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| 1 | Aqueous extracts of microalgae exhibit antioxidant and anticancer activities显示文摘Objective:To investigate the antioxidant and anticancer activities of aqueous extracts of nine microalgal species.Methods:Variable percentages of major secondary metabolites(total phenolic content,terpenoids and alkaloids) as well as phycobiliprotein pigments(phycocyanin, allophycocyanin and phycoerythrin) in the aqueous algal extracts were recorded.Antioxidant activity of the algal extracts was performed using 2,2 diphenyl-1-picrylhydrazyl(DPPH) test and 2,2'azino-bis(ethylbenzthiazoline-6-sulfonic acid(ABTS.) radical cation assay.Anticancer efficiency of the algal water extracts was investigated against Ehrlich Ascites Carcinoma cell(EACC) and Human hepatocellular cancer cell line(HepG2).Results:Antioxidant activity of the algal extracts was performed using DPPH test and ABTS.^+ radical cation assays which revealed 30.1-72.4%and 32.0-75.9%respectively.Anticancer efficiency of the algal water extracts was investigated against Ehdich Ascites Carcinoma Cell(EACC) and Human Hepatocellular cancer cell line(HepG2) with an activity ranged 87.25%and 89.4%respectively.Culturing the promising cyanobacteria species;Nostoc muscorum and Oscillatoria sp.under nitrogen stress conditions(increasing and decreasing nitrate content of the normal BG11 medium,1.5 g/L),increased nitrate concentration(3,6 and 9 g/L) led to a remarkable increase in phycobilin pigments followed by an increase in both antioxidant and anticancer activities in both cyanobacterial species.While the decreased nitrate concentration(0.75,0.37 and 0.0 g/L) induced an obvious decrease in phycobilin pigments with complete absence of allophycocyanin in case of Oscillatoria sp.Conclusions:Nitrogen starvation(0.00 g/L nitrate) induced an increase and comparable antioxidant and anticancer activities to those cultured in the highest nitrate content. | Sanaa MM Shanab Soha SM Mostafa Emad A Shalaby Ghada I Mahmoud | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，8： | 6 |
| 2 | Acaricidal activity of different extracts from Syzygium cumini L.Skeels(Pomposia) against Tetranychus urticae Koch显示文摘Objective:To investigate the acaricidal activity of different extracts from Syzygium cumini(S.cumini)(Pomposia)againsst Tetranyckus urticae Koch(71 urticae)and the biochemical changes in antioxidants enzymes.Methods:Six extracts of S.cumini(Pomposia)at concentrations of 75,150 and 300μg/mL were used to control T.urticae(Koch).Results:The ethanol extract showed the most efficient acaricidal activity agent against T.urticae(98.5%)followed by hexane extract(94.0%),ether and ethyl acetate extract(90.0%).The LC_(50)values of the promising extract-were 85.0,101.0,102.0 and 98.0μ/mL,respectively.The activities of enzymes including ascorbate peroxidase(APX),peroxidase(POD),superoxide dismutase(SOD)and catalase(CAT)in susceptible mites were increased.The activities of all antioxidant enzymes reach the maximum value in mites at LC_(50)with ethanol and ethyl acetate extracts,respectively.Conclusions:The extract of S.cumini has acaricidal acivity against T.urticae,and the ethanol extract is the most efficient. | Abd El-Moneim MR Afify Hossam S El-Beltagi Sayed A Fayed Emad A Shalaby | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，5： | 5 |
| 3 | Interaction of insulin with prokinetic drugs in STZ-induced diabetic mice显示文摘AIM:To study the possible interactions of metoclopramide,domperidone and erythromycin in streptozotocin-induced diabetic mice treated with insulin by various parameters.METHODS:Effects of the individual as well as combined drugs were studied in diabetic mice via estimation of the blood glucose and serum insulin levels,small intestinal transit(SIT),gastric emptying(GE),xylose absorption and glucose tolerance tests.Groups were given insulin 2 IU/kg s.c.,metoclopramide 20 mg/kg p.o.,domperidone 20 mg/kg p.o.and erythromycin 6 mg/kg p.o.individually and in combination.There were also normal and diabetic control groups.The first set of experiments was carried out to investigate the subchronic effect on blood glucose and serum insulin levels in diabetic mice of one week of daily dose administration of the tested drugs individually as well as the combination of insulin with each prokinetic drug.The other five sets of experiments were carried out to investigate the acute effect of a single dose of each drug individually and in combination on blood glucose and serum insulin levels,SIT,GE,oral xylose absorption and glucose tolerance tests.RESULTS:The study included the prokinetic drugs metoclopramide(20 mg/kg),domperidone(20 mg/kg) and erythromycin(6 mg/kg),as well as insulin(2 IU/kg),which was individually effective in decreasing SIT,enhancing GE and increasing xylose absorption significantly in diabetic mice.Erythromycin tended to decrease blood glucose level and increase serum insulin level after 1 wk of daily administration in diabetic mice.Erythromycin potentiated the effect of insulin on blood glucose level and serum insulin level whereas other prokinetic agents failed to do so after repeated dose administration in diabetic mice.Metoclopramide or erythromycin in combination with insulin significantly decreased SIT,in diabetic mice,to lower levels than with insulin alone.Administration of prokinetic drugs along with insulin antagonized the action of insulin on xylose absorption.These combinations also increased the rate of glucose absorption from the gut.CONCLUSION:The present study suggests that prokinetic drugs could potentially improve glycemic control in diabetic gastroparesis by allowing a more predictable absorption of nutrients,matched to the action of exogenous insulin.The use of prokinetics,such as erythromycin,may be interesting in the clinic in decreasing the need for insulin in diabetic patients.The dose of insulin may be safely decreased with erythromycin in chronic treatments. | Mohamed A Fouad Shalaby Hekma A Abd El Latif Mostafa E El Sayed | 2013 | World Journal of Gastrointestinal Pharmacology and Therapeutics2013，4，2： | 3 |
