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| 1 | Predictors of re-hospitalization in patients with chronic heart failure显示文摘Heart failure (HF) is a chronic, progressive illness that is highly prevalent in the United States and worldwide. This morbid illness carries a very poor prognosis, and leads to frequent hospitalizations. Repeat hospitalization in HF is both largely burdensome to the patient and the healthcare system, as it is one of the most costly medical diagnoses among Medicare recipients. For years, investigators have strived to determine methods to reduce hospitalization rates of HF patients. Despite such efforts, recent reports indicate that rehospitalization rates remain persistently high, without any improvement over the past several years and thus, this topic clearly needs aggressive attention. We performed a key-word search of the literature for relevant citations. Published articles, limited to English abstracts indexed primarily in the PubMed database through the year 2011, were reviewed. This article discusses various clinical parameters, serum biomarkers, hemodynamic parameters, and psychosocial factors that have been reviewed in the literature as predictors of re-hospitalization of HF patients. With this information, ourhope is that the future holds better risk-stratification models that will allow providers to identify high-risk patients, and better customize effective interventions according to the needs of each individual HF patient. | Melody Zaya Anita Phan Ernst R Schwarz | 2012 | World Journal of Cardiology2012，4，2： | 5 |
| 2 | Flexibility in the order of action and in the enzymology of the nuclease, polymerases, and ligase of vertebrate non-homologous DNA end joining: relevance to cancer, aging, and the immune system显示文摘加入的 Nonhomologous 脱氧核糖核酸结束(NHEJ ) 是为在人的房间并且在多细胞的优核质的双海滨脱氧核糖核酸裂缝的修理的主要小径。双海滨裂缝的原因经常碎裂在损坏的地点的脱氧核糖核酸,导致在那里的信息的损失。NHEJ 不恢复失去的信息并且可以将切除另外的核苷酸在修理过程期间。修理大量 overhang 并且损坏配置的能力反映 NHEJ 的核酸酶,聚合酶,和连接酶的灵活性。单个部件的灵活性也解释 NHEJ 能在修理脱氧核糖核酸结束的任何给定的对的方法的大数字。局部地,在 NHEJ 的地点,修理可以贡献癌症和老化的信息的损失,而是由 NHEJ 的行动保证染色体的全部片断没被失去。 | Michael R Lieber Haihui Lu Jiafeng Gu Klaus Schwarz | 2008 | Cell Research2008，18，1： | 5 |
| 3 | Second-generation direct-acting-antiviral hepatitis C virus treatment: Efficacy, safety, and predictors of SVR12显示文摘AIM To gather data on the antiviral efficacy and safety of second generation direct acting antiviral(DAA) treatment with respect to sustained virological response(SVR) 12 wk after conclusion of treatment, and to determine predictors of SVR12 in this setting.METHODS Two hundred and sixty patients treated with SOF combination partners PR(n = 51), R(n = 10), SMV(n = 30), DCV(n = 81), LDV(n = 73), or 3D(n = 15).144/260 were pre-treated, 89/260 had liver cirrhosis, 56/260 had portal hypertension with platelets < 100/nL, 25/260 had a MELD score ≥ 10 and 17/260 were postliver transplantation patients. 194/260 had HCV GT1, 44/260 HCV GT3.RESULTS Two hundred and forty/256(93.7%) patients achieved SVR12(m ITT); 4/260 were lost to follow-up. SVR12 rates for subgroups were: 92% for SOF/DCV, 93% for each SOF/SMV, SOF/PR, 94% for SOF/LDV, 100% for 3D, 94% for pretreated, 87% for liver cirrhosis, 82% for patients with platelets < 100/n L, 88% post-liver transplantation, 95% for GT1 a, 93% for GT1 b, 90% for GT3, 100% for GT2, 4, and 6. 