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| 1 | PTEN encoding product:a marker for tumorigenesis and progression of gastric carcinoma显示文摘AIM: To detect the expression of PTEN encoding productin normal mucosa, intestinal metaplasia (IM), dysplasia andcarcinoma of the stomach, and to investigate its clinicalimplication in tumorigenesis and progression of gastriccarcinoma.METHODS: Formalin-fixed paraffin embedded specimens from184 cases of gastric carcinoma, their adjacent normal mucosa,IM and dysplasia were evaluated for PTEN protein expressionby SABC immunohistochemistry. PTEN expression wascompared with tumor stage, lymph node metastasis, Lauren'sand WHO's histological classification of gastric carcinoma.Expression of VEGF was also detected in 60 cases of gastriccarcinoma and its correlation with PTEN was concerned.RESULTS: The positive rates of PTEN protein were 100 %(102/102), 98.5 %(65/66), 66.7 % (4/6) and 47.8 %(88/184)in normal mucosa, IM, dysplasia and carcinoma of the stomach,respectively. The positive rates in dysplasia and carcinomawere lower than in normal mucosa and IM (P<0.01).Advanced gastric cancers expressed less frequent PTEN thanearly gastric cancer (42.9 % v567.6 %, P<0.01). The positiverate of PTEN protein was lower in gastric cancer with thanwithout lymph node metastasis (40.3 % v563.3 %, P<0.01).PTEN was less expressed in diffuse-type than in intestinal-type gastric cancer (41.5 % v557.8 %,P<0.05). Signet ringcell carcinoma showed the expression of PTEN at the lowestlevel (25.0 %, 7/28); less than well and moderatelydifferentiated ones (P<0.01). Expression of PTEN was notcorrelated with expression of VEGF (P>0.05).CONCLUSION: Loss or reduced expression of PTEN proteinoccures commonly in tumorigenesis and progression of gastriccarcinoma. It is suggested that PTEN can be an objective markerfor pathologically biological behaviors of gastric carcinoma. | Lin Yang Li-Ge Kuang Hua-Chuan Zheng Jin-Yi Li Dong-Ying Wu Su-Min Zhang Yan Xin No.4 Lab,Cancer Institute,The First Affiliated Hospital,China Medical University,Shenyang 110001,China Ying Chen Shen Yang Gynecology & Obstetrics Hospital,Shenyang 110014,China | 2003 | World Journal of Gastroenterology2003，9，1： | 127 |
| 2 | Surgical treatment of nonfunctioning islet cell tumor: report of 41 cases显示文摘BACKGROUND: Nonfunctioning islet cell tumor (NIT)as a rare pancreatic endocrine neoplasm is characterized byunspecific clinical symptoms and is hard to diagnose. InChina, NIT accounts for 15%-41% in pancreatic endocrineneoplasms just next to insulinoma. In this study, weevaluated the surgical modalities of NIT.METHODS: From January 1978 through February 2002, 41patients with NIT were treated at the Department of Sur-gery of the First Affiliated Hospital, China Medical Univer-sity, Shenyang, China. Tumors in the head of the pancreaswere noted in 28 patients, and in the body or in the tail in13 patients. The mean diameter of the tumors was 10. 7cm. Fifteen patients underwent enucleation and 21 receivedpancreatectomy. Tumors were unresectable in 5 patientsbecause of extensive infiltration. The mean diameter was9.6 cm in patients treated by enucleation, 13.1 cm in thoseby pancreaticoduodenectomy, 9.9 cm in those by distalpancreatectomy, and 11.6 cm in those with unresectabletumors.RESULTS: The curative resection rate was 88% (n =36),and the complication rate after enucleation and pancreatec-tomy was 33% ( n = 5 ) and 14% (n=3), respectively. Nolocal recurrence was found after both enucleation and pan-createctomy. Liver metastases occurred in 3 patients treatedby enucleation.CONCLUSIONS: Both enucleation and pancreatectomy areeffective for NIT of the pancreas. No local recurrence hasbeen found in patients treated by the two surgical proce-dures. The complication rates of the two modalities arecomparable. | Ke-Jian Guo, Hai-Hui Liao, Yu-Lin Tian, Ren-Xuan Guo, San-Guang He and Kui Shen Department of Surgery, First Affiliated Hospital, Chi-na Medical University, Shenyang 110001 , China | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，3： | 9 |
