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| 1 | Combined transjugular intrahepatic portosystemic shunt and other interventions for hepatocellular carcinoma with portal hypertension显示文摘AIM: To evaluate combination transjugular intrahepatic portosystemic shunt(TIPS) and other interventions for hepatocellular carcinoma(HCC) and portal hypertension.METHODS: Two hundred and sixty-one patients with HCC and portal hypertension underwent TIPS combined with other interventional treatments(transarterial chemoembolization/transarterial embolization,radiofrequency ablation,hepatic arterio-portal fistulas embolization,and splenic artery embolization) from January 1997 to January 2010 at Beijing Shijitan Hospital. Two hundred and nine patients(121 male and 88 female,aged 25-69 years,mean 48.3 ± 12.5 years) with complete clinical data were recruited. We evaluated the safety of the procedure(procedurerelated death and serious complications),change of portal vein pressure before and after TIPS,symptom relief [e.g.,ascites,hydrothorax,esophageal gastricfundus variceal bleeding(EGVB)],cumulative rates of survival,and distributary channel restenosis. The characteristics of the patients surviving ≥ 5 and < 5 years were also analyzed.RESULTS: The portosystemic pressure was decreased from 29.0 ± 4.1 mm Hg before TIPS to 18.1 ± 2.9 mm Hg after TIPS(t = 69.32,P < 0.05). Portosystemic pressure was decreased and portal hypertension symptoms were ameliorated. During the 5 year followup,the total recurrence rate of resistant ascites or hydrothorax was 7.2%(15/209); 36.8%(77/209) for EGVB; and 39.2%(82/209) for hepatic encephalopathy. The cumulative rates of distributary channel restenosis at 1,2,3,4,and 5 years were 17.2%(36/209),29.7%(62/209),36.8%(77/209),45.5%(95/209) and 58.4%(122/209),respectively. No procedure-related deaths and serious complications(e.g.,abdominal bleeding,hepatic failure,and distant metastasis) occurred. Moreover,Child-Pugh score,portal vein tumor thrombosis,lesion diameter,hepatic arterio-portal fistulas,HCC diagnosed before or after TIPS,stent type,hepatic encephalopathy,and type of other interventional treatments were related to 5 year survival after comparing patient characteristics.CONCLUSION: TIPS combined with other interventional treatments seems to be safe and efficacious in patients with HCC and portal hypertension. | Bin Qiu Meng-Fei Zhao Zhen-Dong Yue Hong-Wei Zhao Lei Wang Zhen-Hua Fan Fu-Liang He Shan Dai Jian-Nan Yao Fu-Quan Liu | 2015 | World Journal of Gastroenterology2015，21，43： | 16 |
| 2 | Deletion of an Endoplasmic Reticulum Stress Response Element in a ZmPP2C-A Gene Facilitates Drought Tolerance of Maize Seedlings显示文摘 | Yanli Xiang Xiaopeng Sun Shan Gao Feng Qin Mingqiu Dai | 2017 | Molecular Plant2017，10，3： | 15 |
| 3 | Experimental measurement of the electrical conductivity of single crystal olivine at high temperature and high pressure under different oxygen fugacities显示文摘At 1.0-4.0 GPa and 1123-1473 K and under oxygen fugacity-controlled conditions (Ni + NiO, Fe + Fe3O4, Fe + FeO and Mo+ M0O2 buffers), a YJ-3000t Model six-anvil solid high-pressure apparatus and a Sarltron-1260 Impedance/Gain-Phase analyzer were employed to conduct an in situ measurement of the electrical conductivity of single crystal olivine. Experimental results showed that: (1) within the range of experimentally selected frequencies (103-106 Hz), the electrical conductivity of the sample is of great dependence on the frequency; (2) with the rise of temperature ( T), the electrical conductivity (σ) will increase, and the Arrenhius linear relationship is established between lgσ and 1/T; (3) under the control of oxygen buffer Fe+ Fe3O4, with the rise of pressure, the electrical conductivity tends to decrease whereas the activation enthalpy and independent-of-temperature preexponential factor tend to increase, with the activation energy and activation volume of the sample estimated at (1. 25 ± 0.08) eV and (0.105 ±0.025) cm3/mol, respectively; (4) under given pressure and temperature conditions, the electrical conductivity tends to increase whereas the activation energy tends to decrease with increasing oxygen fugacity; and ( 5) the mechanism of electrical conduction of small polarons can provide insight into the behavior of electrical conduction of olivine under high pressure and high temperature. | DAI Lidong LI Heping LIU Congqiang CUI Tongdi SHAN Shuangming YANG Changjun LIU Qingyou DENG Heming | 2006 | Progress in Natural Science:Materials International2006，16，4： | 9 |
