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| 1 | Histological healing favors lower risk of colon carcinoma in extensive ulcerative colitis显示文摘AIM:To search for the answer in extensive ulcerative colitis as to whether histological inflammation persisting despite endoscopic mucosal healing serves to increase the risk of colon cancer(CC)or high grade dysplasia(HGD).METHODS:This is a single center(Lenox Hill Hospital)retrospective cohort and descriptive study of extensive ulcerative colitis(UC)for 20 years or more with a minimum of 3 surveillance colonoscopies and biopsies performed after the first 10 years of UC diagnosis.Data analyzed included:duration of UC,date of diagnosis of(CC)or(HGD),number of surveillance colonoscopies,and biopsies showing histological inflammation and its severity in each of 6 segments when endoscopic appearance is normal.Two subgroups of patients were compared:group 1 patients who developed CC/HGD and group 2 patients who did not develop CC/HGD.RESULTS:Of 115 patients with longstanding UC reviewed,68 patients met the inclusion criteria.Twenty patients were in group 1 and 48 in group 2.We identified the number of times for each patient when the endoscopic appearance was normal but biopsies nevertheless showed inflammation.Overall,histological disease activity in the absence of gross/endoscopic disease was found in 31.2%(95%CI:28%-35%)of colonoscopies performed on the entire cohort of 68 patients.Histological disease activity when the colonoscopy showed an absence of gross disease activity was more common in group 1 than group 2 patients,88%(95%CI:72%-97%)vs 59%(95%CI:53%-64%).Only 3/20(15%)of patients in group 1 ever had a colonoscopy completely without demonstrated disease activity(i.e.,no endoscopic or histological activity)as compared to 37/48(77%)of patients in group 2,and only 3.3%(95%CI:0.09%-8.3%)of colonoscopies in group 1 had no histological inflammation compared to23%(95%CI:20%-27%)in group 2.CONCLUSION:Progression to HGD or CC in extensive ulcerative colitis of long standing was more frequently encountered among those patients who demonstrate persistent histological inflammation in the absence of gross mucosal disease.Our findings support including the elimination of histological inflammation in the definition of mucosal healing,and support this endpoint as an appropriate goal of therapy because of its risk of increasing dysplasia and colon cancer. | Burton I Korelitz Keith Sultan Megha Kothari Leo Arapos Judy Schneider Georgia Panagopoulos | 2014 | World Journal of Gastroenterology2014，20，17： | 4 |
| 2 | Flocculation of fine fluorite particles with Corynebacterium xerosis显示文摘 | Haas S R Nascimento F R Schneider I A H | 1999 | Revista de Microbiologia1999，30，： | 1 |
| 3 | Hemophagocytic lymphohistiocytosis is associated with deficiencies of cellular cytolysis but normal expression of transcripts relevant to killer - cell - induced ap- optosis 显示文摘 | Schneider EM Lorenz I Muller - Rosenberger M | 2002 | Blood2002，100，8： | 1 |
| 4 | Possible physiological role of H19 RNA显示文摘 | Ayesh S Matouk I Schneider T | 2002 | Mol Carcinog2002，35，2： | 1 |
| 5 | From SHIQ and RDF to OWL: The making of a Web ontology language显示文摘 | HORROCKS I PETER F SCHNEIDER P | 2003 | Web Semantics2003，1，1： | 1 |
| 6 | Reducing OWL entailment to description logic satisfiability显示文摘 | HORROCKS I PATEL SCHNEIDER P F | 2004 | Journal of Web Semantics2004，1，4： | 1 |
| 7 | Circumferential mapping and electric isolation of pulmonary veins in patients with atrial fibrillation显示文摘 | Deisenhofer I Schneider MA Bohlen-Knauf M | 2003 | Am J Cardiol2003，91，2： | 1 |
| 8 | Safety of late second-trimester pregnancy termination by laminaria dilatation and evacuation in patients with previous multiple cesarean sections 显示文摘 | Ben-Ami I Schneider D Svirsky R | 2009 | Am J Obstet Gynecol2009，201，2： | 1 |
| 9 | A comparison of perioperative morbidity, perioperative mortality, and disease- specific survival in elderly women (>or=70 years)versus younger women (<70 years)with endometrioid endometrial cancer显示文摘 | Vaknin Z Ben-Ami I Schneider D | 2009 | Int J Gynecol Cancer2009，19，5： | 1 |
| 10 | Hypo- thalamopituitary dysfunction following traumatic brain injury andan- eurysmal subarachnoid hemorrhage 显示文摘 | Schneider HJ Kreitschmann-Andermahr I Ghigo E | 2007 | JAMA2007，298，12： | 1 |
| 11 | Paravertebral blockade in thoracoscopic surgery显示文摘 | Mowat I Schneider F Ghori A | 2012 | Eur J Cardiothorac Surg2012，42，2： | 1 |
| 12 | Laparoscopic abdomino-perineal resection of the rectum with high intersection of the inferior mesenteric artery显示文摘 | K(o)ckerling F Gastinger I Schneider B | 1992 | Chirurg1992，63，4： | 1 |
| 13 | Simultaneous determination of fluoroquinolones and tetracyclines in chicken musle using HPLC with fuorescence detection显示文摘 | SCHNEIDER M J BBRADEN S E REYES-HERRERA I etal | 2007 | Journal of Chromatography B2007，846，12： | 1 |
| 14 | Importance of conversion for results obtained with laparoscopic colorectal surgery显示文摘 | Marusch F gastinger I Schneider C | 2001 | Dis Colon Rectum2001，44，2： | 1 |
| 15 | Discriminates of twentieth-tentury change in earth surface temperatures显示文摘 | Schneider T I M Held | 2001 | Climate2001，14，： | 1 |
| 16 | Outcome of surgical treatment for superficial dyspareunia from vulvar vestibulitis 显示文摘 | Schneider D Yaron M Bukovsky I | 2001 | J Reprod Med2001，46，： | 1 |
| 17 | Modulated synthesis of Zr-fumarate MOF显示文摘 | Wiβmann G Schaate A Lilienthal S Bremer I Schneider A M | 2012 | Microporous and Mesoporous Materials2012，152，： | 1 |
| 18 | Diabetic atrial fibrillation patients:mortality and risk for stroke or embolism during a 10-year follow-up显示文摘 | Klem I Wehinger C Schneider B | 2003 | Diabetes Metab Res Rev2003，19，4： | 1 |
| 19 | Hydrometallurgical processing of carbon steel EAF dust显示文摘 | HAVLIK T VIDOR E SOUZA B BERNARDES A M SCHNEIDER I A MISKUFOVA A | 2006 | Journal of Hazardous Materials2006，135，13： | 1 |
| 20 | Laparoscopic abdominoperineal excision of the rectum with high ligation of the inferior mesenteric artery in the management of rectal carcinoma显示文摘 | Kockerling F Gastinger I Schneider B | 1993 | Endosc Surg Allied Technol1993，1，1： | 1 |
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