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| 1 | HY5-HDA9 Module Transcriptionally Regulates Plant Autophagy in Response to Light-to-Dark Conversion and Nitrogen Starvation显示文摘Light is arguably one of the most important environmental factors that determines virtually all aspects of plant growth and development,but the molecular link between light signaling and the autophagy pathway has not been elucidated in plants.In this study,we demonstrate that autophagy is activated during light-to-dark conversion though transcriptional upregulation of autophagy-related genes(ATGs).We showed that depletion of the ELONGATED HYPOCOTYL 5(HY5),a key component of light signaling,leads to enhanced autophagy activity and resistance to extended darkness and nitrogen starvation treatments,contributing to higher expression oiATGs.HY5 interacts with and recruits HISTONE DEACETYLASE 9(HDA9)to ATG5 and ATG8e loci to repress their expression by deacetylation of the Lys9 and Lys27 of histone 3.Furthermore,we found that both darkness and nitrogen depletion induce the degradation of HY5 via 26S proteasome and the concomitant disassociation of HDA9 from ATG5 and ATG8e loci,leading to their depression and thereby activated autophagy.Genetic analysis further confirmed that HY5 and HDA9 act synergistically and function upstream of the autophagy pathway.Collectively,our study unveils a previously unknown transcriptional and epigenetic network that regulates autophagy in response to light-to-dark conversion and nitrogen starvation in plants. | Chao Yang Wenjin Shen Lianming Yang Yun Sun Xibao Li Minyi Lai Juan Wei Chaojun Wang Yingchao Xu Faqiang Li Shan Liang Chengwei Yang Shangwei Zhong Ming Luo Caiji Gao | 2020 | Molecular Plant2020，13，3： | 8 |
| 2 | Analysis of Dye Components in Red Ballpoint Pen Inks by Nonaqueous Micellar Electrokinetic Chromatography with LIF Detection 显示文摘 | Jiali Su Jing Xu Shangwei Zhong | 2014 | Chromatographia2014，77，： | 1 |
| 3 | A Molecular Framework of Light-Controlled Phytohormone Action in Arabidopsis显示文摘 | Shangwei Zhong Hui Shi Chang Xue Lei Wang Yanpeng Xi Jigang Li Peter H. Quail Xing Wang Deng Hongwei Guo | 2012 | Current Biology2012，，16： | 1 |
| 4 | Lessons learned from the Wenchuan earthquake显示文摘 | Ji Shen Junxing Kang Yingkang Shi Youping Li Yuanfeng Li Lin Su Jianlin Wu Shangwei Zheng Jie Jiang Weijian Hu Yong Yang Xuefeng Tang Jin Wen Ling Li Jiantong Shen Dake Zhong | 2012 | Journal of Evidence‐Based Medicine2012，，2： | 1 |
| 5 | MicroProteins:Dynamic and accurate regulation of protein activity显示文摘Proteins usually assemble oligomers or high-order complexes to increase their efficiency and specificity in biological processes.The dynamic equilibrium of complex formation and disruption imposes reversible regulation of protein function.MicroProteins are small,single-domain proteins that directly bind target protein complexes and disrupt their assembly.Growing evidence shows that microProteins are efficient regulators of protein activity at the post-translational level.In the last few decades,thousands of plant microProteins have been predicted by computational approaches,but only a few have been experimentally validated.Recent studies highlighted the mechanistic working modes of newly-identified microProteins in Arabidopsis and other plant species.Here,we review characterized microProteins,including their biological roles,regulatory targets,and modes of action.In particular,we focus on microProtein-directed allosteric modulation of key components in light signaling pathways,and we summarize the biogenesis and evolutionary trajectory of known microProteins in plants.Understanding the regulatory mechanisms of microProteins is an important step towards potential utilization of microProteins as versatile biotechnological tools in crop bioengineering. | Qingqing Wu Shangwei Zhong Hui Shi | 2022 | Journal of Integrative Plant Biology2022，64，4： | 0 |
| 6 | Lack of ethylene does not affect reproductive success and synergid cell death in Arabidopsis显示文摘The signaling pathway of the gaseous hormone ethylene is involved in plant reproduction,growth,devel-opment,and stress responses.During reproduction,the two synergid cells of the angiosperm female gametophyte both undergo programmed cell death(PCD)/degeneration but in a different manner:PCD/degeneration of one synergid facilitates pollen tube rupture and thereby the release of sperm cells,while PCD/degeneration of the other synergid blocks supernumerary pollen tubes.Ethylene signaling was postu-lated to participate in some of the synergid cell functions,such as pollen tube attraction and the induction of PCD/degeneration.However,ethylene-mediated induction of synergid PCD/degeneration and the role of ethylene itself have not been firmly established.Here,we employed the CRISPR/Cas9 technology to knock out the five ethylene-biosynthesis 1-aminocyclopropane-1-carboxylic acid oxidase(ACO)genes and created Arabidopsis mutants free of ethylene production.The ethylene-free mutant plants showed normal triple responses when treated with ethylene rather than 1-aminocyclopropane-1-carboxylic acid,but had increased lateral root density and enlarged petal sizes,which are typical phenotypes of mutants defective in ethylene signaling.Using these ethylene-free plants,we further demonstrated that production of ethylene is not necessarily required to trigger PCD/degeneration of the two synergid cells,but certain com-ponents of ethylene signaling including transcription factors ETHYLENE-INSENSITIVE 3(EIN3)and EIN3-LIKE 1(EIL1)are necessary for the death of the persistent synergid cell. | Wenhao Li Qiyun Li Mohan Lyu Zhijuan Wang Zihan Song Shangwei Zhong Hongya Gu Juan Dong Thomas Dresselhaus Sheng Zhong Li-Jia Qu | 2022 | Molecular Plant2022，15，2： | 0 |
| 7 | HY5-HDA9 Module Transcriptionally Regulates Plant Autophagy in Response to Light-to-Dark Conversion and Nitrogen Starvation显示文摘(Molecular Plant 13,515-531;March 2020)After publication of our original manuscript,we became aware of errors in Figure 4.During the preparation of Figure 4C in this article as originally published,we inadvertently duplicated the image of hda9-1(MS-N)as that of the hda9-1-C(MS+N).Also,in Figure 4H,the image of pUBQ10:GFP-ATG8a/hda9-1(MS+L)was mistakenly a duplicate of pUBQ10:GFP-ATG8a/WT(MS+L)shown in Figure S7C.A corrected version of Figure 4 is shown below.The scientific conclusions of this article have not been affected by this correction.The authors apologize for not detecting this error prior to publication and for any inconvenience that may have been caused. | Chao Yang Wenjin Shen Lianming Yang Yun Sun Xibao Li Minyi Lai Juan Wei Chaojun Wang Yingchao Xu Faqiang Li Shan Liang Chengwei Yang Shangwei Zhong Ming Luo Caiji Gao | 2022 | Molecular Plant2022，15，10： | 0 |
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