| 4 | The Leu477 and Leu613 of ORF2-Encoded Protein Are Critical in Forming Neutralization Antigenic Epitope of Hepatitis E Virus Genotype 4显示文摘Hepatitis E virus (HEV) genotype 4 was originally identified in China. Its neutralization antigenic epitopes have not been characterized. Recently, we identified a neutralizing monoclonal antibody (mAb) 1G10, which was generated following immunization of mice with p166Chn, a recombinant protein comprising 464-629 amino acids (aa) of the HEV genotype 4 capsid protein. In this study, a panel of 22 N- and/or C-terminal truncated and 6 site-directed mutated p166Chn proteins were prepared. Only those N- or C-terminal truncated proteins containing the region 477-613 aa could react with the mAb 1G10, suggesting the neutralization epitope of HEV genotype 4 is located between aa477 and aa613. However, a both N- and C-terminal truncated protein, pN477-C613, neither reacted to 1G10 nor elicited neutralizing antibodies in mice, while another both terminal truncated protein, pN472-C617, did, suggesting the flanking regions of the pN477-C613 could help to stabilize and allow presentation of the neutralization epitope to the immune system. Substituting Leu477 and/or Leu613 with the polar, uncharged threonine (Thr) caused ≥ 50% reduction of the mutants' immunoreactivity to 1G10, whereas replacement by hydrophobic phenylalanine (Phe) made little impact on the immunoreactivity, revealing functional associations between hydrophobicity of aa at positions 477 and 613 and the antigenicity of p166Chn. These data suggested Leu477 and Leu613 are critical in forming the neutralization epitope of HEV genotype 4. | Hongmei Zhang Xing Dai Xiangnian Shan Jsihong Meng | 2008 | Cellular & Molecular Immunology2008，5，6： | 9 |
| 5 | A new paleoenvironmental index for anoxic events—Mo isotopes in black shales from Upper Yangtze marine sediments显示文摘This paper investigates the high-solution of Mo isotopes and uses trace-element analyses for fresh and representative black shales and siliceous shales collected from the transition between the Late Ordovician and the Early Silurian at the Wangjiawan section in Yichang and the Late Permian Dalong Formation in the Shangsi Section of Sichuan. The applicability of different geochemical parameters used as paleo-oxygenation indices are also compared. The preliminary results show that V/(V+Ni), U auth (auth U), V/Cr, Ce anom and U/Th have a scattered variation range, but most samples plot within the suboxic-anoxic fields. The suboxic-anoxic environment was dominant during the deposition and formation of the two anoxic facies. These redox indicators show little correspondence to the δ 98 Mo values. The U/Mo ratio can be used as a potential proxy for the paleo-redox conditions due to the possibility that Mo is enriched relative to U at different redox gradients during early diagenesis. This evidence is more significant for the euxinicity condition and corresponds to positive δ 98 Mo (>1.5‰) values with low U/Mo ratios. This evidence is likely related to the depositional conditions near the boundary between anoxic and euxinic environments, which are characterised by low bioturbation or water circulation. Other samples reveal a wide scatter of U/Mo ratios and δ 98 Mo <1.5‰. These results are likely due to punctuated improvements in oxygenation with intense bioturbation or water circulation, which led to the redistribution of trace element. | ZHOU Lian SU Jie HUANG JunHua YAN JiaXing XIE XiNong GAO Shan DAI MengNing Tonger | 2011 | Science China Earth Sciences2011，54，7： | 9 |