| 3 | Performance comparison and parametric study on spiral groove gas film face seals显示文摘Several spiral groove gas film face seals (SGFS) with different layouts are compared quantitatively to analyze their merits and faults and application behaviors. In addition, a parametric study on downstream mode SGFS is conducted to determine its optimal parameters under certain working conditions. In the computation of gas film pressure on the face, finite element method (FEM) is applied to adapt to complicated geometrical boundary. | LIU Yuchuan, SHEN Xinmin, XU Wanfu & WANG ZhiliState Key Laboratory of Tribology, Tsinghua University, Beijing 100084, China School of Mechanical Engineering and Automation, Beijing University of Aeronautics and Astronautics, Beijing 100083, China Lubrication Technology Research Center, Shenyang Institute of Technology, Shenyang 110015, China | 2004 | Science China(Physics,Mechanics & Astronomy)2004，47，z1： | 8 |
| 4 | Efficacy of intraperitoneal thermochemotherapy and immunotherapy in intraperitoneal recurrence after gastrointestinal cancer resection显示文摘AIM:To investigate the prophylactic and therapeutic efficacy of intraperitoneal IL-2 innunotherapy following intraperitoneal thermochemotheray int the metastasis and recurrence of gastric and colorectal cancer after operation. | Qing-Guo Fu Fan-Dong Meng Xiao-Dong Shen Ren-Xuan Guo,The Second General Surgery Department of The First Clinical College,China Medical University,Shenyang 110001,Liaoning Province,China | 2002 | World Journal of Gastroenterology2002，8，6： | 8 |
| 5 | Control allocation and management of redundant control effectors based on bases sequenced optimal method显示文摘For an advanced aircraft, the amount of its effectors is much more than that for a traditional one, the functions of effectors are more complex and the coupling between each other is more severe. Based on the current control allocation research, this paper puts forward the concept and framework of the control allocation and management system for aircrafts with redundancy con-trol effectors. A new optimal control allocation method, bases sequenced optimal (BSO) method, is then presented. By analyz-ing the physical meaning of the allocation process of BSO method, four types of management strategies are adopted by the system, which act on the control allocation process under different flight conditions, mission requirements and effectors work-ing conditions. Simulation results show that functions of the control allocation system are extended and the system adaptability to flight status, mission requirements and effector failure conditions is improved. | YANG LingYu1, FAN YanMing2, SHAO Shan2, ZHONG YouWu1 & SHEN GongZhang1 1 Department of Automation Science and Electrical Engineering, Beihang University, Beijing 100191, China 2 Shenyang Aircraft Design and Research Institute, Shenyang 110035, China | 2010 | Science China(Technological Sciences)2010，53，2： | 6 |
| 6 | Adsorption and Desorption of Gold on the Magnetic Activated Carbon显示文摘Adsorption and desorption of gold on the magnetic activated carbon (MAC) were investigated The adsorption rate of gold is higher than that of conventional coconut carbon in cyanide leach solution The loading gold can be easily desorbed as coconut carbon. Crushed fine magnetic carbon can be selected by a magnetic separator, It is suggested that the MAC can be used in carbon-in-pulp (CIP)process for increasing the recovery rate of | Chonglin WANG Qingcai LIU Xiaozhen CHENG and Zuhong SHEN (Institute of Metal Research, Academia Sinica, Shenyang, 110015, China)(To whom correspondence should be addressed) | 1994 | Journal of Materials Science & Technology1994，10，2： | 3 |