12 patients suffered from relapse, 6 prematurely discontinued treatment, of which 4 died. Negative predictors of SVR12 were a platelet count < 100/nL, MELD score ≥ 10(P < 0.0001), liver cirrhosis(P = 0.005) at baseline. In Interferonfree treatment GT3 had significantly lower SVR rates than GT1(P = 0.016). Side effects were mild. CONCLUSION Excellent SVR12 rates and the favorable side-effect profile of DAA-combination therapy can be well translated into 'real-world'. Patients with advanced liver disease, signs of portal hypertension, especially with platelets < 100/n L and patients with GT3 are in special need for further research efforts to overcome comparatively higher rates of virological failure. | Christoph R Werner Julia M Schwarz Daniel P Egetemeyr Robert Beck Nisar P Malek Ulrich M Lauer Christoph P Berg | 2016 | World Journal of Gastroenterology2016，22，35： | 2 |
| 4 | A model for heap bioleaching of chalcocite with heat balance: mesophiles and moderate thermophiles显示文摘 | Leahy M J Davidson M R Schwarz M P | 2007 | Hyclrometallurgy2007，85，1： | 1 |
| 5 | Psyehosocial aftercare of patients with endometrial or cervical cancer显示文摘 | Singer S Schwarz R | 2002 | Zentralbl Gynakol2002，124，1： | 1 |
| 6 | Band theory for the magnetic moment in the bcc Fe-Co alloy显示文摘 | Schwarz Karlheinz Salahub Dennis R | 1982 | Phys Rev B1982，25，： | 1 |
| 7 | Effect of stream channel size on the delivery of nitrogen to the Gulf of Mexico 显示文摘 | Alexander R B Smith R A Schwarz G E | 2000 | Nature2000，403，6771： | 1 |
| 8 | Uber gewisse nichtfortsetzbare potenzreihen I显示文摘 | SCHWARZ W WALLISSER R | 1973 | Mh Math1973，77，： | 1 |
| 9 | Quantitative analysis of lateral force microscopy experiments 显示文摘 | Schwarz U D Koster P Wiesendanger R | 1996 | Rev Sci Instrum1996，67，7： | 1 |
| 10 | Sonication of echo-contrast agent : A standardized and reproducible methed 显示文摘 | REISNER S A SHAPIRO J R SCHWARZ K Q | 1988 | J Cardiovasc Ultrasonography1988，7，4： | 1 |
| 11 | Mineral trioxide aggregate: a new material for endodontics 显示文摘 | Schwarz R Mauger M Clement D | 1999 | J Am Dent Assoc1999，130，： | 1 |
| 12 | Endovascular cooling for moderate hypothermia in patients with acute stroke:first results of a novel approach显示文摘 | Schwarz S Kollmar R | 2001 | Stroke2001，32，： | 1 |
| 13 | The role of radiotherapy in oseosarcoma显示文摘 | Schwarz R Bruland O Cassoni A | 2010 | Cancer Treat Res2010，152，： | 1 |
| 14 | Cell culture for threedimensional modeling in rotating wall vessels: an application in simulated microgravity显示文摘 | SCHWARZ R P GOODWIN T J WOLF D A | 1992 | J Tissue Culture Methods1992，14，： | 1 |
| 15 | The selective proteasome inhibitors lactacystin and epoxomicin can be used to either up-or down-regulate antigen presentation at nontoxic doses 显示文摘 | Schwarz K de Giuli R Schmidtke G | 2000 | J Immunol2000，164，12： | 1 |
| 16 | Synthesis of molybdenum disilicide by mechanical alloying 显示文摘 | Schwarz R B Srinivasan S R Petrovic J J | 1992 | Mater Sci Eng1992，155，： | 1 |
| 17 | Characteristics of infection with Candida species in patients with necrotizing pancreatitis显示文摘 | Isenmann R Schwarz M Rau B | 2002 | World J Surg2002，26，： | 1 |
| 18 | Sulfur allowance trading and the regional clean air incentives market:a comparative design analysis of two major cap-and-trade permit programs显示文摘 | SCHWARZE R ZAPFEL P | 2000 | Environmental and resource economics2000，，17： | 1 |
| 19 | Equation of state of silicon nitride carbodiimide Si2CN4显示文摘 | SOLOZHENKO V L SCHWARZ M RIEDEL R | 2004 | Solid State Commun2004，132，8： | 1 |
| 20 | In vivo protein transduction: delivery of a biologically active protein into the mouse显示文摘 | SCHWARZE S R HO A VOCERO-AKBANI A | 1999 | Science1999，285，5433： | 1 |
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