| 6 | Trends of Overweight and Obesity in Yi People between 1996 and 2007:An Yi Migrant Study显示文摘Objective To evaluate trends of overweight and obesity prevalence between 1996 and 2007 in Yi farmers and Yi migrants.Methods An Yi migrant study was conducted in Liangshan Yi Autonomous Prefecture,Sichuan Province,China from 1996 to 2007.Data were collected with identical methods,including standardized questionnaire and body measurements.Results Age‐ and sex‐specific body mass index (BMI) significantly increased from 20.02 in 1996 to 22.36 in 2007,among Yi farmers,which was significantly different from those among Yi migrants (23.67 in 2007 and 20.90 in 1996) (P<0.05).Prevalence of obesity rose from 1.21 % in 1996 to 4.55 % in 2007 (OR=1.15,P<0.001) in Yi migrants,while that in Yi farmers from none in 1996 to 0.12 % in 2007 (P>0.05).Prevalence of overweight rose significantly to 26.24 %in 2007 from 17.24 % in 1996 (OR=1.06,P<0.001) in Yi migrants,while that in Yi farmers from 1.29 % in 1996 to 4.45 % in 2007 (OR=1.14,P<0.001).Yi migrants appeared to have a 5.52‐fold higher risk ondeveloping overweight and obesity than Yi farmers have.Conclusion The Yi migrants had a steeper increase of overweight with year and consequently caused more obesity.Change in lifestyle may contribute most likely to higher prevalence of overweight and obesity in Yi migrants. | SHAN GuangLiang WEI DaYing WANG ChunXiu ZHANG JianHua Wang Bin MA MingJu PAN Li YU Tao XUE Fang WU ZhengLai | 2011 | Biomedical and Environmental Sciences2011，24，5： | 9 |
| 7 | Transjugular intrahepatic portosystemic shunt for severe jaundice in patients with acute Budd-Chiari syndrome显示文摘AIM:To evaluate the feasibility of transjugular intrahepatic portosystemic shunt(TIPS)for severe jaundice secondary to acute Budd-Chiari syndrome(BCS).METHODS:From February 2009 to March 2013,37patients with severe jaundice secondary to acute BCS were treated.Sixteen patients without hepatic venule,hepatic veins(HV)obstruction underwent percutaneous angioplasty of the inferior vena cava(IVC)and/or HVs.Twenty-one patients with HV occlusion underwent TIPS.Serum bilirubin,liver function,demographic data and operative data of the two groups of patients were analyzed.RESULTS:Twenty-one patients underwent TIPS and the technical success rate was 100%,with no technical complications.Sixteen patients underwent recanalization of the IVC and/or HVs and the technical success rate was 100%.The mean procedure time for TIPS was 84.0±12.11 min and angioplasty was44.11±5.12 min(P<0.01).The mean portosystemic pressure in the TIPS group decreased significantly from 40.50±4.32 to 16.05±3.50 mm Hg(P<0.01).The mean portosystemic pressure gradient decreased significantly from 33.60±2.62 to 7.30±2.21 mm Hg(P<0.01).At 8 wk after the procedures,in the TIPS group,total bilirubin(TBIL)decreased significantly from 266.24±122.03 before surgery to 40.11±3.52μmol/L(P<0.01)and direct bilirubin(DBIL)decreased significantly from 194.22±69.82μmol/L to 29.82±3.10μmol/L(P<0.01).In the angioplasty group,bilirubin returned to the normal range,with TBIL decreased significantly from 258.22±72.71μmol/L to 13.33±3.54μmol/L(P<0.01)and DBIL from175.08±39.27 to 4.03±1.74μmol/L(P<0.01).Liver function improved faster than TBIL.After 2 wk,in the TIPS group,alanine aminotransferase(ALT)decreased significantly from 50.33±40.61 U/L to 28.67±7.02U/L(P<0.01)and aspartate aminotransferase(AST)from 49.46±34.33 U/L to 26.89±8.68 U/L(P<0.01).In the angioplasty group,ALT decreased significantly from 51.56±27.90 to 14.22±2.59μmol/L(P<0.01)and AST from 60.66±39.89μmol/L to 8.18±1.89μmol/L(P<0.01).After mean follow-up of 12.6 mo,there was no recurrence of jaundice in either group.CONCLUSION:Severe jaundice is not a contraindication for TIPS in patients with acute BCS and TIPS is appropriate for severe jaundice due to BCS. | Fu-Liang He Lei Wang Hong-Wei Zhao Zhen-Hua Fan Meng-Fei Zhao Shan Dai Zhen-Dong Yue Fu-Quan Liu | 2015 | World Journal of Gastroenterology2015，21，8： | 8 |