| 7 | Deformation and recrystallization behavior of a Fe-20Mn-3Si-3Al-0.045C steel under cold-rolling显示文摘The influence of cold rolling reduction on microstructure and mechanical properties of the twinning induced plasticity(TWIP) steel with a chemical composition of Fe-20Mn-3Si-3Al-0.045 C has been investigated.Tensile tests were carried out to explore the mechanical properties of TWIP steel with different cold rolling reductions.The microstructures were observed by optical microscopy and transmission electron microscopy(TEM).The misorientation and the development of recrystallization texture in TWIP steel sheets were investigated by Electron Back Scatter Diffraction(EBSD) technique.The results indicated that the steel exhibited attractively mechanical properties when cold rolling reduction was about 10%.The tensile strength of the steel with a rolling reduction of 10%is higher than 900 MPa and the yield strength is about 800 MPa,while the elongation is above 35%.The microstructure is composed of austenitic matrix and deformation twins at room temperature,at the same time,a significant amount of deformation twins,stacking faults and dislocations are observed by TEM.TEM observations showed the presence of deformation twinning in the sample at low rolling reduction.As the strain increases the volume fraction of twins increases.Mechanical twins play a dominant role during deformation and result in excellent mechanical properties for the investigated steel.By TEM observation,the possible deformation mechanisms can be suggested as:with the increasing strain,formation of the twin will gradually play a more important role during deformation.The interaction between twins and dislocations enhances the strain hardening rate in the sample.Consequently,the necking is delayed and a good ductility is obtained.Twins were always observed in the region with high density of dislocation and faults,suggesting that the interaction among blocked dislocations and faults as well as deformation twins promote the increase in material strength.EBSD observation showed that the textures has evolved according to the following trend:the brass orientation {110}〈112〉and Goss orientation {110}〈001〉are dominant at every strain level,those intensities increase with increasing strain,while with the increase of the strain level,the change of S orientation {123}〈634〉was not obviously. | SHEN Yongfeng~(1)),HUANG Shaoshuai~(1)),ZHANG Rongxing~(1)),XUE Wenying~(2)) and HE Tong~(3)) 1) Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education), Northeastern University,Shenyang 110004,Liaoning,China 2) The State Key Lab of Rolling & Automation,Northeastern University,Shenyang 110004, Liaoning,China 3) Institute of Research,Northeastern University,Shenyang 110004,Liaoning,China | 2010 | Baosteel Technical Research2010，4，S1： | 2 |
| 8 | Analgesic and Anti-inflammatory Effects of Ginger Oil显示文摘Objective Ginger(Zingiber officinale) is widely used as a spice in cooking and as a medicinal herb in traditional herbal medicine.The present study was to investigate the analgesic and anti-inflammatory activities of ginger oil in experimental animal models.Methods The analgesic effect of the oils was evaluated by the 'acetic acid' and 'hot-plate' test models of pain in mice.The anti-inflammatory effect of the oil was investigated in rats,using rat paw edema induced by carrageenan,adjuvant arthritis,and vascular permeability induced by bradykinin,arachidonic acid,and histamine.Indomethacin(1 mg/kg),Aspirin(0.5 g/kg) and Dexamethasone(2.5 mg/kg) were used respectively as reference drugs for comparison.Results The ginger oil(0.25-1.0 g/kg) produced significant analgesic effect against chemically-and thermally-induced nociceptive pain stimuli in mice(P < 0.05,0.01).And the ginger oil(0.25-1.0 g/kg) also significantly inhibited carrageenan-induced paw edema,adjuvant arthritis,and inflammatory mediators-induced vascular permeability in rats(P < 0.05,0.001).Conclusion These findings confirm that the ginger oil can be used to treat pain and chronic inflammation such as rheumatic arthritis. | JIA Yong-liang1,ZHAO Jun-ming2,ZHANG Lin-hui1,SUN Bao-shan2,BAO Meng-jing1,LI Fen-fen1,SHEN Jian1,SHEN Hui-jun1,ZHAO Yu-qing3,4,XIE Qiang-min11.Department of Pharmacology,Medical College of Zhejiang University,Hangzhou 310031,China 2.Liaoning Xinzhong Modern Medicine Co.,Ltd.,Shenyang 110041,China 3.College of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang 110016,China 4.Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education,Shenyang Pharmaceutical University,Shenyang 110016,China | 2011 | Chinese Herbal Medicines2011，3，2： | 2 |
