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| 1 | Liver transplantation for cholangiocarcinoma:Current status and new insights显示文摘Cholangiocarcinoma is a malignant tumor of the biliary system that can be classified into intrahepatic(i CCA),perihiliar(ph CCA) and distal. Initial experiences with orthotopic liver transplantation(OLT) for patientswith i CCA and ph CCA had very poor results and this treatment strategy was abandoned. In the last decade,thanks to a strict selection process and a neoadjuvant chemoradiation protocol,the results of OLT for patients with non-resectable phC CA have been shown to be excellent and this strategy has been extended worldwide in selected transplant centers. Intrahepatic cholangiocarcinoma is a growing disease in most countries and can be diagnosed both in cirrhotic and in non-cirrhotic livers. Even though OLT is contraindicated in most centers,recent investigations analyzing patients that were transplanted with a misdiagnosis of HCC and were found to have an iC CA have shown encouraging results. There is some information suggesting that patients with early stages of the disease could benefit from OLT. In this review we analyze the current stateof-the-art of OLT for cholangiocarcinoma as well as the new insights and future perspectives. | Gonzalo Sapisochín Elena Fernández de Sevilla Juan Echeverri Ramón Charco | 2015 | World Journal of Hepatology2015，7，22： | 8 |
| 2 | A randomized phase II study to compare oxaliplatin plus 5-fluorouracil and leucovorin (FOLFOX4) versus oxaliplatin plus raltitrexed (TOMOX) as first-line chemotherapy for advanced colorectal cancer显示文摘 | Cristina Gravalos Antonieta Salut Carlos García-Girón Rocío García-Carbonero Ana León Isabel Sevilla Joan Maurel Beatriz Esteban Eduardo García-Rico Adolfo Murias Hernán Cortés-Funes | 2012 | Clinical and Translational Oncology2012，，8： | 2 |
| 3 | WJH 6^(th) Anniversary Special Issues(1): Management of hepatocellular carcinoma Management of “very early” hepatocellular carcinoma on cirrhotic patients显示文摘Due to the advances in screening of cirrhotic patients, hepatocellular carcinoma(HCC) is being diagnosed in earlier stages. For this reason the number of patients diagnosed of very early HCC(single tumors ≤ 2 cm) is continuously increasing. Once a patient has been diagnosed with this condition, treatment strategies include liver resection, local therapies or liver transplantation. The decision on which therapy should the patient undergo depends on the general patients performance status and liver disease. Anyway, even in patients with similar conditions, the best treatment offer is debatable. In this review we analyze the state of the art on the management of very early HCC on cirrhotic patients to address the best treatment strategy for this patient population. | Gonzalo Sapisochin Elena Fernandez de Sevilla Juan Echeverri Ramón Charco | 2014 | World Journal of Hepatology2014，6，11： | 2 |
| 4 | Cephalometric features of filipions with angle class I occlusion according to the Munich analysis显示文摘 | Marian A Sevilla N Ingrid R J | 2004 | Angle Orthod2004，75，1： | 1 |
| 5 | Airlift-driven external-loop tubular photobioreactors for outdoor production of microalgae:Assessment of design and performance显示文摘 | Acién Fernández F G Fernández Sevilla J M Sánchez Pérez JA | 2001 | Chemical Engineering Science2001，56，8： | 1 |
| 6 | Cell recognition by foot-and-mouth disease virus that lacks the RGD integrin-binding motif:flexibility in aphthovirus receptor usage显示文摘 | Ruiz-Jarabo CM Sevilla N | 2000 | J Virol2000，74，4： | 1 |
| 7 | Heavy metal biosorption by gellan gum gel beads 显示文摘 | Lazaro N Sevilla A L Mofales S | 2003 | Water Res2003，37，： | 1 |
| 8 | Multiple virulence determinants of foot-and-mouth disease virus in cell culture显示文摘 | BARANOWSKI E SEVILLA N VERDAGUER N | 1998 | J Virol1998，72，： | 1 |
| 9 | , flexibility in aphthovirus receptor usage显示文摘 | Baranowski E Ruiz-Jarabo C M Sevilla N Cell recognition by foot-and-mouth disease virus that lacks the RGD integrin-binding motif | 2000 | J Virol2000，74，： | 1 |
| 10 | Cell recognition by Foot-and-mouth disease virus that lacks the RGD integrin-binding motif: flexibility in aphthovirus receptor usage 显示文摘 | Baranowski E Ruiz- Jarabo C M Sevilla N | 2000 | J Virol2000，74，4： | 1 |
| 11 | A similar pattern of interaction for different antibodies with a major antigenic site of foot-and-mouth disease virus:implications for intratypic antigenic variation显示文摘 | Verdaguer N Sevilla N Valero M L | 1998 | Virology1998，72，： | 1 |
| 12 | Cell recognition by foot-and-mouth disease virus that lacks the RGD integrin-binding motif:flexibility in aphthovirus receptor usage显示文摘 | BARANOWSKI E RUIZ-JARABO C M SEVILLA N | 2000 | J Virol2000，74，： | 1 |
| 13 | The physico-chemical characterization of a boiling stable antifreeze protein from a perennial grass (Lolium perenne)显示文摘 | PUDNEY P D A BUCKLEY S L SIDEBOTTOM C M TWIGG S N SEVILLA M P HOLT C B DAVID R TELFORD J H MCARTHUR A J LILLFORD P J | 2003 | Archives of Biochemistry and Biophysics2003，410，： | 1 |
| 14 | Antigenic properties and population stability of a foot-and-mouth disease virus with an altered Arg- Gly-Asp receptor recognition motif 显示文摘 | RUIZ-JARABO C M SEVILLA N M DA'VILA G | 1999 | J Gen Virol1999，80，： | 1 |
| 15 | Cell recognition by foot-and-mouth disease virus that lacks the RGD integrin-hinding motif:flexibility in aphthovirus receptor usage 显示文摘 | BARANOWSKI E RUI'Z-JARABO C M SEVILLA N | 2000 | J Virol2000，74，： | 1 |
| 16 | Cardiovascular effects of nebivolol in spontaneously hypertensive rats persist after treatment withdrawal显示文摘 | GUERRERO E I ARDANAZ N SEVILLA M A | 2006 | J Hypertens2006，24，1： | 1 |
| 17 | Heavy metal biosorption by gellan gum gel beads显示文摘 | Lázaro N Sevilla A L Morales S Marqués A M | | 0，，09： | 1 |
| 18 | Mul- tiple virulence determinants of foot-and-mouth disease virus in cell culture显示文摘 | BARANOWSKI E SEVILLA N VERDAGUER N etal | 1998 | J Virol1998，72，8： | 1 |
| 19 | Laparoscopic approach to esophageal perforation secondary to pneumatic dilation for achalasia显示文摘 | Andrés Sánchez-Pernaute Elia Pérez Aguirre Pablo Talavera Luis Díez Valladares Julio Pérez Serna Concepción Sevilla Mantilla Antonio Ruiz León Antonio Torres | 2009 | Surgical Endoscopy2009，，5： | 1 |
| 20 | Cell recognition by foot-and-mouth disease virus that lacks the RGD integrin-binding motif: flexibility in aphthovirus re- ceptor usage显示文摘 | BARANOWSKI E RUIZ-JARABO M SEVILLA N | 2000 | J Viro12000，74，4： | 1 |
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