| 8 | Genome-wide association study dissects the genetic bases of salt tolerance in maize seedlings显示文摘Excess salinity is a natural stress that causes crop yield losses worldwide. The genetic bases of maize salt tolerance remain largely unknown. Here we investigated the survival rates of 445 maize natural accessions after salt treatments. A skewed distribution of the salttolerant phenotypes was observed in this population.Genome-wide association studies(GWAS) revealed 57 loci significantly associated with salt tolerance. Forty-nine candidate genes were detected from these loci. About10% of these genes were co-localized with loci from QTL mapping. Forty four percent of the candidate genes were involved in stress responses, ABA signaling,stomata division, DNA binding/transcription regulation and auxin signaling, suggesting that they are key genetic mechanisms of maize salt tolerance. Transgenic studies showed that two genes, the salt-tolerance-associatedgene 4(SAG4, GRMZM2 G077295) and SAG6(GRMZM2 G106056), which encode a protein transport protein and the double-strand break repair protein MRE11,respectively, had positive roles in plant salt tolerance,and their salt-tolerant haplotypes were revealed. The genes we identified in this study provide a list of candidate targets for further study of maize salt tolerance, and of genetic markers and materials that may be used for breeding salt-tolerance in maize. | Xi Luo Bingcai Wang Shan Gao Fei Zhang William Terzaghi Mingqiu Dai | 2019 | Journal of Integrative Plant Biology2019，61，6： | 8 |
| 9 | Whole-genome sequencing provides insights into the genetic diversity and domestication of bitter gourd(Momordica spp.)显示文摘Bitter gourd(Momordica charantia)is a popular cultivated vegetable in Asian and African countries.To reveal the characteristics of the genomic structure,evolutionary trajectory,and genetic basis underlying the domestication of bitter gourd,we performed whole-genome sequencing of the cultivar Dali-11 and the wild small-fruited line TR and resequencing of 187 bitter gourd germplasms from 16 countries.The major gene clusters(Bi clusters)for the biosynthesis of cucurbitane triterpenoids,which confer a bitter taste,are highly conserved in cucumber,melon,and watermelon.Comparative analysis among cucurbit genomes revealed that the Bi cluster involved in cucurbitane triterpenoid biosynthesis is absent in bitter gourd.Phylogenetic analysis revealed that the TR group,including 21 bitter gourd germplasms,may belong to a new species or subspecies independent from M.charantia.Furthermore,we found that the remaining 166 M.charantia germplasms are geographically differentiated,and we identified 710,412,and 290 candidate domestication genes in the South Asia,Southeast Asia,and China populations,respectively.This study provides new insights into bitter gourd genetic diversity and domestication and will facilitate the future genomics-enabled improvement of bitter gourd. | Junjie Cui Yan Yang Shaobo Luo Le Wang Rukui Huang Qingfang Wen Xiaoxia Han Nansheng Miao Jiaowen Cheng Ziji Liu Changyuan Zhang Chengcheng Feng Haisheng Zhu Jianwen Su Xinjian Wan Fang Hu Yu Niu Xiaoming Zheng Yulan Yang Dai Shan Zhensheng Dong Weiming He Narinder P.S.Dhillon Kailin Hu | 2020 | Horticulture Research2020，7，1： | 7 |
| 10 | A comparative study of spatial interpolation methods fordetermining fishery resources density in the Yellow Sea显示文摘Spatial interpolation is a common tool used in the study of fishery ecology, especially for the construction of ecosystem models. To develop an appropriate interpolation method of determining fishery resources density in the Yellow Sea, we tested four frequently used methods, including inverse distance weighted interpolation(IDW), global polynomial interpolation(GPI), local polynomial interpolation(LPI) and ordinary kriging(OK).A cross-validation diagnostic was used to analyze the efficacy of interpolation, and a visual examination was conducted to evaluate the spatial performance of the different methods. The results showed that the original data were not normally distributed. A log transformation was then used to make the data fit a normal distribution. During four survey periods, an exponential model was shown to be the best semivariogram model in August and October 2014, while data from January and May 2015 exhibited the pure nugget effect.Using a paired-samples t test, no significant differences(P>0.05) between predicted and observed data were found in all four of the interpolation methods during the four survey periods. Results of the cross-validation diagnostic demonstrated that OK performed the best in August 2014, while IDW performed better during the other three survey periods. The GPI and LPI methods had