| 9 | Understanding the phase separation characteristics of nucleocapsid protein provides a new therapeutic opportunity against SARS-CoV-2显示文摘Dear Editor To date,tens of millions of people have been infected with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),causing the outbreak of the respiratory disease named the coronavirus disease 2019(COVID-19).As a newly emerged member of the coronavirus family,SARS-CoV-2 is an enveloped positive-strand RNA virus,which has probably the largest genome(approximately 30 kb)among all RNA viruses.The nucleocapsid(N)protein of SARS-CoV-2 is mainly responsible for recognizing and wrapping viral RNA into helically symmetric structures(Malik,2020). | Dan Zhao Weifan Xu Xiaofan Zhang Xiaoting Wang Yiyue Ge Enming Yuan Yuanpeng Xiong Shenyang Wu Shuya Li Nian Wu Tingzhong Tian Xiaolong Feng Hantao Shu Peng Lang Jingxin Li Fengcai Zhu Xiaokun Shen Haitao Li Pilong Li Jianyang Zeng | 2021 | Protein & Cell2021，12，9： | 1 |
| 10 | TENSILE PROPERTIES AND INTERFACIAL FEATURE OF SiC COATED C/Al COMPOSITE WIRES UNDER ISOTHERMAL HEAT TREATMENT显示文摘The effect of different regimes of heat treatment on the tensile strength of SiC coatedcomposite of C fibers reinforced Al wires has been investigated.Their tensile strengthmay increase under treatment either at 500℃ for 2h or 550℃ for 1h,but decreaseover 600℃.After the strength tests of extracted fibers from composite wires,theSiC coating is an excellent protection to C fibers.EPMA and EDAX showed that theC/Al interface of the composite wires is stable under treatment below 600℃,butunstable at | CHEN Xinguo ZHENG Guobin SHEN Zuhong DU Haifeng Institute of Metal Research,Academia Sinica,Shenyang,China | 1992 | Acta Metallurgica Sinica(English Letters)1992，5，11： | 1 |
| 11 | Menstrual Factors,Reproductive Factors and Lung Cancer Risk:A Meta-analysis显示文摘Background and objective Epidemiological studies have suggested that menstrual and reproductive factors may in uence lung cancer risk,but the results are controversial.We therefore carried out a meta-analysis aiming to examine the associations of lung cancer in women with menstrual and reproductive factors.Methods Relevant studies were searched from PubMed database,CNKI,WANFANG DATA and VIP INFORMATION up to January 2012,with no language restrictions.References listed from selected papers were also reviewed.We included studies that reported the estimates of relative risks(RRs) with 95% con dence intervals(CIs) for the association between menstrual and reproductive factors and lung cancer risk.e pooled RRs were calculated a er the heterogeneity test with the so ware Stata 11,and publication bias and sensitivity were evaluated at the same time.Results Twenty-ve articles,representing 24 independent studies,were included in this meta-analysis.Older age at menarche in North America women(RR=0.83;95%CI:0.73-0.94) was associated with a signi cant decreased risk of lung cancer.Longer length of menstrual cycle was also associated with decreased lung cancer risk(RR=0.72;95%CI:0.57-0.90).Other exposures were not signi cantly associated.Conclusions Our analysis provides evidence of the hypothesis that female sex hormones in uence the risk of lung cancer in women,yet additional studies are warranted to extend this nding and to clarify the underlying mechanisms. | Yue ZHANG 1,2,3,Zhihua YIN 1,2,3,Li SHEN 1,2,3,Yan WAN 1,2,3,Baosen ZHOU 1,2,3 1 Department of Epidemiology,School of Public Health,China Medical University,Shenyang 110001,China 2 Key Laboratory of Cancer Etiology and Intervention,Liaoning University,Shenyang 110036,China 3 China Medical University Center For Evidencebased Medicine,Shenyang 110001,China | 2012 | 中国肺癌杂志2012，15，12： | 1 |
