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| 1 | Distribution of pericellular matrix molecules in the temporomandibular joint and their chondroprotective effects against inflammation显示文摘The objectives of this study were to(1) determine the distribution and synthesis of pericellular matrix(PCM) molecules(collagen VI, collagen IV and laminin) in rat temporomandibular joint(TMJ) and(2) investigate the effects of PCM molecules on chondrocytes against inflammation in osteoarthritis. Four zones(fibrous, proliferating, mature and hypertrophic) of condylar cartilage and three bands(anterior, intermediate and posterior) of disc were analysed by immunohistochemistry for the presence of PCM molecules in rat TMJs. Isolated chondrocytes were pre-treated with PCM molecules before being subjected to interleukin(IL)-1β treatment to stimulate inflammation. The responses of the chondrocytes were analysed using gene expression, nitric oxide release and matrix metalloproteinase(MMP)-13 production measures. Histomorphometric analyses revealed that the highest areal deposition of collagen VI(67.4%), collagen IV(45.7%) and laminin(52.4%) was in the proliferating zone of TMJ condylar cartilage. No significant difference in the distribution of PCM molecules was noted among the three bands of the TMJ disc. All three PCM molecules were expressed intracellularly by chondrocytes cultured in the monolayer. Among the PCM molecules, pre-treatment with collagen VI enhanced cellular proliferation, ameliorated IL-1β-induced MMP-3, MMP-9, MMP-13 and inducible nitric oxide synthase gene expression, and attenuated the downregulation of cartilage matrix genes, including collagen I, aggrecan and cartilage oligomeric matrix protein(COMP). Concurrently, collagen VI pretreatment inhibited nitric oxide and MMP-13 production. Our study demonstrates for the first time the distribution and role of PCM molecules, particularly collagen VI, in the protection of chondrocytes against inflammation. | Wern Cui Chu Shipin Zhang Timothy J Sng Yu Jie Ong Wen-Li Tan Vivien Y Ang Casper B Foldager Wei Seong Toh | 2017 | International Journal of Oral Science2017，9，1： | 5 |
| 2 | Immunogenicity of the E1E2 proteins of hepatitis C virus expressed by recombinant adenoviruses 显示文摘 | Seong Y R Choi S Lim J S | 2001 | Vaccine2001，19，2022： | 2 |
| 3 | Analysis of exonic splicing enhancers in the mouse ganadotropin-releasing hormone (GnRH) gene 显示文摘 | Han J Seong J Y Kim K | 2001 | Molecular and Cellular Endocrinology2001，173，12： | 1 |
| 4 | Dose-response relationship in local radiotherapy for hepatocellular carcinoma显示文摘 | Park HC Seong J Han KH | 1996 | Int J Radiat Oncol Biol Phys1996，40，1： | 1 |
| 5 | Intersecting a freeform surface with a general swept surface显示文摘 | Seong J -K Kim K -J Kim M -S | 2005 | ComputerAided Design2005，37，5： | 1 |
| 6 | High-level synthesis of recoverable VLSI microarchitectures显示文摘 | D M Blough F J Kurdahi Seong Yong Ohm | 1999 | IEEE Trans on VLSI Systems1999，7，4： | 1 |
| 7 | Enhancement of tumor radioresponse by wortmannin in C3H/HeJ hepatocarcinoma显示文摘 | Kim W Seong J An JH | 2007 | J Radiat Res(Tokyo)2007，48，3： | 1 |
| 8 | Local radiotherapy for unre- sectable hepatocellular carcinoma patients who failed with tran- scatheter arterial chemoembolization显示文摘 | Seong J Park HC Han KH | 2000 | Int J Radiat Oncol Biol Phys2000，47，5： | 1 |
| 9 | Investigation of curing kinetics of various cycloaliphatic epoxy resins using dynamic thermal analysis显示文摘 | Myong J Y Sang H K Seong D | 2010 | European Polymer Journal2010，46，5： | 1 |
| 10 | Estrogen receptor independent neurotoxic mechanism of bispheno! A, an environmental estrogen 显示文摘 | LEE Y M SEONG M J LEE J W | 2007 | J Vet Sci2007，8，1： | 1 |
| 11 | Simulation of deformation twins and deformation texture in an AZ31 Mg alloy under uniaxial compression 显示文摘 | CHOI S H SHIN E J SEONG B S | 2007 | Acta Materialia2007，55，12： | 1 |
| 12 | Experiments on Fourier Phases for Synthesis of Non-Gaussian Spikes in Turbulence Time Series显示文摘 | SEONG S H PETERKA J A | 2001 | Journal of Wind Engineering and Industrial Aerodynamics2001，89，6： | 1 |
| 13 | 显示文摘 | Jang J S Park S J Seong T Y | 2000 | Appl Phys Lett2000，88，： | 1 |
| 14 | Dose-response relationship in local radiotherapy for hepatocellular carcinoma显示文摘 | Seong J Han KH | 2002 | Int J Radiat Oncol Biol Phys2002，54，1： | 1 |
| 15 | Dose-response relationship in local radiotherapy for hepatocellular carcinoma显示文摘 | Park HC Seong J Hart KH | 2002 | Int J Radiat Oncol BiolPhys2002，54，1： | 1 |
| 16 | Local radiotherapy as a emnple- ment to incomplete transeatheter arterial ehemoembolization in lo- cally advanced hepatoeellular carcinoma 显示文摘 | Shim SJ Seong J Han KH | 2005 | Liver Int2005，25，6： | 1 |
| 17 | New hybrid method for simultaneousimprovement of tensile and impact properties of carbon fiber reinforcedcomposites显示文摘 | Seong Y K Soo J B Jae R Y | 2011 | Carbon2011，49，15： | 1 |
| 18 | Tyrosinase inhibitory polyphenols from roots of morus lhou 显示文摘 | Seong H J Young B R Marcus J C et a1 | 2009 | Journal of Agricultural and Food Chemistry2009，57，4： | 1 |
| 19 | Intrinsically Microporous Soluble Polyimides Incorporating Troger’s Base for Membrane Gas Separation显示文摘 | Zhuang Y Seong J G Do Y S | 2014 | Macromolecules2014，47，10： | 1 |
| 20 | Dose-response relation- ship in local radiotherapy for hepatocellular carcinoma显示文摘 | Park HC Seong J Han KH | 2002 | Int J Radiat Oncol Biol Phys2002，54，1： | 1 |
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