tumors of the rectum compared with endoscopic submucosal resection with a ligation device显示文摘AIM To evaluate the efficacy and safety of endoscopic submucosal dissection(ESD) for small rectal submucosal tumors(SMTs).METHODS Between August 2008 and March 2016, 39 patients were treated with endoscopic submucosal resection with a ligation device(ESMR-L)(n = 21) or ESD(n = 18) for small rectal SMTs in this study. Twenty-five lesions were confirmed by histological evaluation of endoscopic biopsy prior to the procedure, and 14 lesions were not evaluated by endoscopic biopsy. The results for the ESMR-L group and the ESD group were retrospectively compared, including baseline characteristics and therapeutic outcomes.RESULTS The rate of en bloc resection was 100% in both groups. Although the rate of complete endoscopic resectionwas higher in the ESD group than in the ESMR-L group(100% vs 95.2%), there were no significant differences between the two groups(P = 0.462). In one patient in the ESMR-L group with a previously biopsied tumor, histological complete resection with a vertical margin involvement of carcinoid tumor could not be achieved, whereas there was no incomplete resection in the ESD group. The mean length of the procedure was significantly greater in the ESD group than in the ESMR-L group(14.7 ± 6.4 min vs 5.4 ± 1.7 min, P < 0.05). The mean period of the hospitalization was also significantly longer in the ESD group than in the ESMR-L group(3.7 ± 0.9 d vs 2.8 ± 1.5 d, P < 0.05). Postoperative bleeding was occurred in one patient in the ESMR-L group.CONCLUSION Both ESMR-L and ESD were effective for treatment of small rectal SMTs. ESMR-L was simpler to perform than ESD and took less time. | Hideaki Harada Satoshi Suehiro Daisuke Murakami Ryotaro Nakahara Takanori Shimizu Yasushi Katsuyama Yasunaga Miyama Kenji Hayasaka Shigetaka Tounou | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，2： | 5 |
| 8 | Short- and long-term outcomes of endoscopic submucosal dissection for undifferentiated early gastric cancer显示文摘 | Seiichiro Abe Ichiro Oda Haruhisa Suzuki Satoru Nonaka Shigetaka Yoshinaga Tomoyuki Odagaki Hirokazu Taniguchi Ryoji Kushima Yutaka Saito | 2013 | Endoscopy2013，，09： | 5 |
| 9 | Advances in inducing adaptive immunity using cell-based cancer vaccines: clinical applications in pancreatic cancer显示文摘The incidence of pancreatic ductal adenocarcinoma(PDA) is on the rise, and the prognosis is extremely poor because PDA is highly aggressive and notoriously difficult to treat. Although gemcitabine- or 5-fluorouracil-based chemotherapy is typically offered as a standard of care, most patients do not survive longer than 1 year. Therefore, the development of alternative therapeutic approaches for patients with PDA is imperative. As PDA cells express numerous tumor-associated antigens that are suitable vaccine targets, one promising treatment approach is cancer vaccines. During the last few decades, cell-based cancer vaccines have offered encouraging results in preclinical studies. Cell-based cancer vaccines are mainly generated by presenting whole tumor cells or dendritic cells to cells of the immune system. In particular, several clinical trials have explored cell-based cancer vaccines as a promising therapeutic approach for patients with PDA. Moreover, chemotherapy and cancer vaccines can synergize to result in increased efficacies in patients with PDA. In this review, we will discuss both the effect of cell-based cancer vaccines and advances in terms of future strategies of cancer vaccines for the treatment of PDA patients. | Mikio Kajihara Kazuki Takakura Tomoya Kanai Zensho Ito Yoshihiro Matsumoto Shigetaka Shimodaira Masato Okamoto Toshifumi Ohkusa Shigeo Koido | 2016 | World Journal of Gastroenterology2016，22，18： | 4 |
| 10 | Impact of dendritic cell vaccines pulsed with Wilms’ tumour-1 peptide antigen on the survival of patients with advanced non-small cell lung cancers显示文摘 | Hidenori Takahashi Masato Okamoto Shigetaka Shimodaira Shun-ichi Tsujitani Masaki Nagaya Takefumi Ishidao Junji Kishimoto Yoshikazu Yonemitsu | 2012 | European Journal of Cancer2012，，： | 3 |
