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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Four-year follow-up of endoscopic gastroplication for the treatment of gastroesophageal reflux disease显示文摘AIM:To evaluate the long-term effect of Endocinch treatment for gastroesophageal reflux disease(GERD).METHODS:After unblinding and crossover,50 patients(32 males,18 females; mean age 46 years) with pH-proven chronic GERD were recruited from an initial randomized,placebo-controlled,single-center study,and included in the present prospective open-label follow-up study.Initially,three gastroplications using the Endocinch device were placed under deep sedation in a standardized manner.Optional retreatment was offered in the first year with 1 or 2 extra gastroplications.At baseline,3 mo after(re) treatment and yearly proton pump inhibitor(PPI) use,GERD symptoms,quality of life(QoL) scores,adverse events and treatment failures(defined as:patients using > 50% of their baseline PPI dose or receiving alternative antireflux therapy) were assessed.Intention-to-treat analysis was performed.RESULTS:Median follow-up was 48 mo [interquartile range(IQR):38-52].Three patients were lost to follow-up.In 44% of patients retreatment was done after a median of 4 mo(IQR:3-8).No serious adverse events occurred.At the end of follow-up,symptom scores and4 out of 6 QoL subscales were improved(all P < 0.01compared to baseline).However,80% of patients required PPIs for their GERD symptoms.Ultimately,64% of patients were classified as treatment failures.In 60% a post-procedural endoscopy was carried out,of which in 16% reflux esophagitis was diagnosed.CONCLUSION:In the 4-year follow-up period,the subset of GERD patients that benefit from endoscopic gastroplication kept declining gradually,nearly half opted for retreatment and 80% required PPIs eventually. | Matthijs P Schwartz J Rieneke C Schreinemakers André J P M Smout | 2013 | World Journal of Gastrointestinal Pharmacology and Therapeutics2013，4，4： | 4 |
| 3 | 子宫颈癌累及泌尿生殖道:潜在的诊断困境显示文摘Schwartz L E, Khani F, Bishop J A, et al. Carcinoma of the u- terine cervix involving the genitourinary tract: a potential diag- nostic dilemma. Am J Surg Pathol, 2016,40(1) :27 -35.有关子宫颈癌继发累及泌尿生殖道的记载非常少见。由于形态学上这些肿瘤可以类似于尿路上皮癌,也可以与膀胱的原发性鳞状细胞癌和原发性腺癌非常相似,故诊断具有极大的挑战性。作者收集了约翰霍普金斯医院从1984年至今的泌尿生殖器咨询案例,主要包括原发性膀胱癌与子宫颈癌继发性累及膀胱的鉴别诊断病例。作者确定了10例满足这些标准的病例。 | Schwartz L E Khani F Bishop J A 魏建国 许春伟 | 2016 | 临床与实验病理学杂志2016，32，2： | 3 |
| 4 | Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries显示文摘冠的动脉把血流动带到心肌肉。理解冠的动脉的发展程序提供卓见进冠的动脉疾病的治疗。多重来源被描述了为包括 proepicardium,湾穴 venosus (SV ) ,和心内膜贡献冠的动脉。然而,冠的容器的发展起源仍然在强烈学习下面。我们为学习冠的开发生产了一个新基因工具,一只 AplnCreER 老鼠在开发冠的容器明确地衬里 recombinase,它表示可诱导的 Cre。冠的开发和 AplnCreER 命运跟踪的预定正式就职的定量分析证明 subepicardial endothelial 房间(EC ) 的子孙两个都入侵紧缩的心肌层形成冠的动脉并且在表面上留下生产静脉。我们发现这些 subepicardial EC 是 intramyocardial 的主要来源在发展中的心的冠的容器。在 vitro 将生物的活组织移植于培养基中培养,试金显示这些 subepicardial EC 的多数从 SV 和中庭的心内膜,然而并非从室的心内膜产生。Apln 积极的房间的同种细胞的分析显示单个 subepicardial EC 同等地作出贡献到冠的动脉和静脉。一起,这些数据建议 subepicardial EC 是 intramyocardial 的主要来源在室的冠的动脉墙,和那冠的动脉和静脉在发展中的心有普通起源。 | Xueying Tian Tianyuan Hu Hui Zhang Lingjuan He Xiuzhen Huang Qiaozhen Liu Wei Yu Liang He Zhongzhou Yang Zhen Zhang Tao P Zhong Xiao Yang Zhen Yang Yan Yan Antonio Baldini Yunfu Sun Jie Lu Robert J Schwartz Sylvia M Evans Adriana C Gittenberger-de Groot Kristy Red-Horse Bin Zhou | 2013 | Cell Research2013，23，9： | 3 |