| 12 | K X-ray fluorescent source for energy-channel calibration of the spectrometer显示文摘A new K X-ray fluorescent source for calibrating the X or γ-ray multichannel analyzer spectrometer is introduced. A detailed description of the K fluorescent source device is given. The calibration method used and experimental results obtained are presented. The purity and efficiency of K fluorescence photons from this device are discussed. This new fluorescent source may be used as a substitute for radioactive nuclides for the energy-channel calibration of some MCA spectrometers. | TAN Da-Gang, QIN Yue-Ting (Department of Physics, Shen yang Normal University, Shenyang 110084 ) Techniques | 2001 | Nuclear Science and Techniques2001，12，4： | 1 |
| 13 | Sodium Activity in Molten Aluminum Measured with a Solid Electrolyte显示文摘The sodium activities in aluminium in equilibrium with cryolite-alumina melt and during electrolysiswere determined by EMF with Naβ-Al2O3 solid electrolyte.With this sodium activities,we calculatethe activities of NaF and AIF3 in the cryolite-alumina melt.The potential difference of discharge be-tween sodium ions and aluminum ions at cathode of Hall-Heroult cell was also obtained from thesodium activity in aluminum. | Gang XIE Shanghai Institute of Metallurgy,Academia Sinica,Shanghai,200050,ChinaShiyin SHEN Northeast University of Technology,Shenyang,110006,China | 1993 | Journal of Materials Science & Technology1993，9，5： | 1 |
| 14 | VARIATIONAL CALCULATION OF THERMODYNAMIC PROPERTIES OF SUPERCOOLED LIQUID METALS显示文摘By means of Gibbs-Bogoliubov (GB) thermodynamic variational calculation,thethermodynamic properties of the supercooled liquid metals,such as the 3rd family elementsAl,Ga and Tl and transition metal Ti were calculated using the hard-sphere (HS) system asreference.The values of mean atomic volume,Helmholtz free energy,internal energy andentropy as well as specific heat at constant volume,isothermal bulk modulus,thermal expan-sion coefficient and specfic heat under constant pressure were evaluated.The glass transitiontemperature,T_g,is easily obtained from the C_p-T plot.The glass forming ability for metalcan be predicted from T_g/T_m,which is in agreement with the experimental results. | SHEN Tao WANG Jingtang Institute of Metal Research,Academia Sinica National Laboratory of Rapidly Solidified Non-equilibrium Alloys,Shenyang,China | 1990 | Acta Metallurgica Sinica(English Letters)1990，3，12： | 0 |
| 15 | A NEW MECHANISM OF ULTRASOUND ATTENUATION IN SINTERED METAL POWDERS显示文摘ANEWMECHANISMOFULTRASOUNDATTENUATIONINSINTEREDMETALPOWDERS￥Z.C.Shen(InternationalCentreforMaterialsPhysics,ChineseAcademyofSc... | Z. C. Shen( International Centre for Materials Physics, Chinese Academy of Sciences, Shenyang 110015, China Suzhou Professional University, Suzhou 215002, China) | 1996 | Acta Metallurgica Sinica(English Letters)1996，9，5： | 0 |
| 16 | COLD-WORKING AND HEAT-CRACKING IN Ni-Cu-BASE MONEL ALLOY K-500显示文摘COLDWORKINGANDHEATCRACKINGINNiCuBASEMONELALLOYK500①YuanChao1,2,YangHongcai1,WangZhixing1andGuoJianting21DepartmentofMate... | Yuan Chao1, 2, Yang Hongcai1, Wang Zhixing1 and Guo Jianting21 Department of Materials Science and Engineering, Northeastern University, Shenyang 110006, P. R. China2 Institute of Metal Research, Chinese Academy of Sciences, Shen | 1998 | 中国有色金属学会会刊:英文版1998，8，1： | 0 |
| 17 | Differential bone metabolism and protein expression in mice fed a high-fat diet versus Daurian ground squirrels following natural pre-hibernation fattening显示文摘This study compared the effects on bone metabolism and morphology of pathological obesity induced by excessive fat intake in a non-hibernator(mice)versus healthy obesity due to pre-hibernation fattening in a hibernator(ground squirrels).Kunming mice were fed a high-fat diet to provide a model of pathological obesity(OB group).Daurian ground squirrels fattened naturally in their pre-hibernation season(PRE group)were used as a healthy obesity model.Micro-computed tomography(micro-CT)and three-point bending tests were used to determine the microstructure and mechanical properties of bone.Western blots were used to analyze protein expression levels related to bone metabolism(Runt-related transcription factor 