| 11 | Dendritic cell-based cancer immunotherapy for colorectal cancer显示文摘Colorectal cancer(CRC) is one of the most common cancers and a leading cause of cancer-related mortality worldwide. Although systemic therapy is the standard care for patients with recurrent or metastatic CRC, the prognosis is extremely poor. The optimal sequence of therapy remains unknown. Therefore, alternative strategies, such as immunotherapy, are needed for patients with advanced CRC. This review summarizes evidence from dendritic cell-based cancer immunotherapy strategies that are currently in clinical trials. In addition, we discuss the possibility of antitumor immune responses through immunoinhibitory PD-1/PD-L1 pathway blockade in CRC patients. | Mikio Kajihara Kazuki Takakura Tomoya Kanai Zensho Ito Keisuke Saito Shinichiro Takami Shigetaka Shimodaira Masato Okamoto Toshifumi Ohkusa Shigeo Koido | 2016 | World Journal of Gastroenterology2016，22，17： | 3 |
| 12 | Prognostic factors related to add-on dendritic cell vaccines on patients with inoperable pancreatic cancer receiving chemotherapy: a multicenter analysis显示文摘 | Masanori Kobayashi Shigetaka Shimodaira Kazuhiro Nagai Masahiro Ogasawara Hidenori Takahashi Hirofumi Abe Mitsugu Tanii Masato Okamoto Sun-ichi Tsujitani Seiichi Yusa Takefumi Ishidao Junji Kishimoto Yuta Shibamoto Masaki Nagaya Yoshikazu Yonemitsu | 2014 | Cancer Immunology, Immunotherapy2014，，： | 2 |
| 13 | Endoscopic submucosal dissection for early gastric cancer in the remnant stomach after gastrectomy显示文摘 | Satoru Nonaka Ichiro Oda Makomo Makazu Shin Haruyama Seiichiro Abe Haruhisa Suzuki Shigetaka Yoshinaga Takeshi Nakajima Ryoji Kushima Yutaka Saito | 2013 | Gastrointestinal Endoscopy2013，，1： | 2 |
| 14 | Bone metastasis from early gastric cancer following non-curative endoscopic submucosal dissection显示文摘A 67-year-old male underwent endoscopic submucosal dissection(ESD)to treat early gastric cancer(EGC)in 2001.The lesion(50 mm × 25 mm diameter)was histologically diagnosed as poorly differentiated adenocarcinoma,with an ulcer finding.Although the tumor was confined to the mucosa with no evidence of lymphovascular involvement,the ESD was regarded as a noncurative resection due to the histological type,tumor size,and existence of an ulcer finding(as indicated by the 2010 Japanese gastric cancer treatment guidelines,ver.3).Despite strong recommendation for subsequent gastrectomy,the patient refused surgery.An alternative follow-up routine was designed,which included five years of biannual clinical examinations to detect and measure serum tumor markers and perform visual assessment of recurrence by endoscopy and computed tomography scan after which the examinations were performed annually.The patient's condition remained stable for eight years,until a complaint of back pain in 2010 prompted further clinical investigation.Bone scintigraphy indicated increased uptake.Histological examination of biopsy specimens taken from the lumbar spine revealed adenocarcinoma resembling the carcinoma cells from the EGC that had been treated previously by ESD,and which was consistent with immunohistochemical findings of gastrointestinal tract cancer.Thus,the diagnosis of bone metastasis from EGC was made.The reported rates of EGC recurrence in surgically resected cases range 1.4%-3.4%,but among these bone metastasis is very rare.To our knowledge,this is the first reported case of bone metastasis from EGC following a non-curative ESD and occurring after an eight-year disease-free interval. | Hiroyuki Kawabata Ichiro Oda Haruhisa Suzuki Satoru Nonaka Shigetaka Yoshinaga Hitoshi Katai Hirokazu Taniguchi Ryoji Kushima Yutaka Saito | 2013 | World Journal of Gastroenterology2013，19，30： | 2 |
| 15 | Pulsed electric current sintering of silicon nitride 显示文摘 | MOTOHIRO Suganuma YASUNORI Kitagawa SHIGETAKA Wada | 2003 | J Am Ceram Soc2003，86，38： | 1 |
| 16 | Dielectric Breakdown Properties of Polylactic Acid with β-Crystalline Chitin 显示文摘 | OI Tom KATSUYOSHI Shinyama FUJITA Shigetaka | 2011 | IEEJ Transactions on Electri- cal and Electronic Engineering2011，6，3： | 1 |
| 17 | Generation and molecular motion of grafted polymethacrylate chains on an isotactic polypropylene film surface显示文摘 | Katsuhiro Yamamoto Shigetaka Shimada | 2004 | Macromolecules2004，37，： | 1 |
| 18 | An Integrated Motor Assist Hybrid System-Development of the 'Insight',a Personal Hybrid Coupe显示文摘 | Kaoru Aoki Shigetaka Kuroda | 2000 | SAE Transactions2000，109，3： | 1 |
| 19 | Structure of FR900359,a cyclic depsipeptide from ardisia crenata sims显示文摘 | MAMORU F SHIGETAKA K YUKIYOSHI M | 1988 | J Org Chem1988，53，12： | 1 |
| 20 | Novel uterine sarcoma preoperative diagnosis score predicts the need for surgery in patients presenting with a uterine mass显示文摘 | Tomonori Nagai Yasushi Takai Taichi Akahori Hiroaki Ishida Tatsuya Hanaoka Takahiro Uotani Sho Sato Shigetaka Matsunaga Kazunori Baba Hiroyuki Seki | 2014 | SpringerPlus2014，，： | 1 |
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