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| 1 | Structural variation in complex genome: detection, integration and function显示文摘Structural variations (SVs) are mutations with large-scale changes (generally>50 bp) in the genome. SVs are major sources of the genetic diversity of organisms and thus are of high relevance to phenotype variations, gene dosage and evolutionary genetics. Except detecting SVs through comparative genetic analyses, dozens of software had been developed based on the alignment of short-reads to a single linear genome in the past decades (Guan and Sung, 2016). | Ning Yang Shenshen Wu Jianbing Yan | 2019 | Science China(Life Sciences)2019，62，8： | 2 |
| 2 | Validation and Spatiotemporal Distribution of GEOS-5-Based Planetary Boundary Layer Height and Relative Humidity in China显示文摘Few studies have specifically focused on the validation and spatiotemporal distribution of planetary boundary layer height(PBLH) and relative humidity(RH) data in China. In this analysis, continuous PBLH and surface-level RH data simulated from GEOS-5 between 2004 and 2012, were validated against ground-based observations. Overall, the simulated RH was consistent with the statistical data from meteorological stations, with a correlation coefficient of 0.78 and a slope of 0.9. However, the simulated PBLH was underestimated compared to LIDAR data by a factor of approximately two,which was primarily because of poor simulation in late summer and early autumn. We further examined the spatiotemporal distribution characteristics of two factors in four regions—North China, South China, Northwest China, and the Tibetan Plateau. The results showed that the annual PBLH trends in all regions were fairly moderate but sensitive to solar radiation and precipitation, which explains why the PBLH values were ranked in order from largest to smallest as follows: Tibetan Plateau, Northwest China, North China, and South China. Strong seasonal variation of the PBLH exhibited high values in summer and low values in winter, which was also consistent with the turbulent vertical exchange. Not surprisingly, the highest RH in South China and the lowest RH in desert areas of Northwest China(less than 30%). Seasonally, South China exhibited little variation, whereas Northwest China exhibited its highest humidity in winter and lowest humidity in spring,the maximum values in the other regions were obtained from July to September. | Yidan SI Shenshen LI Liangfu CHEN Chao YU Zifeng WANG Yang WANG Hongmei WANG | 2018 | Advances in Atmospheric Sciences2018，35，4： | 2 |
| 3 | Phosphorylation of a wheat aquaporin at two sites enhances both plant growth and defense显示文摘Eukaryotic aquaporins share the characteristic of functional multiplicity in transporting distinct substrates and regulating various processes,but the underlying molecular basis for this is largely unknown.Here,we report that the wheat(Triticum aestivum)aquaporin TaPIP2;10 undergoes phosphorylation to promote photosynthesis and productivity and to confer innate immunity against pathogens and a generalist aphid pest.In response to elevated atmospheric CO_(2)concentrations,TaPIP2;10 is phosphorylated at the serine residue S280 and thereafter transports CO_(2)into wheat cells,resulting in enhanced photosynthesis and increased grain yield.In response to apoplastic H_(2)O_(2) induced by pathogen or insect attacks,TaPIP2;10 is phosphorylated at S121 and this phosphorylated form transports H_(2)O_(2) into the cytoplasm,where H_(2)O_(2)intensifies host defenses,restricting further attacks.Wheat resistance and grain yield could be simultaneously increased by TaPIP2;10 overexpression or by expressing a TaPIP2;10 phosphomimic with aspartic acid substitutions at S121 and S280,thereby improving both crop productivity and immunity. | Kai Lu Xiaochen Chen Xiaohui Yao Yuyan An Xuan Wang Lina Qin Xiaoxu Li Zuodong Wang Shuo Liu Zhimao Sun Liyuan Zhang Lei Chen Baoyan Li Baoyou Liu Weiyang Wang Xinhua Ding Yonghua Yang Meixiang Zhang Shenshen Zou Hansong Dong | 2022 | Molecular Plant2022，15，11： | 2 |
| 4 | High-efficiency Gaussian key reconciliation in continuous variable quantum key distribution显示文摘Efficient reconciliation is a crucial step in continuous variable quantum key distribution. The progressive-edge-growth(PEG) algorithm is an efficient method to construct relatively short block length low-density parity-check(LDPC) codes. The qua-sicyclic construction method can extend short block length codes and further eliminate the shortest cycle. In this paper, by combining the PEG algorithm and quasi-cyclic construction method, we design long block length irregular LDPC codes with high error-correcting capacity. Based on these LDPC codes, we achieve high-efficiency Gaussian key reconciliation with slice recon-ciliation based on multilevel coding/multistage decoding with an efficiency of 93.7%. | ZengLiang Bai XuYang Wang ShenShen Yang YongMin Li | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，1： | 2 |