| 4 | Prospects of effective microorganisms technology in wastes treatment in Egypt显示文摘Sludge dewatering and treatment may cost as much as the wastewater treatment.Usually large proportion of the pollutants in wastewater is organic.They are attacked by saprophytic microorganisms,i.e.organisms that feed upon dead organic matter.Activity of organisms causes decomposition of organic matter and destroys them,where the bacteria convert the organic matter or other constituents in the wastewater to new cells,water,gases and other products.Demolition activities,including renovation/remodeling works and complete or selective removal/demolishing of existing structures either by man-made processes or by natural disasters,create an extensive amount of wastes.These demolition wastes are characterized as heterogeneous mixtures of building materials that are usually contaminated with chemicals and dirt.In developing countries, it is estimated that demolition wastes comprise 20%to 30%of the total annual solid wastes.In Egypt,the daily quantity of construction and demolition(C&D) waste has been estimated as 10 000 tones.That is equivalent to one third of the total daily municipal solid wastes generated per day in Egypt.The zabbaliin have since expanded their activities and now take the waste they collect back to their garbage villages where it is sorted into recyclable components:paper,plastics, rags,glass,metal and food.The food waste is fed to pigs and the other items are sold to recycling centers.This paper summarizes the wastewater and solid wastes management in Egypt now and future. | Emad A Shalaby | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，3： | 2 |
| 5 | Randomized clinical Trial of stapled versus Milligan-Morgan Haemorrhoidectomy 显示文摘 | Shalaby R Desoky A | 2001 | Br J Surg2001，88，： | 1 |
| 6 | Enhanced system for link and mode identification for personal travel surveys based on global positioning systems显示文摘 | Tsui S Y A Shalaby A S | 2006 | Transportation Research Record: Journal of the Transportation Research Board2006，1972，1： | 1 |
| 7 | Assessment of inorganic lead specie and total organo-alkyl lead in some Egyptian agricultural soils显示文摘 | ELSOKKARY H I AMER A M SHALABY E A | 1995 | Environmental Pollution1995，，87： | 1 |
| 8 | Mood Disorders and Outcome in Patients Receiving Cardiac Resynchronization Therapy 显示文摘 | Shalaby A Brumberg G EI--Saed A | 2012 | Pacing Clin Electrophysiol2012，35，3： | 1 |
| 9 | Epidemiological aspects ofmango malformation disease caused by Fusarium mangiferae andsource of infection in seedlings cultivated in orchards in Egypt显示文摘 | YOUSSEF S A MAYMONB M ZVEIBIL A GUETA D K SZTEJN-BERG A SHALABY A FREEMAN S | 2007 | Plant Pathology2007，56，： | 1 |
| 10 | Remote sensing and GIS for mapping and monitoring land cover and land-use changes in the Northwestern coastal zone of Egypt显示文摘 | Shalaby A Tateishi R | 2007 | Applied Geography2007，，27： | 1 |
| 11 | Significance of biogenic amines to food safety andhuman health显示文摘 | SHALABY A R | 1996 | Food Research International1996，29，7： | 1 |
| 12 | Rising rates of cardiac rhythm management device infections in the United States: 1996 through 2003显示文摘 | Voigt A Shalaby A Saba S | 2006 | J Am Coil Cardiol2006，48，3： | 1 |
| 13 | A multilevel structural technique for fingerprint representation and matching显示文摘 | Shalaby M A W Ahmad M O | 2013 | Signal Processing2013，93，1： | 1 |
| 14 | Feasibility of flex-route as a feedertransit service to rail stations in the suburbs : case study intoronto 显示文摘 | Alshalalfah B Shalaby A | 2011 | Journal of Urban Planning and Development2011，138，1： | 1 |
| 15 | Milligan-Morgan haemorrhoidectomy显示文摘 | Shalaby R Desoky A Randomized clinical trial of stapled versus | 2001 | Br J Surgy2001，88，8： | 1 |
| 16 | Significance of biogenic amines to food safety and human health显示文摘 | SHALABY A R | 1996 | Food Research International1996，29，7： | 1 |
| 17 | Effects ofphosphodiesterase - 5 inhibitor on ischemic kidney injury duringnephron sparing surgery : quantitative assessment by NGAL andKIM-1 显示文摘 | Lahoud Y Hussein 0 Shalabi A | 2015 | World J Urol2015，33，12： | 1 |
| 18 | Laparoscopic inguinal hernia repair; experience with 874 children显示文摘 | Shalaby R Ismail M Samaha A | 2014 | J Pediatr Surg2014，49，3： | 1 |
| 19 | Cavitation corrosion behaviour of cast nickel-aluminium bronze in seawater 显示文摘 | Al-Hashem A Caceres P G Raid W Shalaby H M | 1995 | Corrosion Science1995，51，5： | 1 |
| 20 | Failure of blood-island formation and vasculogenesis in Flk-1- deficient mice 显示文摘 | Shalaby F Rossant J Yamaguchi T P et a l | 1995 | Nature1995，376，6535： | 1 |
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