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| 1 | Predictive value of multi-detector computed tomography for accurate diagnosis of serous cystadenoma:Radiologic-pathologic correlation显示文摘AIM:To identify multi-detector computed tomography(MDCT) features most predictive of serous cystadenomas(SCAs),correlating with histopathology,and to study the impact of cyst size and MDCT technique on reader performance.METHODS:The MDCT scans of 164 patients with surgically verified pancreatic cystic lesions were reviewed by two readers to study the predictive value of various morphological features for establishing a diagnosis of SCAs.Accuracy in lesion characterization and reader conf idence were correlated with lesion size(≤3cm or≥3cm) and scanning protocols(dedicated vs routine).RESULTS:28/164 cysts(mean size,39 mm;range,8-92mm) were diagnosed as SCA on pathology.The MDCT features predictive of diagnosis of SCA were microcystic appearance(22/28,78.6%),surface lobulations(25/28,89.3%) and central scar(9/28,32.4%).Stepwise logistic regression analysis showed that only microcystic appearance was signifi cant for CT diagnosis of SCA(P=0.0001).The sensitivity,specificity and PPV of central scar and of combined microcystic appearance and lobulations were 32.4%/100%/100% and 68%/100%/100%,respectively.The reader confidence was higher for lesions>3cm(P=0.02) and for MDCT scans performed using thin collimation(1.25-2.5mm) compared to routine 5 mm collimation exams(P>0.05).CONCLUSION:Central scar on MDCT is diagnostic of SCA but is seen in only one third of SCAs.Microcystic morphology is the most significant CT feature in diagnosis of SCA.A combination of microcystic appearance and surface lobulations offers accuracy comparable to central scar with higher sensitivity. | Anjuli A Shah Nisha I Sainani Avinash Kambadakone Ramesh Zarine K Shah Vikram Deshpande Peter F Hahn Dushyant V Sahani | 2009 | World Journal of Gastroenterology2009，15，22： | 11 |
| 2 | Structural basis of anti-PD-L1 monoclonal antibody avelumab for tumor therapy显示文摘 | Kefang Liu ShuguangTan Yan Chai Danqing Chen Hao Song Catherine Wei-Hong Zhang yi Shi Jun Liu Wenjie Tan Jianxin Lyu Shah Gao Jinghua Yan Jianxun Qi George F Gao | 2017 | Cell Research2017，27，1： | 11 |
| 3 | Perspectives on the prevention and treatment of infection for orthopedic tissue engineering applications显示文摘The emergence of orthopedic tissue engineering devices as viable clinical solutions demands that the field address significant clinical complications associated with the implantation of foreign materials in the body,especially infection.While tissue engineering has focused on the development of methods to regenerate and repair,until recently there has been a relative dearth of literature regarding the intersection of tissue engineering and infection.In particular,local delivery of antimicrobials has long been of clinical interest,but only recently has that been translated into the realm of tissue engineering.In this perspective,we briefly review major modes of local delivery for infection prevention and treatment and discuss possible strategies for preventing implant-associated infections. | SHAH Sarita R KASPER F Kurtis MIKOS Antonios G | 2013 | Chinese Science Bulletin2013，58，35： | 4 |
| 4 | Laparoscopic vs open partial colectomy in elderly patients:Insights from the American College of Surgeons- National Surgical Quality Improvement Program database显示文摘AIM: To compare the outcomes between the laparoscopic and open approaches for partial colectomy in elderly patients aged 65 years and over using the American College of Surgeons- National Surgical Quality Improvement Program(ACS NSQIP) database. METHODS: The ACS NSQIP database for the years 2005-2011 was queried for all patients 65 years and above who underwent partial colectomy. 1:1 propensity score matching using the nearest- neighbor method was performed to ensure both groups had similar preoperative comorbidities. Outcomes including postoperative complications, length of stay and mortality were compared between the laparoscopic and open groups. χ2 and Fisher's exact test were used for discrete variables and Student's t-test for continuous variables. P < 0.05 was considered significant and odds ratios with 95%CI were reported when applicable. RESULTS: The total number of patients in the ACS NSQIP database of the years 2005-2011 was 1777035. We identified 27604 elderly patients who underwent partial colectomy with complete data sets. 12009(43%) of the cases were done laparoscopically and15595(57%) were done with open. After propensity score matching, there were 11008 patients each in the laparoscopic(LC) and open colectomy(OC) cohorts. The laparoscopic approach had lower post-operative complications(LC 15.2%, OC 23.8%, P < 0.001), shorter length of stay(LC 6.61 d, OC 9.62 d, P < 0.001) and lower mortality(LC 1.6%, OC 2.9%, P < 0.001). CONCLUSION: Even after propensity score matching, elderly patients in the ACS NSQIP database having a laparoscopic partial colectomy had better outcomes than those having open colectomies. In the absence of specific contraindications, elderly patients requiring a partial colectomy should be offered the laparoscopic approach. | Umashankkar Kannan Vemuru Sunil K Reddy Amar N Mukerji Vellore S Parithivel Ajay K Shah Brian F Gilchrist Daniel T Farkas | 2015 | World Journal of Gastroenterology2015，21，45： | 3 |
