|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 2 | Risk of Intestinal Cancer in Inflammatory Bowel Disease: A Population-Based Study From Olmsted County, Minnesota显示文摘 | Tine Jess Edward V. Loftus Fernando S. Velayos W. Scott Harmsen Alan R. Zinsmeister Thomas C. Smyrk Cathy D. Schleck William J. Tremaine L. Joseph Melton Pia Munkholm William J. Sandborn | 2006 | Gastroenterology2006，，4： | 3 |
| 3 | Epidemiology of Eosinophilic Esophagitis Over Three Decades in Olmsted County, Minnesota显示文摘 | Ganapathy A. Prasad Jeffery A. Alexander Cathy D. Schleck Alan R. Zinsmeister Thomas C. Smyrk Richard M. Elias G. Richard Locke Nicholas J. Talley | 2009 | Clinical Gastroenterology and Hepatology2009，，10： | 2 |
| 4 | Dyspepsia and dyspepsia subgroups: a population based study 显示文摘 | Talley NJ Zinsmeister AR Schleck CD | 1992 | Gastroenterology1992，102，41： | 1 |
| 5 | Risk of gastroparesis in subjects with type 1 and 2 diabetes in the ge- neral population显示文摘 | CHOUNG R S LOCKE G R SCHLECK C D | 2012 | The American Journal of Gastroenterolo- gy2012，107，1： | 1 |
| 6 | Cumulative incidence of chronic constipation:a population based study 1988-2003显示文摘 | Choung R S Locke G R Schleck C D | 2007 | Aliment Pharmacol Ther2007，26，： | 1 |
| 7 | Risk of Intestinal Cancer in Inflammatory Bowel Disease: A Population-Based Study From Olmsted County, Minnesota显示文摘 | Tine Jess Edward V. Loftus Fernando S. Velayos W. Scott Harmsen Alan R. Zinsmeister Thomas C. Smyrk Cathy D. Schleck William J. Tremaine L. Joseph Melton Pia Munkholm William J. Sandborn | 2006 | Gastroenterology2006，，4： | 1 |
| 8 | Solitary fibrous tumors of the pleura:results of surgical treatment and longterm prognosis 显示文摘 | Harrison-Phipps KM Nichols FC Schleck CD | 2009 | J Thorac Cardiovaso Surg2009，138，1： | 1 |
| 9 | Dyspepsia and dyspepsia subgroups:a population-based study显示文摘 | Talley NJ Zinsmeister AR Schleck CD Melton LJ 3rd | 1992 | Gastroenterology1992，102，41： | 1 |
| 10 | Solitary fibrous tumors of the pleura:Results of surgical treatment and long-term prognosis显示文摘 | HARRISON-PHIPPS KM NICHOLS FC SCHLECK CD | 2009 | J Thorac Cardiovasc Surg2009，138，1： | 1 |
| 11 | Nat ural histor y offunctional gastrointestinal disorders:a 12-year longitudinalpopulation-based study显示文摘 | Halder SL Locke GR 3rd Schleck CD | 2007 | Gastroenterology2007，133，3： | 1 |
| 12 | Dislocation of bipolar hemiarthroplasty:rate,contributing factors,and outcome显示文摘 | Sierra RJ Schleck CD Cabanela ME | | 0，，： | 1 |
| 13 | Bowel Disturbances Are the Most Important Risk Factors for Late Onset Fecal Incontinence: A Population-Based Case-Control Study in Women显示文摘 | Adil E. Bharucha Alan R. Zinsmeister Cathy D. Schleck L. Joseph Melton | 2010 | Gastroenterology2010，，5： | 1 |
| 14 | Dislocation of bipolar hemiarthroplasty:rate,contributing factors,and outcome显示文摘 | Sierra RJ Schleck CD Cabanela ME | 2006 | Clin Orthop Relat Res2006，442，： | 1 |
| 15 | The cumulative long-term risk of dislocation after primary charnley total hip arthroplasty显示文摘 | Berry DJ Knoch MV Schleck CD | 2004 | J Bone Joint Surg(Am)2004，86，： | 1 |
| 16 | Cumulative incidence of chronic constipation: a population- based study 1988-2003 显示文摘 | Choung Rs Locke GR 3rd Schleck CD | 2007 | Aliment Pharmacol Ther2007，26，1112： | 1 |
| 17 | Dyspepsia and dyspepsia subgroups:a population-based study显示文摘 | Zinmeister A R Schleck C D | 1992 | J Gastroentrol1992，102，41： | 1 |
| 18 | Natural history of functional gastrointestinal disorders: a 12-year longitudinal population-based study显示文摘 | Halder SLj Locke GR 3rd Schleck CD | 2007 | Gastroenterology2007，133，3： | 1 |
| 19 | Current tobacco use is assoeiated with higher rates of implant revision and deep in- fection after total hip or knee arthroplasty: a prospective co- hort study 显示文摘 | Lewallen J Singh C Schleck W | 2015 | BMC Med2015，13，1： | 1 |
| 20 | Alimentary tract measurements as indicators of diets of small mammal显示文摘 | Schleck JO Millar JS | 1985 | Mammalia1985，49，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员