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| 1 | Alendronate loaded graphene oxide functionalized collagen sponge for the dual effects of osteogenesis and anti-osteoclastogenesis in osteoporotic rats显示文摘Graphene Oxide(GO)-related hydrogels have been extensively studied in hard tissue repair,because GO can not only enhance the mechanical properties of polymers but also promote osteogenic differentiation of mesenchymal stem cells.However,simple GO-related hydrogels are not ideal for the repair of osteoporotic bone defects as the overactive osteoclasts in osteoporosis.Alendronate(Aln)is known to inhibit osteoclasts and may bind to GO through covalent connection.Therefore,delivering Aln in GO-related hydrogels may be effective to repair osteoporotic bone defects.Here,we developed a control-released system which is constructed by collagen(Col)-GO sponges loaded with Aln(Col-GO-Aln)for osteoporotic bone defect repair.In vitro,Col-GO-Aln sponges prolonged the release period of Aln,and the sponge containing 0.05%(w/v)GO released Aln faster than sponge with 0.2%GO.Furthermore,tartrate-resistant acid phosphatase(TRAP)and F-actin staining demonstrated that Col-GO-Aln sponges effectively inhibited osteoclastogenesis of monocyte-macrophages.In vivo,micro-CT scan showed that the volume of newborn bone in defect site by 0.05%GO sponge was nearly three times larger than that of other groups.Moreover,the CT and histological examinations of rat femur proved that Col-GO-Aln sponges decreased the number of osteoclasts and suppressed the systemic bone loss in osteoporotic rats.These findings reveal that the application of GO as carriers of anti-osteoporosis drugs is a viable treatment for osteoporosis.The results also underscore the potential of GO-related hydrogels with Aln-releasing capacity for bone regeneration in osteoporosis. | Yuyang Zeng Muran Zhou Lifeng Chen Huimin Fang Shaokai Liu Chuchao Zhou Jiaming Sun Zhenxing Wang | 2020 | Bioactive Materials2020，5，4： | 10 |
| 2 | Cancer incidence and mortality in Henan province,2012显示文摘Objective: Population-based cancer registration data in 2012 from all available cancer registries in Henan province were collected by Henan Office for Cancer Research and Control. The numbers of new cancer cases and cancer deaths in Henan province with compiled cancer incidence and mortality rates were estimated.Methods: In 2015, all registries' data in Henan province were qualified for the national cancer registry annual report in 2012. The pooled data were stratified by area(urban/rural), gender, age group(0, 1-4, 5-9, 10-14, …, 85+) and cancer type. New cancer cases and deaths were estimated using age-specific rates and corresponding population of Henan province in 2012. The Chinese census data in 2000 and Segi's population were applied for age-standardized rates. All the rates were expressed per 100,000 person-years.Results: Qualified 19 cancer registries(4 urban and 15 rural registries) covered 16,082,688 populations of Henan province in 2012. The percentage of cases with morphologically verified(MV%) and death certificateonly cases(DCO%) were 69.84% and 2.30%, respectively, and the mortality to incidence rate ratio(M/I) was 0.64. It was estimated that there were 248,510 new cancer cases and 158,630 cancer deaths in Henan province in 2012. The incidence rate was 266.17/100,000(288.61/100,000 in males and 241.86/100,000 in females), the age-standardized incidence rates by Chinese standard population(ASIRC) and by world standard population(ASIRW) were 208.95/100,000 and 206.41/100,000 with the cumulative incidence rate(0-74 years old) of 24.30%. The crude incidence rate in urban areas was higher than that in rural areas. However, after adjusted by age, the cancer incidence rate in rural was higher than that in urban areas. The crude mortality of all cancers in Henan province was 169.90/100,000(201.23/100,000 in males and 135.95/100,000 in females). The age-standardized mortality rates by Chinese standard population(ASMRC) and by world standard population(ASMRW) were 131.20/100,000 and 130.80/100,000, respectively. Among the patients aged 0-74 years, the cumulative mortality rate was 15.03%. The crude cancer mortality rate in urban areas was higher than that of rural areas. However, the age-standardized rate in rural areas was higher than that of urban areas. Cancers of