| 5 | Characteristics of Clostridium difficile infection in patients hospitalized with myelodysplastic syndrome or acute myelogenous leukemia显示文摘AIM To evaluate factors associated with Clostridium difficile infection (CDI) and outcomes of CDI in the myelodysplastic syndrome(MDS) and acute myeloid leukemia (AML) population.METHODS After IRB approval,all MDS/AML patients hospitalized at the University of Maryland Greenebaum Comprehensive Cancer Center between August 2011 and December 2013 were identified.Medical charts were reviewed for demographics,clinical information,development of CDI,complications of CDI,and mortality.Patients with CDI,defined as having a positive stool PCR done for clinical suspicion of CDI,were compared to those without CDI in order to identify predictors of disease.A t-test was used for comparison of continuous variables and chisquare or Fisher's exact tests were used for categorical variables,as appropriate.RESULTS Two hundred and twenty-three patients (60.1% male,mean age 61.3 years,13% MDS,87% AML) had 594 unique hospitalizations during the study period.Thirtyfour patients (15.2%) were diagnosed with CDI.Factors significantly associated with CDI included lower albumin at time of hospitalization (P < 0.0001),prior diagnosis of CDI (P < 0.0001),receipt of cytarabine-based chemotherapy (P = 0.015),total days of neutropenia (P = 0.014),and total days of hospitalization (P = 0.005).Gender (P = 0.10),age (P = 0.77),proton-pump inhibitor use (P = 0.73),receipt of antibiotics (P = 0.66),and receipt of DNA hypomethylating agent-based chemotherapy (P = 0.92) were not significantly associated with CDI.CONCLUSION CDI is common in the MDS/AML population.Factors significantly associated with CDI in this population include low albumin,prior CDI,use of cytarabine-based chemotherapy,and prolonged neutropenia.In this study,we have identified a subset of patients in which prophylaxis studies could be targeted. | Kamini Shah Bryan F Curtin Christopher Chu Daniel Hwang Mark H Flasar Erik von Rosenvinge | 2017 | World Journal of Clinical Oncology2017，8，5： | 3 |
| 6 | Improving the sensitivity of the Barthel Index for stroke rehabilitation显示文摘 | Shah S Vanclay F Cooper B | 1989 | Journal of Clinical Epidemiology1989，42，8： | 1 |
| 7 | Feeding trials of village children in Pakistan显示文摘 | F H Shah | 1984 | Protein research1984，50，： | 1 |
| 8 | Trabeculecto- my with mitomycin C in fractory glaucoma associated with non- necrotizing anterior scleritis 显示文摘 | Williams TA Sii F Chaing M Murray PI Shah P | 2009 | Ocal Immunol Inflamm2009，17，5： | 1 |
| 9 | Signed directed graph modeling and validation of industrial processes by process knowledge and process data 显示文摘 | YANG F SHAH S L XIAO D Y | 2012 | Interntional Journal of Applied Mathematics and Computer Science2012，22，1： | 1 |
| 10 | Improving the sensitivity of the Barthel Index for stroke rehabilitation 显示文摘 | Shah S Vanclay F Cooper B | 1989 | J Clin Epidemiol1989，42，8： | 1 |
| 11 | A systematic review of randomized trials evaluating regional techniques for postthoracotomy analgesia显示文摘 | Joshi GP Bonnet F Shah R | 2008 | Anesth Analg2008，107，3： | 1 |
| 12 | The role of peroxisome proliferator-activated receptors in carcinogenesis and chemoprevention 显示文摘 | Peters J M Shah Y M Gonzalez F J | 2012 | Nat Rev Cancer2012，12，3： | 1 |
| 13 | Speciation of arsenic and chromium in coal and combustion ash by XAFS spectroscopy显示文摘 | HUFFMAN G P HUGGINS F E SHAH N ZHAO J | 1994 | Fuel Process Technol1994，39，13： | 1 |
| 14 | Temporary self-expandable metal stent placement for treatment of post-sphincterotomy bleeding显示文摘 | Shah JN Marson F Binmoeller KF | | 0，，： | 1 |
| 15 | Conversion of amides to esters by the nickel-catalysed activation of amide CN bonds显示文摘 | Hie L Nathel N F F Shah T K | 2015 | Nature2015，524，： | 1 |
| 16 | Synthesis of the enantiomers ofPk 11195 and comparison of their behaviours as radi- oligands for Pk binding sites in rats显示文摘 | Shah F Hume SP Pik/e VW | 1994 | Nucl Med Biol1994，21，4： | 1 |
| 17 | Advantages of soft X-ray absorption over TEM-EELS for solid carbon studies-a comparative study on diesel soot with EELS and NEXAFS 显示文摘 | Braun A Huggins F E Shah N | 2005 | Physital Review B Condensed Matter2005，43，1： | 1 |
| 18 | Chronic,treatment-resistant depression and right tronto-striatal atrophy显示文摘 | Shah P J Glabus M F Goodwin G M | 2002 | J Clin Psychiatry2002，63，： | 1 |
| 19 | Identification of a salicylic acid-responsive element in the promoter of the tobacco pathogenesis-related beta-1,3-glucanase gene,PR-2d显示文摘 | SHAH J Klessig D F | 1996 | Plant J1996，10，6： | 1 |
| 20 | Design and analysis of post-coded OFDM systems显示文摘 | Shah S F A Tewfik A H | 2008 | IEEE Transactions on Wireless Communications2008，12，7： | 1 |
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