relatively poor interpolation results compared to IDW and OK. With respect to the spatial distribution, OK was balanced and was not as disconnected as IDW nor as overly smooth as GPI and LPI, although OK still produced a few 'bull's-eye' patterns in some areas.However, the degree of autocorrelation sometimes limits the application of OK. Thus, OK is highly recommended if data are spatially autocorrelated. With respect to feasibility and accuracy, we recommend IDW to be used as a routine interpolation method. IDW is more accurate than GPI and LPI and has a combination of desirable properties, such as easy accessibility and rapid processing. | CHEN Yunlong SHAN Xiujuan JIN Xianshi YANG Tao DAI Fangqun YANG Dingtian | 2016 | Acta Oceanologica Sinica2016，35，12： | 7 |
| 11 | Hepatic blood inflow occlusion without hemihepatic artery control in treatment of hepatocellular carcinoma显示文摘AIM:To investigate the clinical significance of hepatic blood inflow occlusion without hemihepatic artery control (BIOwHAC) in the treatment of hepatocellular carcinoma (HCC).METHODS:Fifty-nine patients with HCC were divided into 3 groups based on the technique used for achieving hepatic vascular occlusion:group 1,vascular occlusion was achieved by the Pringle maneuver (n=20);group 2,by hemihepatic vascular occlusion (HVO) (n=20);and group 3,by BIOwHAC (n=19).We compared the procedures among the three groups in term of operation time,intraoperative bleeding,postoperative liver function,postoperative complications,and length of hospital stay.RESULTS:There were no statistically significant differences (P > 0.05) in age,sex,pathological diagnosis,preoperative Child's disease grade,hepatic function,and tumor size among the three groups.No intraoperative complications or deaths occurrred,and there were no significant intergroup differences (P > 0.05) in intraoperative bleeding,hepatic function change 3 and 7 d after operation,the incidence of complications,and length of hospital stay.BIOwHAC and Pringle maneuver required a significantly shorter operation time than HVO;the difference in the serum alanine aminotransferase or aspartate aminotransferase levels before and 1 d after operation was more significant in the BIOwHAC and HVO groups than in the Pringle maneuver group (P < 0.05).CONCLUSION:BIOwHAC is convenient and safe;this technique causes slight hepatic ischemia-reperfusion injury similar to HVO. | Shan Jin,Department of General Surgery,Affiliated Hospital of Inner Mongolia Medical College,Hohhot 010050,Inner Mongolia Autonomous Region,China Chao-Liu Dai,Department of Hepatobiliary Surgery,Shengjing Hospital,China Medical University,Shenyang,Liaoning Province,China | 2010 | World Journal of Gastroenterology2010，16，46： | 6 |
| 12 | Anp32e, a higher eukaryotic histone chaperone directs preferential recognition for H2A,Z显示文摘H2A.Z 是在所有种类的高度保存的 histone 变体。H2A.Z 的染色质免职被改变复杂 SWR1 和它的哺乳动物的对应物 SRCAP 的酵母染色质明确地催化。然而, H2A.Z 被 non-histone 蛋白质优先地被认出的机制留下逃犯。这里,我们识别了 Anp32e,为 H2A.Z Anp32e 的新奇更高优核质特定的 histone 女伴优先地在 vitro 并且在 vivo 把 dimers 而非 H2A-H2B dimers 与 H2A.Z-H2B 联系并且分裂 non-nucleosomal 总数由 DNA 和 H2A-H2B 形成了。我们与 H2A.Z-H2B 在建筑群决定了 Anp32e 女伴领域(186-232 ) 的水晶结构更暗淡。在这结构,包含 Anp32e 残余 214-224 的区域,在另外的 Anp32 家庭蛋白质不在,明确地与扩大 H2A.Z α 交往; C 螺旋,哪个展览一个意外 conformational 变化。Anp32e 的染色体宽的介绍表明在 Anp32e 和 H2A.Z 房间 overexpressing Anp32e 之间的显著合作占有在 +1 nucleosomes 显示了强壮的全球 H2A.Z 损失,而房间显示的 Anp32e 弄空在 +1 nucleosomes 的中等全球 H2A.Z 增加。这建议 Anp32e 可以帮助解决 non-nucleosomal H2A.Z 总数并且也在 +1 nucleosomes,和后者便于 H2A.Z 的移动可以帮助 RNA 聚合酶 II 通过第一个 nucleosomal 障碍。 | Zhuo Mao Lu Pan Weixiang Wang Jian Sun Shah Shan Qiang Dong Xiaoping Liang Linchang Dai Xiaojun Ding She Chen Zhuqiang Zhang Bing Zhu Zheng Zhou | 2014 | Cell Research2014，24，4： | 6 |