lung, stomach, esophagus, liver, female breast, colorectum, cervix, brain, uterus and ovary were the most common cancers, accounting for about 82.80% of all cancer new cases. Lung cancer, stomach cancer, esophageal cancer, liver cancer, colorectal cancer, female breast cancer, brain cancer, leukemia, pancreatic cancer and cervix cancer were the leading causes of cancer deaths, accounting for about 88.50% of all cancer deaths. The burden between urban and rural, males and females were different.Conclusions: Registration data of Henan province was qualified to provide basic information on population-based cancer incidence, mortality for cancer prevention and control. The upper digestive tract cancer burden in Henan province, especially for males in rural areas, was higher. The incidence rate of female breast cancer was higher in urban areas. Targeted prevention, early detection and treatment programs should be carried out by health department to control the cancer burden. | Shuzheng Liu Qiong Chen Peiliang Quan Meng Zhang Shaokai Zhang Lanwei Guo Xibin Sun Chengzeng Wang | 2016 | Chinese Journal of Cancer Research2016，28，3： | 5 |
| 3 | ZnO nanorod gas sensor for NOz detection 显示文摘 | LIU FANGTSO GAO SHIANGFU PEI SHAOKAI | 2009 | J Taiwan Inst Chem Eng2009，40，15： | 1 |
| 4 | Mapping of Wbph6(t)-a new gene resistant to white-backed planthopper显示文摘Whitebacked planthopper (WBPH, Sogatella furcifera Horvath) is one of the most destructive insects for rice. The utilization of WBPH resistance genes is always an efficient solution to this problem. Besides five WBPH resistance genes registered, Wbph1, Wbph2, Wbph3, wbph4, and Wbph5, classical segregation analysis and allelism test showed that several rice landraces from Yunan Province, China, carried a new dominant resistance gene Wbph6(t). We herein reported the mapping of Wbph6(t) by using DNA markers. | MA Liangyong ZHUANG Jieyun LIU Grannie MIN Shaokai LI Ximing CNRRI Hangzhou 310006,China | 2001 | Chinese Rice Research Newsletter2001，9，4： | 1 |
| 5 | Soluble Fms-like Tyrosine Kinase-1 Expression Inhibits the Growth of Multiple Myeloma in Nude Mice显示文摘Angiogenesis 包括多重骨髓瘤(公里) 是在生长和前进 ofhematological 恶意的一个必要因素。脉管的 endothelial 生长因素和它的受体被显示了是为治疗肿瘤的目标。这研究探索效果在裸体老鼠的公里房间线 KM3 的生长上的可溶的脉管的 endothelial 生长因素受体 Fms-liketyrosine kinase-1 (sFLT-1 ) 的调停 ofadenovirus 的交货。sFLT-1 cDNA 被反向的抄写聚合酶链反应从人的脐的静脉 endothelial 房间放大并且被用作 transgene 构造带 sFLT-1 (ADV-sFLT ) 的 adenoviral 向量。Cellproliferation 和 3-[4,5-dimethylthiazol-2-yl ]-2,5-diphenyltetrazolium 溴化物试金被执行在人的脐的静脉 endothelial 房间和 KM3 房间 invitro 上评估 ADV-sFLT 的效果。十八只女 BALB/c 裸体老鼠与 KM3 房间皮下地被接种,并且他们随机被划分成三个组并且与 ADV-sFLT 静脉内地注射了, ADV-LacZ,缓冲 orphosphate 盐(PBS ) 。KM3 异种皮移植的体积一个星期被测量两次。在起始的处理,在与 ADV-sFLT 对待的鼠标的公里异种皮移植的卷, ADV-LacZ,或 PBS 以后的三个星期是 770.32 ± 2 8.73 mm^3, 1983.36 ± 4 3.72 mm^3,和 2042.05 ± 8 2.31 mm^3,分别地(P<0.01, ADV-sFLT 对 ADV-LacZ 或 PBS ) 。微容器密度的价值在与 ADV-sFLT, ADV-LacZ,和 PBS 治疗的肿瘤是 29.17 ± 6 .85,79.17 ± 7 .35,和 78.83 ± 8 .54,分别地(P<0.01, ADV-sFLT 对 ADV-LacZ 或 PBS ) 。这研究建议调停侵入人体气管粘膜的病菌的 sFLT-1gene 极大地禁止在老鼠异种皮移植的生长和 angiogenesis,和力量为公里作为新治疗服务的导出公里的肿瘤。 | Junru LIU Juan LI Chang SU Beihui HUANG Shaokai LUO | 2007 | Acta Biochimica et Biophysica Sinica2007，39，7： | 1 |
| 6 | A comparative study of the measurements of perceived risk among contractors in China显示文摘 | LIU Shaokai YAN Hong | 2013 | International Journal of Project Management2013，31，2： | 1 |
| 7 | Genetic Analysis of the Resistance in Six Newly-bred Rice Varieties to the Whitebacked Planthopper,Sogatella furcifera显示文摘The paper reports the study on resistance in 6 newly-bred rice varieties, such as Nongxiang 16and 9234, to the whitebacked planthopper, Sogatella furcifera. In crossing with the susceptible Taichnng Native 1 (TN1), the resistance of their F1 and F2 populations and the back-crossed BC1F1 populations have been evaluated. The resistance to S. furcifera in Zhenongda 6022, 9234 and Zhongjian 96-3 was controlled by a single dominant gene, and by a single recessive gene in Nongxiang 16, R40 and Shuhui 881, respectively.These varieties possessed good agronomical characteristics and could be used in further rice breeding and rice production. | LI Xi-ming, MA Liang-yong, LIU Guang-jie, ZHUANG Jie-yun, SHEN Jun-hui and MIN Shaokai(China National Rice Research Institute, Hangzhou 310006) | 2002 | Agricultural Sciences in China2002，1，3： | 0 |
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