|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Remote ischaemic conditioning for stroke: unanswered questions and future directions显示文摘Remote ischaemic conditioning(RIC)refers to a process whereby periods of intermittent ischaemia,typically via the cyclical application of a blood pressure cuff to a limb at above systolic pressure,confers systemic protection against ischaemia in spatially distinct vascular territories.The mechanisms underlying this have not been characterised fully but have been shown to involve neural,hormonal and systemic inflammatory signalling cascades.Preclinical and early clinical studies have been promising and suggest beneficial effects of RIC in acute ischaemic stroke,symptomatic intracranial stenosis and vascular cognitive impairment.Through systematic searches of several clinical trials databases we identified 48 active clinical trials of RIC in ischaemic stroke,intracerebral haemorrhage and subarachnoid haemorrhage.We summarise the different RIC protocols and outcome measures studied in ongoing clinical trials and highlight which studies are most likely to elucidate the underlying biological mechanisms of RIC and characterise its efficacy in the near future.We discuss the uncertainties of RIC including the optimal frequency and duration of therapy,target patient groups,cost-effectiveness,the confounding impact of medications and the absence of a clinically meaningful biomarker of the conditioning response.With several large clinical trials of RIC expected to report their outcomes within the next 2 years,this review aims to highlight the most important studies and unanswered questions that will need to be addressed before this potentially widely accessible and low-cost intervention can be used in clinical practice. | Sheharyar Baig Bethany Moyle Krishnan Padmakumari Sivaraman Nair Jessica Redgrave Arshad Majid Ali Ali | 2021 | Stroke & Vascular Neurology2021，6，2： | 2 |
| 2 | Ryanodine receptors contribute to bile acid-induced pathological calcium signaling and pancreatitis in mice显示文摘 | Sohail Z. Husain Abrahim I. Orabi Kamaldeen A. Muili Yuhuan Luo Sheharyar Sarwar Syeda Maham Mahmood Dong Wang Rayman Choo-Wing Vijay P. Singh Jerome Parness Meena Ananthanaravanan Vineet Bhandari George Perides | 2012 | AJP: Gastrointestinal and Liver Physiology2012，，12： | 1 |
| 3 | What effect does sthma treatment have on airway remodeling? Current perspectives显示文摘 | Sheharyar RD Ravi KV William WB | 2011 | Journal of Allergy and Cinical Immunology2011，128，3： | 1 |
| 4 | Presentation delay in breast cancer patients and its association with sociodemographic factors in North Pakistan显示文摘Background: There is strong evidence that delayed diagnosis of breast cancer is associated with poor survival. The objectives were to determine the frequency of breast cancer patients with delayed presentation, the reasons of delay and its association with different socio-demographic variables in our settings.Methods: We interviewed 315 histologically confirmed breast cancer patients. Delay was defined as more than 3 months from appearance of symptoms to the consultation from doctor. Questions were asked from each patient which could reflect their understanding about the disease and which could be the likely reasons for their delayed presentation.Results: A total of 39.01%(n=123) of patients presented late and out of those, 40.7% wasted time using alternative medicines; 25.2% were not having enough resources; 17.1% presented late due to painless lump; 10.6% felt shyness and 6.5% presented late due to other reasons. Higher age, negative family history, <8 school years of education and low to middle socio-economic status were significantly associated with delayed presentation(P<0.05). Education and socioeconomic status were two independent variables related to the delayed presentation after adjustment for others [odds ratios(OR) of 2.26, 2.29 and 95% confidence intervals(CI) was 1.25-4.10, 1.06-4.94 respectively].Conclusions: Significant percentage of women with breast cancer in North Pakistan is experiencing presentation delay due to their misconceptions about the disease. Coordinated efforts with public health department are needed to educate the focused groups and mitigating the barriers identified in the study. Long term impact will be reduced overall burden of the disease in the region. | Muhammad Aleem Khan Sheharyar Hanif Sundas Iqbal Muhammad Faheem Shahzad Sehrish Shafique Muhammad Taha Khan | 2015 | Chinese Journal of Cancer Research2015，27，3： | 1 |
| 5 | A Framework for Creating a Distributed Rendering Environment on the Compute Clusters 显示文摘 | Sheharyar A Bouhali O | 2014 | International Journal of Advanced Computer Science & Applications2014，4，6： | 1 |
| 6 | Frequency of otitis media with effusion among children aged 1-5 years presenting to immunization center of tertiary care hospitals,Rawalpindi显示文摘Objective:We conducted this study to assess the etiopathogenic relation of otitis media with effusion(OME)in a group of children aged 1-5 years among the local population of Rawalpindi.Methods:This was a cross-sectional retrospective study.Study was conducted among the children presenting to the immunization center of three tertiary care hospitals of Rawalpindi.Otitis media was assessed by clinical examination and tympanometry from August 2019 to January 2020.Multi-factor regression analysis was then applied to recognize the statistical significance and association of various risk factors to OME.Results:Out of 400 children enrolled in this study,108(27.0%)had OME,out of which 65(60.2%)were males and 30(27.8%)were of age group 2-3 years.Multivariable regression analysis of risk factors associated with OME showed it was strongly associated with snoring(P<0.001),last year symptoms(attack of ear aches with hearing loss[P=0.002]),drugs(URTI antibiotics[P=0.026],All 3 drugs[P=0.013]).Conclusions:We found out that OME is a common disease which if not identified or treated timely can lead to other hard to cure health problems.Control of its etiopathogenic factors can play a major role in its prevention. | Nida Riaz Muhammad Ajmal Muhammad Sheharyar Khan | 2022 | World Journal of Otorhinolaryngology-Head and Neck Surgery2022，8，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员