| 13 | Improved quantum bacterial foraging algorithm for tuning parameters of fractional-order PID controller显示文摘The quantum bacterial foraging optimization(QBFO)algorithm has the characteristics of strong robustness and global searching ability. In the classical QBFO algorithm, the rotation angle updated by the rotation gate is discrete and constant,which cannot affect the situation of the solution space and limit the diversity of bacterial population. In this paper, an improved QBFO(IQBFO) algorithm is proposed, which can adaptively make the quantum rotation angle continuously updated and enhance the global search ability. In the initialization process, the modified probability of the optimal rotation angle is introduced to avoid the existence of invariant solutions. The modified operator of probability amplitude is adopted to further increase the population diversity.The tests based on benchmark functions verify the effectiveness of the proposed algorithm. Moreover, compared with the integerorder PID controller, the fractional-order proportion integration differentiation(PID) controller increases the complexity of the system with better flexibility and robustness. Thus the fractional-order PID controller is applied to the servo system. The tuning results of PID parameters of the fractional-order servo system show that the proposed algorithm has a good performance in tuning the PID parameters of the fractional-order servo system. | LIU Lu SHAN Liang DAI Yuewei LIU Chenglin QI Zhidong | 2018 | Journal of Systems Engineering and Electronics2018，29，1： | 6 |
| 14 | Managing esophageal fistulae by endoscopic transluminal drainage in esophageal cancer patients with superior mediastinal sepsis after esophagectomy显示文摘The management of postoperative leaks into the mediastinum after esophagectomy remains a challenge. We describe our clinical management of this complication through endoscopic transluminal drainage. Between 2008 and 2011, 4 patients with esophageal squamous cell carcinoma (ESCC) who underwent McKeown-type esophagectomy with two-field lymphadenectomy experienced complicated anastomotic fistulae in the presence of superior mediastinal sepsis. All 4 patients underwent endoscopic transluminal drainage, and all survived. The mean healing period was 50 days (range, 31 to 58 days), the mean stay in the intensive care unit was 7.3 days (range, 1 to 18 days), and the mean hospital stay was 64.5 days (range, 49 to 70 days). Endoscopically guided transluminal drainage should be considered for ESCC patients with superior mediastinal fistulae after esophagectomy. | Yu-Zhen Zheng Shu-Qin Dai Hong-Bo Shan Xiao-Yan Gao Lan-Jun Zhang Xun Cao Jian-Fei Zhu Jun-Ye Wang | 2013 | Chinese Journal of Cancer2013，32，8： | 6 |
| 15 | Biological responses of small yellow croaker(Larimichthys polyactis) to multiple stressors: a case study in the Yellow Sea, China显示文摘Temporal changes in biological characteristics of small yellow croaker Larimichthys polyactis in the Yellow Sea were examined for the period of 1960–2008. The body size and age of small yellow croaker decreased substantially, in particular, average length of fish in 2008 was reduced by ~85% than those occurring in 1985, and at that time ~93% of the total catch was dominated by one-year-old individuals. Correspondingly, growth parameters also varied significantly over the years, i.e., k(growth coefficient) and t_0(zero-length age) gradually increased from 0.26 and –0.58 year in 1960 to 0.56 and –0.25 year in 2008, respectively. Although, L∞(body length)sharply decreased from 34.21 cm in 1960 to 24.06 cm in 2008, and t_r(inflexion age) decreased from 3.78 year in1960 to 1.61 year in 2008. There was a great increase both in natural mortality coefficient and fishing mortality coefficient. However, according to the gray correlation analysis, changes in the biological characteristics of small yellow croaker were induced by different stressors ranked as: fishing vessel power>feeding grade>sea surface temperature. This study suggests that the active fishery management measures for biological characters of fish populations should be considered. | SHAN Xiujuan LI Xiansen YANG Tao SHARIFUZZAMAN S M ZHANG Guozheng JIN Xianshi DAI Fangqun | 2017 | Acta Oceanologica Sinica2017，36，10： | 5 |