2(RunX2),osteocalcin(OCN),alkaline phosphatase(ALP),osteoprotegerin(OPG),receptor activator of nuclear factor-κB ligand(RANKL),cathepsin K,matrix metallopeptidase 9(MMP9),patched protein homolog 1(Ptch1),phosphorylatedβ-catenin(P-β-catenin),and glycogen synthase kinase-3β(GSK-3β)).Compared with controls,there was no obvious bone loss in the OB mice,and the stiffness of the femur was increased significantly.Compared with summer active squirrels,bone formation was enhanced but the mechanical properties did not change in the PRE group squirrels.In OB mice,western blots showed significantly increased expression levels of all proteins except RunX2,OPG,and Ptch1.PRE ground squirrels showed significantly increased expression of most proteins except OCN and Ptch1,which decreased significantly,and P-β-catenin and OPG,which did not change.In conclusion,for non-hibernating mice,moderate obesity had a certain protective effect on bones,demonstrating two-way regulation,increasing both bone loss and bone formation.For pre-hibernating ground squirrels,the healthy obesity acquired before hibernation had a positive effect on the microstructure of bones,and also enhanced the expression levels of proteins related to bone formation,bone resorption,and Wnt signaling. | Xuli GAO Shenyang SHEN Qiaohua NIU Weilan MIAO Yuting HAN Ziwei HAO Ning AN Yingyu YANG Yu ZHANG Han ZHANG Kenneth BSTOREY Hui CHANG | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，12： | 0 |
| 18 | HOT CORROSION OF Ni_3Al-0.2B IN MOLTEN NaCl-(Na,K)_2SO_4显示文摘Hot corrosion of intermetallic compound Ni3Al-0.2B was studied by electrochemicaltechniques combined with physical analyses.It was found that hot corrosion resistanceof Ni3Al-0.2B is rather inferior.Sulfidation-oxidation is responsible for the acceleratedcorrosion.The addition of 6at.-% Cr and 0.5at.-% Zr to Ni3Al-0.2B may accelerateits corrosion. | WU Weitao ZHANG Jianqing ZENG Chaoliu NIU Yan SHEN Weiliang Corrosion Science Laboratory,Institute of Corrosion and Protection of Metals,Academia Sinica,Shenyang,China Professor,Institute of Corrosion and Protection of Metals,Academia Sinica,Shenyang 110015,China | 1993 | Acta Metallurgica Sinica(English Letters)1993，6，7： | 0 |
| 19 | ON THE IN-SITU FORMING TiB_2 REINFORCED AI COMPOSITE显示文摘The in-situ forming TiB2 reinforced Al composite was favorably prepared by reaction-sintering of pure Al,Ti and B powders under vacuum.The TiB2 is of submicrosize andfree from lattice defect in the main.A superior room,temperature strength and modulus,as well as good elevated temperature properties were obtained as comparison with thatof pure Al. | MA Zongyi BI Jing LU Yuxiong SHEN Hongwei GAO Yinxuan Institute of Metal Research,Academia Sinica,Shenyang,China Shenyang 110015,China Institute of Metal Research,Academia Sinica | 1993 | Acta Metallurgica Sinica(English Letters)1993，6，8： | 0 |
| 20 | THE NMR CONFORMATIONAL STUDIES OF BACITRACIN A显示文摘Bacitracin consists of a mixture of several closely related polypeptide antibiotics produced from Bacillus licheniformis.The major component, Bacitracin A, is a cyclic dodecapeptide(Fig, 1), which has strong bacteriocidal effect on the G+ bacteria. The bacteriocidal activity requires the presence of divalent cations such as Zn(?)+, As we know, the biological function of ploypeptides and proteins are closely related to their three-dimensional structure. Bacitracin A is very important for the demonstration of the coordination site of metal and the relationship | Xiu Weng HAN~*, Jian Yi NI, Xi Jia MIAO and Jie Han HU Dalian Institute of Chemical Physics, Academis Sinica, 116023. Laboratory of Applied Organic Chemistry, Lanzhou University, 730000 Jian ZHUANG, Guan Hong WENG and Xiao Mao ZHONG National Key Laboratory of Bio-Organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Academia Sinica, 200032 Jun Den YANG and Xiang Peng DAI,#:Hong WANG and Chuan Ze SHEN Shenyang Institute of Ecology, #: Shenyang Institute of Automation, Academia Siniea, 110015 | 1993 | Chinese Chemical Letters1993，4，5： | 0 |
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