| 5 | A novel risperi- done-loaded SAIB-PL- GA mixture matrix depot with a re- duced burst release: effects of solvents and PLGA on drug re- lease behaviors in vitro/in vivo 显示文摘 | Xia Lin Yang Shenshen Gou Jingxin | 2012 | J Mater Sci Mater Med2012，23，2： | 1 |
| 6 | 5 emissions control during the Beijing 2008 Olympic Games 显示文摘 | LIU Yang HE Kebin LI Shenshen A statistical model to evaluate the effectiveness of PM2 | 2012 | Environment International2012，44，： | 1 |
| 7 | Increased dissolution and oral absorption of itraconazole/Soluplus extrudate compared with itraconazole nanosuspension显示文摘 | Keru Zhang Hongxia Yu Qing Luo Shenshen Yang Xia Lin Yu Zhang Bin Tian Xing Tang | 2013 | European Journal of Pharmaceutics and Biopharmaceutics2013，，： | 1 |
| 8 | Technology for improving the bioavailability of small molecules extracted from traditional Chinese medicines显示文摘 | WenJun Zhang ShenShen Yang HaiBin He | 2009 | Expert Opin Drug Deliv2009，6，11： | 1 |
| 9 | Design and transition characteristics of a standard model for hypersonic boundary layer transition research显示文摘To understand fundamental problems in hypersonic laminar-turbulent boundary layer transition for three-dimensional complex vehicles,a new standard model with typical lifting-body features has been proposed,named as hypersonic transition research vehicle(HyTRV).The configuration of HyTRV is fully analytical,and details of the design process are discussed in this study.The transition characteristics for HyTRV are investigated using three combined methods,i.e.,theoretical analyses,numerical simulations,and wind tunnel experiments.Results show that the fully analytic parameterization design of HyTRV can satisfy the model simplification requirements from both numerical simulations and wind tunnel experiments.Meanwhile,the flow field of HyTRV reveals typical transition mechanisms in six relatively separated regions,including the streamwise vortex instability,crossflow instability,secondary instability,and attachment-line instability.Therefore,the proposed HyTRV model is valuable for fundamental researches in hypersonic boundary layer transition. | Shenshen Liu Xianxu Yuan Zhiyong Liu Qiang Yang Guohua Tu Xi Chen Yewei Gui Jianqiang Chen | 2021 | Acta Mechanica Sinica2021，37，11： | 0 |
| 10 | Disease X Testing:The results of an international external quality assessment exercise显示文摘The United Nations Secretary-General Mechanism(UNSGM)for investigation of the alleged use of chemical and biological weapons is the only established international mechanism of this type under the UN.The UNGSM may launch an international investigation,relying on a roster of expert consultants,qualified experts,and analytical laboratories nominated by the member states.Under the framework of the UNSGM,we organized an external quality assurance exercise for nominated laboratories,named the Disease X Test,to improve the ability to discover and identify new pathogens that may cause possible epidemics and to determine their animal origin.The“what-if”scenario was to identify the etiological agent responsible for an outbreak that has tested negative for many known pathogens,including viruses and bacteria.Three microbes were added to the samples,Dabie bandavirus,Mammarenavirus,and Gemella spp.,of which the last two have not been taxonomically named or published.The animal samples were from Rattus norvegicus,Marmota himalayana,New Zealand white rabbit,and the tick Haemaphysalis longicornis.Of the 11 international laboratories that participated in this activity,six accurately identified pathogen X as a new Mammarenavirus,and five correctly identified the animal origin as R.norvegicus.These results showed that many laboratories under the UNSGM have the capacity and ability to identify a new virus during a possible international investigation of a suspected biological event.The technical details are discussed in this report. | Tian Qin Han Zheng Xuelian Luo Wen Zhang Jing Yang Yamin Sun Na Han Yuanhai You Liang Lu Xin Lu Di Xiao Shenshen Jiang Xuexin Hou Jinxing Lu Biao Kan Jianzhong Zhang Jianguo | 2022 | Journal of Biosafety and Biosecurity2022，4，2： | 0 |
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