| 16 | Change patterns of oncomelanid snail burden in areas within the Yangtze River drainage after the three gorges dam operated显示文摘Background:An'integrated control'strategy has been implemented within seven provinces at highest risk for schistosomiasis along Yangtze River in Peoples'Republic of China(P.R.China)since 2004.Since O ncom elania hupensis is the only intermediate host of the blood fluke(Schistosom a japonicum),controlling the distribution of snails is considered an essential and effeaive way to reduce the risk of schistosomiasis infection.The study aimed to determine the snail area burden and annual trend among provinces with potential risk for schistosomiasis along the Yangtze River,above and below the Three Gorges Dam(TGD).Methods:This retrospective study utilized data previously collected from the National Parasitic Diseases Control Information Management System(NPDCIMS)on annual snail surveys from 2009 to 2017.Descriptive statistics were performed for analyzing the snail burden by provinces,counties,type of environmental location and year,and mapping was conducted to present the snails distribution.Results:From 2009 to 2017,the total snail infested area decreased by 4.22%,from 372253 hm^2 to 356553 hm^2 within the seven high risk provinces.The majority of snails were found in the marshland and lake regions,outside of control embankments.The total snail burden trend remained relatively stable in upstream regions above the TGD from 2010 to 2015,while the trend decreased within downstream regions during this period.In 2016 and 2017,the total snail burden trend increased in both upstream and downstream provinces,however,upstream saw a larger increase.From 2009 to 2017,there were a total of 5990 hm^2 of newly developed snail areas in the seven study provinces and the majority were concentrated in regions below the TGD,accounting for 5610 hm^2(93.70%).Conclusions:There has been a decline in total snail counts from 2009 to 2017.Meanwhile,new snail breeding areas were formed mainly within provinces downstream the TGD due to spread of snails,indicated that the oncomelanid snail would be difficult to completely eliminate.We suggest that the national schistosomiasis integrated control strategy,including mollusciding and environmental modification,will need to be enhanced significantly going forward to achieve a greater reduaion in snail burden and ultimately to achieve elimination. | Si-Min Dai Jeffrey Edwards Zhou Guan Shan Lv Shi-Zhu Li Li-Juan Zhang Jun Feng Ning Feng Xiao-Nong Zhou Jing Xu | 2019 | Infectious Diseases of Poverty2019，8，3： | 4 |
| 17 | Experimental Study on the Electrical Conductivity of Orthopyroxene at High Temperature and High Pressure under Different Oxygen Fugacities显示文摘At presure 1.0–4.0 GPa and temperature 1073–1423 K and under oxygen partial pressure conditions, a YJ-3000t multi-anvil solid high-pressure apparatus and Sarltron-1260 Impedance/Gain-Phase analyzer were employed toconduct an in-situ measurement of the electrical conductivity of orthopyroxene. The buffering reagents consist of Ni+NiO,Fe+Fe3O4, Fe+FeO and Mo+MoO2 in order to control the environmental oxygen fugacity. Experimental results made clearthat: (1) within the measuring frequency range from 10? to 106 Hz, the complex impedance (R) is of intensive dependence 1on the frequency; (2) The electrical conductivity (σ) tends to increase along to the rise of temperature (T), and Log σ vs. 1/T fit the Arrenhius linear relations; (3) Under the control of oxygen buffer Fe+Fe3O4, with the rise of pressure, theactivation enthalpy tends to increase whereas the electrical conductivity tends to decrease. The activation energy andactivation volume of the main current carriers of orthopyroxene have been obtained, which are (1.715±0.035) eV and (0.03±0.01) cm3/mol, respectively; (4) Under given pressure and temperature, the electrical conductivity tends to increase withincreasing oxygen fugacity, while under given pressure the activation enthalpy tends to decrease with increasing oxygenfugacity; and (5) The sample’s small polarons mechanism has provided a reasonable explanations to the conductionbehavior at high temperature and high pressure. | DAI Lidong LI Heping LIU Congqiang SHAN Shuangming CUI Tongdi SU Genli | 2005 | Acta Geologica Sinica(English Edition)2005，79，6： | 4 |