| 5 | Application of positron emission tomography/computed tomography in radiation treatment planning for head and neck cancers显示文摘18-fluorodeoxygluocose positron emission tomography/computed tomography(18FDG-PET/CT) provides significant information in multiple settings in the management of head and neck cancers(HNC). This article seeks to define the additional benefit of PET/CT as related to radiation treatment planning for squamous cell carcinomas(SCCs) of the head and neck through a review of relevant literature. By helping further define both primary and nodal volumes, radiation treatment planning can be improved using PET/CT. Special attention is paid to the independent benefit of PET/CT in targeting mucosal primaries as well as in detecting nodal metastases. The utility of PET/CT is also explored for treatment planning in the setting of SCC of unknown primary as PET/CT may help define a mucosal target volume by guiding biopsies for examination under anesthesia thus changing the treatment paradigm and limiting the extent of therapy. Implications of the use of PET/CT for proper target delineation in patients with artifact from dental procedures are discussed and the impact of dental artifact on CT-based PET attenuation correction is assessed. Finally, comment is made upon the role of PET/CT in the high-risk post-operative setting, particularly in the context of radiation dose escalation. Real case examples are used in these settings to elucidate the practical benefits of PET/CT as related to radiation treatment planning in HNCs. | Musaddiq J Awan Farzan Siddiqui David Schwartz Jiankui Yuan Mitchell Machtay Min Yao | 2015 | World Journal of Radiology2015，7，11： | 2 |
| 6 | Consistent regulatory policy under uncertainty显示文摘 | Brennan M J Schwartz E S | 1982 | The Bell Journal of Economics1982，13，2： | 2 |
| 7 | Autophagy regulates adipose mass and differentiation in mice显示文摘 | Singh Rajat Xiang Youqing Wang Yongjun Baikati Kiran Cuervo Ana Maria Luu Yen K Tang Yan Pessin Jeffrey E Schwartz Gary J Czaja Mark J | 2009 | Journal of Clinical Investigation2009，，11： | 2 |
| 8 | Patients with chronic obstructive pulmonary disease are at increased risk of death associated with urban particle air pollution: a case-crossover analysis 显示文摘 | Sunyer J Schwartz J Tobias A | 2000 | Am J Epidemiol2000，151，： | 2 |
| 9 | A case-crossover analysis of air pollution and mortality in Philadelphia显示文摘 | Neas LM Schwartz J Dockery D | 1999 | Environ Health Perspect1999，107，： | 2 |
| 10 | Isolation and characterization of neural progenitor cells from post-mortem human cortex显示文摘 | SCHWARTZ P H BRYANT P J FUJA T J | 2003 | J Neurosci Res2003，74，6： | 1 |
| 11 | Convertible bonds: valuation and optimal strategies or call and conversion显示文摘 | Brennan M J Schwartz E S | 1977 | Journal of Finance1977，32，： | 1 |
| 12 | Lead-induced anemia: doseresponse relationships and evidence for a threshold 显示文摘 | Schwartz J Landrigan P J Baker E L | 1990 | American Journal Public Health1990，80，： | 1 |
| 13 | Basal insulin therapy in type 2 diabetes:28-week comparison of insulin glargine (HOE 901)and NPH insulin显示文摘 | Donley DW Schwartz SL | 2001 | Diabetes Care2001，24，： | 1 |
| 14 | Basal insulin glargine in patients with type 1 diabetes:28-week comparison of insulin glagine(HOE 901)and NPH insulin显示文摘 | Rosenstock J Schwartz SL Clarkk CM Jr | 2001 | Diabetes Care2001，24，4： | 1 |
| 15 | Wide band imped- ance matching: H∞ performance bounds显示文摘 | SCHWARTZ D F ALLEN J C | 2004 | IEEE Transactions on Circuit and Systems--II: Express Briefs2004，51，7： | 1 |
| 16 | Response and immunoresistance tobotulinum toxin injections显示文摘 | Jankovic J Schwartz KS | 1995 | Neurology1995，45，： | 1 |
| 17 | A proteornics approach to understanding protein ubiquitination显示文摘 | Peng J Schwartz D Elias JE | 2003 | Nat Biotechnol2003，21，： | 1 |
| 18 | Basal insulin therapy in type 2 diabetes:28-week comparison of insulin glargine(HOE901) and NPH insulin显示文摘 | Rosenstock J Schwartz SL Clark CM Jr | 2001 | Diabetes Care2001，24，4： | 1 |
| 19 | Time course of appearance and disappearance of human mast cell tryptase in the circulation after anaphylaxis显示文摘 | Schwartz LB Yunginger JW Miller J Bokhari R Dull D | 1989 | J Clin Invest1989，83，5： | 1 |
| 20 | Automotive Engine-Oil Condition Monitoring显示文摘 | Smolenski D J Schwartz S E | 1994 | Lubrication Engineering1994，50，9： | 1 |
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