| 18 | Frequency-modulated continuous waves controlled by space-time-coding metasurface with nonlinearly periodic phases显示文摘The rapid development of space-time-coding metasurfaces(STCMs)offers a new avenue to manipulate spatial electromagnetic beams,waveforms,and frequency spectra simultaneously with high efficiency.To date,most studies are primarily focused on harmonic generations and independent controls of finite-order harmonics and their spatial waves,but the manipulations of continuously temporal waveforms that include much rich frequency spectral components are still limited in both theory and experiment based on STCM.Here,we propose a theoretical framework and method to generate frequency-modulated continuous waves(FMCWs)and control their spatial propagation behaviors simultaneously via a novel STCM with nonlinearly periodic phases.Since the carrier frequency of FMCW changes with time rapidly,we can produce customized time-varying reflection phases at will by the required FMCW under the illumination of a monochromatic wave.More importantly,the propagation directions of the time-varying beams can be controlled by encoding the metasurface with different initial phase gradients.A programmable STCM prototype with a full-phase range is designed and fabricated to realize reprogrammable FMCW functions,and experimental results show good agreement with the theoretical analyses. | Jun Chen Ke Jun Yan Dai Jun Wei Zhang Zhanye Chen Ming Zheng Chen Yunfeng Lu Lei Zhang Li Wang Qun Yan Zhou Long Li Jin Shan Ding Qiang Cheng Tie Jun Cui | 2022 | Light(Science & Applications)2022，11，10： | 4 |
| 19 | Low-temperature activation of methane over rare earth metals promoted Zn/HZSM-5 zeolite catalysts in the presence of ethylene显示文摘At low temperature of 723 K, methane can be easily activated in the presence of ethylene in the feed, and converted to higher hydrocarbons (C2–C4) and aromatics (C6–C10), through its reaction over rare metals modified Zn/HZSM-5 zeolite catalysts without undesirable carbon oxides formation. Methane can get 37.3% conversion over the above catalysts under low temperature, and the catalysts show a longer lifetime than usual metal supported HZSM-5 zeolite catalysts without adding any rare earth metals. The effects of methane activation over various rare earth metal promoted Zn/HZSM-5 catalysts on the products and influences of several reaction conditions such as temperature, catalyst lifetime and molar ratio of CH4/C2H4 have been discussed. | Hengqiang Zhang Aiguo Kong Yongjie Ding Chengyong Dai Yongkui Shan | 2011 | Journal of Natural Gas Chemistry2011，20，3： | 4 |
| 20 | Expressions of Nucleoside Diphosphate Kinase (nm23) in Tumor Tissues are Related with Metastasis and Length of Survival of Patients with Hepatocellular Carcinoma显示文摘Objective To evaluate the relationship of expressions of nucleoside diphosphate kinase (nm23) and proliferating cell nuclear antigen (PCNA), as well as apoptosis, with the prognosis of HCC patients by analyzing their pathological and clinical data. Methods The expressions of nm23 and PCNA were analyzed by immunohistochemistry and the apoptotic phenomena were detected by TUNEL technique in the liver samples from 43 HCC tissues, 39 para-neoplastic tissues, and 10 normal tissues. The mean apoptosis index (AI) and proliferative index (PI) in individual sample were calculated. Results As shown by the detection, 32.6% of carcinomas had negative nm23 signal in tumor tissues, whereas all para-neoplastic and normal tissues had positive nm23. The AI in nm23 positive HCC was significantly higher than that in nm23 negative one, with statistical difference (P<0.05). Furthermore, the expressions of nm23, and the values of AI and PI were contrastively analyzed with some main pathological and clinical data of HCC. It revealed that HCC with extrahepatic metastasis showed remarkable correlation with the negative nm23 (P=0.013) and higher PI values of HCC (P=0.015). The disease-free survival in HCC patients with negative nm23 expression was significantly poorer than that in patients with positive nm23 expression. Conclusion These data suggest that expressions of nm23 protein in tumor tissues are correlated with occurrences of metastasis and length of survival of the HCC patients, which may be an indicator for their prognosis. | RUN AN JIE MENG QI SHI XIAO-XIA DAI JING-HONG CHEN YAN-JUN LEI BING SHAN CHEN GAO YONG-LIE CHU XIAO-PING DONG | 2010 | Biomedical and Environmental Sciences2010，23，4： | 4 |
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